CleftGeneDB-Search

Gene: FRAS1

Basic information

Tag	Content
Uniprot ID	Q86XX4; A2RRR8; Q86UZ4; Q8N3U9; Q8NAU7; Q96JW7; Q9H6N9; Q9P228;
Entrez ID	80144
Genbank protein ID	AAH52281.1; BAB55399.1; BAB15216.1; CAD54734.1; BAA96024.2; CAD38554.1; AAI31821.1; AAH64487.1;
Genbank nucleotide ID	NM_001166133.1; NM_025074.6;
Ensembl protein ID	ENSP00000326330; ENSP00000422834;
Ensembl nucleotide ID	ENSG00000138759
Gene name	Extracellular matrix protein FRAS1
Gene symbol	FRAS1
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description
Sequence	MGVLKVWLGL ALALAEFAVL PHHSEGACVY QDSLLADATI WKPDSCQSCR CHGDIVICKP 60 AVCRNPQCAF EKGEVLQIAA NQCCPECVLR TPGSCHHEKK IHEHGTEWAS SPCSVCSCNH 120 GEVRCTPQPC PPLSCGHQEL AFIPEGSCCP VCVGLGKPCS YEGHVFQDGE DWRLSRCAKC 180 LCRNGVAQCF TAQCQPLFCN QDETVVRVPG KCCPQCSARS CSAAGQVYEH GEQWSENACT 240 TCICDRGEVR CHKQACLPLR CGKGQSRARR HGQCCEECVS PAGSCSYDGV VRYQDEMWKG 300 SACEFCMCDH GQVTCQTGEC AKVECARDEE LIHLDGKCCP ECISRNGYCV YEETGEFMSS 360 NASEVKRIPE GEKWEDGPCK VCECRGAQVT CYEPSCPPCP VGTLALEVKG QCCPDCTSVH 420 CHPDCLTCSQ SPDHCDLCQD PTKLLQNGWC VHSCGLGFYQ AGSLCLACQP QCSTCTSGLE 480 CSSCQPPLLM RHGQCVPTCG DGFYQDRHSC AVCHESCAGC WGPTEKHCLA CRDPLHVLRD 540 GGCESSCGKG FYNRQGTCSA CDQSCDSCGP SSPRCLTCTE KTVLHDGKCM SECPGGYYAD 600 ATGRCKVCHN SCASCSGPTP SHCTACSPPK ALRQGHCLPR CGEGFYSDHG VCKACHSSCL 660 ACMGPAPSHC TGCKKPEEGL QVEQLSDVGI PSGECLAQCR AHFYLESTGI CEACHQSCFR 720 CAGKSPHNCT DCGPSHVLLD GQCLSQCPDG YFHQEGSCTE CHPTCRQCHG PLESDCISCY 780 PHISLTNGNC RTSCREEQFL NLVGYCADCH HLCQHCAADL HNTGSICLRC QNAHYLLLGD 840 HCVPDCPSGY YAERGACKKC HSSCRTCQGR GPFSCSSCDT NLVLSHTGTC STTCFPGHYL 900 DDNHVCQPCN THCGSCDSQA SCTSCRDPNK VLLFGECQYE SCAPQYYLDF STNTCKECDW 960 SCSACSGPLK TDCLQCMDGY VLQDGACVEQ CLSSFYQDSG LCKNCDSYCL QCQGPHECTR 1020 CKGPFLLLEA QCVQECGKGY