CleftGeneDB-Search

Gene: RSPO2

Basic information

Tag	Content
Uniprot ID	Q6UXX9; B3KVP0; Q4G0U4; Q8N6X6;
Entrez ID	340419
Genbank protein ID	AAQ88533.1; AAH36554.1; AAH27938.1; EAW91916.1; BAG53852.1;
Genbank nucleotide ID	NM_001317942.1; NM_001282863.1; NM_178565.4;
Ensembl protein ID	ENSP00000276659; ENSP00000428940; ENSP00000427937;
Ensembl nucleotide ID	ENSG00000147655
Gene name	R-spondin-2
Gene symbol	RSPO2
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21909076, PubMed:21727895, PubMed:22615920). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (PubMed:29769720).
Sequence	MQFRLFSFAL IILNCMDYSH CQGNRWRRSK RASYVSNPIC KGCLSCSKDN GCSRCQQKLF 60 FFLRREGMRQ YGECLHSCPS GYYGHRAPDM NRCARCRIEN CDSCFSKDFC TKCKVGFYLH 120 RGRCFDECPD GFAPLEETME CVEGCEVGHW SEWGTCSRNN RTCGFKWGLE TRTRQIVKKP 180 VKDTILCPTI AESRRCKMTM RHCPGGKRTP KAKEKRNKKK KRKLIERAQE QHSVFLATDR 240 ANQ 243

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Developmental stage	Species	Evidence	Details
1:1 ortholog	RSPO2	482004	F1P932			Canis lupus familiaris	Prediction	More>>
1:1 ortholog	RSPO2	100860771	A0A452FDY5			Capra hircus	Prediction	More>>
1:1 ortholog	RSPO2	100056523	A8C9U1			Equus caballus	Prediction	More>>
1:1 ortholog	RSPO2	340419	Q6UXX9			Homo sapiens	Prediction	More>>
1:1 ortholog	Rspo2	239405	Q8BFU0	CPO,CLP	E14.5, E15.5	Mus musculus	Publication	More>>
1:1 ortholog	RSPO2	464335	A0A2I3RH49			Pan troglodytes	Prediction	More>>
1:1 ortholog	RSPO2		A0A5G2RDB4			Sus scrofa	Prediction	More>>
1:1 ortholog	Rspo2	500863	I7GAZ6			Rattus norvegicus	Prediction	More>>
1:1 ortholog	rspo2	566054	F1Q5C9			Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs1468346288	p.Gln2Lys	missense variant	-	NC_000008.11:g.108082635G>T	gnomAD
COSM4932095	p.Gln2Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.108082634T>C	NCI-TCGA Cosmic
rs1271453894	p.Arg4Cys	missense variant	-	NC_000008.11:g.108082629G>A	TOPMed,gnomAD
rs1271453894	p.Arg4Gly	missense variant	-	NC_000008.11:g.108082629G>C	TOPMed,gnomAD
rs757934532	p.Leu5Pro	missense variant	-	NC_000008.11:g.108082625A>G	ExAC,TOPMed,gnomAD
rs555188515	p.Leu5Phe	missense variant	-	NC_000008.11:g.108082626G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs555188515	p.Leu5Ile	missense variant	-	NC_000008.11:g.108082626G>T	1000Genomes,ExAC,TOPMed,gnomAD
rs1270740681	p.Phe6Leu	missense variant	-	NC_000008.11:g.108082623A>G	TOPMed
NCI-TCGA novel	p.Ser7Cys	missense variant	-	NC_000008.11:g.108082619G>C	NCI-TCGA
NCI-TCGA novel	p.Phe8Cys	missense variant	-	NC_000008.11:g.108082616A>C	NCI-TCGA
rs752314217	p.Leu10Val	missense variant	-	NC_000008.11:g.108082611G>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ile11Thr	missense variant	-	NC_000008.11:g.108082607A>G	NCI-TCGA
rs148112629	p.Ile11Val	missense variant	-	NC_000008.11:g.108082608T>C	ESP,ExAC,TOPMed,gnomAD
rs148112629	p.Ile11Leu	missense variant	-	NC_000008.11:g.108082608T>G	ESP,ExAC,TOPMed,gnomAD
rs761309497	p.Ile11Met	missense variant	-	NC_000008.11:g.108082606G>C	ExAC,TOPMed,gnomAD
rs773874508	p.Leu13Pro	missense variant	-	NC_000008.11:g.108082601A>G	ExAC,gnomAD
rs1345485042	p.Cys15Arg	missense variant	-	NC_000008.11:g.108082596A>G	gnomAD
rs370155369	p.Met16Val	missense variant	-	NC_000008.11:g.108082593T>C	ESP,ExAC,TOPMed,gnomAD
COSM1094782	p.Asp17Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.108082590C>T	NCI-TCGA Cosmic
COSM6112004	p.Asp17Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.108082588A>T	NCI-TCGA Cosmic
rs768980014	p.Ser19Arg	missense variant	-	NC_000008.11:g.108082582G>T	ExAC,gnomAD
rs1454064180	p.Gly23Ser	missense variant	-	NC_000008.11:g.108082572C>T	gnomAD
rs541770055	p.Asn24Lys	missense variant	-	NC_000008.11:g.108082567G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs143724513	p.Arg25Gly	missense variant	-	NC_000008.11:g.108082566G>C	ESP,ExAC,TOPMed,gnomAD
rs770791000	p.Arg27Ile	missense variant	-	NC_000008.11:g.108082559C>A	ExAC,TOPMed,gnomAD
rs777420823	p.Arg28His	missense variant	-	NC_000008.11:g.108082556C>T	ExAC,gnomAD
rs777420823	p.Arg28Leu	missense variant	-	NC_000008.11:g.108082556C>A	ExAC,gnomAD
COSM145895	p.Arg28Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.108082557G>A	NCI-TCGA Cosmic
rs758105036	p.Ser29Cys	missense variant	-	NC_000008.11:g.108082554T>A	ExAC,gnomAD
rs752266481	p.Lys30Glu	missense variant	-	NC_000008.11:g.108082551T>C	ExAC
NCI-TCGA novel	p.Lys30Arg	missense variant	-	NC_000008.11:g.108082550T>C	NCI-TCGA
NCI-TCGA novel	p.Lys30Thr	missense variant	-	NC_000008.11:g.108082550T>G	NCI-TCGA
rs368258992	p.Arg31Pro	missense variant	-	NC_000008.11:g.108082547C>G	ESP
NCI-TCGA novel	p.Ser33Arg	missense variant	-	NC_000008.11:g.107989240A>C	NCI-TCGA
rs763230106	p.Tyr34Cys	missense variant	-	NC_000008.11:g.107989238T>C	ExAC,gnomAD
rs1399270598	p.Val35Ile	missense variant	-	NC_000008.11:g.107989236C>T	TOPMed
rs765464784	p.Ser36Leu	missense variant	-	NC_000008.11:g.107989232G>A	ExAC,gnomAD
rs1158899940	p.Asn37Ser	missense variant	-	NC_000008.11:g.107989229T>C	TOPMed
rs1366699334	p.Asn37Lys	missense variant	-	NC_000008.11:g.107989228A>T	TOPMed
rs759729631	p.Gly42Arg	missense variant	-	NC_000008.11:g.107989215C>G	ExAC,TOPMed
RCV000656658	p.Gly42Ter	frameshift	TETRAAMELIA SYNDROME 2 (TETAMS2)	NC_000008.11:g.107989216del	ClinVar
rs1249794255	p.Cys43Tyr	missense variant	-	NC_000008.11:g.107989211C>T	gnomAD
NCI-TCGA novel	p.Cys43Arg	missense variant	-	NC_000008.11:g.107989212A>G	NCI-TCGA
NCI-TCGA novel	p.Leu44Val	missense variant	-	NC_000008.11:g.107989209A>C	NCI-TCGA
rs368908416	p.Ser45Pro	missense variant	-	NC_000008.11:g.107989206A>G	ESP,ExAC,gnomAD
rs766437369	p.Ser45Phe	missense variant	-	NC_000008.11:g.107989205G>A	ExAC,TOPMed,gnomAD
rs867807924	p.Cys46Phe	missense variant	-	NC_000008.11:g.107989202C>A	gnomAD
rs760755130	p.Cys46Trp	missense variant	-	NC_000008.11:g.107989201A>C	ExAC,gnomAD
COSM3924472	p.Asp49Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107989194C>T	NCI-TCGA Cosmic
rs1344257606	p.Asn50Ser	missense variant	-	NC_000008.11:g.107989190T>C	TOPMed
NCI-TCGA novel	p.Gly51Glu	missense variant	-	NC_000008.11:g.107989187C>T	NCI-TCGA
COSM453838	p.Gly51Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107989187C>A	NCI-TCGA Cosmic
COSM748829	p.Gly51Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107989188C>G	NCI-TCGA Cosmic
rs747919315	p.Cys52Arg	missense variant	-	NC_000008.11:g.107989185A>G	ExAC,gnomAD
rs774174845	p.Cys52Phe	missense variant	-	NC_000008.11:g.107989184C>A	ExAC,gnomAD
rs768464293	p.Ser53Asn	missense variant	-	NC_000008.11:g.107989181C>T	ExAC,gnomAD
COSM748830	p.Ser53Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107989180G>C	NCI-TCGA Cosmic
rs539897843	p.Arg54Gln	missense variant	-	NC_000008.11:g.107989178C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs1460069208	p.Arg54Ter	stop gained	-	NC_000008.11:g.107989179G>A	gnomAD
rs1280882436	p.Cys55Arg	missense variant	-	NC_000008.11:g.107989176A>G	TOPMed
NCI-TCGA novel	p.Gln57His	missense variant	-	NC_000008.11:g.107989168C>A	NCI-TCGA
rs779767746	p.Leu59Phe	missense variant	-	NC_000008.11:g.107989162C>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Phe60Leu	missense variant	-	NC_000008.11:g.107989161A>G	NCI-TCGA
rs149399382	p.Phe60Leu	missense variant	-	NC_000008.11:g.107989159G>C	ESP,TOPMed
rs149399382	p.Phe60Leu	missense variant	-	NC_000008.11:g.107989159G>T	ESP,TOPMed
COSM748831	p.Phe62Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107989154A>G	NCI-TCGA Cosmic
COSM748832	p.Leu63Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107989152G>A	NCI-TCGA Cosmic
rs182334537	p.Arg64Gln	missense variant	-	NC_000008.11:g.107989148C>T	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg64Ter	stop gained	-	NC_000008.11:g.107989149G>A	NCI-TCGA
rs182334537	p.Arg64Pro	missense variant	-	NC_000008.11:g.107989148C>G	1000Genomes,ExAC,TOPMed,gnomAD
