CleftGeneDB-Search

Gene: TMEM107

Basic information

Tag	Content
Uniprot ID	Q6UX40; A0PJV7; Q6NSE3; Q6ZRX9; Q96T82;
Entrez ID	84314
Genbank protein ID	AAQ88889.1; BAC87177.1; AAK38512.1; AAI27650.1; AAH70231.1;
Genbank nucleotide ID	NM_032354.3; NM_183065.2;
Ensembl protein ID	ENSP00000436674; ENSP00000314116; ENSP00000402732;
Ensembl nucleotide ID	ENSG00000179029
Gene name	Transmembrane protein 107
Gene symbol	TMEM107
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (PubMed:26518474).
Sequence	MGRVSGLVPS RFLTLLAHLV VVITLFWSRD SNIQACLPLT FTPEEYDKQD IQLVAALSVT 60 LGLFAVELAG FLSGVSMFNS TQSLISIGAH CSASVALSFF IFERWECTTY WYIFVFCSAL 120 PAVTEMALFV TVFGLKKKPF

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Protein disorder visualization from D2P2 is currently unavailable.

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	TMEM107	509812	A4IFS9		Bos taurus	Prediction	More>>
1:1 ortholog	TMEM107	102173966	A0A452G122		Capra hircus	Prediction	More>>
1:1 ortholog	TMEM107	100062420	F6ZQI0		Equus caballus	Prediction	More>>
1:1 ortholog	TMEM107	84314	Q6UX40		Homo sapiens	Prediction	More>>
1:1 ortholog	Tmem107	66910	Q9CPV0	CPO	Mus musculus	Publication	More>>
1:1 ortholog	TMEM107	100620379	I3LUH9		Sus scrofa	Prediction	More>>
1:1 ortholog	Tmem107	691750	D3ZFW5		Rattus norvegicus	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs758042017	p.Arg3Gln	missense variant	-	NC_000017.11:g.8176279C>T	ExAC,gnomAD
rs758042017	p.Arg3Pro	missense variant	-	NC_000017.11:g.8176279C>G	ExAC,gnomAD
rs1158816213	p.Gly6Arg	missense variant	-	NC_000017.11:g.8176271C>T	TOPMed
rs746705243	p.Pro9His	missense variant	-	NC_000017.11:g.8176261G>T	TOPMed,gnomAD
rs746705243	p.Pro9Leu	missense variant	-	NC_000017.11:g.8176261G>A	TOPMed,gnomAD
rs779192623	p.Pro9Ser	missense variant	-	NC_000017.11:g.8176262G>A	ExAC,TOPMed,gnomAD
rs746705243	p.Pro9Arg	missense variant	-	NC_000017.11:g.8176261G>C	TOPMed,gnomAD
rs764486156	p.Arg11His	missense variant	-	NC_000017.11:g.8176255C>T	ExAC,gnomAD
rs756257026	p.Phe12Leu	missense variant	-	NC_000017.11:g.8176251G>T	ExAC,TOPMed,gnomAD
rs1172454509	p.Thr14Met	missense variant	-	NC_000017.11:g.8176246G>A	gnomAD
rs752816091	p.Ala17Thr	missense variant	-	NC_000017.11:g.8176238C>T	ExAC,gnomAD
rs759772085	p.Leu25Ter	stop gained	-	NC_000017.11:g.8176213A>T	ExAC,TOPMed,gnomAD
rs759772085	p.Leu25Ser	missense variant	-	NC_000017.11:g.8176213A>G	ExAC,TOPMed,gnomAD
rs991836698	p.Phe26Leu	missense variant	-	NC_000017.11:g.8176209G>C	TOPMed,gnomAD
rs1178144948	p.Phe26Ile	missense variant	-	NC_000017.11:g.8176211A>T	gnomAD
rs765044785	p.Trp27Ser	missense variant	-	NC_000017.11:g.8176207C>G	ExAC,gnomAD
rs553369646	p.Arg29Gly	missense variant	-	NC_000017.11:g.8176202G>C	1000Genomes,ExAC,gnomAD
rs776684584	p.Arg29Pro	missense variant	-	NC_000017.11:g.8176201C>G	ExAC,TOPMed,gnomAD
rs752678483	p.Asp30Glu	missense variant	-	NC_000017.11:g.8176024G>C	ExAC,TOPMed,gnomAD
rs1049214287	p.Asp30Asn	missense variant	-	NC_000017.11:g.8176026C>T	TOPMed,gnomAD
rs767410741	p.Gln34His	missense variant	-	NC_000017.11:g.8176012C>G	ExAC,TOPMed,gnomAD
rs1392368949	p.Gln34Ter	stop gained	-	NC_000017.11:g.8176014G>A	gnomAD
rs1466090000	p.Cys36Ter	stop gained	-	NC_000017.11:g.8176006G>T	gnomAD
rs759112528	p.Pro38Leu	missense variant	-	NC_000017.11:g.8176001G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Leu39Val	missense variant	-	NC_000017.11:g.8175999G>C	NCI-TCGA
rs762443312	p.Thr40Met	missense variant	-	NC_000017.11:g.8175995G>A	ExAC,TOPMed,gnomAD
rs569789530	p.Thr40Ser	missense variant	-	NC_000017.11:g.8175996T>A	1000Genomes,ExAC,gnomAD
rs1220984648	p.Pro43Leu	missense variant	-	NC_000017.11:g.8175986G>A	TOPMed
rs770238344	p.Pro43Thr	missense variant	-	NC_000017.11:g.8175987G>T	ExAC,TOPMed,gnomAD
COSM986190	p.Glu44Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000017.11:g.8175982C>A	NCI-TCGA Cosmic
rs1555526172	p.Glu45Gly	missense variant	-	NC_000017.11:g.8175980T>C	-
rs1555526172	p.Glu45Gly	missense variant	Orofaciodigital syndrome 16 (OFD16)	NC_000017.11:g.8175980T>C	UniProt,dbSNP
VAR_079328	p.Glu45Gly	missense variant	Orofaciodigital syndrome 16 (OFD16)	NC_000017.11:g.8175980T>C	UniProt
rs1261826107	p.Glu45Lys	missense variant	-	NC_000017.11:g.8175981C>T	TOPMed
RCV000495828	p.Glu45Gly	missense variant	OROFACIODIGITAL SYNDROME XVI (OFD16)	NC_000017.11:g.8175980T>C	ClinVar
rs747145199	p.Tyr46Ter	stop gained	-	NC_000017.11:g.8175976A>C	ExAC,gnomAD
rs1430166494	p.Tyr46Cys	missense variant	-	NC_000017.11:g.8175977T>C	TOPMed,gnomAD
rs1201413781	p.Lys48Asn	missense variant	-	NC_000017.11:g.8175970C>G	TOPMed
rs779940342	p.Lys48Arg	missense variant	-	NC_000017.11:g.8175971T>C	ExAC,gnomAD
rs377543068	p.Asp50His	missense variant	-	NC_000017.11:g.8175966C>G	ESP
rs1314276935	p.Ile51Thr	missense variant	-	NC_000017.11:g.8175962A>G	gnomAD
rs143165118	p.Leu53Pro	missense variant	-	NC_000017.11:g.8175855A>G	ESP,TOPMed
rs1241028740	p.Leu53Met	missense variant	-	NC_000017.11:g.8175856G>T	gnomAD
rs892821655	p.Ala55Val	missense variant	-	NC_000017.11:g.8175849G>A	TOPMed
rs745927685	p.Ala56Gly	missense variant	-	NC_000017.11:g.8175846G>C	ExAC,TOPMed,gnomAD