FADHAKHKCT ACPQGCLQCS HRDRCHLCDH GFFLKSGLCV 1080 YNCVPGFSVH TSNETCSGKI HTPSLHVNGS LILPIGSIKP LDFSLLNVQD QEGRVEDLLF 1140 HVVSTPTNGQ LVLSRNGKEV QLDKAGRFSW KDVNEKKVRF VHSKEKLRKG YLFLKISDQQ 1200 FFSEPQLINI QAFSTQAPYV LRNEVLHISR GERATITTQM LDIRDDDNPQ DVVIEIIDPP 1260 LHGQLLQTLQ SPATPIYQFQ LDELSRGLLH YAHDGSDSTS DVAVLQANDG HSFHNILFQV 1320 KTVPQNDRGL QLVANSMVWV PEGGMLQITN RILQAEAPGA SAEEIIYKIT QDYPQFGEVV 1380 LLVNMPADSP ADEGQHLPDG RTATPTSTFT QQDINEGIVW YRHSGAPAQS DSFRFEVSSA 1440 SNAQTRLESH MFNIAILPQT PEAPKVSLEA SLHMTAREDG LTVIQPHSLS FINSEKPSGK 1500 IVYNITLPLH PNQGIIEHRD HPHSPIRYFT QEDINQGKVM YRPPPAAPHL QELMAFSFAG 1560 LPESVKFHFT VSDGEHTSPE MVLTIHLLPS DQQLPVFQVT APRLAVSPGG STSVGLQVVV 1620 RDAETAPKEL FFELRRPPQH GVLLKHTAEF RRPMATGDTF TYEDVEKNAL QYIHDGSSTR 1680 EDSMEISVTD GLTVTMLEVR VEVSLSEDRG PRLAAGSSLS ITVASKSTAI ITRSHLAYVD 1740 DSSPDPEIWI QLNYLPSYGT LLRISGSEVE ELSEVSNFTM EDINNKKIRY SAVFETDGHL 1800 VTDSFYFSVS DMDHNHLDNQ IFTIMITPAE NPPPVIAFAD LITVDEGGRA PLSFHHFFAT 1860 DDDDNLQRDA IIKLSALPKY GCIENTGTGD RFGPETASDL EASFPIQDVL ENYIYYFQSV 1920 HESIEPTHDI FSFYVSDGTS RSEIHSINIT IERKNDEPPR MTLQPLRVQL SSGVVISNSS 1980 LSLQDLDTPD NELIFVLTKK PDHGHVLWRQ TASEPLENGR VLVQGSTFTY QDILAGLVGY 2040 VPSVPGMVVD EFQFSLTDGL HVDTGRMKIY TELPASDTPH LAINQGLQLS AGSVARITEQ 2100 HLKVTDIDSD DHQVMYIMKE DPGAGRLQMM KHGNLEQISI KGPIRSFTQA DISQGQPEYS 2160 HGTGEPGGSF AFKFDVVDGE GNRLIDKSFS ISISEDKSPP VITTNKGLVL DENSVKKITT 2220 LQLSATDQDS GPTELIYRIT RQPQLGHLEH AASPGIQISS FTQADLTSRN VQYVHSSEAE 2280 KHSDAFSFTL SDGVSEVTQT FHITLHPVDD SLPVVQNLGM RVQEGMRKTI TEFELKAVDA 2340 DTEAESVTFT IVQPPRHGTI ERTSNGQHFH LTSTFTMKDI YQNRVSYSHD GSNSLKDRFT 2400 FTVSDGTNPF FIIEEGGKEI MTAAPQPFRV DILPVDDGTP RIVTNLGLQW LEYMDGKATN 2460 LITKKELLTM DPDTEDAQLV YEITTGPKHG FVENKLQPGR AAATFTQEDV NLGLIRYVLH 2520 KEKIREMMDS FQFLVKDSKP NVVSDNVFHI QWSLISFKYT SYNVSEKAGS VSVTVQRTGN 2580 LNQYAIVLCR TEQGTASSSS QPGQQDYVEY AGQVQFDERE DTKSCTIVIN DDDVFENVES 2640 FTVELSMPAY ALLGEFTQAK VIINDTEDEP TLEFDKKIYW VNESAGFLFA PIERKGDASS 2700 IVSAICYTVP KSAMGSLFYA LESGSDFKSR GMSAASRVIF GPGVTMSTCD VMLIDDSEYE 2760 EEEEFEIALA DASDNARIGR VATAKVLISG PNDASTVSLG NTAFTVSEDA GTVKIPVIRH 2820 GTDLSTFASV WCATRPSDPA SATPGVDYVP SSRKVEFGPG VIEQYCTLTI LDDTQYPVIE 2880 GLETFVVFLS SAQGAELTKP FQAVIAINDT FQDVPSMQFA KDLLLVKEKE GVLHVPITRS 2940 GDLSYESSVR CYTQSHSAQV MEDFEERQNA DSSRITFLKG DKVKNCTVYI HDDSMFEPEE 3000 QFRVYLGLPL GNHWSGARIG KNNMATITIS NDEDAPTIEF EEAAYQVREP AGPDAIAILN 3060 IKVIRRGDQN RTSKVRCSTR DGSAQSGVDY YPKSRVLKFS PGVDHIFFKV EILSNEDREW 3120 HESFSLVLGP DDPVEAVLGD VTTATVTILD QEAAGSLILP APPIVVTLAD YDHVEEVTKE 3180 GVKKSPSPGY PLVCVTPCDP HFPRYAVMKE RCSEAGINQT SVQFSWEVAA PTDGNGARSP 3240 FETITDNTPF TSVNHMVLDS IYFSRRFHVR CVAKAVDKVG HVGTPLRSNI VTIGTDSAIC 3300 HTPVVAGTSR GFQAQSFIAT LKYLDVKHKE HPNRIHISVQ IPHQDGMLPL ISTMPLHNLH 3360 FLLSESIYRH QHVCSNLVTT YDLRGLAEAG FLDDVVYDST ALGPGYDRPF QFDPSVREPK 3420 TIQLYKHLNL KSCVWTFDAY YDMTELIDVC GGSVTADFQV RDSAQSFLTV HVPLYVSYIY 3480 VTAPRGWASL EHHTEMEFSF FYDTVLWRTG IQTDSVLSAR LQIIRIYIRE DGRLVIEFKT 3540 HAKFRGQFVM EHHTLPEVKS FVLTPDHLGG IEFDLQLLWS AQTFDSPHQL WRATSSYNRK 3600 DYSGEYTIYL IPCTVQPTQP WVDPGEKPLA CTAHAPERFL IPIAFQQTNR PVPVVYSLNT 3660 EFQLCNNEKV FLMDPNTSDM SLAEMDYKGA FSKGQILYGR VLWNPEQNLN SAYKLQLEKV 3720 YLCTGKDGYV PFFDPTGTIY NEGPQYGCIQ PNKHLKHRFL LLDRNQPEVT DKYFHDVPFE 3780 AHFASELPDF HVVSNMPGVD GFTLKVDALY KVEAGHQWYL QVIYIIGPDT ISGPRVQRSL 3840 TAPLRRNRRD LVEPDGQLIL DDSLIYDNEG DQVKNGTNMK SLNLEMQELA VAASLSQTGA 3900 SIGSALAAIM LLLLVFLVAC FINRKCQKQR KKKPAEDILE EYPLNTKVEV PKRHPDRVEK 3960 NVNRHYCTVR NVNILSEPEA AYTFKGAKVK RLNLEVRVHN NLQDGTEV 4008

