| Tag | Content |
|---|---|
| Uniprot ID | Q8IZL9; A2A389; A2A390; B4DQX1; O95137; Q5EDC4; Q5VYW1; Q9BUF4; |
| Entrez ID | 23552 |
| Genbank protein ID | BAG52110.1; EAW62748.1; BAG61083.1; AAH02655.1; AAW82349.1; EAW62746.1; AAF43778.1; AAC98920.1; AAN28684.1; |
| Genbank nucleotide ID | NM_178432.3; NM_001170640.1; NM_001039803.2; NM_001170639.1; NM_012119.4; |
| Ensembl protein ID | ENSP00000322343; ENSP00000365043; ENSP00000474485; ENSP00000365031; ENSP00000338975; |
| Ensembl nucleotide ID | ENSG00000156345 |
| Gene name | Cyclin-dependent kinase 20 |
| Gene symbol | CDK20 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'. |
| Sequence | MDQYCILGRI GEGAHGIVFK AKHVETGEIV ALKKVALRRL EDGFPNQALR EIKALQEMED 60 NQYVVQLKAV FPHGGGFVLA FEFMLSDLAE VVRHAQRPLA QAQVKSYLQM LLKGVAFCHA 120 NNIVHRDLKP ANLLISASGQ LKIADFGLAR VFSPDGSRLY THQVATRWYR APELLYGARQ 180 YDQGVDLWSV GCIMGELLNG SPLFPGKNDI EQLCYVLRIL GTPNPQVWPE LTELPDYNKI 240 SFKEQVPMPL EEVLPDVSPQ ALDLLGQFLL YPPHQRIAAS KALLHQYFFT APLPAHPSEL 300 PIPQRLGGPA PKAHPGPPHI HDFHVDRPLE ESLLNPELIR PFILEG 346 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.