| Tag | Content |
|---|---|
| Uniprot ID | Q6X4U4; A8MUA6; Q96HJ7; Q9Y3U3; |
| Entrez ID | 25928 |
| Genbank protein ID | AAL57219.1; AAQ83296.1; BAG52710.1; CAB43243.2; AAH08484.1; AAQ96855.1; BAC20331.1; |
| Genbank nucleotide ID | NM_015464.2; XM_017011943.1; |
| Ensembl protein ID | ENSP00000304930; ENSP00000379889; |
| Ensembl nucleotide ID | ENSG00000171243 |
| Gene name | Sclerostin domain-containing protein 1 |
| Gene symbol | SOSTDC1 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. |
| Sequence | MLPPAIHFYL LPLACILMKS CLAFKNDATE ILYSHVVKPV PAHPSSNSTL NQARNGGRHF 60 SNTGLDRNTR VQVGCRELRS TKYISDGQCT SISPLKELVC AGECLPLPVL PNWIGGGYGT 120 KYWSRRSSQE WRCVNDKTRT QRIQLQCQDG STRTYKITVV TACKCKRYTR QHNESSHNFE 180 SMSPAKPVQH HRERKRASKS SKHSMS 206 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.