COSM708547	p.Ala56Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000017.11:g.8175847C>A	NCI-TCGA Cosmic
rs1397722725	p.Thr60Ile	missense variant	-	NC_000017.11:g.8175834G>A	gnomAD
rs780895688	p.Gly62Val	missense variant	-	NC_000017.11:g.8175828C>A	ExAC,gnomAD
rs747945881	p.Gly62Ser	missense variant	-	NC_000017.11:g.8175829C>T	ExAC,TOPMed,gnomAD
rs1203000720	p.Val66Met	missense variant	-	NC_000017.11:g.8175817C>T	TOPMed
rs1488298029	p.Leu68Arg	missense variant	-	NC_000017.11:g.8175810A>C	TOPMed
rs979857583	p.Leu68Val	missense variant	-	NC_000017.11:g.8175811G>C	TOPMed
rs766320339	p.Ala69Asp	missense variant	-	NC_000017.11:g.8175807G>T	ExAC,gnomAD
rs765045090	p.Gly70Cys	missense variant	-	NC_000017.11:g.8175805C>A	ExAC,gnomAD
rs761499511	p.Gly70Asp	missense variant	-	NC_000017.11:g.8175804C>T	ExAC,gnomAD
rs765045090	p.Gly70Ser	missense variant	-	NC_000017.11:g.8175805C>T	ExAC,gnomAD
rs1416997604	p.Leu72Phe	missense variant	-	NC_000017.11:g.8175799G>A	gnomAD
rs969768247	p.Ser73Leu	missense variant	-	NC_000017.11:g.8175795G>A	TOPMed
NCI-TCGA novel	p.Gly74Ter	stop gained	-	NC_000017.11:g.8175793C>A	NCI-TCGA
rs1024416036	p.Val75Ile	missense variant	-	NC_000017.11:g.8175790C>T	TOPMed
rs1379136806	p.Asn79Ser	missense variant	-	NC_000017.11:g.8175777T>C	TOPMed
rs139253975	p.Ser83Gly	missense variant	-	NC_000017.11:g.8175766T>C	ESP,ExAC,TOPMed,gnomAD
rs1350125374	p.Ile85Thr	missense variant	-	NC_000017.11:g.8175759A>G	gnomAD
rs752106357	p.Ile87Thr	missense variant	-	NC_000017.11:g.8174613A>G	ExAC,TOPMed,gnomAD
rs755459310	p.Ile87Val	missense variant	-	NC_000017.11:g.8174614T>C	ExAC,gnomAD
rs766838320	p.Ala89Val	missense variant	-	NC_000017.11:g.8174607G>A	ExAC,gnomAD
rs1263560335	p.Cys91Tyr	missense variant	-	NC_000017.11:g.8174601C>T	TOPMed
rs763090139	p.Ser92Asn	missense variant	-	NC_000017.11:g.8174598C>T	ExAC,gnomAD
rs1365234036	p.Ser94Thr	missense variant	-	NC_000017.11:g.8174593A>T	TOPMed,gnomAD
rs1408799401	p.Ser94Phe	missense variant	-	NC_000017.11:g.8174592G>A	gnomAD
rs765395687	p.Val95Gly	missense variant	-	NC_000017.11:g.8174589A>C	ExAC,gnomAD
rs762032078	p.Ala96Val	missense variant	-	NC_000017.11:g.8174586G>A	ExAC,TOPMed,gnomAD
rs1023372990	p.Ala96Thr	missense variant	-	NC_000017.11:g.8174587C>T	TOPMed
rs1485211497	p.Ser98Phe	missense variant	-	NC_000017.11:g.8174580G>A	gnomAD
NCI-TCGA novel	p.Phe99Leu	missense variant	-	NC_000017.11:g.8174576G>T	NCI-TCGA
VAR_079329	p.Phe100del	inframe_deletion	Orofaciodigital syndrome 16 (OFD16) [MIM:617563]	-	UniProt
VAR_079329	p.Phe100del	inframe_deletion	Meckel syndrome 13 (MKS13) [MIM:617562]	-	UniProt
rs775179939	p.Phe102Leu	missense variant	-	NC_000017.11:g.8174567G>T	ExAC,TOPMed,gnomAD
COSM4852818	p.Glu103Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000017.11:g.8174566C>G	NCI-TCGA Cosmic
rs538821271	p.Arg104Gly	missense variant	-	NC_000017.11:g.8174563G>C	1000Genomes,ExAC,gnomAD
rs538821271	p.Arg104Ser	missense variant	-	NC_000017.11:g.8174563G>T	1000Genomes,ExAC,gnomAD
rs1368021784	p.Arg104Pro	missense variant	-	NC_000017.11:g.8174562C>G	TOPMed
rs1368021784	p.Arg104His	missense variant	-	NC_000017.11:g.8174562C>T	TOPMed
NCI-TCGA novel	p.Trp105Ter	stop gained	-	NC_000017.11:g.8174558C>T	NCI-TCGA
rs745637850	p.Glu106Asp	missense variant	-	NC_000017.11:g.8174555C>G	ExAC,gnomAD
COSM4070948	p.Cys107Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000017.11:g.8174554A>G	NCI-TCGA Cosmic
rs1371849426	p.Thr109Met	missense variant	-	NC_000017.11:g.8174547G>A	gnomAD
rs770976637	p.Tyr112Ter	stop gained	-	NC_000017.11:g.8174537G>T	ExAC,TOPMed,gnomAD
rs1203515924	p.Ala119Gly	missense variant	-	NC_000017.11:g.8174270G>C	gnomAD
rs1415518421	p.Ala122Thr	missense variant	-	NC_000017.11:g.8174262C>T	gnomAD
rs761706473	p.Glu125Val	missense variant	-	NC_000017.11:g.8174252T>A	ExAC,gnomAD
rs1261556427	p.Ala127Thr	missense variant	-	NC_000017.11:g.8174247C>T	TOPMed,gnomAD
RCV000495830	p.Leu128Ter	frameshift	Meckel syndrome 13 (MKS13)	NC_000017.11:g.8174242del	ClinVar
rs747577985	p.Val130Ile	missense variant	-	NC_000017.11:g.8174238C>T	ExAC,gnomAD
rs747577985	p.Val130Leu	missense variant	-	NC_000017.11:g.8174238C>G	ExAC,gnomAD
rs780962917	p.Val132Leu	missense variant	-	NC_000017.11:g.8174232C>G	ExAC,TOPMed,gnomAD
rs780962917	p.Val132Ile	missense variant	-	NC_000017.11:g.8174232C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Leu135Pro	missense variant	-	NC_000017.11:g.8174222A>G	NCI-TCGA
rs1212456331	p.Lys136Gln	missense variant	-	NC_000017.11:g.8174220T>G	gnomAD
rs780331583	p.Lys137Glu	missense variant	-	NC_000017.11:g.8174217T>C	ExAC,gnomAD
rs750897292	p.Lys137Asn	missense variant	-	NC_000017.11:g.8174215C>A	ExAC,TOPMed,gnomAD
rs758934871	p.Lys137Arg	missense variant	-	NC_000017.11:g.8174216T>C	ExAC,TOPMed,gnomAD
rs779269009	p.Pro139Arg	missense variant	-	NC_000017.11:g.8174210G>C	ExAC,gnomAD
rs757401163	p.Phe140Leu	missense variant	-	NC_000017.11:g.8174206G>T	ExAC,gnomAD
NCI-TCGA novel	p.Phe140Leu	missense variant	-	NC_000017.11:g.8174206G>C	NCI-TCGA
rs371112854	p.Ter141Trp	stop lost	-	NC_000017.11:g.8174203T>C	ESP,ExAC
NCI-TCGA novel	p.Ter141ArgGluUnkThrTerUnk	stop lost	-	NC_000017.11:g.8174205A>G	NCI-TCGA

