| Tag | Content |
|---|---|
| Uniprot ID | Q64028; P70359; Q64307; Q8BZ80; |
| Entrez ID | 13619 |
| Genbank protein ID | AAB31766.1; AAH46535.1; AAC28974.1; BAC29400.1; |
| Genbank nucleotide ID | NM_001271579.1 |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Polyhomeotic-like protein 1 |
| Gene symbol | Phc1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 16024804; 9367423; |
| Functional description | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression (By similarity). |
| Sequence | METESEQNSS STNGSSSSGA SSRPQIAQMS LYERQAVQAL QALQRQPNAA QYFHQFMLQQ 60 QLSNAQLHSL AAVQQATIAA SRQASSPNSS TAQQQTATTQ ASMNLATTSA AQLISRSQSV 120 SSPSATTLTQ SVLLGNTTSP PLNQSQAQMY LRPQLGNLLQ VNRTLGRNVP LASQLILMPN 180 GAVAAVQQEV PPAQSPGVHA DADQVQNLAV RNQQASAQGP QMPGSTQKAI PPGASPVSGL 240 SQTSSQALAV AQASSGASGQ SLNLSQAGGG SGNSLPGSMG PGGGGQAPGG LGQLPSSGLT 300 GGSCPRKGTG VVQPLPAAQT VTVSQGSQTE AESAAAKKAE ADGSGQQSVG MNLTRTATPA 360 PSQTLISSAT YTQIQPHSLI QQQQQIHLQQ KQVVIQQQIA IHHQQQFQHR QSQLLHTATH 420 LQLAQQQQQQ QQQQQQQQQQ QQQQQQQQGT TLTAPQPPQV PPTQQVPPSQ SQQQAQTLVV 480 QPMLQSSPLT LPPEPTSKPP IPIQSKPPVA PIKPPQLGAA KMSATQQPPP HIPVQVVGTR 540 QPGSAQAQAL GLAQLAAAVP TPRGITGAVQ PGQAHLASSP PSSQAAPGAL QECPPALAAG 600 MTLAPVQGTA HVVKGGPTAS SPVVAQVPAA FYMQSVHLPG KAQTLAVKRK AESEEERDDL 660 SALASVLPTK ASPAAESPKV IEEKNSLGEK AEPVASLNAN PPNSDLVALA PTPSAPPPTL 720 ALVSRQMGDS KPPQAIVKPQ ILTHIIEGFV IQEGAEPFPV GCSQFLKETE KPLQAGLPTG 780 LNESQPSGPL GGDSPSVELE KKANLLKCEY CGKYAPAEQF RGSKRFCSMT CAKRYNVSCS 840 HQFRLKRKKM KEFQEASYAR VRRRGPRRSS SDIARAKIQG KRHRGQEDSS RGSDNSSYDE 900 ALSPTSPGPL SVRAGHGERD LGNTITTPST PELQGINPVF LSSNPSQWSV EEVYEFIASL 960 QGCQEIAEEF RSQEIDGQAL LLLKEEHLMS AMNIKLGPAL KICAKINVLK ET 1012 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003677 | DNA binding | IEA |
| GO:0003682 | chromatin binding | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0008270 | zinc ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007275 | multicellular organism development | IEA |
| GO:0016574 | histone ubiquitination | ISS |
| GO:0016574 | histone ubiquitination | ISO |
| GO:0071300 | cellular response to retinoic acid | IDA |
| GO:1990830 | cellular response to leukemia inhibitory factor | IEP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001739 | sex chromatin | IDA |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0016604 | nuclear body | IDA |
| GO:0031519 | PcG protein complex | ISO |
| GO:0035102 | PRC1 complex | ISS |
| GO:0035102 | PRC1 complex | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1257604 | PIP3 activates AKT signaling | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-212436 | Generic Transcription Pathway | IEA |
| R-MMU-2262752 | Cellular responses to stress | IEA |
| R-MMU-2559580 | Oxidative Stress Induced Senescence | IEA |
| R-MMU-2559583 | Cellular Senescence | IEA |
| R-MMU-2990846 | SUMOylation | IEA |
| R-MMU-3108214 | SUMOylation of DNA damage response and repair proteins | IEA |
| R-MMU-3108232 | SUMO E3 ligases SUMOylate target proteins | IEA |
| R-MMU-3899300 | SUMOylation of transcription cofactors | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-4551638 | SUMOylation of chromatin organization proteins | IEA |
| R-MMU-4570464 | SUMOylation of RNA binding proteins | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |
| R-MMU-6807070 | PTEN Regulation | IEA |
| R-MMU-73857 | RNA Polymerase II Transcription | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| R-MMU-8878171 | Transcriptional regulation by RUNX1 | IEA |
| R-MMU-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | IEA |
| R-MMU-8943724 | Regulation of PTEN gene transcription | IEA |
| R-MMU-8953750 | Transcriptional Regulation by E2F6 | IEA |
| R-MMU-8953897 | Cellular responses to external stimuli | IEA |
| R-MMU-9006925 | Intracellular signaling by second messengers | IEA |
| Pfam ID | Pfam Term |
|---|---|
| PF00536 | SAM_1 |