rs189754456	p.Glu66Asp	missense variant	-	NC_000008.11:g.107989141T>G	1000Genomes,TOPMed
rs745308347	p.Glu66Lys	missense variant	-	NC_000008.11:g.107989143C>T	ExAC,gnomAD
rs778172689	p.Gly67Arg	missense variant	-	NC_000008.11:g.107989140C>G	ExAC,gnomAD
rs1455373749	p.Gly67Val	missense variant	-	NC_000008.11:g.107989139C>A	gnomAD
COSM3643898	p.Gly67Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107989139C>T	NCI-TCGA Cosmic
COSM6112005	p.Gly67Trp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107989140C>A	NCI-TCGA Cosmic
rs758888137	p.Arg69Ser	missense variant	-	NC_000008.11:g.107989134G>T	ExAC,TOPMed,gnomAD
rs758888137	p.Arg69Cys	missense variant	-	NC_000008.11:g.107989134G>A	ExAC,TOPMed,gnomAD
rs747238565	p.Arg69His	missense variant	-	NC_000008.11:g.107989133C>T	ExAC,TOPMed,gnomAD
RCV000656660	p.Arg69Cys	missense variant	HUMEROFEMORAL HYPOPLASIA WITH RADIOTIBIAL RAY DEFICIENCY (HHRRD)	NC_000008.11:g.107989134G>A	ClinVar
VAR_081036	p.Arg69Cys	Missense	Humerofemoral hypoplasia with radiotibial ray deficiency (HHRRD) [MIM:618022]	-	UniProt
rs1449497581	p.Gln70His	missense variant	-	NC_000008.11:g.107989129C>G	gnomAD
COSM284715	p.Gln70His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107989129C>A	NCI-TCGA Cosmic
VAR_081037	p.Gln70_Gln243del	inframe_deletion	Tetraamelia syndrome 2 (TETAMS2) [MIM:618021]	-	UniProt
rs765551185	p.Tyr71Cys	missense variant	-	NC_000008.11:g.107989127T>C	ExAC,gnomAD
NCI-TCGA novel	p.Gly72Glu	missense variant	-	NC_000008.11:g.107989124C>T	NCI-TCGA
COSM3884665	p.Gly72Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107989124C>G	NCI-TCGA Cosmic
COSM5538411	p.Gly72Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107989125C>T	NCI-TCGA Cosmic
rs1205170970	p.Glu73Gln	missense variant	-	NC_000008.11:g.107989122C>G	TOPMed,gnomAD
rs1284433818	p.Pro79Leu	missense variant	-	NC_000008.11:g.107989103G>A	gnomAD
rs1303112979	p.Gly81Glu	missense variant	-	NC_000008.11:g.107989097C>T	gnomAD
rs139268055	p.Gly81Arg	missense variant	-	NC_000008.11:g.107989098C>T	ESP,TOPMed,gnomAD
rs754077477	p.Tyr82His	missense variant	-	NC_000008.11:g.107989095A>G	ExAC,gnomAD
rs1319262945	p.Tyr83Cys	missense variant	-	NC_000008.11:g.107989091T>C	gnomAD
NCI-TCGA novel	p.Gly84Glu	missense variant	-	NC_000008.11:g.107989088C>T	NCI-TCGA
rs760703263	p.His85Gln	missense variant	-	NC_000008.11:g.107989084G>T	ExAC,gnomAD
rs202023955	p.Arg86Gln	missense variant	-	NC_000008.11:g.107989082C>T	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Arg86Leu	missense variant	-	NC_000008.11:g.107989082C>A	NCI-TCGA
rs773297160	p.Arg86Ter	stop gained	-	NC_000008.11:g.107989083G>A	ExAC,TOPMed,gnomAD
rs146879547	p.Ala87Ser	missense variant	-	NC_000008.11:g.107989080C>A	ESP,ExAC,TOPMed,gnomAD
rs866661505	p.Pro88Leu	missense variant	-	NC_000008.11:g.107989076G>A	gnomAD
rs774354810	p.Pro88Ser	missense variant	-	NC_000008.11:g.107989077G>A	ExAC,gnomAD
rs774354810	p.Pro88Ala	missense variant	-	NC_000008.11:g.107989077G>C	ExAC,gnomAD
rs374497297	p.Asp89Glu	missense variant	-	NC_000008.11:g.107989072A>T	ESP,TOPMed
rs1157466005	p.Asp89His	missense variant	-	NC_000008.11:g.107989074C>G	TOPMed,gnomAD
NCI-TCGA novel	p.Asp89ArgPheSerTerUnkUnk	frameshift	-	NC_000008.11:g.107989078_107989079insT	NCI-TCGA
rs1243442989	p.Met90Arg	missense variant	-	NC_000008.11:g.107989070A>C	gnomAD
rs1468343162	p.Met90Val	missense variant	-	NC_000008.11:g.107989071T>C	TOPMed,gnomAD
rs1441104270	p.Asn91Asp	missense variant	-	NC_000008.11:g.107989068T>C	TOPMed
rs962970462	p.Arg95Gly	missense variant	-	NC_000008.11:g.107989056T>C	TOPMed,gnomAD
NCI-TCGA novel	p.Arg95Lys	missense variant	-	NC_000008.11:g.107960817C>T	NCI-TCGA
rs568583994	p.Arg95Ser	missense variant	-	NC_000008.11:g.107960816T>A	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Cys96Phe	missense variant	-	NC_000008.11:g.107960814C>A	NCI-TCGA
COSM1488888	p.Ile98Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107960809T>A	NCI-TCGA Cosmic
rs1195642001	p.Asn100His	missense variant	-	NC_000008.11:g.107960803T>G	gnomAD
rs775374943	p.Cys101Arg	missense variant	-	NC_000008.11:g.107960800A>G	ExAC,gnomAD
rs769378904	p.Asp102Val	missense variant	-	NC_000008.11:g.107960796T>A	ExAC
COSM3643897	p.Asp102Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107960797C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Phe105Leu	missense variant	-	NC_000008.11:g.107960788A>G	NCI-TCGA
rs776067721	p.Asp108Glu	missense variant	-	NC_000008.11:g.107960777G>T	ExAC,gnomAD
rs1370386696	p.Asp108Tyr	missense variant	-	NC_000008.11:g.107960779C>A	NCI-TCGA Cosmic
rs1370386696	p.Asp108Tyr	missense variant	-	NC_000008.11:g.107960779C>A	TOPMed
rs1348823437	p.Cys110Arg	missense variant	-	NC_000008.11:g.107960773A>G	gnomAD
NCI-TCGA novel	p.Cys110Tyr	missense variant	-	NC_000008.11:g.107960772C>T	NCI-TCGA
NCI-TCGA novel	p.Lys112Gln	missense variant	-	NC_000008.11:g.107960767T>G	NCI-TCGA
rs770458544	p.Lys112Asn	missense variant	-	NC_000008.11:g.107960765C>A	ExAC,TOPMed,gnomAD
rs746453626	p.Lys114Arg	missense variant	-	NC_000008.11:g.107960760T>C	ExAC,gnomAD
rs769106083	p.Gly116Asp	missense variant	-	NC_000008.11:g.107960754C>T	ExAC,TOPMed,gnomAD
rs769106083	p.Gly116Val	missense variant	-	NC_000008.11:g.107960754C>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.His120Asn	missense variant	-	NC_000008.11:g.107960743G>T	NCI-TCGA
rs756359748	p.Arg121Gly	missense variant	-	NC_000008.11:g.107960740T>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gly122Asp	missense variant	-	NC_000008.11:g.107960736C>T	NCI-TCGA
rs867580351	p.Gly122Ser	missense variant	-	NC_000008.11:g.107960737C>T	TOPMed
rs192607553	p.Arg123Ser	missense variant	-	NC_000008.11:g.107960734G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs192607553	p.Arg123Cys	missense variant	-	NC_000008.11:g.107960734G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs376412378	p.Arg123His	missense variant	-	NC_000008.11:g.107960733C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
COSM3884662	p.Glu127Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000008.11:g.107960722C>A	NCI-TCGA Cosmic
rs752947067	p.Cys128Tyr	missense variant	-	NC_000008.11:g.107960718C>T	ExAC,gnomAD
rs1359670074	p.Pro129Leu	missense variant	-	NC_000008.11:g.107960715G>A	gnomAD
rs764147792	p.Pro129Ser	missense variant	-	NC_000008.11:g.107960716G>A	ExAC,TOPMed,gnomAD
COSM748834	p.Gly131Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107960710C>A	NCI-TCGA Cosmic
rs142649056	p.Ala133Val	missense variant	-	NC_000008.11:g.107960703G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
COSM6112006	p.Pro134Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107960700G>T	NCI-TCGA Cosmic
rs1554576888	p.Glu137Ter	stop gained	-	NC_000008.11:g.107960692C>A	-
rs1214561465	p.Glu137Ala	missense variant	-	NC_000008.11:g.107960691T>G	gnomAD
RCV000656659	p.Glu137Ter	nonsense	TETRAAMELIA SYNDROME 2 (TETAMS2)	NC_000008.11:g.107960692C>A	ClinVar
NCI-TCGA novel	p.Glu137Lys	missense variant	-	NC_000008.11:g.107960692C>T	NCI-TCGA
VAR_081038	p.Glu137_Gln243del	inframe_deletion	Tetraamelia syndrome 2 (TETAMS2) [MIM:618021]	-	UniProt
rs948771132	p.Thr138Ile	missense variant	-	NC_000008.11:g.107960688G>A	TOPMed,gnomAD
rs938897531	p.Met139Thr	missense variant	-	NC_000008.11:g.107960685A>G	TOPMed
rs373151135	p.Met139Val	missense variant	-	NC_000008.11:g.107960686T>C	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu140Lys	missense variant	-	NC_000008.11:g.107960683C>T	NCI-TCGA
rs368950936	p.Cys141Arg	missense variant	-	NC_000008.11:g.107960680A>G	ESP,ExAC,TOPMed,gnomAD
rs368950936	p.Cys141Gly	missense variant	-	NC_000008.11:g.107960680A>C	ESP,ExAC,TOPMed,gnomAD
rs377563913	p.Val142Met	missense variant	-	NC_000008.11:g.107960677C>T	ESP,ExAC,TOPMed,gnomAD
rs1157598979	p.Val147Phe	missense variant	-	NC_000008.11:g.107958257C>A	gnomAD
NCI-TCGA novel	p.Gly148Val	missense variant	-	NC_000008.11:g.107958253C>A	NCI-TCGA
rs1418395272	p.Gly148Ala	missense variant	-	NC_000008.11:g.107958253C>G	gnomAD
COSM76300	p.Gly148Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107958254C>T	NCI-TCGA Cosmic
rs147756016	p.His149Arg	missense variant	-	NC_000008.11:g.107958250T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs147756016	p.His149Leu	missense variant	-	NC_000008.11:g.107958250T>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs150297181	p.Ser151Arg	missense variant	-	NC_000008.11:g.107958243G>C	ESP,ExAC,TOPMed,gnomAD
rs543739350	p.Ser151Asn	missense variant	-	NC_000008.11:g.107958244C>T	ExAC,TOPMed,gnomAD
rs1178258792	p.Glu152Asp	missense variant	-	NC_000008.11:g.107958240T>A	TOPMed
rs140125293	p.Glu152Lys	missense variant	-	NC_000008.11:g.107958242C>T	ESP,ExAC,TOPMed,gnomAD
rs140125293	p.Glu152Ter	stop gained	-	NC_000008.11:g.107958242C>A	ESP,ExAC,TOPMed,gnomAD
rs1252075737	p.Trp153Ser	missense variant	-	NC_000008.11:g.107958238C>G	TOPMed
rs767003645	p.Gly154Glu	missense variant	-	NC_000008.11:g.107958235C>T	ExAC,gnomAD
COSM3924471	p.Gly154Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107958236C>T	NCI-TCGA Cosmic
COSM748835	p.Ser157Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107958225G>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Asn159Tyr	missense variant	-	NC_000008.11:g.107958221T>A	NCI-TCGA
rs776068927	p.Arg161Cys	missense variant	-	NC_000008.11:g.107958215G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg161Pro	missense variant	-	NC_000008.11:g.107958214C>G	NCI-TCGA
rs770159956	p.Arg161His	missense variant	-	NC_000008.11:g.107958214C>T	ExAC,TOPMed,gnomAD
rs1311412050	p.Cys163Arg	missense variant	-	NC_000008.11:g.107958209A>G	gnomAD
NCI-TCGA novel	p.Gly164Glu	missense variant	-	NC_000008.11:g.107958205C>T	NCI-TCGA
COSM3643894	p.Gly164Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107958206C>T	NCI-TCGA Cosmic
rs771315758	p.Gly168Ala	missense variant	-	NC_000008.11:g.107958193C>G	ExAC,gnomAD
rs1362294787	p.Leu169Arg	missense variant	-	NC_000008.11:g.107958190A>C	gnomAD
rs747227279	p.Leu169Met	missense variant	-	NC_000008.11:g.107958191G>T	ExAC,TOPMed,gnomAD
rs778053213	p.Thr173Ile	missense variant	-	NC_000008.11:g.107958178G>A	ExAC,gnomAD
rs758562140	p.Arg174Trp	missense variant	-	NC_000008.11:g.107958176G>A	ExAC,TOPMed,gnomAD
rs369770616	p.Arg174Gln	missense variant	-	NC_000008.11:g.107958175C>T	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Gln175Ter	stop gained	-	NC_000008.11:g.107958173G>A	NCI-TCGA
rs200806324	p.Ile176Met	missense variant	-	NC_000008.11:g.107958168A>C	ESP,ExAC,TOPMed,gnomAD
COSM6179486	p.Val177Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107958167C>G	NCI-TCGA Cosmic
rs1465807706	p.Lys179Asn	missense variant	-	NC_000008.11:g.107958159C>A	TOPMed,gnomAD
rs1017150632	p.Pro180Gln	missense variant	-	NC_000008.11:g.107958157G>T	gnomAD
rs1429320861	p.Val181Ala	missense variant	-	NC_000008.11:g.107958154A>G	gnomAD
COSM3643893	p.Val181Gly	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107958154A>C	NCI-TCGA Cosmic
rs1173067908	p.Val181Leu	missense variant	-	NC_000008.11:g.107958155C>A	gnomAD
NCI-TCGA novel	p.Lys182Asn	missense variant	-	NC_000008.11:g.107958150T>A	NCI-TCGA
NCI-TCGA novel	p.Lys182Glu	missense variant	-	NC_000008.11:g.107958152T>C	NCI-TCGA
NCI-TCGA novel	p.Asp183Tyr	missense variant	-	NC_000008.11:g.107958149C>A	NCI-TCGA
rs754851458	p.Asp183Asn	missense variant	-	NC_000008.11:g.107958149C>T	ExAC,gnomAD
COSM258679	p.Asp183Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107958147G>T	NCI-TCGA Cosmic
rs766158953	p.Thr184Ala	missense variant	-	NC_000008.11:g.107958146T>C	ExAC,TOPMed,gnomAD
rs1211522253	p.Ile185Thr	missense variant	-	NC_000008.11:g.107958142A>G	gnomAD
rs750305724	p.Ile185Val	missense variant	-	NC_000008.11:g.107958143T>C	TOPMed,gnomAD
rs601558	p.Leu186Gln	missense variant	-	NC_000008.11:g.107958139A>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs601558	p.Leu186Pro	missense variant	-	NC_000008.11:g.107958139A>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1312739300	p.Leu186Val	missense variant	-	NC_000008.11:g.107958140G>C	gnomAD
rs1206425262	p.Pro188Thr	missense variant	-	NC_000008.11:g.107958134G>T	TOPMed,gnomAD
NCI-TCGA novel	p.Thr189Ala	missense variant	-	NC_000008.11:g.107958131T>C	NCI-TCGA
NCI-TCGA novel	p.Ala191Asp	missense variant	-	NC_000008.11:g.107958124G>T	NCI-TCGA
rs1277215213	p.Glu192Ala	missense variant	-	NC_000008.11:g.107958121T>G	gnomAD
rs1379826246	p.Ser193Thr	missense variant	-	NC_000008.11:g.107958119A>T	gnomAD
rs773684845	p.Met198Val	missense variant	-	NC_000008.11:g.107958104T>C	ExAC,gnomAD
rs1395955480	p.Met198Thr	missense variant	-	NC_000008.11:g.107958103A>G	gnomAD
rs765819930	p.Met200Val	missense variant	-	NC_000008.11:g.107958098T>C	ExAC,gnomAD
rs777116789	p.Pro204Arg	missense variant	-	NC_000008.11:g.107958085G>C	ExAC,gnomAD
rs1034128365	p.Pro204Ser	missense variant	-	NC_000008.11:g.107958086G>A	TOPMed
rs1023648455	p.Thr209Ile	missense variant	-	NC_000008.11:g.107901181G>A	TOPMed,gnomAD
rs181500705	p.Lys211Asn	missense variant	-	NC_000008.11:g.107901174C>A	1000Genomes,ExAC,TOPMed,gnomAD
rs1012287687	p.Lys211Arg	missense variant	-	NC_000008.11:g.107901175T>C	TOPMed
NCI-TCGA novel	p.Lys211Gln	missense variant	-	NC_000008.11:g.107901176T>G	NCI-TCGA
rs773694222	p.Lys211Glu	missense variant	-	NC_000008.11:g.107901176T>C	ExAC,gnomAD
rs188606837	p.Ala212Thr	missense variant	-	NC_000008.11:g.107901173C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs759429253	p.Ala212Val	missense variant	-	NC_000008.11:g.107901172G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu214Asp	missense variant	-	NC_000008.11:g.107901165C>A	NCI-TCGA
COSM3833853	p.Glu214Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107901165C>G	NCI-TCGA Cosmic
COSM3924470	p.Glu214Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107901167C>T	NCI-TCGA Cosmic
COSM748836	p.Lys215Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107901162C>G	NCI-TCGA Cosmic
rs1462832583	p.Arg216Ser	missense variant	-	NC_000008.11:g.107901159C>G	TOPMed
rs1289590827	p.Asn217Lys	missense variant	-	NC_000008.11:g.107901156G>T	TOPMed,gnomAD
rs749323272	p.Lys218Gln	missense variant	-	NC_000008.11:g.107901155T>G	ExAC,gnomAD
rs902694121	p.Lys218Asn	missense variant	-	NC_000008.11:g.107901153C>G	TOPMed
rs779998286	p.Lys220Asn	missense variant	-	NC_000008.11:g.107901147C>A	NCI-TCGA
rs779998286	p.Lys220Asn	missense variant	-	NC_000008.11:g.107901147C>A	ExAC,gnomAD
rs769669271	p.Lys221Asn	missense variant	-	NC_000008.11:g.107901144T>A	ExAC,gnomAD
rs745711987	p.Arg222Thr	missense variant	-	NC_000008.11:g.107901142C>G	ExAC
NCI-TCGA novel	p.Leu224Met	missense variant	-	NC_000008.11:g.107901137G>T	NCI-TCGA
rs780932645	p.Leu224Pro	missense variant	-	NC_000008.11:g.107901136A>G	ExAC,gnomAD
rs1337639104	p.Arg227Gly	missense variant	-	NC_000008.11:g.107901128T>C	TOPMed
rs757000039	p.Ala228Ser	missense variant	-	NC_000008.11:g.107901125C>A	ExAC,TOPMed,gnomAD
rs777423714	p.Ala228Asp	missense variant	-	NC_000008.11:g.107901124G>T	ExAC,TOPMed,gnomAD
rs777423714	p.Ala228Val	missense variant	-	NC_000008.11:g.107901124G>A	ExAC,TOPMed,gnomAD
rs1488233215	p.Gln231Glu	missense variant	-	NC_000008.11:g.107901116G>C	gnomAD
NCI-TCGA novel	p.Ser233Ile	missense variant	-	NC_000008.11:g.107901109C>A	NCI-TCGA
NCI-TCGA novel	p.Ser233Arg	missense variant	-	NC_000008.11:g.107901108G>T	NCI-TCGA
rs564925416	p.Ser233Gly	missense variant	-	NC_000008.11:g.107901110T>C	1000Genomes,ExAC,TOPMed,gnomAD
COSM1094776	p.Ser233Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000008.11:g.107901109C>T	NCI-TCGA Cosmic
rs761237646	p.Val234Ile	missense variant	-	NC_000008.11:g.107901107C>T	ExAC,TOPMed,gnomAD
rs546074157	p.Val234Ala	missense variant	-	NC_000008.11:g.107901106A>G	1000Genomes,ExAC,gnomAD
rs761237646	p.Val234Ile	missense variant	-	NC_000008.11:g.107901107C>T	NCI-TCGA
rs1274451054	p.Leu236Arg	missense variant	-	NC_000008.11:g.107901100A>C	TOPMed
rs762180746	p.Leu236Val	missense variant	-	NC_000008.11:g.107901101G>C	ExAC,gnomAD
rs768883871	p.Asp239Ala	missense variant	-	NC_000008.11:g.107901091T>G	ExAC,gnomAD
rs890171455	p.Arg240Thr	missense variant	-	NC_000008.11:g.107901088C>G	TOPMed
rs1296285320	p.Arg240Ter	stop gained	-	NC_000008.11:g.107901089T>A	gnomAD
rs370736291	p.Ala241Thr	missense variant	-	NC_000008.11:g.107901086C>T	ESP,TOPMed,gnomAD
rs769760824	p.Gln243Pro	missense variant	-	NC_000008.11:g.107901079T>G	ExAC,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0003873	Rheumatoid Arthritis	disease	BEFREE
C0009319	Colitis	disease	BEFREE
C0009375	Colonic Neoplasms	group	BEFREE
C0009402	Colorectal Carcinoma	disease	BEFREE
C0010346	Crohn Disease	disease	BEFREE
C0021390	Inflammatory Bowel Diseases	group	BEFREE
C0162311	Androgenetic Alopecia	disease	GWASCAT
C0235974	Pancreatic carcinoma	disease	BEFREE
C0239946	Fibrosis, Liver	disease	BEFREE
C0346629	Malignant neoplasm of large intestine	disease	BEFREE
C0346647	Malignant neoplasm of pancreas	disease	BEFREE
C0596263	Carcinogenesis	phenotype	BEFREE
C0751690	Malignant Peripheral Nerve Sheath Tumor	disease	BEFREE
C1458155	Mammary Neoplasms	group	BEFREE
C1527249	Colorectal Cancer	disease	BEFREE
C2239176	Liver carcinoma	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005102	signaling receptor binding	IPI
GO:0005515	protein binding	IPI
GO:0008201	heparin binding	IEA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001649	osteoblast differentiation	IEA
GO:0016055	Wnt signaling pathway	IEA
GO:0030177	positive regulation of Wnt signaling pathway	NAS
GO:0030177	positive regulation of Wnt signaling pathway	IDA
GO:0030282	bone mineralization	IEA
GO:0035115	embryonic forelimb morphogenesis	IEA
GO:0035116	embryonic hindlimb morphogenesis	IEA
GO:0042489	negative regulation of odontogenesis of dentin-containing tooth	IEA
GO:0060173	limb development	IMP
GO:0060437	lung growth	IEA
GO:0060441	epithelial tube branching involved in lung morphogenesis	IEA
GO:0060535	trachea cartilage morphogenesis	IEA
GO:0071542	dopaminergic neuron differentiation	IEA
GO:0090263	positive regulation of canonical Wnt signaling pathway	IEA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	NAS
GO:0005576	extracellular region	TAS
GO:0009986	cell surface	IEA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-4641263	Regulation of FZD by ubiquitination	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of RSPO2 mRNA	19933214
C511621	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter analog results in decreased expression of RSPO2 mRNA]	27216425
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of RSPO2 mRNA	22230336
D000082	Acetaminophen	Acetaminophen results in decreased expression of RSPO2 mRNA	30723492
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of RSPO2 gene	27153756
D000077237	Arsenic Trioxide	Arsenic Trioxide results in decreased expression of RSPO2 mRNA	26705709
C015001	arsenite	arsenite results in increased methylation of RSPO2 promoter	23974009
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of RSPO2 mRNA	22316170
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of RSPO2 mRNA	27195522
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in decreased expression of RSPO2 mRNA	30951980
C006780	bisphenol A	bisphenol A results in increased expression of RSPO2 mRNA	30248606
C006780	bisphenol A	bisphenol A results in decreased expression of RSPO2 mRNA	30951980
C006780	bisphenol A	bisphenol A results in decreased expression of RSPO2 mRNA	25181051
C000611646	bisphenol F	bisphenol F results in decreased expression of RSPO2 mRNA	30951980
C473711	Chir 99021	Chir 99021 inhibits the reaction [Particulate Matter analog results in decreased expression of RSPO2 mRNA]	27216425
D003471	Cuprizone	Cuprizone results in decreased expression of RSPO2 mRNA	27523638
D003561	Cytarabine	Cytarabine results in decreased expression of RSPO2 mRNA	21198554
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of RSPO2 mRNA	31326446
C516138	dorsomorphin	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C118739	entinostat	entinostat results in decreased expression of RSPO2 mRNA	26272509
C118739	entinostat	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
D004958	Estradiol	Estradiol results in increased expression of RSPO2 mRNA	19484750
D000431	Ethanol	Ethanol affects the expression of RSPO2 mRNA	30319688
D000431	Ethanol	Ethanol affects the splicing of RSPO2 mRNA	30319688
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of RSPO2 mRNA	23550701
C119620	kenpaullone	kenpaullone results in increased expression of RSPO2 mRNA	25711857
D008558	Melphalan	Melphalan results in decreased expression of RSPO2 mRNA	22363485
C042720	mercuric bromide	mercuric bromide results in decreased expression of RSPO2 mRNA	26272509
C042720	mercuric bromide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of RSPO2 mRNA	28001369
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of RSPO2 mRNA	23179753; 26272509;
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of RSPO2 mRNA	26011545
D000077767	Panobinostat	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
D000077767	Panobinostat	Panobinostat results in decreased expression of RSPO2 mRNA	26272509
D052638	Particulate Matter	2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter analog results in decreased expression of RSPO2 mRNA]	27216425
D052638	Particulate Matter	Chir 99021 inhibits the reaction [Particulate Matter analog results in decreased expression of RSPO2 mRNA]	27216425
D052638	Particulate Matter	Particulate Matter analog results in decreased expression of RSPO2 mRNA	27216425
D020245	p-Chloromercuribenzoic Acid	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of RSPO2 mRNA	26272509
D010662	Phenylmercuric Acetate	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of RSPO2 mRNA	26272509
D010936	Plant Extracts	Plant Extracts results in decreased expression of RSPO2 mRNA	23557933
C020806	tetrabromobisphenol A	tetrabromobisphenol A results in decreased expression of RSPO2 mRNA	31326446
C041181	tetrachlorodian	tetrachlorodian results in decreased expression of RSPO2 mRNA	31326446
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of RSPO2 mRNA	16922920; 24928892;
D014241	Trichloroethylene	Trichloroethylene results in decreased methylation of RSPO2 gene	27618143
C012589	trichostatin A	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of RSPO2 mRNA	24935251; 26272509;
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of RSPO2 mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in decreased expression of RSPO2 mRNA	23179753; 24383497; 24935251; 26272509; 28001369;
D014635	Valproic Acid	Valproic Acid results in decreased methylation of RSPO2 gene	29154799
D014635	Valproic Acid	Valproic Acid results in decreased expression of RSPO2 mRNA	24896083
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of RSPO2 gene	25560391
D000077337	Vorinostat	Vorinostat results in decreased expression of RSPO2 mRNA	26272509

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0025	Alternative splicing
KW-0217	Developmental protein
KW-0225	Disease mutation
KW-1015	Disulfide bond
KW-0325	Glycoprotein
KW-0358	Heparin-binding
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0964	Secreted
KW-0716	Sensory transduction
KW-0732	Signal
KW-0879	Wnt signaling pathway

Interpro

InterPro ID	InterPro Term
IPR006212	Furin_repeat
IPR009030	Growth_fac_rcpt_cys_sf
IPR042993	RSPO2
IPR000884	TSP1_rpt
IPR036383	TSP1_rpt_sf

PROSITE

PROSITE ID	PROSITE Term
PS50092	TSP1

Pfam

Pfam ID	Pfam Term
PF15913	Furin-like_2

Gene: RSPO2

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction