| Tag | Content |
|---|---|
| Uniprot ID | Q6AZB0; Q6KAM5; Q6P5H3; Q7TMJ3; Q8CE73; Q8CE91; Q8R377; Q923W7; |
| Entrez ID | 117606 |
| Genbank protein ID | AAH26443.1; AAH62892.1; AAH56138.1; AAK71999.1; AAH78631.1; BAC26176.1; BAC26110.1; BAD21432.1; |
| Genbank nucleotide ID | NM_172506.2 |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Brother of CDO |
| Gene symbol | Boc |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 21183473 |
| Functional description | Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. |
| Sequence | MTTCRRERPI LTLLWILMAT AGCLADLNEV PQVTVQPMST VQKLGGTVIL GCVVEPPWMN 60 VTWRFNGKEL NGSDDALGVF ITRGTLVIAA LNNHTVGRYQ CVARMPAGAV ASVPATVTLA 120 NLQDFKLDVQ HVIEVDEGNT AVIACHLPES HPKAQVRYSV KQEWLEASRD NYLIMPSGNL 180 QIVNASQEDE GMYKCAAYNP VTQEVKTSGS GDRLRVRRST AEAARIIYPL EAQTVIVTKG 240 QSLILECVAS GIPPPRVTWA KDGSSIAAYN KTRFLLSNLL IDTTSEEDSG TYRCMASNGV 300 GDPGAAVILY NVQVFEPPEV TVELSQLVIP WGQSAKLTCE VRGNPPPSVL WLRNAVPLTS 360 SQRLRLSRRA LRVVSVGPED EGVYQCMAEN AVGSAHAVVQ LRTARPDTTL RPGRDTKPIA 420 ATPPMPPSRP SRPDQMLREQ PGLVKPPTSS VQPTSLKCPG EEQVAPAEAP IILSSPRTSK 480 TDSYELVWRP RHEGSSRTPI LYYVVKHRKV TNSSDDWTIS GIPANQHRLT LTRLDPGSLY 540 EVEMAAYNCA GEGQTAMVTF RTGRRPKPEI VASKEQQIQR DDPGASLQSS SQPDHGRLSP 600 PEAPDRPTIS TASETSVYVT WIPRGNGGFP IQSFRVEYKK LKKVGDWILA TSAIPPSRLS 660 VEITGLEKGI SYKFRVRALN MLGESEPSAP SRPYVVSGYS GRVYERPVAG PYITFTDAVN 720 ETTIMLKWMY IPASNNNTPI HGFYIYYRPT DSDNDSDYKK DMVEGDRYWH SISHLQPETS 780 YDIKMQCFNE GGESEFSNVM ICETKARKFS GQPGRPPPLT LAPPQPPPLE TMERPVGTGA 840 MVARASDLPY LIVGVVLGSI VLIIVTFIPF CLWRAWSKQK HTTDLGFPRS ALLSSSCQYT 900 MVPLEGLPGH QANGQPYLGG VSGRACVSRV HGSRGCPAAT VGCPGRKPQQ HCPGELAQQR 960 EDTNSQLRQP IVSNGYDLQN QQVARGPQCA SGVGAFLYTL PDDSTHQLLQ PQDCCHLQKQ 1020 PVTTCQTAVR RTSESPGLES SWDPPYHSGP RCCLGLVPVE EVDSSDSCQV GGGDWSSQHP 1080 SGTYTGQERG MRFSPSPSVH VSFETPPPTI |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007224 | smoothened signaling pathway | IDA |
| GO:0007411 | axon guidance | IMP |
| GO:0007411 | axon guidance | ISO |
| GO:0016202 | regulation of striated muscle tissue development | ISO |
| GO:0030030 | cell projection organization | IMP |
| GO:0045663 | positive regulation of myoblast differentiation | IMP |
| GO:0098609 | cell-cell adhesion | TAS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005654 | nucleoplasm | ISO |
| GO:0005886 | plasma membrane | TAS |
| GO:0005887 | integral component of plasma membrane | ISA |
| GO:0009986 | cell surface | TAS |
| GO:0030424 | axon | IDA |
| GO:0030426 | growth cone | IDA |
| GO:0043025 | neuronal cell body | IDA |
| GO:0044295 | axonal growth cone | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-525793 | Myogenesis | IEA |
| R-MMU-5358351 | Signaling by Hedgehog | IEA |
| R-MMU-5632684 | Hedgehog 'on' state | IEA |
| R-MMU-5635838 | Activation of SMO | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0025 | Alternative splicing |
| KW-0130 | Cell adhesion |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0393 | Immunoglobulin domain |
| KW-0472 | Membrane |
| KW-0621 | Polymorphism |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |