| Tag | Content |
|---|---|
| Uniprot ID | Q64010 |
| Entrez ID | 12928 |
| Genbank protein ID | AAB30755.1; BAC25976.1; |
| Genbank nucleotide ID | NM_133656.5 |
| Ensembl protein ID | ENSMUSP00000017920 |
| Ensembl nucleotide ID | ENSMUSG00000017776 |
| Gene name | Adapter molecule crk |
| Gene symbol | Crk |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 16880535 |
| Functional description | Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. |
| Sequence | MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY 60 IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVAR 120 SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG 180 MIPVPYVEKY RPASASVSAL IGGNQEGSHP QPLGGPEPGP YAQPSVNTPL PNLQNGPIYA 240 RVIQKRVPNA YDKTALALEV GELVKVTKIN VSGQWEGECN GKRGHFPFTH VRLLDQQNPD 300 EDFS 304 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | ISO |
| GO:0005070 | SH3/SH2 adaptor activity | ISO |
| GO:0005070 | SH3/SH2 adaptor activity | IPI |
| GO:0005159 | insulin-like growth factor receptor binding | ISO |
| GO:0005515 | protein binding | IPI |
| GO:0008092 | cytoskeletal protein binding | ISO |
| GO:0017124 | SH3 domain binding | ISO |
| GO:0019899 | enzyme binding | ISO |
| GO:0019904 | protein domain specific binding | ISO |
| GO:0030674 | protein binding, bridging | ISO |
| GO:0042169 | SH2 domain binding | ISO |
| GO:0043621 | protein self-association | ISO |
| GO:0045309 | protein phosphorylated amino acid binding | ISO |
| GO:0045309 | protein phosphorylated amino acid binding | IDA |
| GO:0046875 | ephrin receptor binding | ISO |
| GO:0046875 | ephrin receptor binding | IPI |
| GO:0097110 | scaffold protein binding | ISO |
| GO:1990782 | protein tyrosine kinase binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001764 | neuron migration | IGI |
| GO:0001878 | response to yeast | IEA |
| GO:0002685 | regulation of leukocyte migration | IGI |
| GO:0006629 | lipid metabolic process | IGI |
| GO:0008360 | regulation of cell shape | ISS |
| GO:0008360 | regulation of cell shape | ISO |
| GO:0009966 | regulation of signal transduction | ISO |
| GO:0009967 | positive regulation of signal transduction | IEA |
| GO:0014911 | positive regulation of smooth muscle cell migration | ISO |
| GO:0016358 | dendrite development | IGI |
| GO:0021766 | hippocampus development | IGI |
| GO:0021987 | cerebral cortex development | IGI |
| GO:0030010 | establishment of cell polarity | IGI |
| GO:0030036 | actin cytoskeleton organization | ISS |
| GO:0030036 | actin cytoskeleton organization | ISO |
| GO:0030307 | positive regulation of cell growth | ISO |
| GO:0032956 | regulation of actin cytoskeleton organization | ISS |
| GO:0032956 | regulation of actin cytoskeleton organization | ISO |
| GO:0032956 | regulation of actin cytoskeleton organization | IGI |
| GO:0033628 | regulation of cell adhesion mediated by integrin | IGI |
| GO:0035020 | regulation of Rac protein signal transduction | ISO |
| GO:0035685 | helper T cell diapedesis | IGI |
| GO:0035728 | response to hepatocyte growth factor | ISO |
| GO:0038026 | reelin-mediated signaling pathway | IGI |
| GO:0042542 | response to hydrogen peroxide | ISO |
| GO:0043087 | regulation of GTPase activity | ISS |
| GO:0043087 | regulation of GTPase activity | ISO |
| GO:0043393 | regulation of protein binding | ISO |
| GO:0045953 | negative regulation of natural killer cell mediated cytotoxicity | ISO |
| GO:0048013 | ephrin receptor signaling pathway | ISS |
| GO:0048013 | ephrin receptor signaling pathway | ISO |
| GO:0050773 | regulation of dendrite development | IGI |
| GO:0060326 | cell chemotaxis | IGI |
| GO:0061045 | negative regulation of wound healing | ISO |
| GO:0061847 | response to cholecystokinin | ISO |
| GO:0071560 | cellular response to transforming growth factor beta stimulus | ISO |
| GO:0071732 | cellular response to nitric oxide | ISO |
| GO:0090630 | activation of GTPase activity | IGI |
| GO:0098749 | cerebellar neuron development | IGI |
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | ISS |
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | ISO |
| GO:1901652 | response to peptide | ISO |
| GO:1990090 | cellular response to nerve growth factor stimulus | ISO |
| GO:1990314 | cellular response to insulin-like growth factor stimulus | ISO |
| GO:1990859 | cellular response to endothelin | ISO |
| GO:2000146 | negative regulation of cell motility | ISO |
| GO:2000404 | regulation of T cell migration | IGI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005737 | cytoplasm | IEA |
| GO:0005886 | plasma membrane | IEA |
| GO:0015629 | actin cytoskeleton | IDA |
| GO:0032991 | protein-containing complex | ISO |
| GO:0045121 | membrane raft | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109582 | Hemostasis | IEA |
| R-MMU-1280215 | Cytokine Signaling in Immune system | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-166520 | Signaling by NTRKs | IEA |
| R-MMU-168249 | Innate Immune System | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-169893 | Prolonged ERK activation events | IEA |
| R-MMU-170984 | ARMS-mediated activation | IEA |
| R-MMU-186763 | Downstream signal transduction | IEA |
| R-MMU-186797 | Signaling by PDGF | IEA |
| R-MMU-187037 | Signaling by NTRK1 (TRKA) | IEA |
| R-MMU-187687 | Signalling to ERKs | IEA |
| R-MMU-194138 | Signaling by VEGF | IEA |
| R-MMU-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | IEA |
| R-MMU-2029482 | Regulation of actin dynamics for phagocytic cup formation | IEA |
| R-MMU-354192 | Integrin signaling | IEA |
| R-MMU-372708 | p130Cas linkage to MAPK signaling for integrins | IEA |
| R-MMU-4420097 | VEGFA-VEGFR2 Pathway | IEA |
| R-MMU-449147 | Signaling by Interleukins | IEA |
| R-MMU-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | IEA |
| R-MMU-6806834 | Signaling by MET | IEA |
| R-MMU-76002 | Platelet activation, signaling and aggregation | IEA |
| R-MMU-76009 | Platelet Aggregation (Plug Formation) | IEA |
| R-MMU-8848021 | Signaling by PTK6 | IEA |
| R-MMU-8849471 | PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases | IEA |
| R-MMU-8875555 | MET activates RAP1 and RAC1 | IEA |
| R-MMU-8875656 | MET receptor recycling | IEA |
| R-MMU-8875878 | MET promotes cell motility | IEA |
| R-MMU-9006927 | Signaling by Non-Receptor Tyrosine Kinases | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| R-MMU-912631 | Regulation of signaling by CBL | IEA |