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	FRAS1	478446	J9P6T8		Canis lupus familiaris	Prediction	More>>
1:1 ortholog	FRAS1		A0A452G0M2		Capra hircus	Prediction	More>>
1:1 ortholog	FRAS1	80144	Q86XX4		Homo sapiens	Prediction	More>>
1:1 ortholog	Fras1	231470	Q80T14	CPO	Mus musculus	Publication	More>>
1:1 ortholog	FRAS1	461226	H2R4C8		Pan troglodytes	Prediction	More>>
1:1 ortholog	Fras1		F1M3H3		Rattus norvegicus	Prediction	More>>
1:1 ortholog	fras1	563428	F1Q633		Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs4859905	p.Asp32Gly	missense variant	-	NC_000004.12:g.78066003A>G	UniProt,dbSNP
VAR_069150	p.Asp32Gly	missense variant	-	NC_000004.12:g.78066003A>G	UniProt
rs7699637	p.Pro209Ser	missense variant	-	NC_000004.12:g.78265046C>T	UniProt,dbSNP
VAR_055808	p.Pro209Ser	missense variant	-	NC_000004.12:g.78265046C>T	UniProt
rs7682296	p.Tyr228His	missense variant	-	NC_000004.12:g.78265103T>C	UniProt,dbSNP
VAR_055809	p.Tyr228His	missense variant	-	NC_000004.12:g.78265103T>C	UniProt
rs6838959	p.Ser429Tyr	missense variant	-	NC_000004.12:g.78284435C>A	UniProt,dbSNP
VAR_055811	p.Ser429Tyr	missense variant	-	NC_000004.12:g.78284435C>A	UniProt
rs12504081	p.Leu466Ile	missense variant	-	NC_000004.12:g.78284545T>A	UniProt,dbSNP
VAR_055812	p.Leu466Ile	missense variant	-	NC_000004.12:g.78284545T>A	UniProt
rs35030041	p.Met590Thr	missense variant	-	NC_000004.12:g.78315684T>C	UniProt,dbSNP
VAR_055813	p.Met590Thr	missense variant	-	NC_000004.12:g.78315684T>C	UniProt
rs345513	p.Asp687Gly	missense variant	-	NC_000004.12:g.78318909A>G	UniProt,dbSNP
VAR_069151	p.Asp687Gly	missense variant	-	NC_000004.12:g.78318909A>G	UniProt
rs345512	p.Ile710Leu	missense variant	-	NC_000004.12:g.78318977A>C	UniProt,dbSNP
VAR_069152	p.Ile710Leu	missense variant	-	NC_000004.12:g.78318977A>C	UniProt
rs17459809	p.Gly1023Glu	missense variant	-	NC_000004.12:g.78374168G>A	UniProt,dbSNP
VAR_055816	p.Gly1023Glu	missense variant	-	NC_000004.12:g.78374168G>A	UniProt
rs12512164	p.Glu1136Lys	missense variant	-	NC_000004.12:g.78379839G>A	UniProt,dbSNP
VAR_055817	p.Glu1136Lys	missense variant	-	NC_000004.12:g.78379839G>A	UniProt
rs17003213	p.Ala1626Val	missense variant	-	NC_000004.12:g.78430325C>T	UniProt,dbSNP
VAR_055818	p.Ala1626Val	missense variant	-	NC_000004.12:g.78430325C>T	UniProt
rs4388111	p.Asp2545Asn	missense variant	-	NC_000004.12:g.78473548G>A	UniProt,dbSNP
VAR_069153	p.Asp2545Asn	missense variant	-	NC_000004.12:g.78473548G>A	UniProt

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0001193	Apert syndrome	disease	MGD
C0003119	Anophthalmos	disease	HPO
C0003466	Anus, Imperforate	disease	HPO
C0008924	Cleft upper lip	disease	HPO
C0009081	Congenital clubfoot	disease	MGD
C0010038	Corneal Opacity	phenotype	HPO
C0010417	Cryptorchidism	disease	HPO
C0014065	Congenital cerebral hernia	disease	HPO
C0018777	Conductive hearing loss	disease	BEFREE;HPO
C0018798	Congenital Heart Defects	group	HPO
C0020255	Hydrocephalus	disease	HPO
C0020534	Orbital separation excessive	phenotype	HPO
C0023075	Laryngostenosis	disease	HPO
C0024433	Macrostomia	disease	BEFREE;CTD_human
C0024636	Malocclusion	phenotype	HPO
C0025312	Meningomyelocele	disease	HPO
C0025362	Mental Retardation	disease	HPO
C0026010	Microphthalmos	disease	HPO
C0029925	Ovarian Carcinoma	disease	GWASCAT
C0031900	Pierre Robin Syndrome	disease	MGD
C0039075	Syndactyly	disease	BEFREE
C0040433	Tooth Crowding	phenotype	HPO
C0152021	Congenital heart disease	group	HPO
C0152427	Polydactyly	disease	GENOMICS_ENGLAND
C0156394	Hypertrophy of clitoris	disease	HPO
C0221060	Mobius Syndrome	disease	MGD
C0221352	Syndactyly of fingers	disease	HPO
C0221357	Brachydactyly	disease	BEFREE
C0238394	Female Pseudohermaphroditism	disease	HPO
C0238441	Subglottic stenosis	phenotype	HPO
C0239234	Low set ears	phenotype	HPO
C0262374	Stricture of anus	phenotype	HPO
C0262650	Abnormality of the thymus	phenotype	HPO
C0265224	Freeman-Sheldon syndrome	disease	MGD
C0265233	Cryptophthalmos syndrome	disease	BEFREE;CLINVAR;CTD_human;MGD;ORPHANET
C0265240	Goldenhar Syndrome	disease	MGD
C0265660	Syndactyly of the toes	disease	HPO
C0265756	Congenital atresia of larynx	disease	HPO
C0265783	Congenital hypoplasia of lung	disease	HPO
C0266111	Bifid tongue	disease	HPO
C0266294	Unilateral agenesis of kidney	disease	BEFREE;ORPHANET
C0266295	Congenital hypoplasia of kidney	disease	HPO
C0266362	Ambiguous Genitalia	disease	HPO
C0266387	Bicornuate uterus	disease	HPO
C0266435	Congenital hypoplasia of penis	disease	HPO
C0266589	Congenital ear anomaly NOS (disorder)	group	HPO
C0266667	Cyclocephaly	disease	MGD
C0271215	Blindness, Legal	disease	HPO
C0281890	Laryngeal web	disease	HPO
C0311249	Cryptophthalmos	disease	HPO
C0392485	Congenital diverticulum of pharynx	disease	BEFREE
C0423903	Low intelligence	phenotype	HPO
C0424688	Small head	phenotype	HPO
C0426421	Wide nose	phenotype	HPO
C0431448	Absent eyebrow	phenotype	HPO
C0431483	Simple ear	phenotype	HPO
C0431659	Hypoplasia of scrotum	phenotype	HPO
C0432066	Congenital malformation syndromes affecting facial appearance	disease	MGD
C0456909	Blindness	phenotype	HPO
C0521719	Clouding of corneal stroma	disease	HPO
C0542519	Congenital absence of kidney	disease	BEFREE
C0578682	Madarosis of eyebrow	disease	HPO
C0584837	Choanal stenosis	phenotype	HPO
C0677886	Epithelial ovarian cancer	disease	GWASCAT
C0685787	Cleft face	disease	HPO
C0685891	Congenital hypoplasia of thymus	disease	HPO
C0687154	Acrocephalopolysyndactyly	disease	MGD
C0848558	Hypospadias	group	HPO
C0857379	Abnormality of the pinna	phenotype	HPO
C0917816	Mental deficiency	disease	HPO
C1317785	Tooth size discrepancy	phenotype	HPO
C1321884	Atresia of vagina	disease	HPO
C1398325	Absent auditory canals	disease	HPO
C1510460	Orofaciodigital Syndrome I	disease	MGD
C1609433	Congenital absence of kidneys syndrome	disease	BEFREE
C1619700	RENAL ADYSPLASIA	disease	BEFREE
C1691215	Penile hypospadias	disease	HPO
C1827524	Wide spaced nipples	phenotype	HPO
C1834055	Underdeveloped nasal alae	phenotype	HPO
C1836542	Depressed nasal bridge	phenotype	HPO
C1839764	Broad flat nasal bridge	phenotype	HPO
C1840305	Absent external auditory canals	phenotype	HPO
C1840644	Diaphragm, Complete Agenesis Of	disease	CLINVAR
C1843005	Absent eyelashes	phenotype	HPO
C1843367	Poor school performance	phenotype	HPO
C1843496	Bilateral microphthalmos	disease	HPO
C1844537	Cleft ala nasi	phenotype	HPO
C1845447	Cupped ears (finding)	phenotype	HPO
C1846460	Abnormality of the outer ear	phenotype	HPO
C1848670	Aplasia/Hypoplasia of the phalanges of the hand	phenotype	HPO
C1849338	Abnormality of the umbilicus	phenotype	HPO
C1849367	Nasal bridge wide	phenotype	HPO
C1853406	Difficulty in tongue movements	phenotype	HPO
C1856019	Abnormal cortical gyration	phenotype	HPO
C1857079	Atretic auditory canal	disease	HPO
C1857190	Wide pubic symphysis	phenotype	HPO
C1857453	Renal hypoplasia/aplasia	phenotype	HPO
C1857455	Extension of hair growth on temples to lateral eyebrow	phenotype	HPO
C1857456	Morphological abnormality of the middle ear	phenotype	HPO
C1857486	Low-set, posteriorly rotated ears	phenotype	HPO
C1863872	Upper eyelid coloboma	phenotype	HPO
C1865305	Hypoplastic superior helix	phenotype	HPO
C1866190	Atresia of the external auditory canal	phenotype	HPO
C1968949	Cakut	disease	GENOMICS_ENGLAND
C2750433	Bifid Nose With Or Without Anorectal And Renal Anomalies	disease	BEFREE
C2981150	Uranostaphyloschisis	disease	HPO
C3179508	Aplasia/Hypoplasia of the thumb	phenotype	HPO
C3550546	Depressed nasal root/bridge	phenotype	HPO
C3714581	Multicystic Dysplastic Kidney	disease	HPO
C3714756	Intellectual Disability	group	GENOMICS_ENGLAND;HPO
C4020876	Dull intelligence	phenotype	HPO
C4020892	Capuchin ears	disease	HPO
C4021254	Cutaneous finger syndactyly	disease	HPO
C4024757	Malformed lacrimal ducts	phenotype	HPO
C4024773	Lacrimal duct aplasia	disease	HPO
C4024990	Aplasia/Hypoplasia of the sternum	phenotype	HPO
C4025208	Severe T-cell immunodeficiency	disease	HPO
C4025329	Abnormality of the anus	phenotype	HPO
C4025412	Midline nasal groove	phenotype	HPO
C4025717	Abnormality of the small intestine	phenotype	HPO
C4025787	Calvarial skull defect	phenotype	HPO
C4255098	Cleft tongue	phenotype	HPO
C4280421	Abnormally small eyeball on both sides	phenotype	HPO
C4280422	Bilateral nanophthalmos	disease	HPO
C4280495	Concave bridge of nose	phenotype	HPO
C4280581	Aplasia of eyebrows	phenotype	HPO
C4280582	Agenesis of eyebrows	phenotype	HPO
C4280596	Calvarial defect	phenotype	HPO
C4280613	Angle class 3 malocclusion	phenotype	HPO
C4280614	Angle class 2 malocclusion	disease	HPO
C4280617	Tooth mass arch size discrepancy	phenotype	HPO
C4280618	Inadequate arch length for tooth size	phenotype	HPO
C4280625	Decreased size of eyeball	phenotype	HPO
C4280626	Aplasia of eyelashes	phenotype	HPO
C4280627	Failure of development of eyelashes	phenotype	HPO
C4280676	Hypokinesia of the tongue	phenotype	HPO
C4280808	Abnormally small eyeball	phenotype	HPO
C4476535	Nostril coloboma	disease	HPO

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005201	extracellular matrix structural constituent	ISS
GO:0046872	metal ion binding	IEA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0002009	morphogenesis of an epithelium	IEA
GO:0003338	metanephros morphogenesis	IEA
GO:0007154	cell communication	IEA
GO:0015031	protein transport	IEA
GO:0030326	embryonic limb morphogenesis	IEA
GO:0043588	skin development	IEA
GO:0060021	roof of mouth development	IEA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005604	basement membrane	ISS
GO:0005886	plasma membrane	IEA
GO:0016021	integral component of membrane	IEA
GO:0062023	collagen-containing extracellular matrix	ISS

Reactome Pathway

Reactome ID	Reactome Term	Evidence

Drugs and compounds information

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of FRAS1 mRNA	27291303
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in increased expression of FRAS1 mRNA	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRAS1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRAS1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRAS1 mRNA	27188386
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of FRAS1 mRNA	22079614
C496492	abrine	abrine results in decreased expression of FRAS1 mRNA	31054353
D000082	Acetaminophen	Acetaminophen affects the expression of FRAS1 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of FRAS1 protein	20106945
D000393	Air Pollutants	Air Pollutants analog results in decreased expression of FRAS1 mRNA	21757418
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of FRAS1 mRNA	28522335
D000638	Amiodarone	Amiodarone results in increased expression of FRAS1 mRNA	19774075
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of FRAS1 mRNA	24449571
D001104	Arbutin	Arbutin results in decreased expression of FRAS1 mRNA	17103032
C015001	arsenite	arsenite results in decreased expression of FRAS1 mRNA	23974009
D001280	Atrazine	Atrazine results in decreased expression of FRAS1 mRNA	25929836
D001280	Atrazine	Atrazine results in increased expression of FRAS1 mRNA	29505797
C030935	benz(a)anthracene	benz(a)anthracene results in decreased expression of FRAS1 mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the methylation of FRAS1 intron	30157460
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of FRAS1 mRNA	20106945; 21632981; 22316170; 26238291;
C044887	beta-methylcholine	beta-methylcholine affects the expression of FRAS1 mRNA	21179406
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of FRAS1 mRNA	30951980
C006780	bisphenol A	bisphenol A results in decreased expression of FRAS1 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of FRAS1 gene	28505145
C000611646	bisphenol F	[bisphenol F co-treated with LIF protein] results in decreased expression of FRAS1 mRNA	30951980
C000611646	bisphenol F	bisphenol F results in increased expression of FRAS1 mRNA	30951980
C018475	butyraldehyde	butyraldehyde results in decreased expression of FRAS1 mRNA	26079696
D002117	Calcitriol	Calcitriol results in increased expression of FRAS1 mRNA	26485663
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of FRAS1 mRNA	27392435
D002945	Cisplatin	[Cisplatin co-treated with Paclitaxel] results in increased expression of FRAS1 mRNA	20705681
D002945	Cisplatin	[Cisplatin co-treated with Panobinostat] affects the expression of FRAS1 mRNA	21791302
D002945	Cisplatin	Cisplatin results in decreased expression of FRAS1 mRNA	27392435
D003042	Cocaine	Cocaine results in increased expression of FRAS1 mRNA	17898221
D003471	Cuprizone	Cuprizone results in decreased expression of FRAS1 mRNA	27523638
D003471	Cuprizone	Cuprizone results in increased expression of FRAS1 mRNA	26577399
D016572	Cyclosporine	Cyclosporine results in decreased expression of FRAS1 mRNA	25562108
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of FRAS1 mRNA	24317228
D003907	Dexamethasone	Dexamethasone results in increased expression of FRAS1 mRNA	25047013
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in decreased expression of FRAS1 mRNA	28962523
C000944	dicrotophos	dicrotophos results in increased expression of FRAS1 mRNA	28302478
D004041	Dietary Fats	Dietary Fats results in decreased expression of FRAS1 mRNA	30120929
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of FRAS1 mRNA	29505797
C516138	dorsomorphin	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRAS1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRAS1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRAS1 mRNA	27188386
D004726	Endosulfan	Endosulfan results in decreased expression of FRAS1 mRNA	29391264
C118739	entinostat	entinostat results in increased expression of FRAS1 mRNA	27188386
D004958	Estradiol	[Estradiol co-treated with TGFB1 protein] results in decreased expression of FRAS1 mRNA	30165855
D000431	Ethanol	Ethanol results in decreased expression of FRAS1 mRNA	29018328
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of FRAS1 mRNA	17942748
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of FRAS1 mRNA	28189721
D017313	Fenretinide	Fenretinide results in decreased expression of FRAS1 mRNA	28973697
C010974	glyphosate	glyphosate results in decreased methylation of FRAS1 gene	31011160
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of FRAS1 mRNA	27392435
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of FRAS1 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of FRAS1 mRNA	26011545
D008777	Methyltestosterone	Methyltestosterone results in increased expression of FRAS1 mRNA	29191790
D009151	Mustard Gas	Mustard Gas affects the expression of FRAS1 mRNA	15651846
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in decreased expression of FRAS1 mRNA	25554681; 25620056;
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of FRAS1 mRNA	25554681; 25620056;
D009532	Nickel	Nickel results in decreased expression of FRAS1 mRNA	24768652
C007350	nitrofen	nitrofen results in decreased expression of FRAS1 mRNA	26519041
C007350	nitrofen	nitrofen results in decreased expression of FRAS1 protein	26519041
D010100	Oxygen	Oxygen deficiency results in increased expression of FRAS1 mRNA	26516004
D017239	Paclitaxel	[Cisplatin co-treated with Paclitaxel] results in increased expression of FRAS1 mRNA	20705681
D000077767	Panobinostat	[Cisplatin co-treated with Panobinostat] affects the expression of FRAS1 mRNA	21791302
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of FRAS1 mRNA	29458080
D010629	Phenformin	Phenformin results in decreased expression of FRAS1 mRNA	31324951
D010662	Phenylmercuric Acetate	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRAS1 mRNA	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of FRAS1 mRNA	26272509
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of FRAS1 mRNA	23608068
D011192	Potassium Dichromate	Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FRAS1 mRNA]	23608068
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of FRAS1 mRNA	25825206
D012402	Rotenone	Rotenone results in decreased expression of FRAS1 mRNA	28374803
D012715	Sesame Oil	Sesame Oil results in decreased expression of FRAS1 mRNA	29191790
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of FRAS1 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of FRAS1 mRNA	23806026
D012834	Silver	Silver affects the expression of FRAS1 mRNA	27131904
C017947	sodium arsenite	sodium arsenite affects the methylation of FRAS1 gene	28589171
C017947	sodium arsenite	sodium arsenite results in decreased expression of FRAS1 mRNA	29301061
D013605	T-2 Toxin	T-2 Toxin results in increased expression of FRAS1 mRNA	31299295
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of FRAS1 mRNA	26377647
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of FRAS1 mRNA	28973375
D008063	Thioctic Acid	Thioctic Acid inhibits the reaction [Potassium Dichromate results in increased expression of FRAS1 mRNA]	23608068
C009495	titanium dioxide	titanium dioxide affects the expression of FRAS1 mRNA	23557971
C009495	titanium dioxide	titanium dioxide results in decreased expression of FRAS1 mRNA	30012374
C024746	tobacco tar	tobacco tar results in increased expression of FRAS1 mRNA	19559774
D014212	Tretinoin	Tretinoin results in decreased expression of FRAS1 mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of FRAS1 mRNA	21934132
C011559	tributyltin	tributyltin results in increased expression of FRAS1 mRNA	29505797
C012589	trichostatin A	[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRAS1 mRNA	27188386
C012589	trichostatin A	trichostatin A results in increased expression of FRAS1 mRNA	26272509
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate affects the expression of FRAS1 mRNA	26179874
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of FRAS1 mRNA	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of FRAS1 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of FRAS1 mRNA	23179753; 24383497; 26272509; 27188386;
D014635	Valproic Acid	Valproic Acid affects the expression of FRAS1 mRNA	17292431
D014635	Valproic Acid	Valproic Acid results in decreased expression of FRAS1 mRNA	29427782

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0025	Alternative splicing
KW-0106	Calcium
KW-1003	Cell membrane
KW-0325	Glycoprotein
KW-0472	Membrane
KW-0479	Metal-binding
KW-0597	Phosphoprotein
KW-0621	Polymorphism
KW-1185	Reference proteome
KW-0677	Repeat
KW-0732	Signal
KW-0812	Transmembrane
KW-1133	Transmembrane helix

Interpro

InterPro ID	InterPro Term
IPR038081	CalX-like_sf
IPR003644	Calx_beta
IPR039005	CSPG_rpt
IPR000742	EGF-like_dom
IPR006212	Furin_repeat
IPR009030	Growth_fac_rcpt_cys_sf
IPR001007	VWF_dom

PROSITE

PROSITE ID	PROSITE Term
PS51854	CSPG
PS01208	VWFC_1
PS50184	VWFC_2

Pfam

Pfam ID	Pfam Term
PF03160	Calx-beta
PF00093	VWC

Gene: FRAS1

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction