CleftGeneDB-Search

Gene: TEX11

Basic information

Tag	Content
Uniprot ID	Q8IYF3; A8K8V6; Q5JQQ8; Q96LZ4; Q96M47; Q9BXU6;
Entrez ID	56159
Genbank protein ID	BAB71520.1; BAF85160.1; AAK31973.1; AAH36016.2; EAX05331.1; BAB71465.1;
Genbank nucleotide ID	NM_031276.2; XM_011530996.1; NM_001003811.1;
Ensembl protein ID	ENSP00000379226; ENSP00000363440; ENSP00000340995; ENSP00000363453;
Ensembl nucleotide ID	ENSG00000120498
Gene name	Testis-expressed protein 11
Gene symbol	TEX11
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Manually collected
Reference	26449438
Functional description	Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers.
Sequence	MISAHCNLRL LCSSDSSASA SQVAGTTEVV ENLVTNDNSP NIPEAIDRLF SDIANINRES 60 MAEITDIQIE EMAVNLWNWA LTIGGGWLVN EEQKIRLHYV ACKLLSMCEA SFASEQSIQR 120 LIMMNMRIGK EWLDAGNFLI ADECFQAAVA SLEQLYVKLI QRSSPEADLT MEKITVESDH 180 FRVLSYQAES AVAQGDFQRA SMCVLQCKDM LMRLPQMTSS LHHLCYNFGV ETQKNNKYEE 240 SSFWLSQSYD IGKMDKKSTG PEMLAKVLRL LATNYLDWDD TKYYDKALNA VNLANKEHLS 300 SPGLFLKMKI LLKGETSNEE LLEAVMEILH LDMPLDFCLN IAKLLMDHER ESVGFHFLTI 360 IHERFKSSEN IGKVLILHTD MLLQRKEELL AKEKIEEIFL AHQTGRQLTA ESMNWLHNIL 420 WRQAASSFEV QNYTDALQWY YYSLRFYSTD EMDLDFTKLQ RNMACCYLNL QQLDKAKEAV 480 AEAERHDPRN VFTQFYIFKI AVIEGNSERA LQAIITLENI LTDEESEDND LVAERGSPTM 540 LLSLAAQFAL ENGQQIVAEK ALEYLAQHSE DQEQVLTAVK CLLRFLLPKI AEMPESEDKK 600 KEMDRLLTCL NRAFVKLSQP FGEEALSLES RANEAQWFRK TAWNLAVQCD KDPVMMREFF 660 ILSYKMSQFC PSDQVILIAR KTCLLMAVAV DLEQGRKAST AFEQTMFLSR ALEEIQTCND 720 IHNFLKQTGT FSNDSCEKLL LLYEFEVRAK LNDPLLESFL ESVWELPHLE TKTFETIAII 780 AMEKPAHYPL IALKALKKAL LLYKKEEPID ISQYSKCMHN LVNLSVPDGA SNVELCPLEE 840 VWGYFEDALS HISRTKDYPE MEILWLMVKS WNTGVLMFSR SKYASAEKWC GLALRFLNHL 900 TSFKESYETQ MNMLYSQLVE ALSNNKGPVF HEHGYWSKSD

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Species	Evidence	Details
1:1 ortholog	TEX11	56159	Q8IYF3	Homo sapiens	Publication	More>>
1:1 ortholog	Tex11	83558	Q14AT2	Mus musculus	Prediction	More>>
1:1 ortholog	TEX11		H2R4P5	Pan troglodytes	Prediction	More>>
1:1 ortholog	Tex11		D3Z868	Rattus norvegicus	Prediction	More>>
1:1 ortholog	tex11		F1QIP8	Danio rerio	Prediction	More>>

Identified variants/mutations related to cleft phenotype

Gene symbol	Significant Variants/SNPS	Methods	PubMed ID
TEX11	c.2541A>C; p.D847E	WES and Sanger sequencing	26449438

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs1344192441	p.Ser3Leu	missense variant	-	NC_000023.11:g.70897539G>A	TOPMed
rs1202826814	p.His5Tyr	missense variant	-	NC_000023.11:g.70897534G>A	TOPMed
rs186262417	p.Cys6Ter	stop gained	-	NC_000023.11:g.70897529G>T	1000Genomes,TOPMed,gnomAD
rs1250506630	p.Cys6Ser	missense variant	-	NC_000023.11:g.70897531A>T	TOPMed
rs1037576205	p.Asn7Ser	missense variant	-	NC_000023.11:g.70897527T>C	TOPMed,gnomAD
rs1320559199	p.Arg9Cys	missense variant	-	NC_000023.11:g.70897522G>A	TOPMed,gnomAD
rs1005238755	p.Cys12Arg	missense variant	-	NC_000023.11:g.70897513A>G	TOPMed
rs1168374113	p.Asp15Asn	missense variant	-	NC_000023.11:g.70897504C>T	TOPMed
rs1350790590	p.Ser16Pro	missense variant	-	NC_000023.11:g.70897501A>G	TOPMed
rs747440106	p.Thr27Ala	missense variant	-	NC_000023.11:g.70897468T>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Leu33Met	missense variant	-	chrX:g.70880095G>T	NCI-TCGA
rs141951098	p.Val34Leu	missense variant	-	NC_000023.11:g.70880092C>G	ESP,ExAC,TOPMed,gnomAD
rs1234114625	p.Val34Ala	missense variant	-	NC_000023.11:g.70880091A>G	gnomAD
rs1334521076	p.Thr35Arg	missense variant	-	NC_000023.11:g.70880088G>C	gnomAD
rs1291671125	p.Pro40Ser	missense variant	-	NC_000023.11:g.70880074G>A	TOPMed,gnomAD
rs1179943501	p.Ile42Leu	missense variant	-	NC_000023.11:g.70880068T>A	TOPMed
rs904176751	p.Ala45Thr	missense variant	-	NC_000023.11:g.70880059C>T	TOPMed
rs1470073033	p.Ala45Val	missense variant	-	NC_000023.11:g.70880058G>A	TOPMed
rs1412987331	p.Arg48Thr	missense variant	-	NC_000023.11:g.70880049C>G	TOPMed
rs1380500294	p.Ser51Asn	missense variant	-	NC_000023.11:g.70880040C>T	gnomAD
rs1326402590	p.Asp52Asn	missense variant	-	NC_000023.11:g.70880038C>T	TOPMed,gnomAD
NCI-TCGA novel	p.Asp52Asn	missense variant	-	chrX:g.70880038C>T	NCI-TCGA
rs767439893	p.Ile56Ser	missense variant	-	NC_000023.11:g.70880025A>C	ExAC,TOPMed,gnomAD
rs996784363	p.Ala62Thr	missense variant	-	NC_000023.11:g.70880008C>T	TOPMed
COSM1315653	p.Glu63Ter	stop gained	Variant assessed as Somatic; HIGH impact.	chrX:g.70880005C>A	NCI-TCGA Cosmic
rs751261544	p.Ile67Ser	missense variant	-	NC_000023.11:g.70879992A>C	ExAC,TOPMed,gnomAD
rs756069493	p.Ile69Val	missense variant	-	NC_000023.11:g.70873307T>C	ExAC,gnomAD
rs1392057829	p.Glu71Lys	missense variant	-	NC_000023.11:g.70873301C>T	gnomAD
COSM3563034	p.Glu71Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70873301C>T	NCI-TCGA Cosmic
rs1224644533	p.Met72Ile	missense variant	-	NC_000023.11:g.70873296C>T	TOPMed
rs372882973	p.Trp79Arg	missense variant	-	NC_000023.11:g.70873277A>G	ESP,ExAC,gnomAD
NCI-TCGA novel	p.Gly84Arg	missense variant	-	chrX:g.70873262C>T	NCI-TCGA
NCI-TCGA novel	p.Gly85Arg	missense variant	-	chrX:g.70873259C>T	NCI-TCGA
COSM277651	p.Asn90His	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70873244T>G	NCI-TCGA Cosmic
rs763873466	p.Glu91Lys	missense variant	-	NC_000023.11:g.70873241C>T	ExAC,TOPMed,gnomAD
rs762516688	p.Glu92Lys	missense variant	-	NC_000023.11:g.70873238C>T	ExAC,gnomAD
NCI-TCGA novel	p.Arg96Ile	missense variant	-	chrX:g.70873225C>A	NCI-TCGA
rs756997139	p.His98Asn	missense variant	-	NC_000023.11:g.70860934G>T	ExAC,TOPMed,gnomAD
rs746751241	p.His98Arg	missense variant	-	NC_000023.11:g.70860933T>C	ExAC,TOPMed,gnomAD
rs1257803300	p.Ala110Gly	missense variant	-	NC_000023.11:g.70860897G>C	TOPMed
COSM6119215	p.Ala110Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70860897G>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ser111Ter	stop gained	-	chrX:g.70860894G>C	NCI-TCGA
COSM3914190	p.Ser111Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70860894G>A	NCI-TCGA Cosmic
rs1423488984	p.Ala113Ser	missense variant	-	NC_000023.11:g.70860889C>A	TOPMed,gnomAD
NCI-TCGA novel	p.Ala113Asp	missense variant	-	chrX:g.70860888G>T	NCI-TCGA
COSM1315652	p.Ser114Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70860885G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ser117Cys	missense variant	-	chrX:g.70860877T>A	NCI-TCGA
rs752390103	p.Ile118Ser	missense variant	-	NC_000023.11:g.70860873A>C	ExAC,gnomAD
rs764706779	p.Gln119Glu	missense variant	-	NC_000023.11:g.70860871G>C	ExAC,gnomAD
COSM1228992	p.Arg120Ter	stop gained	Variant assessed as Somatic; HIGH impact.	chrX:g.70860868G>A	NCI-TCGA Cosmic
rs1486675411	p.Arg120Ter	stop gained	-	NC_000023.11:g.70860868G>A	gnomAD
rs1281185459	p.Ile122Val	missense variant	-	NC_000023.11:g.70860862T>C	gnomAD
NCI-TCGA novel	p.Met123Ile	missense variant	-	chrX:g.70860857C>T	NCI-TCGA
rs1409837902	p.Asn125Tyr	missense variant	-	NC_000023.11:g.70853325T>A	TOPMed
rs1401602484	p.Met126Val	missense variant	-	NC_000023.11:g.70853322T>C	gnomAD
COSM4828853	p.Met126Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70853320C>T	NCI-TCGA Cosmic
rs1290827505	p.Arg127Gly	missense variant	-	NC_000023.11:g.70853319T>C	TOPMed
rs767787700	p.Ile128Leu	missense variant	-	NC_000023.11:g.70853316T>A	TOPMed,gnomAD
rs6525433	p.Lys130Arg	missense variant	-	NC_000023.11:g.70853309T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1314256178	p.Glu131Lys	missense variant	-	NC_000023.11:g.70853307C>T	TOPMed
COSM3973817	p.Glu131Ter	stop gained	Variant assessed as Somatic; HIGH impact.	chrX:g.70853307C>A	NCI-TCGA Cosmic
rs1231349120	p.Glu131Asp	missense variant	-	NC_000023.11:g.70853305T>A	TOPMed
NCI-TCGA novel	p.Asp134His	missense variant	-	chrX:g.70853298C>G	NCI-TCGA
COSM457934	p.Ala135Val	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70853294G>A	NCI-TCGA Cosmic
rs746007852	p.Asn137Thr	missense variant	-	NC_000023.11:g.70853288T>G	ExAC,gnomAD
NCI-TCGA novel	p.Phe138Val	missense variant	-	chrX:g.70853286A>C	NCI-TCGA
NCI-TCGA novel	p.Leu139Ter	frameshift	-	chrX:g.70853284A>-	NCI-TCGA
rs770843069	p.Ile140Met	missense variant	-	NC_000023.11:g.70853278G>C	ExAC,TOPMed,gnomAD
rs746940663	p.Ala141Thr	missense variant	-	NC_000023.11:g.70853277C>T	ExAC
rs1187226342	p.Glu143Val	missense variant	-	NC_000023.11:g.70853270T>A	gnomAD
COSM1124524	p.Glu143Ter	stop gained	Variant assessed as Somatic; HIGH impact.	chrX:g.70853271C>A	NCI-TCGA Cosmic
rs777581837	p.Glu143Lys	missense variant	-	NC_000023.11:g.70853271C>T	ExAC
rs191462531	p.Gln146Arg	missense variant	-	NC_000023.11:g.70853261T>C	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Ala148Val	missense variant	-	chrX:g.70853255G>A	NCI-TCGA
rs996795407	p.Val149Leu	missense variant	-	NC_000023.11:g.70853253C>A	TOPMed
NCI-TCGA novel	p.Ala150Asp	missense variant	-	chrX:g.70853249G>T	NCI-TCGA
NCI-TCGA novel	p.Leu152Gln	missense variant	-	chrX:g.70853149A>T	NCI-TCGA
rs746945464	p.Tyr156His	missense variant	-	NC_000023.11:g.70853138A>G	ExAC,gnomAD
rs773083176	p.Val157Ile	missense variant	-	NC_000023.11:g.70853135C>T	ExAC,TOPMed,gnomAD
rs773083176	p.Val157Ile	missense variant	-	chrX:g.70853135C>T	NCI-TCGA,NCI-TCGA Cosmic
rs181134374	p.Lys158Gln	missense variant	-	NC_000023.11:g.70853132T>G	1000Genomes,ExAC,TOPMed,gnomAD
rs1294569476	p.Lys158Asn	missense variant	-	NC_000023.11:g.70853130T>G	TOPMed
rs897271752	p.Ile160Phe	missense variant	-	NC_000023.11:g.70853126T>A	TOPMed
COSM1124523	p.Arg162Met	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70853119C>A	NCI-TCGA Cosmic
rs1468763544	p.Ser163Arg	missense variant	-	NC_000023.11:g.70853117T>G	gnomAD
rs898803761	p.Pro165Ser	missense variant	-	NC_000023.11:g.70853111G>A	TOPMed,gnomAD
rs1300917198	p.Asp168Gly	missense variant	-	NC_000023.11:g.70853101T>C	TOPMed
rs747871574	p.Leu169Phe	missense variant	-	NC_000023.11:g.70853097C>G	ExAC,TOPMed
rs1444272112	p.Thr170Ser	missense variant	-	NC_000023.11:g.70853096T>A	gnomAD
rs143246552	p.Met171Val	missense variant	-	NC_000023.11:g.70853093T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
RCV000173008	p.Met171Val	missense variant	Spermatogenic failure, X-linked, 2 (SPGFX2)	NC_000023.11:g.70853093T>C	ClinVar
rs1295740489	p.Glu172Asp	missense variant	-	NC_000023.11:g.70853088C>A	gnomAD
rs1341488009	p.Thr175Ala	missense variant	-	NC_000023.11:g.70853081T>C	TOPMed
rs1365016323	p.Glu177Lys	missense variant	-	NC_000023.11:g.70853075C>T	TOPMed,gnomAD
rs1296061122	p.Ser178Asn	missense variant	-	NC_000023.11:g.70853071C>T	gnomAD
rs1247146060	p.Ser178Gly	missense variant	-	NC_000023.11:g.70853072T>C	TOPMed
rs779587803	p.Asp179Asn	missense variant	-	NC_000023.11:g.70853069C>T	ExAC,gnomAD
rs1489381711	p.His180Leu	missense variant	-	NC_000023.11:g.70853065T>A	TOPMed
rs375000923	p.Val183Met	missense variant	-	NC_000023.11:g.70853057C>T	ESP,ExAC,gnomAD
NCI-TCGA novel	p.Ser185Cys	missense variant	-	chrX:g.70853050G>C	NCI-TCGA
NCI-TCGA novel	p.Ala191Thr	missense variant	-	chrX:g.70833593C>T	NCI-TCGA
rs1298977936	p.Ala193Thr	missense variant	-	NC_000023.11:g.70833587C>T	gnomAD
NCI-TCGA novel	p.Ala193SerPheSerTerUnkUnk	frameshift	-	chrX:g.70833587_70833588insAACT	NCI-TCGA
rs779629000	p.Gln194Arg	missense variant	-	NC_000023.11:g.70833583T>C	ExAC,TOPMed,gnomAD
rs149131292	p.Asp196Asn	missense variant	-	NC_000023.11:g.70833578C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1175408403	p.Gln198Arg	missense variant	-	NC_000023.11:g.70833571T>C	gnomAD
rs1341513691	p.Ser201Phe	missense variant	-	NC_000023.11:g.70833562G>A	TOPMed
rs370291538	p.Met202Thr	missense variant	-	NC_000023.11:g.70833559A>G	ESP,ExAC,gnomAD
rs1450617584	p.Met202Ile	missense variant	-	NC_000023.11:g.70833558C>T	TOPMed
NCI-TCGA novel	p.Gln206Leu	missense variant	-	chrX:g.70833547T>A	NCI-TCGA
rs1414528872	p.Asp209Asn	missense variant	-	NC_000023.11:g.70833539C>T	gnomAD
COSM1469097	p.Asp209Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70833539C>A	NCI-TCGA Cosmic
rs1196396837	p.Met210Thr	missense variant	-	NC_000023.11:g.70833535A>G	gnomAD
rs1420664018	p.Met212Thr	missense variant	-	NC_000023.11:g.70833529A>G	gnomAD
NCI-TCGA novel	p.Leu221Val	missense variant	-	chrX:g.70806781G>C	NCI-TCGA
rs1455114798	p.His222Tyr	missense variant	-	NC_000023.11:g.70806778G>A	gnomAD
NCI-TCGA novel	p.Gln233Lys	missense variant	-	chrX:g.70806745G>T	NCI-TCGA
NCI-TCGA novel	p.Lys234Asn	missense variant	-	chrX:g.70806740C>A	NCI-TCGA
rs768423064	p.Asn236Asp	missense variant	-	NC_000023.11:g.70806736T>C	ExAC,gnomAD
rs149967739	p.Tyr238Cys	missense variant	-	NC_000023.11:g.70806729T>C	ESP,gnomAD
rs775355719	p.Ser242Tyr	missense variant	-	chrX:g.70806717G>T	NCI-TCGA
rs775355719	p.Ser242Tyr	missense variant	-	NC_000023.11:g.70806717G>T	ExAC,gnomAD
rs1233129234	p.Gln247Lys	missense variant	-	NC_000023.11:g.70744218G>T	gnomAD
COSM3563032	p.Ser248Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70744214C>T	NCI-TCGA Cosmic
COSM1124522	p.Ser248Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70744214C>A	NCI-TCGA Cosmic
rs762509635	p.Tyr249Phe	missense variant	-	NC_000023.11:g.70744211T>A	1000Genomes,ExAC,TOPMed,gnomAD
rs1352574436	p.Asp250His	missense variant	-	NC_000023.11:g.70744209C>G	TOPMed
rs1249191150	p.Asp250Val	missense variant	-	NC_000023.11:g.70744208T>A	gnomAD
NCI-TCGA novel	p.Asp250Ala	missense variant	-	chrX:g.70744208T>G	NCI-TCGA
rs767565935	p.Ile251Phe	missense variant	-	NC_000023.11:g.70744206T>A	ExAC,TOPMed
rs1294101701	p.Met254Ile	missense variant	-	NC_000023.11:g.70744195C>T	TOPMed
NCI-TCGA novel	p.Met254Thr	missense variant	-	chrX:g.70744196A>G	NCI-TCGA
rs757383142	p.Asp255Asn	missense variant	-	NC_000023.11:g.70744194C>T	ExAC,gnomAD
rs751491935	p.Asp255Gly	missense variant	-	NC_000023.11:g.70744193T>C	ExAC,gnomAD
NCI-TCGA novel	p.Lys256Glu	missense variant	-	chrX:g.70744191T>C	NCI-TCGA
rs762957753	p.Thr259Ile	missense variant	-	NC_000023.11:g.70744181G>A	ExAC,TOPMed,gnomAD
rs376793868	p.Thr259Ala	missense variant	-	NC_000023.11:g.70744182T>C	ESP,ExAC,gnomAD
rs762957753	p.Thr259Ile	missense variant	-	chrX:g.70744181G>A	NCI-TCGA
rs376793868	p.Thr259Ser	missense variant	-	NC_000023.11:g.70744182T>A	ESP,ExAC,gnomAD
rs1236503664	p.Gly260Arg	missense variant	-	NC_000023.11:g.70744179C>T	TOPMed
rs775098071	p.Pro261Ser	missense variant	-	NC_000023.11:g.70744176G>A	ExAC,gnomAD
rs1283604357	p.Lys266Asn	missense variant	-	NC_000023.11:g.70740791T>A	TOPMed
COSM6119219	p.Val267Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70740790C>T	NCI-TCGA Cosmic
COSM3424917	p.Leu268Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70740787G>T	NCI-TCGA Cosmic
rs1164466971	p.Arg269Gln	missense variant	-	NC_000023.11:g.70740783C>T	TOPMed,gnomAD
rs756553436	p.Arg269Trp	missense variant	-	NC_000023.11:g.70740784G>A	ExAC,gnomAD
rs781457497	p.Thr273Met	missense variant	-	NC_000023.11:g.70740771G>A	ExAC,TOPMed,gnomAD
rs370599644	p.Asn274Ser	missense variant	-	NC_000023.11:g.70740768T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs764252789	p.Tyr275Cys	missense variant	-	NC_000023.11:g.70740765T>C	ExAC,gnomAD
COSM1469096	p.Trp278Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70740756C>A	NCI-TCGA Cosmic
rs996232982	p.Thr281Ala	missense variant	-	NC_000023.11:g.70740748T>C	gnomAD
NCI-TCGA novel	p.Tyr283His	missense variant	-	chrX:g.70740742A>G	NCI-TCGA
rs1479630994	p.Tyr284Cys	missense variant	-	NC_000023.11:g.70740738T>C	gnomAD
rs776556073	p.Asp285Tyr	missense variant	-	NC_000023.11:g.70740736C>A	ExAC,TOPMed,gnomAD
rs776556073	p.Asp285Asn	missense variant	-	chrX:g.70740736C>T	NCI-TCGA
rs776556073	p.Asp285Asn	missense variant	-	NC_000023.11:g.70740736C>T	ExAC,TOPMed,gnomAD
rs1453413711	p.Leu288Phe	missense variant	-	NC_000023.11:g.70740727G>A	TOPMed
rs375896248	p.Asn289Ser	missense variant	-	NC_000023.11:g.70740723T>C	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Asn292Thr	missense variant	-	chrX:g.70740714T>G	NCI-TCGA
rs372375453	p.Glu297Lys	missense variant	-	NC_000023.11:g.70725343C>T	ESP,ExAC,TOPMed,gnomAD
rs368140818	p.His298Tyr	missense variant	-	NC_000023.11:g.70725340G>A	ESP,ExAC,TOPMed,gnomAD
COSM25584	p.Ser301Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70725330G>A	NCI-TCGA Cosmic
COSM4841191	p.Ser301Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70725330G>T	NCI-TCGA Cosmic
COSM1715107	p.Met308Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70725308C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Lys309Asn	missense variant	-	chrX:g.70725305T>G	NCI-TCGA
rs1442546702	p.Leu311Phe	missense variant	-	NC_000023.11:g.70725301G>A	gnomAD
rs747262390	p.Gly314Ser	missense variant	-	NC_000023.11:g.70725292C>T	ExAC,TOPMed,gnomAD
rs575754903	p.Glu315Lys	missense variant	-	NC_000023.11:g.70725289C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs778845628	p.Ser317Cys	missense variant	-	NC_000023.11:g.70725282G>C	ExAC,gnomAD
COSM1124520	p.Ser317Pro	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70725283A>G	NCI-TCGA Cosmic
rs1312102683	p.Glu319Lys	missense variant	-	NC_000023.11:g.70725277C>T	TOPMed
NCI-TCGA novel	p.Glu319Lys	missense variant	-	chrX:g.70725277C>T	NCI-TCGA
rs1414225026	p.Glu320Asp	missense variant	-	NC_000023.11:g.70725272T>A	gnomAD
rs1014233938	p.Glu323Asp	missense variant	-	NC_000023.11:g.70725263T>G	TOPMed,gnomAD
rs914609885	p.Val325Ala	missense variant	-	NC_000023.11:g.70722693A>G	TOPMed
COSM4862675	p.Val325Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70722693A>T	NCI-TCGA Cosmic
rs1263202185	p.Met326Val	missense variant	-	NC_000023.11:g.70722691T>C	TOPMed
NCI-TCGA novel	p.His330Tyr	missense variant	-	chrX:g.70722679G>A	NCI-TCGA
rs1478507641	p.Leu331Arg	missense variant	-	NC_000023.11:g.70722675A>C	TOPMed
rs1157252761	p.Asp332Val	missense variant	-	NC_000023.11:g.70722672T>A	gnomAD
rs1325231564	p.Met333Val	missense variant	-	NC_000023.11:g.70722670T>C	gnomAD
rs1476208283	p.Asp336Gly	missense variant	-	NC_000023.11:g.70722660T>C	gnomAD
NCI-TCGA novel	p.Asp336Gly	missense variant	-	chrX:g.70722660T>C	NCI-TCGA
rs374217762	p.Asn340Lys	missense variant	-	NC_000023.11:g.70722647G>T	ESP,ExAC,TOPMed,gnomAD
rs1471807161	p.Ile341Val	missense variant	-	NC_000023.11:g.70722646T>C	gnomAD
rs1391048608	p.Ala342Val	missense variant	-	NC_000023.11:g.70722642G>A	gnomAD
COSM4380213	p.His348Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70722625G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Arg350LysPheSerTerUnkUnk	frameshift	-	chrX:g.70722618_70722619insT	NCI-TCGA
NCI-TCGA novel	p.Glu351Ter	stop gained	-	chrX:g.70682824C>A	NCI-TCGA
rs1164088818	p.Glu351Gly	missense variant	-	NC_000023.11:g.70682823T>C	gnomAD
NCI-TCGA novel	p.Ser352Tyr	missense variant	-	chrX:g.70682820G>T	NCI-TCGA
COSM1124519	p.Ser352Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70682820G>A	NCI-TCGA Cosmic
rs1056191384	p.Phe355Ser	missense variant	-	NC_000023.11:g.70682811A>G	TOPMed
rs760003842	p.Thr359Met	missense variant	-	chrX:g.70682799G>A	NCI-TCGA
rs760003842	p.Thr359Met	missense variant	-	NC_000023.11:g.70682799G>A	ExAC,gnomAD
rs761167331	p.His362Asn	missense variant	-	NC_000023.11:g.70682791G>T	ExAC,gnomAD
COSM1124518	p.Glu363Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70682788C>T	NCI-TCGA Cosmic
rs201471690	p.Arg364His	missense variant	-	NC_000023.11:g.70682784C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs773463882	p.Arg364Cys	missense variant	-	chrX:g.70682785G>A	NCI-TCGA,NCI-TCGA Cosmic
rs773463882	p.Arg364Gly	missense variant	-	NC_000023.11:g.70682785G>C	ExAC,TOPMed,gnomAD
rs773463882	p.Arg364Cys	missense variant	-	NC_000023.11:g.70682785G>A	ExAC,TOPMed,gnomAD
rs1344575473	p.Phe365Cys	missense variant	-	NC_000023.11:g.70682781A>C	TOPMed
rs748351059	p.Lys366Gln	missense variant	-	NC_000023.11:g.70682779T>G	ExAC,gnomAD
rs1488563150	p.Lys366Thr	missense variant	-	NC_000023.11:g.70682778T>G	gnomAD
rs774542802	p.Ser368Leu	missense variant	-	NC_000023.11:g.70682772G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu369Lys	missense variant	-	chrX:g.70682770C>T	NCI-TCGA
rs977597709	p.Ile371Asn	missense variant	-	NC_000023.11:g.70682763A>T	gnomAD
rs977597709	p.Ile371Thr	missense variant	-	NC_000023.11:g.70682763A>G	gnomAD
rs1277438610	p.Ile371Leu	missense variant	-	NC_000023.11:g.70682764T>G	gnomAD
COSM5066585	p.Gly372Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70682760C>T	NCI-TCGA Cosmic
COSM6119224	p.Leu375Met	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70682752G>T	NCI-TCGA Cosmic
rs1388885484	p.Asp380Gly	missense variant	-	NC_000023.11:g.70682736T>C	gnomAD
rs749226768	p.Met381Val	missense variant	-	NC_000023.11:g.70682734T>C	ExAC,gnomAD
COSM6187499	p.Lys386Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70682717C>A	NCI-TCGA Cosmic
rs1169164404	p.Leu390Pro	missense variant	-	NC_000023.11:g.70682706A>G	gnomAD
rs1372440853	p.Leu390Ile	missense variant	-	NC_000023.11:g.70682707G>T	gnomAD
NCI-TCGA novel	p.Leu390Arg	missense variant	-	chrX:g.70682706A>C	NCI-TCGA
NCI-TCGA novel	p.Lys392Asn	missense variant	-	chrX:g.70682699C>A	NCI-TCGA
NCI-TCGA novel	p.Ile395Met	missense variant	-	chrX:g.70682690A>C	NCI-TCGA
rs756129568	p.Glu396Lys	missense variant	-	NC_000023.11:g.70682689C>T	ExAC,gnomAD
NCI-TCGA novel	p.Glu397Ter	stop gained	-	chrX:g.70682686C>A	NCI-TCGA
rs1175350982	p.Ile398Thr	missense variant	-	NC_000023.11:g.70682682A>G	TOPMed,gnomAD
NCI-TCGA novel	p.Phe399Leu	missense variant	-	chrX:g.70682678A>T	NCI-TCGA
rs1433539772	p.Leu400Ser	missense variant	-	NC_000023.11:g.70682676A>G	gnomAD
rs150528179	p.Gln403Arg	missense variant	-	NC_000023.11:g.70678883T>C	ESP,ExAC,gnomAD
rs150528179	p.Gln403Leu	missense variant	-	NC_000023.11:g.70678883T>A	ESP,ExAC,gnomAD
rs1316679274	p.Gly405Glu	missense variant	-	NC_000023.11:g.70678877C>T	gnomAD
rs768856343	p.Glu411Asp	missense variant	-	NC_000023.11:g.70678858T>A	ExAC,gnomAD
rs775722432	p.Trp415Cys	missense variant	-	NC_000023.11:g.70678846C>A	ExAC,TOPMed,gnomAD
rs1192348306	p.Leu416Phe	missense variant	-	NC_000023.11:g.70678843T>G	TOPMed
rs769718746	p.His417Gln	missense variant	-	NC_000023.11:g.70678840G>C	ExAC,TOPMed,gnomAD
rs745821043	p.Leu420Val	missense variant	-	NC_000023.11:g.70678833G>C	ExAC,TOPMed,gnomAD
COSM4862558	p.Trp421Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70678829C>G	NCI-TCGA Cosmic
rs1392568993	p.Ala425Thr	missense variant	-	NC_000023.11:g.70678818C>T	TOPMed
NCI-TCGA novel	p.Ala425Thr	missense variant	-	chrX:g.70678818C>T	NCI-TCGA
rs746657583	p.Ser426Arg	missense variant	-	NC_000023.11:g.70678813A>C	ExAC,TOPMed,gnomAD
COSM3992563	p.Ser426Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70678814C>T	NCI-TCGA Cosmic
rs1016690543	p.Ser427Asn	missense variant	-	NC_000023.11:g.70678811C>T	TOPMed,gnomAD
COSM292828	p.Phe428LeuPheSerTerUnkUnk	frameshift	Variant assessed as Somatic; HIGH impact.	chrX:g.70678807A>-	NCI-TCGA Cosmic
COSM3845269	p.Glu429Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70678806C>T	NCI-TCGA Cosmic
rs1269049143	p.Thr434Ser	missense variant	-	NC_000023.11:g.70670501G>C	gnomAD
rs775667438	p.Asp435Ala	missense variant	-	NC_000023.11:g.70670498T>G	ExAC,TOPMed,gnomAD
rs1234421331	p.Ala436Thr	missense variant	-	NC_000023.11:g.70670496C>T	TOPMed
COSM6008711	p.Ala436Val	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70670495G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Leu437Ile	missense variant	-	chrX:g.70670493G>T	NCI-TCGA
NCI-TCGA novel	p.Gln438His	missense variant	-	chrX:g.70670488T>A	NCI-TCGA
rs759491904	p.Tyr441Cys	missense variant	-	NC_000023.11:g.70670480T>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ser443Tyr	missense variant	-	chrX:g.70670474G>T	NCI-TCGA
rs746739636	p.Thr449Ile	missense variant	-	NC_000023.11:g.70670456G>A	ExAC,gnomAD
rs199871594	p.Thr449Ala	missense variant	-	NC_000023.11:g.70670457T>C	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Thr449Ser	missense variant	-	chrX:g.70670456G>C	NCI-TCGA
rs1365611506	p.Asp450Glu	missense variant	-	NC_000023.11:g.70670452A>C	gnomAD
rs4844247	p.Glu451Lys	missense variant	-	NC_000023.11:g.70670451C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Met452Ile	missense variant	-	chrX:g.70670446C>T	NCI-TCGA
rs1392265395	p.Phe456Leu	missense variant	-	NC_000023.11:g.70670436A>G	gnomAD
rs747838848	p.Thr457Ser	missense variant	-	NC_000023.11:g.70670432G>C	ExAC,gnomAD
NCI-TCGA novel	p.Asn462ThrPheSerTerUnk	frameshift	-	chrX:g.70670417T>-	NCI-TCGA
NCI-TCGA novel	p.Ala464Thr	missense variant	-	chrX:g.70670412C>T	NCI-TCGA
rs1456954813	p.Cys465Gly	missense variant	-	NC_000023.11:g.70670409A>C	gnomAD
rs941159712	p.Leu473Val	missense variant	-	NC_000023.11:g.70670385G>C	gnomAD
COSM3563030	p.Asp474Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70670382C>T	NCI-TCGA Cosmic
rs1323780348	p.Val480Met	missense variant	-	NC_000023.11:g.70651540C>T	gnomAD
NCI-TCGA novel	p.Glu484Lys	missense variant	-	chrX:g.70651528C>T	NCI-TCGA
NCI-TCGA novel	p.Arg485Gln	missense variant	-	chrX:g.70651524C>T	NCI-TCGA
COSM1497343	p.Arg485Ter	stop gained	Variant assessed as Somatic; HIGH impact.	chrX:g.70651525G>A	NCI-TCGA Cosmic
rs1385768042	p.Arg485Gln	missense variant	-	NC_000023.11:g.70651524C>T	gnomAD
rs759598658	p.Asp487Asn	missense variant	-	NC_000023.11:g.70651519C>T	ExAC,gnomAD
rs770715653	p.Arg489Thr	missense variant	-	NC_000023.11:g.70651512C>G	ExAC,gnomAD
rs1210524250	p.Arg489Gly	missense variant	-	NC_000023.11:g.70651513T>C	TOPMed
rs770715653	p.Arg489Lys	missense variant	-	NC_000023.11:g.70651512C>T	ExAC,gnomAD
NCI-TCGA novel	p.Asn490Tyr	missense variant	-	chrX:g.70651510T>A	NCI-TCGA
rs760637499	p.Asn490Ser	missense variant	-	NC_000023.11:g.70651509T>C	ExAC,gnomAD
rs772959829	p.Val491Ile	missense variant	-	NC_000023.11:g.70651507C>T	ExAC,gnomAD
rs771905076	p.Phe492Cys	missense variant	-	NC_000023.11:g.70651503A>C	ExAC,gnomAD
COSM4862159	p.Gln494Ter	stop gained	Variant assessed as Somatic; HIGH impact.	chrX:g.70651498G>A	NCI-TCGA Cosmic
rs1207215808	p.Ile497Met	missense variant	-	NC_000023.11:g.70651487T>C	gnomAD
rs1266790102	p.Ile497Arg	missense variant	-	NC_000023.11:g.70651488A>C	gnomAD
rs144438018	p.Ile497Val	missense variant	-	NC_000023.11:g.70651489T>C	ESP,ExAC,TOPMed,gnomAD
rs1263475450	p.Ile503Val	missense variant	-	NC_000023.11:g.70651471T>C	TOPMed,gnomAD
rs778499884	p.Ile503Thr	missense variant	-	NC_000023.11:g.70651470A>G	ExAC
NCI-TCGA novel	p.Glu504Gln	missense variant	-	chrX:g.70651468C>G	NCI-TCGA
rs1483378881	p.Glu504Gln	missense variant	-	NC_000023.11:g.70651468C>G	gnomAD
COSM4901803	p.Gly505Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70651465C>T	NCI-TCGA Cosmic
rs144149425	p.Asn506Lys	missense variant	-	NC_000023.11:g.70651460G>T	ESP,ExAC,TOPMed,gnomAD
rs144149425	p.Asn506Lys	missense variant	-	NC_000023.11:g.70651460G>C	ESP,ExAC,TOPMed,gnomAD
rs748692382	p.Ser507Cys	missense variant	-	NC_000023.11:g.70651458G>C	ExAC,TOPMed,gnomAD
rs1225961297	p.Ser507Pro	missense variant	-	NC_000023.11:g.70651459A>G	TOPMed,gnomAD
rs1225961297	p.Ser507Thr	missense variant	-	NC_000023.11:g.70651459A>T	TOPMed,gnomAD
rs748692382	p.Ser507Tyr	missense variant	-	NC_000023.11:g.70651458G>T	ExAC,TOPMed,gnomAD
rs779642423	p.Glu508Lys	missense variant	-	NC_000023.11:g.70651456C>T	ExAC,gnomAD
COSM1124516	p.Arg509Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70651452C>A	NCI-TCGA Cosmic
COSM3563029	p.Arg509Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70651452C>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ala513Val	missense variant	-	chrX:g.70629726G>A	NCI-TCGA
rs768148480	p.Ala513Thr	missense variant	-	NC_000023.11:g.70629727C>T	ExAC,gnomAD
rs748997672	p.Thr516Ala	missense variant	-	NC_000023.11:g.70629718T>C	ExAC,gnomAD
rs760892950	p.Thr516Ile	missense variant	-	NC_000023.11:g.70629717G>A	1000Genomes,ExAC,gnomAD
rs1351844566	p.Leu517Val	missense variant	-	NC_000023.11:g.70629715A>C	TOPMed
NCI-TCGA novel	p.Glu518Asp	missense variant	-	chrX:g.70629710C>A	NCI-TCGA
rs147097227	p.Asn519Thr	missense variant	-	NC_000023.11:g.70629708T>G	ESP,ExAC,TOPMed,gnomAD
rs1278948309	p.Asn519His	missense variant	-	NC_000023.11:g.70629709T>G	TOPMed
NCI-TCGA novel	p.Asp523Asn	missense variant	-	chrX:g.70629697C>T	NCI-TCGA
rs1335352653	p.Asp523His	missense variant	-	NC_000023.11:g.70629697C>G	gnomAD
rs1220744701	p.Ser526Pro	missense variant	-	NC_000023.11:g.70629688A>G	TOPMed
rs778488744	p.Glu527Gly	missense variant	-	NC_000023.11:g.70629684T>C	ExAC,TOPMed,gnomAD
rs778488744	p.Glu527Val	missense variant	-	NC_000023.11:g.70629684T>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu527ValPheSerTerUnkUnk	frameshift	-	chrX:g.70629684_70629685insAGACACAGAAGAGACCTTTA	NCI-TCGA
rs748403753	p.Asp528Gly	missense variant	-	NC_000023.11:g.70629681T>C	ExAC,gnomAD
NCI-TCGA novel	p.Asp528LeuPheSerTerUnk	frameshift	-	chrX:g.70629682_70629683insAG	NCI-TCGA
COSM6187503	p.Asp530Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70629674A>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ala533Thr	missense variant	-	chrX:g.70629667C>T	NCI-TCGA
COSM3563028	p.Glu534Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70629664C>T	NCI-TCGA Cosmic
rs1175422491	p.Glu534Lys	missense variant	-	NC_000023.11:g.70629664C>T	gnomAD
NCI-TCGA novel	p.Met540Val	missense variant	-	chrX:g.70629646T>C	NCI-TCGA
rs755124384	p.Leu544Ser	missense variant	-	NC_000023.11:g.70629633A>G	ExAC,gnomAD
NCI-TCGA novel	p.Glu551Asp	missense variant	-	chrX:g.70629611C>A	NCI-TCGA
rs749468065	p.Gln555Lys	missense variant	-	NC_000023.11:g.70624915G>T	ExAC
COSM1132275	p.Ile556Val	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70624912T>C	NCI-TCGA Cosmic
NCI-TCGA novel	p.Leu562Trp	missense variant	-	chrX:g.70624893A>C	NCI-TCGA
NCI-TCGA novel	p.Leu565Ser	missense variant	-	chrX:g.70624884A>G	NCI-TCGA
NCI-TCGA novel	p.Ala566Ser	missense variant	-	chrX:g.70624882C>A	NCI-TCGA
COSM1228993	p.Leu576Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70624852G>T	NCI-TCGA Cosmic
rs756344129	p.Thr577Ile	missense variant	-	NC_000023.11:g.70624848G>A	ExAC,gnomAD
NCI-TCGA novel	p.Ala578Thr	missense variant	-	chrX:g.70624846C>T	NCI-TCGA
rs1249602743	p.Val579Ile	missense variant	-	NC_000023.11:g.70624843C>T	gnomAD
COSM4898505	p.Lys580Met	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70624839T>A	NCI-TCGA Cosmic
rs1438744662	p.Leu583Val	missense variant	-	NC_000023.11:g.70623999G>C	TOPMed,gnomAD
rs1350493086	p.Arg584His	missense variant	-	NC_000023.11:g.70623995C>T	TOPMed,gnomAD
rs867999229	p.Arg584Cys	missense variant	-	NC_000023.11:g.70623996G>A	TOPMed
COSM1715106	p.Arg584His	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70623995C>T	NCI-TCGA Cosmic
rs867999229	p.Arg584Ser	missense variant	-	NC_000023.11:g.70623996G>T	TOPMed
rs759282918	p.Leu587Ile	missense variant	-	NC_000023.11:g.70623987G>T	ExAC,gnomAD
rs1422599964	p.Pro588Leu	missense variant	-	NC_000023.11:g.70623983G>A	gnomAD
NCI-TCGA novel	p.Ala591Thr	missense variant	-	chrX:g.70623975C>T	NCI-TCGA
rs776240375	p.Met593Ile	missense variant	-	NC_000023.11:g.70623967C>A	ExAC,gnomAD
rs770614604	p.Pro594Leu	missense variant	-	chrX:g.70623965G>A	NCI-TCGA
rs770614604	p.Pro594Leu	missense variant	-	NC_000023.11:g.70623965G>A	ExAC
rs1448619578	p.Glu597Lys	missense variant	-	NC_000023.11:g.70623957C>T	gnomAD
COSM258165	p.Glu602Ter	stop gained	Variant assessed as Somatic; HIGH impact.	chrX:g.70610536C>A	NCI-TCGA Cosmic
rs367895713	p.Met603Val	missense variant	-	NC_000023.11:g.70610533T>C	ESP,ExAC,TOPMed,gnomAD
rs753602584	p.Asp604Asn	missense variant	-	NC_000023.11:g.70610530C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg605Gln	missense variant	-	chrX:g.70610526C>T	NCI-TCGA
COSM1124514	p.Arg605Ter	stop gained	Variant assessed as Somatic; HIGH impact.	chrX:g.70610527G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Leu607Ser	missense variant	-	chrX:g.70610520A>G	NCI-TCGA
rs200375710	p.Cys609Tyr	missense variant	-	NC_000023.11:g.70610514C>T	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg612Lys	missense variant	-	chrX:g.70610505C>T	NCI-TCGA
rs769159981	p.Arg612Ser	missense variant	-	NC_000023.11:g.70610504T>G	ExAC,TOPMed,gnomAD
rs748136631	p.Val615Leu	missense variant	-	NC_000023.11:g.70609172C>A	ExAC,gnomAD
rs899490660	p.Val615Ala	missense variant	-	NC_000023.11:g.70609171A>G	TOPMed
rs1458382171	p.Leu617Phe	missense variant	-	NC_000023.11:g.70609166G>A	gnomAD
rs139166251	p.Pro620Arg	missense variant	-	NC_000023.11:g.70609156G>C	ESP,ExAC,TOPMed,gnomAD
rs1356655384	p.Pro620Ala	missense variant	-	NC_000023.11:g.70609157G>C	TOPMed
rs754888467	p.Glu624Lys	missense variant	-	NC_000023.11:g.70609145C>T	ExAC,TOPMed,gnomAD
rs1419073971	p.Ala625Gly	missense variant	-	NC_000023.11:g.70609141G>C	gnomAD
rs753691449	p.Leu626Ser	missense variant	-	NC_000023.11:g.70609138A>G	ExAC
rs766000467	p.Glu629Gln	missense variant	-	NC_000023.11:g.70609130C>G	ExAC,TOPMed,gnomAD
rs1483764414	p.Asn633Lys	missense variant	-	NC_000023.11:g.70609116A>T	TOPMed,gnomAD
COSM6119230	p.Gln636Pro	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70609108T>G	NCI-TCGA Cosmic
rs368829218	p.Trp637Arg	missense variant	-	NC_000023.11:g.70609106A>G	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg639Gln	missense variant	-	chrX:g.70609099C>T	NCI-TCGA
rs1184455196	p.Thr641Ser	missense variant	-	NC_000023.11:g.70609094T>A	TOPMed
rs1410393922	p.Ala642Thr	missense variant	-	NC_000023.11:g.70609091C>T	gnomAD
rs1298337752	p.Leu645Phe	missense variant	-	NC_000023.11:g.70607019C>A	TOPMed
NCI-TCGA novel	p.Val654Leu	missense variant	-	chrX:g.70606994C>A	NCI-TCGA
COSM3563025	p.Met655Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70606989C>T	NCI-TCGA Cosmic
COSM72948	p.Met655Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70606990A>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Met656Ile	missense variant	-	chrX:g.70606986C>T	NCI-TCGA
rs754977606	p.Ile661Thr	missense variant	-	NC_000023.11:g.70606972A>G	ExAC,gnomAD
NCI-TCGA novel	p.Ile661TyrPheSerTerUnk	frameshift	-	chrX:g.70606973_70606974insA	NCI-TCGA
NCI-TCGA novel	p.Ser663Tyr	missense variant	-	chrX:g.70606966G>T	NCI-TCGA
COSM1124513	p.Tyr664Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70606963T>C	NCI-TCGA Cosmic
rs1484944012	p.Met666Val	missense variant	-	NC_000023.11:g.70605517T>C	TOPMed
rs769530525	p.Met666Ile	missense variant	-	NC_000023.11:g.70605515C>T	ExAC,gnomAD
rs1210879579	p.Ser672Ala	missense variant	-	NC_000023.11:g.70605499A>C	TOPMed
rs756919847	p.Leu677Pro	missense variant	-	NC_000023.11:g.70605483A>G	ExAC,gnomAD
rs756919847	p.Leu677Arg	missense variant	-	NC_000023.11:g.70605483A>C	ExAC,gnomAD
rs1473803724	p.Ile678Thr	missense variant	-	NC_000023.11:g.70605480A>G	TOPMed
rs202064716	p.Arg680Gln	missense variant	-	NC_000023.11:g.70605474C>T	ESP,ExAC,TOPMed,gnomAD
rs1406736013	p.Lys681Glu	missense variant	-	NC_000023.11:g.70605472T>C	TOPMed
NCI-TCGA novel	p.Thr682Ala	missense variant	-	chrX:g.70605469T>C	NCI-TCGA
rs777298782	p.Leu685Phe	missense variant	-	NC_000023.11:g.70605460G>A	ExAC,gnomAD
rs755448482	p.Val688Gly	missense variant	-	NC_000023.11:g.70605450A>C	ExAC,gnomAD
rs1421446151	p.Ala689Thr	missense variant	-	NC_000023.11:g.70605448C>T	gnomAD
NCI-TCGA novel	p.Glu693Gln	missense variant	-	chrX:g.70605436C>G	NCI-TCGA
NCI-TCGA novel	p.Gly695Glu	missense variant	-	chrX:g.70605429C>T	NCI-TCGA
COSM1686327	p.Arg696Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70605426C>T	NCI-TCGA Cosmic
RCV000173009	p.Ala698Thr	missense variant	Spermatogenic failure, X-linked, 2 (SPGFX2)	NC_000023.11:g.70605421C>T	ClinVar
rs140984555	p.Ala698Thr	missense variant	-	NC_000023.11:g.70605421C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
COSM3406549	p.Ser699Ter	stop gained	Variant assessed as Somatic; HIGH impact.	chrX:g.70605417G>T	NCI-TCGA Cosmic
rs750813136	p.Glu703Val	missense variant	-	NC_000023.11:g.70605405T>A	ExAC,TOPMed,gnomAD
rs757962095	p.Arg710Cys	missense variant	-	NC_000023.11:g.70591808G>A	ExAC,gnomAD
COSM1469090	p.Glu713Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70591798T>G	NCI-TCGA Cosmic
rs1412151866	p.Ile715Thr	missense variant	-	NC_000023.11:g.70591792A>G	gnomAD
rs1336871415	p.Thr717Ala	missense variant	-	NC_000023.11:g.70591787T>C	TOPMed,gnomAD
NCI-TCGA novel	p.Cys718Phe	missense variant	-	chrX:g.70591783C>A	NCI-TCGA
COSM6187505	p.Cys718Ter	stop gained	Variant assessed as Somatic; HIGH impact.	chrX:g.70591782G>T	NCI-TCGA Cosmic
rs1408551678	p.Asn719Ser	missense variant	-	NC_000023.11:g.70591780T>C	gnomAD
rs1404671794	p.Asp720Val	missense variant	-	NC_000023.11:g.70591777T>A	TOPMed,gnomAD
rs756666108	p.His722Arg	missense variant	-	NC_000023.11:g.70591771T>C	ExAC,gnomAD
rs373821400	p.Gln727His	missense variant	-	NC_000023.11:g.70591755T>G	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Phe731Leu	missense variant	-	chrX:g.70554793G>T	NCI-TCGA
rs376047420	p.Ser732Leu	missense variant	-	NC_000023.11:g.70554791G>A	ESP,ExAC,TOPMed,gnomAD
rs1337652466	p.Asp734Tyr	missense variant	-	NC_000023.11:g.70554786C>A	gnomAD
rs1160423060	p.Cys736Arg	missense variant	-	NC_000023.11:g.70554780A>G	gnomAD
rs771769122	p.Leu740Phe	missense variant	-	NC_000023.11:g.70554768G>A	ExAC,gnomAD
rs151048734	p.Val747Ile	missense variant	-	NC_000023.11:g.70554747C>T	ESP,ExAC,TOPMed,gnomAD
COSM6187507	p.Asp753Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70554729C>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Leu756Val	missense variant	-	chrX:g.70554720G>C	NCI-TCGA
COSM4848367	p.Glu761Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70554705C>T	NCI-TCGA Cosmic
rs143644139	p.Val763Leu	missense variant	-	NC_000023.11:g.70554699C>A	ESP,ExAC,TOPMed,gnomAD
rs200139216	p.Val763Ala	missense variant	-	NC_000023.11:g.70554698A>G	ExAC,TOPMed,gnomAD
rs1249479557	p.Glu765Gly	missense variant	-	NC_000023.11:g.70554692T>C	gnomAD
COSM1497345	p.His768Pro	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70554683T>G	NCI-TCGA Cosmic
rs757760270	p.Thr771Ala	missense variant	-	NC_000023.11:g.70554675T>C	ExAC,gnomAD
COSM3563024	p.Lys772Glu	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70554672T>C	NCI-TCGA Cosmic
NCI-TCGA novel	p.Thr776Ala	missense variant	-	chrX:g.70554660T>C	NCI-TCGA
rs1433357782	p.Ile779Val	missense variant	-	NC_000023.11:g.70554651T>C	TOPMed
rs1282035365	p.Ile779Thr	missense variant	-	NC_000023.11:g.70553414A>G	TOPMed
rs1485266259	p.Met782Thr	missense variant	-	NC_000023.11:g.70553405A>G	gnomAD
rs1239794640	p.Glu783Asp	missense variant	-	NC_000023.11:g.70553401T>G	gnomAD
rs1205572216	p.Ala786Val	missense variant	-	NC_000023.11:g.70553393G>A	gnomAD
COSM1124512	p.His787Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70553389G>C	NCI-TCGA Cosmic
rs760404246	p.Tyr788Cys	missense variant	-	NC_000023.11:g.70553387T>C	ExAC,gnomAD
rs771582546	p.Pro789Thr	missense variant	-	NC_000023.11:g.70553385G>T	ExAC,gnomAD
NCI-TCGA novel	p.Pro789His	missense variant	-	chrX:g.70553384G>T	NCI-TCGA
rs1298024192	p.Ala792Val	missense variant	-	NC_000023.11:g.70553375G>A	gnomAD
NCI-TCGA novel	p.Ala792Val	missense variant	-	chrX:g.70553375G>A	NCI-TCGA
rs747873016	p.Leu793Phe	missense variant	-	NC_000023.11:g.70553373G>A	ExAC,gnomAD
COSM1124511	p.Lys798Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70553356C>A	NCI-TCGA Cosmic
rs768268510	p.Leu802Phe	missense variant	-	NC_000023.11:g.70553346G>A	ExAC,TOPMed,gnomAD
rs1302431284	p.Lys804Arg	missense variant	-	NC_000023.11:g.70553339T>C	gnomAD
rs1338579232	p.Lys805Met	missense variant	-	NC_000023.11:g.70553336T>A	TOPMed
NCI-TCGA novel	p.Glu806Gly	missense variant	-	chrX:g.70553333T>C	NCI-TCGA
NCI-TCGA novel	p.Glu806Gln	missense variant	-	chrX:g.70553334C>G	NCI-TCGA
rs1210179902	p.Glu807Asp	missense variant	-	NC_000023.11:g.70553329T>A	TOPMed
rs1422541197	p.Pro808Gln	missense variant	-	NC_000023.11:g.70553327G>T	gnomAD
rs781735348	p.Ile811Val	missense variant	-	NC_000023.11:g.70553319T>C	ExAC,gnomAD
rs781735348	p.Ile811Leu	missense variant	-	NC_000023.11:g.70553319T>G	ExAC,gnomAD
rs781735348	p.Ile811Leu	missense variant	-	NC_000023.11:g.70553319T>A	ExAC,gnomAD
rs1290920334	p.Ile811Thr	missense variant	-	NC_000023.11:g.70553318A>G	TOPMed
rs202136447	p.Gln813Arg	missense variant	-	NC_000023.11:g.70553312T>C	ExAC,TOPMed,gnomAD
rs143397565	p.Gln813Lys	missense variant	-	NC_000023.11:g.70553313G>T	ESP,ExAC,TOPMed
rs201040035	p.Ser815Arg	missense variant	-	NC_000023.11:g.70553307T>G	1000Genomes,ExAC
rs140957385	p.Asn820Asp	missense variant	-	NC_000023.11:g.70552233T>C	ESP,TOPMed,gnomAD
rs761355754	p.Val822Ile	missense variant	-	NC_000023.11:g.70552227C>T	ExAC,gnomAD
rs761355754	p.Val822Leu	missense variant	-	NC_000023.11:g.70552227C>G	ExAC,gnomAD
rs1469887273	p.Asn823His	missense variant	-	NC_000023.11:g.70552224T>G	gnomAD
rs1427917315	p.Leu824Phe	missense variant	-	NC_000023.11:g.70552221G>A	gnomAD
COSM4110775	p.Pro827Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70552212G>A	NCI-TCGA Cosmic
rs774117470	p.Ala830Val	missense variant	-	NC_000023.11:g.70552202G>A	ExAC,TOPMed,gnomAD
rs1253261339	p.Ala830Thr	missense variant	-	NC_000023.11:g.70552203C>T	TOPMed,gnomAD
rs774117470	p.Ala830Val	missense variant	-	chrX:g.70552202G>A	NCI-TCGA
rs1253261339	p.Ala830Ser	missense variant	-	NC_000023.11:g.70552203C>A	TOPMed,gnomAD
NCI-TCGA novel	p.Ser831Pro	missense variant	-	chrX:g.70552200A>G	NCI-TCGA
rs762490798	p.Ser831Leu	missense variant	-	chrX:g.70552199G>A	NCI-TCGA
rs762490798	p.Ser831Leu	missense variant	-	NC_000023.11:g.70552199G>A	ExAC,gnomAD
rs1324379138	p.Asn832Ser	missense variant	-	NC_000023.11:g.70552196T>C	gnomAD
rs747562165	p.Val833Ile	missense variant	-	NC_000023.11:g.70552194C>T	ExAC,TOPMed,gnomAD
rs371524119	p.Glu834Gln	missense variant	-	NC_000023.11:g.70552191C>G	ESP,ExAC,gnomAD
rs1390635635	p.Leu835Pro	missense variant	-	NC_000023.11:g.70552187A>G	gnomAD
COSM4923390	p.Leu838Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70552178A>T	NCI-TCGA Cosmic
COSM1491202	p.Glu840Ter	stop gained	Variant assessed as Somatic; HIGH impact.	chrX:g.70552173C>A	NCI-TCGA Cosmic
rs772547120	p.Tyr844Cys	missense variant	-	NC_000023.11:g.70552160T>C	ExAC,gnomAD
rs16991177	p.Asp847Glu	missense variant	-	NC_000023.11:g.70552150A>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1452825580	p.Ala848Gly	missense variant	-	NC_000023.11:g.70552148G>C	gnomAD
rs780146584	p.Arg854Leu	missense variant	-	NC_000023.11:g.70552130C>A	ExAC,TOPMed,gnomAD
rs780146584	p.Arg854His	missense variant	-	NC_000023.11:g.70552130C>T	ExAC,TOPMed,gnomAD
rs753874381	p.Arg854Cys	missense variant	-	NC_000023.11:g.70552131G>A	ExAC,gnomAD
rs1289976436	p.Asp857Gly	missense variant	-	NC_000023.11:g.70529995T>C	gnomAD
NCI-TCGA novel	p.Asp857Tyr	missense variant	-	chrX:g.70529996C>A	NCI-TCGA
rs772461116	p.Pro859Ala	missense variant	-	NC_000023.11:g.70529990G>C	ExAC,gnomAD
NCI-TCGA novel	p.Ile863Thr	missense variant	-	chrX:g.70529977A>G	NCI-TCGA
COSM172371	p.Leu864Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70529975G>T	NCI-TCGA Cosmic
rs1165914544	p.Leu866Met	missense variant	-	NC_000023.11:g.70529969G>T	gnomAD
rs768834428	p.Thr873Ile	missense variant	-	NC_000023.11:g.70529947G>A	ExAC,gnomAD
NCI-TCGA novel	p.Val875Ile	missense variant	-	chrX:g.70529942C>T	NCI-TCGA
rs1484882277	p.Ser879Gly	missense variant	-	NC_000023.11:g.70529930T>C	gnomAD
rs756250033	p.Ser881Gly	missense variant	-	NC_000023.11:g.70529924T>C	ExAC,gnomAD
NCI-TCGA novel	p.Lys882Thr	missense variant	-	chrX:g.70529920T>G	NCI-TCGA
NCI-TCGA novel	p.Ala884Val	missense variant	-	chrX:g.70529914G>A	NCI-TCGA
rs1222993065	p.Ser885Pro	missense variant	-	NC_000023.11:g.70529912A>G	gnomAD
NCI-TCGA novel	p.Ala886Thr	missense variant	-	chrX:g.70529909C>T	NCI-TCGA
rs374367768	p.Glu887Lys	missense variant	-	NC_000023.11:g.70529906C>T	ESP,ExAC,TOPMed,gnomAD
rs374367768	p.Glu887Lys	missense variant	-	chrX:g.70529906C>T	NCI-TCGA
rs781122355	p.Gly891Ser	missense variant	-	NC_000023.11:g.70529894C>T	ExAC,gnomAD
NCI-TCGA novel	p.Leu892Arg	missense variant	-	chrX:g.70529890A>C	NCI-TCGA
NCI-TCGA novel	p.Ala893Thr	missense variant	-	chrX:g.70529888C>T	NCI-TCGA
rs764025236	p.Leu894Phe	missense variant	-	NC_000023.11:g.70529883C>G	ExAC,gnomAD
rs758103906	p.Arg895His	missense variant	-	NC_000023.11:g.70529881C>T	ExAC,gnomAD
rs1385053997	p.Arg895Gly	missense variant	-	NC_000023.11:g.70529882G>C	TOPMed
NCI-TCGA novel	p.Arg895Cys	missense variant	-	chrX:g.70529882G>A	NCI-TCGA
rs764836814	p.Asn898Lys	missense variant	-	NC_000023.11:g.70529871G>C	ExAC,gnomAD
rs1259438531	p.His899Tyr	missense variant	-	NC_000023.11:g.70529870G>A	TOPMed,gnomAD
rs139092522	p.Thr901Asn	missense variant	-	NC_000023.11:g.70529863G>T	ESP,ExAC,TOPMed,gnomAD
rs768027475	p.Ser906Ile	missense variant	-	NC_000023.11:g.70529848C>A	ExAC,gnomAD
COSM457931	p.Ser906Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70529848C>T	NCI-TCGA Cosmic
rs762267271	p.Ser906Arg	missense variant	-	NC_000023.11:g.70529847G>C	ExAC,gnomAD
rs1011465821	p.Tyr915His	missense variant	-	NC_000023.11:g.70529175A>G	TOPMed
rs1411971320	p.Tyr915Cys	missense variant	-	NC_000023.11:g.70529174T>C	gnomAD
rs150726887	p.Ser916Gly	missense variant	-	NC_000023.11:g.70529172T>C	ESP,ExAC,TOPMed,gnomAD
rs1382858891	p.Leu918Phe	missense variant	-	NC_000023.11:g.70529166G>A	TOPMed
COSM289181	p.Leu918Ile	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70529166G>T	NCI-TCGA Cosmic
rs370371866	p.Val919Met	missense variant	-	NC_000023.11:g.70529163C>T	ESP,ExAC,gnomAD
COSM5431431	p.Val919Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70529163C>A	NCI-TCGA Cosmic
rs377040267	p.Ala921Glu	missense variant	-	NC_000023.11:g.70529156G>T	ESP,ExAC,gnomAD
rs1480104374	p.Ser923Asn	missense variant	-	NC_000023.11:g.70529150C>T	TOPMed,gnomAD
rs1310485179	p.Asn925Lys	missense variant	-	NC_000023.11:g.70529143G>C	TOPMed
rs200029838	p.Gly927Arg	missense variant	-	NC_000023.11:g.70529139C>G	ExAC,TOPMed,gnomAD
COSM1124510	p.Pro928Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	chrX:g.70529136G>T	NCI-TCGA Cosmic
NCI-TCGA novel	p.Val929Gly	missense variant	-	chrX:g.70529132A>C	NCI-TCGA
NCI-TCGA novel	p.Val929Phe	missense variant	-	chrX:g.70529133C>A	NCI-TCGA
rs1183769925	p.His931Gln	missense variant	-	NC_000023.11:g.70529125A>T	gnomAD
rs374729936	p.His933Arg	missense variant	-	NC_000023.11:g.70529120T>C	ESP,ExAC,TOPMed,gnomAD
rs374729936	p.His933Leu	missense variant	-	NC_000023.11:g.70529120T>A	ESP,ExAC,TOPMed,gnomAD
rs1324267120	p.Gly934Ser	missense variant	-	NC_000023.11:g.70529118C>T	gnomAD
rs763243018	p.Tyr935Ter	stop gained	-	NC_000023.11:g.70529113G>T	ExAC
rs144188602	p.Ser937Asn	missense variant	-	NC_000023.11:g.70529108C>T	ESP,ExAC,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0004509	Azoospermia	disease	BEFREE;HPO
C0021364	Male infertility	disease	HPO
C0241355	Small testicle	phenotype	HPO
C1839841	SPERMATOGENIC FAILURE, X-LINKED, 2	disease	CLINVAR;CTD_human;UNIPROT
C1862265	Increased circulating gonadotropin level	phenotype	HPO
C4021107	Non-obstructive azoospermia	disease	BEFREE;HPO
C4021768	Abnormality of metabolism/homeostasis	group	HPO
C4023106	Obstructive azoospermia	disease	HPO

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005515	protein binding	IPI

GO:Biological Process

GO ID	GO Term	Evidence
GO:0000712	resolution of meiotic recombination intermediates	IEA
GO:0006311	meiotic gene conversion	ISS
GO:0007060	male meiosis chromosome segregation	IBA
GO:0007130	synaptonemal complex assembly	IBA
GO:0007131	reciprocal meiotic recombination	ISS
GO:0007131	reciprocal meiotic recombination	IBA
GO:0008584	male gonad development	IEA
GO:0009566	fertilization	IEA
GO:0043066	negative regulation of apoptotic process	IEA
GO:0051026	chiasma assembly	IEA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0000801	central element	IBA
GO:0000795	synaptonemal complex	ISS
GO:0000795	synaptonemal complex	IBA

Reactome Pathway

Reactome ID	Reactome Term	Evidence

Drugs and compounds information

ID	Drug Name	Action	PubMed
D000082	Acetaminophen	Acetaminophen results in decreased expression of TEX11 mRNA	29067470
D020106	Acrylamide	Acrylamide results in increased expression of TEX11 mRNA	30807115
D020106	Acrylamide	Acrylamide results in increased expression of TEX11 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of TEX11 intron	30157460
C029753	aflatoxin B2	aflatoxin B2 results in decreased methylation of TEX11 intron	30157460
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of TEX11 mRNA	26377693
C030935	benz(a)anthracene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TEX11 mRNA	27858113
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the methylation of TEX11 intron	30157460
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TEX11 mRNA	27858113
C006703	benzo(b)fluoranthene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TEX11 mRNA	27858113
C006703	benzo(b)fluoranthene	benzo(b)fluoranthene results in increased expression of TEX11 mRNA	26377693
C006780	bisphenol A	bisphenol A results in decreased expression of TEX11 mRNA	25181051
D002737	Chloroprene	Chloroprene results in decreased expression of TEX11 mRNA	23125180
C031180	chrysene	[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of TEX11 mRNA	27858113
D003033	Coal Tar	Coal Tar results in decreased expression of TEX11 mRNA	27858113
D016572	Cyclosporine	Cyclosporine results in decreased expression of TEX11 mRNA	20106945
D007840	Latex	Latex analog results in increased expression of TEX11 mRNA	24768652
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of TEX11 mRNA	25554681
D010100	Oxygen	[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of TEX11 mRNA	30529165
D010634	Phenobarbital	Phenobarbital affects the expression of TEX11 mRNA	19159669
C005556	propionaldehyde	propionaldehyde results in increased expression of TEX11 mRNA	26079696
D053260	Soot	Soot affects the expression of TEX11 mRNA	26551751
C016766	sulforafan	sulforafan results in decreased expression of TEX11 mRNA	30529165
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of TEX11 mRNA	21570461
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of TEX11 mRNA	20133372
D014212	Tretinoin	Tretinoin results in increased expression of TEX11 mRNA	28689802
D014635	Valproic Acid	Valproic Acid results in increased expression of TEX11 mRNA	28001369
D014635	Valproic Acid	Valproic Acid affects the expression of TEX11 mRNA	17292431
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of TEX11 gene	25560391

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0025	Alternative splicing
KW-0158	Chromosome
KW-0225	Disease mutation
KW-0469	Meiosis
KW-0621	Polymorphism
KW-1185	Reference proteome

Interpro

InterPro ID	InterPro Term
IPR013940	Spo22/ZIP4/TEX11
IPR042861	TEX11
IPR011990	TPR-like_helical_dom_sf
IPR019734	TPR_repeat

PROSITE

PROSITE ID	PROSITE Term

Pfam

Pfam ID	Pfam Term
PF08631	SPO22

Gene: TEX11

Basic information

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Identified variants/mutations related to cleft phenotype

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction