Gene: Kat6a

Basic information

Tag Content
Uniprot ID Q8BZ21; Q8BW52; Q8BYH1; Q8C1F3;
Entrez ID
Genbank protein ID BAC30401.1; BAC25728.1; BAC35729.1; BAC29621.1;
Genbank nucleotide ID
Ensembl protein ID
Ensembl nucleotide ID
Gene name Histone acetyltransferase KAT6A
Gene symbol Kat6a
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 22921202; 16651658;
Functional description Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2 (By similarity). Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML (By similarity).
Sequence
MVKLANPLYT EWILEAIKKV KKQKQRPSEE RICNAVSSSH GLDRRTVLEQ LELSVKDGTI 60
LKVSNKGLNS YKDPDNPGRI ALPKPRNHGK LDTKQSVDWN KLLKRAFEGL AETGGSTLKS 120
IERFLKSQKD VSAACGGSAA PGFHQQLRLA IKRAVGHGRL LKDGPLYRLN TKAASAEGKE 180
GCESLSCLPP VSLLPHEKDK PVAEPIPICS FCLGTKEQNR EKQPEELVSC ADCGNSGHPS 240
CLKFSPELTV RVKALRWQCI ECKTCSSCRD QGKNADNMLF CDSCDRGFHM ECCDPPLTRM 300
PKGMWICQIC RPRKKGRKLL QKKAAQIKRR YANPIGRPKN RLKKQNTVSK GPFSKVRTGP 360
GRGRKRKITV SSQSASSSEE GYLERIDGLD FCRDSNAPLK FNKKTKGLID GLTKFFTPSP 420
DGRKARGEVV DYSEQYRIRK KGNRKSSTSD WPTDNQDGWE SKQENEERLF GSQEIMTERD 480
MELFRDIQEQ ALQKVGVTGP PDPQVRCPSV IEFGKYEIHT WYSSPYPQEY SRLPKLYLCE 540
FCLKYMKSRT ILQQHMKKCG WFHPPANEIY RKNNISVFEV DGNVSTIYCQ NLCLLAKLFL 600
DHKTLYYDVE PFLFYVLTQN DVKGCHLVGY FSKEKHCQQK YNVSCIMILP QYQRKGYGRF 660
LIDFSYLLSK REGQAGSPEK PLSDLGRLSY MAYWKSVILE CLYHQNDKQI SIKKLSKLTG 720
VCPQDITSTL HHLRMLDFRS DQFVIIRREK LIQDHMAKLQ LNLRPVDVDP ECLRWTPVIV 780
SNSVVSEDED EEADEGEKEE PQGQERELET RVKVGKSVSR EKKDQESSSL IETDKKPEVK 840
ELASSSRLSK QALPRDSLPA NSQPPRRGRC GRKNRKTQER FGDKDSKMLV DETLSASQEQ 900
YGDCEEKSET SQERFTEMEE QLAAPQVQAD GKPDIPKGRF SESVELWRGQ LKKSPETLKC 960
RLPEGNDRLP CCYTDGDRAF FRGFSESSEE EEEPESPRSN SPPILTKPTL KRKKPILHRR 1020
RRVRKRKHHN SSVVTETISE TTEVLDEPFE DSDSERPMPR LEPTFEMEEE EEEEEEESEL 1080
FPRGYFHCLS SQDILRCQSS SKRPSKEEEE EEEESDDADD TPVLKPVSLL RKCDVNSASL 1140
EPDTSTPMKK KKGWPKGKSR KPIHWKKRPG RKPGFKLNQE IIAASAQECI VEPVVPIKPG 1200
RKPRTQENEE IVEVKEDLLE ERKEEMHTEP DEEAEEEEDT TSSDIRAMSP LDSSNSPEAE 1260
PKEPEPEEED EKPSDDQRQS EEEPQELEEQ EQEEEDEVTT EANQNEDHDA DDEDEGHLDS 1320
LKTKEPEEQP AREDDKEEPG IQGSFLAANM QDSRENTKDK DEAEPDSEED QPSHEASVVS 1380
ETMPGSEEDH EEDSNTKEEL IELKEEEEIP HSELDLETVQ AVQSLTQEES SEHEGAYQDC 1440
EETLAACQTL QSYTHTDEDP QMSMVEDCHA SEHNSPISSI PSHPSQSVRS VNSPSMPALE 1500
SGYTQISPEQ GSLSAPSMQN METSPMMDVP SVSDHSQQVV DSGFSDLGSI ESTTENYENP 1560
SSYDSTMGSS ICGNNSSQSS CSYGGLSSSS SLTQNSCVVT QQMANMGNSC SMLQQNTVQP 1620
AANCNIKSPQ TCVVERPPSN QQPPPPPPPP PPPQQPQPPP QQQAAPQPPP PQPQQQQQQQ 1680
QQPPPPQQQP QPPPPQQQPP LSQCSMNNSF TAAPMIMEIP ESGSTGNISI YERIPGDFGA 1740
GSYSQPSATF SLAKLQQLTN TIMDPHAMPY SHSPAVTSYA TSVSLSNTGL AQLAPSHPLA 1800
GTPQAQATMT PPPNLASTTM NLTSPLLQCN MSATNIGIPH TQRLQGQMPV KGHISIRSKS 1860
APLPSATAHQ QQLYGRSPPA VAMQAGPRAL AVQRGMNMGV NLMPTPAYNV NSMNMNTLNA 1920
MNSYRMTQPM MNSSYHSNPA YMNQTAQYPM QMQMGMMGSQ AYTQQPMQPN PHGNMMYTGP 1980
SHHSYMNAAG VPKQSLNGPY MRR 2003

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0003677 DNA bindingISS
GO:0003677 DNA bindingISO
GO:0003682 chromatin bindingIGI
GO:0003713 transcription coactivator activityIEA
GO:0004402 histone acetyltransferase activityISS
GO:0004402 histone acetyltransferase activityISO
GO:0004402 histone acetyltransferase activityIBA
GO:0005515 protein bindingIPI
GO:0008134 transcription factor bindingISS
GO:0008134 transcription factor bindingISO
GO:0008270 zinc ion bindingISS
GO:0008270 zinc ion bindingISO
GO:0016407 acetyltransferase activityISS
GO:0016407 acetyltransferase activityISO
GO:0042393 histone bindingIBA

GO:Biological Process

GO ID GO Term Evidence
GO:0003007 heart morphogenesisIGI
GO:0003007 heart morphogenesisIMP
GO:0006334 nucleosome assemblyIEA
GO:0006473 protein acetylationISS
GO:0006473 protein acetylationISO
GO:0010628 positive regulation of gene expressionISO
GO:0016573 histone acetylationISS
GO:0016573 histone acetylationISO
GO:0030099 myeloid cell differentiationISS
GO:0030099 myeloid cell differentiationISO
GO:0035019 somatic stem cell population maintenanceIMP
GO:0035162 embryonic hemopoiesisIMP
GO:0035909 aorta morphogenesisIGI
GO:0035909 aorta morphogenesisIMP
GO:0043433 negative regulation of DNA-binding transcription factor activityIMP
GO:0043966 histone H3 acetylationISS
GO:0043966 histone H3 acetylationISO
GO:0043966 histone H3 acetylationIBA
GO:0043966 histone H3 acetylationIMP
GO:0045892 negative regulation of transcription, DNA-templatedISS
GO:0045892 negative regulation of transcription, DNA-templatedISO
GO:0045892 negative regulation of transcription, DNA-templatedIBA
GO:0045893 positive regulation of transcription, DNA-templatedISS
GO:0045893 positive regulation of transcription, DNA-templatedISO
GO:0045944 positive regulation of transcription by RNA polymerase IIIBA
GO:0060325 face morphogenesisIGI
GO:0060325 face morphogenesisIMP
GO:0090398 cellular senescenceISS
GO:0090398 cellular senescenceISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0000123 histone acetyltransferase complexIBA
GO:0000786 nucleosomeIEA
GO:0000790 nuclear chromatinIBA
GO:0005634 nucleusISS
GO:0005634 nucleusISO
GO:0005634 nucleusIDA
GO:0005634 nucleusIBA
GO:0005730 nucleolusISO
GO:0005829 cytosolISO
GO:0016605 PML bodyISS
GO:0016605 PML bodyISO
GO:0016607 nuclear speckISO
GO:0070776 MOZ/MORF histone acetyltransferase complexISS
GO:0070776 MOZ/MORF histone acetyltransferase complexISO
GO:0070776 MOZ/MORF histone acetyltransferase complexIBA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0010 Activator
KW-0012 Acyltransferase
KW-0156 Chromatin regulator
KW-1017 Isopeptide bond
KW-0479 Metal-binding
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0677 Repeat
KW-0678 Repressor
KW-0804 Transcription
KW-0805 Transcription regulation
KW-0808 Transferase
KW-0832 Ubl conjugation
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR016181 Acyl_CoA_acyltransferase
IPR002717 HAT_MYST-type
IPR005818 Histone_H1/H5_H15
IPR031280 KAT6A
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR040706 Zf-MYST
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

PROSITE

PROSITE ID PROSITE Term
PS51504 H15
PS51726 MYST_HAT
PS01359 ZF_PHD_1
PS50016 ZF_PHD_2

Pfam

Pfam ID Pfam Term
PF01853 MOZ_SAS
PF00628 PHD
PF17772 zf-MYST

Protein-miRNA interaction