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0009714	Hepatic Fibrosis, Congenital	disease	HPO
C0010417	Cryptorchidism	disease	HPO
C0014065	Congenital cerebral hernia	disease	HPO
C0020534	Orbital separation excessive	phenotype	HPO
C0025990	Micrognathism	disease	HPO
C0026010	Microphthalmos	disease	HPO
C0029124	Optic Atrophy	disease	HPO
C0029294	Orofaciodigital Syndromes	disease	BEFREE;CLINVAR
C0079924	Oligohydramnios	phenotype	HPO
C0086543	Cataract	disease	HPO
C0152427	Polydactyly	disease	BEFREE
C0265215	Meckel-Gruber syndrome	disease	ORPHANET
C0266544	Microcornea	disease	HPO
C0424688	Small head	phenotype	HPO
C0431362	Lobar Holoprosencephaly	disease	HPO
C0431399	Familial aplasia of the vermis	disease	BEFREE
C0431904	Ulnar polydactyly of fingers	disease	HPO
C1167713	Decreased corneal diameter	phenotype	HPO
C1301937	Talipes	disease	HPO
C1510460	Orofaciodigital Syndrome I	disease	BEFREE
C1510497	Lens Opacities	phenotype	HPO
C1709353	Osteofibrous Dysplasia	disease	BEFREE
C1842876	Depressed nasal ridge	phenotype	HPO
C1853235	Sclerocornea	disease	HPO
C1857130	Hypoplastic mandible condyle	phenotype	HPO
C1857486	Low-set, posteriorly rotated ears	phenotype	HPO
C1857679	Sloping forehead	phenotype	HPO
C1866231	Full cheeks	phenotype	HPO
C2112129	Postaxial foot polydactyly	disease	HPO
C2748653	Chubby cheeks	phenotype	HPO
C2981150	Uranostaphyloschisis	disease	HPO
C3550658	Maternal oligohydramnios	phenotype	HPO
C3552713	Talipes foot deformities	phenotype	HPO
C3714506	Meckel syndrome type 1	disease	BEFREE
C3714581	Multicystic Dysplastic Kidney	disease	HPO
C3806443	Puffy cheeks	phenotype	HPO
C4020865	Fibular polydactyly	disease	HPO
C4024589	Aplasia/Hypoplasia of the mandible	phenotype	HPO
C4024748	Aplasia/Hypoplasia of the iris	phenotype	HPO
C4025844	Chorioretinal abnormality	phenotype	HPO
C4277690	Ciliopathies	group	BEFREE;GENOMICS_ENGLAND
C4280625	Decreased size of eyeball	phenotype	HPO
C4280647	Hypertrophy of cheeks	phenotype	HPO
C4280648	Hyperplasia of cheeks	phenotype	HPO
C4280808	Abnormally small eyeball	phenotype	HPO
C4476523	Decreased projection of lower jaw	phenotype	HPO
C4476524	Decreased projection of mandible	phenotype	HPO
C4476525	Retrusion of lower jaw	phenotype	HPO
C4539714	MECKEL SYNDROME 13	disease	CLINVAR
C4539715	JOUBERT SYNDROME 29	disease	CLINVAR
C4539729	OROFACIODIGITAL SYNDROME XVI	disease	CLINVAR;UNIPROT

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0003674	molecular_function	ND
GO:0005515	protein binding	IPI

GO:Biological Process

GO ID	GO Term	Evidence
GO:0021532	neural tube patterning	IEA
GO:0042733	embryonic digit morphogenesis	IEA
GO:0060271	cilium assembly	ISS
GO:0060271	cilium assembly	IDA
GO:1904491	protein localization to ciliary transition zone	IBA
GO:1905515	non-motile cilium assembly	IBA
GO:1905515	non-motile cilium assembly	IMP

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0016021	integral component of membrane	IEA
GO:0035869	ciliary transition zone	IBA
GO:0035869	ciliary transition zone	IDA
GO:0036038	MKS complex	IBA
GO:0036038	MKS complex	IDA

Reactome Pathway

Reactome ID	Reactome Term	Evidence

Drugs and compounds information

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of TMEM107 mRNA	19095052
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM107 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM107 mRNA	27188386
C496492	abrine	abrine results in decreased expression of TMEM107 mRNA	31054353
D000082	Acetaminophen	Acetaminophen results in increased expression of TMEM107 mRNA	22230336
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of TMEM107 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of TMEM107 mRNA	23630614
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of TMEM107 mRNA	26705709
D001554	Benzene	Benzene results in decreased expression of TMEM107 mRNA	15929907
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of TMEM107 mRNA	30951980
C006780	bisphenol A	bisphenol A affects the expression of TMEM107 mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of TMEM107 mRNA	25047013
C006780	bisphenol A	bisphenol A results in decreased expression of TMEM107 mRNA	26063408
C006780	bisphenol A	bisphenol A affects the expression of TMEM107 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of TMEM107 mRNA	30816183
D002117	Calcitriol	Calcitriol results in decreased expression of TMEM107 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in decreased expression of TMEM107 mRNA	21592394
D002737	Chloroprene	Chloroprene results in increased expression of TMEM107 mRNA	23125180
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TMEM107 gene	20938992
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of TMEM107 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of TMEM107 mRNA	27392435; 27594783;
D003375	Coumestrol	[Coumestrol co-treated with Resveratrol] results in increased expression of TMEM107 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of TMEM107 mRNA	19167446
D003471	Cuprizone	Cuprizone results in increased expression of TMEM107 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of TMEM107 mRNA	25562108
D003634	DDT	DDT results in increased expression of TMEM107 mRNA	25014179
C516138	dorsomorphin	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM107 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM107 mRNA	27188386
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal results in decreased expression of TMEM107 mRNA	29667321
D004365	Drugs, Chinese Herbal	Drugs, Chinese Herbal results in increased expression of TMEM107 mRNA	23811387
D004726	Endosulfan	Endosulfan results in increased expression of TMEM107 mRNA	29391264
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of TMEM107 mRNA	23649840
D017313	Fenretinide	Fenretinide results in decreased expression of TMEM107 mRNA	28973697
D017313	Fenretinide	Fenretinide results in increased expression of TMEM107 mRNA	28973697
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TMEM107 gene	20938992
D005557	Formaldehyde	Formaldehyde results in increased expression of TMEM107 mRNA	23649840
C039281	furan	furan results in increased expression of TMEM107 mRNA	27387713
C000593030	GSK-J4	GSK-J4 results in decreased expression of TMEM107 mRNA	29301935
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of TMEM107 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of TMEM107 mRNA	27392435
D019344	Lactic Acid	Lactic Acid results in decreased expression of TMEM107 mRNA	30851411
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TMEM107 gene	20938992
D008727	Methotrexate	Methotrexate results in decreased expression of TMEM107 mRNA	24449571
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of TMEM107 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of TMEM107 mRNA	23649840
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in decreased expression of TMEM107 mRNA	25554681
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in increased expression of TMEM107 mRNA	25620056
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of TMEM107 mRNA	25554681
D009285	Naphthoquinones	Naphthoquinones results in increased expression of TMEM107 mRNA	23811387
C017096	n-butoxyethanol	n-butoxyethanol results in increased expression of TMEM107 mRNA	19812364
D009532	Nickel	Nickel results in decreased expression of TMEM107 mRNA	25583101
D020245	p-Chloromercuribenzoic Acid	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TMEM107 mRNA	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of TMEM107 mRNA	26272509
C006253	pirinixic acid	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TMEM107 mRNA	19710929
D011441	Propylthiouracil	Propylthiouracil results in increased expression of TMEM107 mRNA	24780913
D000077185	Resveratrol	[Coumestrol co-treated with Resveratrol] results in increased expression of TMEM107 mRNA	19167446
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of TMEM107 mRNA	21427059
C017947	sodium arsenite	sodium arsenite affects the expression of TMEM107 mRNA	29319823
D053260	Soot	Soot affects the expression of TMEM107 mRNA	26551751
C016766	sulforafan	sulforafan results in increased expression of TMEM107 mRNA	30529165
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in decreased expression of TMEM107 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of TMEM107 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TMEM107 mRNA	21570461
C009495	titanium dioxide	titanium dioxide affects the expression of TMEM107 mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in decreased expression of TMEM107 mRNA	29264374
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of TMEM107 mRNA	28065790
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of TMEM107 mRNA	26179874
D014414	Tungsten	Tungsten results in increased expression of TMEM107 mRNA	30912803
D014520	Urethane	Urethane results in increased expression of TMEM107 mRNA	28818685
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TMEM107 mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of TMEM107 mRNA	19101580; 23179753; 26272509; 28001369;
D014635	Valproic Acid	Valproic Acid results in increased expression of TMEM107 mRNA	21427059
C025643	vinclozolin	vinclozolin results in decreased expression of TMEM107 mRNA	23555832
D014750	Vincristine	Vincristine results in decreased expression of TMEM107 mRNA	23649840

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0025	Alternative splicing
KW-0966	Cell projection
KW-1186	Ciliopathy
KW-0970	Cilium biogenesis/degradation
KW-0217	Developmental protein
KW-0225	Disease mutation
KW-0325	Glycoprotein
KW-0981	Meckel syndrome
KW-0472	Membrane
KW-1185	Reference proteome
KW-0812	Transmembrane
KW-1133	Transmembrane helix

Interpro

InterPro ID	InterPro Term
IPR029248	TMEM107

PROSITE

PROSITE ID	PROSITE Term

Pfam

Pfam ID	Pfam Term
PF14995	TMEM107