| Tag | Content |
|---|---|
| Uniprot ID | Q8BLY1; Q9WVN9; |
| Entrez ID | 64075 |
| Genbank protein ID | AAH31804.1; AAD41590.1; BAC30750.1; |
| Genbank nucleotide ID | NM_022316.2; NM_001146217.1; |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | SPARC-related modular calcium-binding protein 1 |
| Gene symbol | Smoc1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 21750680 |
| Functional description | Probable regulator of osteoblast differentiation. Plays essential roles in both eye and limb development. |
| Sequence | MLPARVRLLT PHLLLVLVQL SPAGGHRTTG PRFLISDRDP PCNPHCPRTQ PKPICASDGR 60 SYESMCEYQR AKCRDPALAV VHRGRCKDAG QSKCRLERAQ ALEQAKKPQE AVFVPECGED 120 GSFTQVQCHT YTGYCWCVTP DGKPISGSSV QNKTPVCSGP VTDKPLSQGN SGRKVSFRFF 180 LTLNSDDGSK PTPTMETQPV FDGDEITAPT LWIKHLVIKD SKLNNTNVRN SEKVHSCDQE 240 RQSALEEARQ NPREGIVIPE CAPGGLYKPV QCHQSTGYCW CVLVDTGRPL PGTSTRYVMP 300 SCESDARAKS VEADDPFKDR ELPGCPEGKK MEFITSLLDA LTTDMVQAIN SAAPTGGGRF 360 SEPDPSHTLE ERVAHWYFSQ LDSNSSDDIN KREMKPFKRY VKKKAKPKKC ARRFTDYCDL 420 NKDKVISLPE LKGCLGVSKE GGSLGSFPQG KRAGTNPFIG RLV 463 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005509 | calcium ion binding | IEA |
| GO:0050840 | extracellular matrix binding | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001654 | eye development | ISO |
| GO:0001654 | eye development | IMP |
| GO:0010811 | positive regulation of cell-substrate adhesion | IDA |
| GO:0030154 | cell differentiation | IEA |
| GO:0030198 | extracellular matrix organization | IDA |
| GO:0045667 | regulation of osteoblast differentiation | ISO |
| GO:0060173 | limb development | ISO |
| GO:0060173 | limb development | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005604 | basement membrane | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0025 | Alternative splicing |
| KW-0084 | Basement membrane |
| KW-0106 | Calcium |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-1015 | Disulfide bond |
| KW-0272 | Extracellular matrix |
| KW-0325 | Glycoprotein |
| KW-0479 | Metal-binding |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0964 | Secreted |
| KW-0732 | Signal |