| Tag | Content |
|---|---|
| Uniprot ID | Q6QNF3 |
| Entrez ID | 442985 |
| Genbank protein ID | AAS48371.1 |
| Genbank nucleotide ID | NM_001003382.1; XM_005618872.2; XM_005618873.2; |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Platelet-derived growth factor receptor beta |
| Gene symbol | PDGFRB |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor (By similarity). |
| Sequence | MQVPGTMPAP VLKGQALWLP LLLMLSPQAS GGLVITPPGP ELVLNISSTF VLTCSGPAPV 60 VWERLSQEPL QKMARTQDGT FSSTLTLTNV TGLDTGEYFC TYKGSHGLEP DGRKRLYIFV 120 PDPTMGFLPV DPEELFIFLT EITEITIPCR VTDPRLVVTL HEKKVDIPLP IPYDHQRGFS 180 GTFEDKTYVC KTTIGDKEVD SEAYYVYSLQ VSSINVSVNA VQTVVRQGEN ITIMCIVTGN 240 EVVNFEWTYP RMESGRLVEP VTDFLFNVPS HIRSILHIPS AELGDSGTYI CNVSESVNDH 300 RDEKSINVTV VESGYVRLLG ELDAVQFAEL HRSRALQVVF EAYPPPTVVW FKDNRTLGDS 360 SAGEIALSTR NVSETRYVSE LTLVRVKVAE AGYYTMRAFH EDAEAQLSFQ LQVNVPVRVL 420 ELSESHPASG EQTVRCRGRG MPQPHLTWST CSDLKRCPRE LPPTPLGNSS EEESQLETNV 480 TYWPEDQEFE VVSTLRLRRV DQPLSVRCTL HNLLGHDMQE VTVVPHSLPF KVVVISAILA 540 LVVLTIISLI ILIMLWQKKP RYEIRWKVIE SVSSDGHEYI YVDPMQLPYD STWELPRDQL 600 VLGRTLGSGA FGQVVEATAH GLSHSQATMK VAVKMLKSTA RSSEKQALMS ELKIMSHLGP 660 HLNVVNLLGA CTKGGPIYII TEYCRYGDLV DYLHRNKHTF LQLCSDKRRP PSAELYSNAL 720 PAGLPLPSHV SLPGESDGGY MDMSKDESVD YVPMLDMKGG VKYADIESSS YMAPYDNYVP 780 TAPERTCRAT LINESPVLSY TDLVGFSYQV ANGMEFLASK NCVHRDLAAR NVLICEGKLV 840 KICDFGLARD IMRDSNYISK GSTFLPLKWM APESIFNSLY TTLSDVWSFG ILLWEIFTLG 900 GTPYPELPMN EQFYNAIKRG YRMAQPAHAS DEIYEIMQKC WEEKFEIRPP FSQLVLLLER 960 LLGEGYKKKY QQVDEEFLRS DHPAVLRSQA RLPGFPGLRS PLDTSSVLYT AVQPNEGDND 1020 YIIPLPDPKP EVADGPLESS PSLASSTLNE VNTSSTISCD SPLEPQEEPE PEPEPQPEPQ 1080 VVPEPPLDSS CPGPRAEAED SFL 1103 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term |
|---|---|
| GO:0016324 | apical plasma membrane |
| GO:0005737 | cytoplasm |
| GO:0031410 | cytoplasmic vesicle |
| GO:0005887 | integral component of plasma membrane |
| GO:0031226 | intrinsic component of plasma membrane |
| GO:0043202 | lysosomal lumen |
| GO:0005634 | nucleus |
| GO:0005886 | plasma membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0019838 | growth factor binding |
| GO:0005019 | platelet-derived growth factor beta-receptor activity |
| GO:0048407 | platelet-derived growth factor binding |
| GO:0005017 | platelet-derived growth factor-activated receptor activity |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0016477 | cell migration |
| GO:0060981 | cell migration involved in coronary angiogenesis |
| GO:0035441 | cell migration involved in vasculogenesis |
| GO:0006935 | chemotaxis |
| GO:0002244 | hematopoietic progenitor cell differentiation |
| GO:0007275 | multicellular organism development |
| GO:0018108 | peptidyl-tyrosine phosphorylation |
| GO:0046488 | phosphatidylinositol metabolic process |
| GO:0048015 | phosphatidylinositol-mediated signaling |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0033674 | positive regulation of kinase activity |
| GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| GO:0010863 | positive regulation of phospholipase C activity |
| GO:0032516 | positive regulation of phosphoprotein phosphatase activity |
| GO:0014911 | positive regulation of smooth muscle cell migration |
| GO:0048661 | positive regulation of smooth muscle cell proliferation |
| GO:0046777 | protein autophosphorylation |
| GO:0061298 | retina vasculature development in camera-type eye |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0145 | Chemotaxis |
| KW-0968 | Cytoplasmic vesicle |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0458 | Lysosome |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| KW-0832 | Ubl conjugation |
| InterPro ID | InterPro Term |
|---|---|
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR013151 | Immunoglobulin |
| IPR011009 | Kinase-like_dom_sf |
| IPR027288 | PGFRB |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR001824 | Tyr_kinase_rcpt_3_CS |