| Tag | Content |
|---|---|
| Uniprot ID | Q7TPD1; A1A595; E9QP06; Q08EB9; Q08EC0; Q80UP0; |
| Entrez ID | 225055 |
| Genbank protein ID | AAI28480.1; AAH49946.1; AAI17885.1; AAH55343.1; AAI17886.1; |
| Genbank nucleotide ID | NM_001081034.2; NM_001348248.1; XM_006524204.3; |
| Ensembl protein ID | ENSMUSP00000121206; ENSMUSP00000157024; ENSMUSP00000005504; |
| Ensembl nucleotide ID | ENSMUSG00000005371 |
| Gene name | F-box only protein 11 |
| Gene symbol | Fbxo11 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5 |
| Data sources | Manually collected |
| Reference | 17035249; 19580641; 10932191; |
| Functional description | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. |
| Sequence | MNSVRAANRR PRRVSRPRPV QQQQQQPPQQ PPPQPPQQQP PPQPPQQPPQ QQPPPPPQQQ 60 PPPPPPPPPP PPQDRNNAGE RDDVPADMVA EESGPGAQNS PYQLRRKTLL PKRTACPTKS 120 SMEGASTSTT ENFGHRAKRA RVSGKSQDLS AAPAEQYLQE KLPDEVVLKI FSYLLEQDLC 180 RAACVCKRFS ELANDPILWK RLYMEVFEYT RPMMHPEPGK FYQINPEEYE HPNPWKESFQ 240 QLYKGAHVKP GFAEHFYSNP ARYKGRENML YYDTIEDALG GVQEAHFDGL IFVHSGIYTD 300 EWIYIESPIT MIGAAPGKVA DKVIIENTRD STFVFMEGSE DAYVGYMTIR FNPDDKSAQH 360 HNAHHCLEIT VNCSPIIDHC IIRSTCTVGS AVCVSGQGAC PTIKHCNISD CENVGLYITD 420 HAQGIYEDNE ISNNALAGIW VKNHGNPIIR RNHIHHGRDV GVFTFDHGMG YFESCNIHRN 480 RIAGFEVKAY ANPTVVRCEI HHGQTGGIYV HEKGRGQFIE NKIYANNFAG VWITSNSDPT 540 IRGNSIFNGN QGGVYIFGDG RGLIEGNDIY GNALAGIQIR TNSCPIVRHN KIHDGQHGGI 600 YVHEKGQGVI EENEVYSNTL AGVWVTTGST PVLRRNRIHS GKQVGVYFYD NGHGVLEDND 660 IYNHMYSGVQ IRTGSNPKIR RNKIWGGQNG GILVYNSGLG CIEDNEIFDN AMAGVWIKTD 720 SNPTLRRNKI HDGRDGGICI FNGGRGLLEE NDIFRNAQAG VLISTNSHPV LRKNRIFDGF 780 AAGIEITNHA TATLEGNQIF NNRFGGLFLA SGVNVTMKDN KIMNNQDAIE KAVSRGQCLY 840 KISSYTSYPM HDFYRCHTCN TTDRNAICVN CIKKCHQGHD VEFIRHDRFF CDCGAGTLSN 900 PCTLAGEPTH DTDTLYDSAP PIESNTLQHN |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IBA |
| GO:0004842 | ubiquitin-protein transferase activity | IMP |
| GO:0005515 | protein binding | IPI |
| GO:0008270 | zinc ion binding | IEA |
| GO:0016274 | protein-arginine N-methyltransferase activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006464 | cellular protein modification process | ISO |
| GO:0006511 | ubiquitin-dependent protein catabolic process | IBA |
| GO:0007605 | sensory perception of sound | IMP |
| GO:0016567 | protein ubiquitination | IEA |
| GO:0016567 | protein ubiquitination | IBA |
| GO:0035246 | peptidyl-arginine N-methylation | IEA |
| GO:0042981 | regulation of apoptotic process | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IEA |
| GO:0005634 | nucleus | ISO |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005694 | chromosome | IEA |
| GO:0005730 | nucleolus | ISO |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IBA |
| GO:0005829 | cytosol | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1280218 | Adaptive Immune System | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |
| R-MMU-8951664 | Neddylation | IEA |
| R-MMU-983168 | Antigen processing: Ubiquitination & Proteasome degradation | IEA |
| R-MMU-983169 | Class I MHC mediated antigen processing & presentation | IEA |