| Tag | Content |
|---|---|
| Uniprot ID | Q8JZZ7; E9Q6C7; Q8BM90; |
| Entrez ID | |
| Genbank protein ID | BAC98025.1; BAC28707.1; AAH34660.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSMUSP00000101734 |
| Ensembl nucleotide ID | ENSMUSG00000028184 |
| Gene name | Adhesion G protein-coupled receptor L2 |
| Gene symbol | Adgrl2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Calcium-independent receptor of low affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. |
| Sequence | MVSSGCRMRS LWFIIIISFS PSTEGFSRAA LPFGLVRREL SCEGYSIDLR CPGSDVIMIE 60 SANYGRTDDK ICDADPFQME NTDCYLPDAF KIMTQRCNNR TQCIVVTGSD VFPDPCPGTY 120 KYLEVQYECV PYSKMLVFVC PGTLKAIVDS PCIYEAEQKS GAWCKDPLQA ADKIYFMPWT 180 PYRTDTLIEY ASLEDFQNSR QTTTYKLPNR VDGTGFVVYD GAVFFNKERT RNIVKFDLRT 240 RIKSGEAIIN YANYHDTSPY RWGGKTDIDL AVDENGLWVI YATEQNNGMI VISQLNPYTL 300 RFEATWETAY DKRAASNAFM ICGVLYVVRS VYQDNESEAG KNTIDYIYNT RLSRGEYVDV 360 PFPNQYQYIA AVDYNPRDNQ LYVWNNNFIL RYSLEFGPPD PAQVPTTAVT ITSSAELFKT 420 TISTTSSASQ RGPVSSTAAG PQDGSRGTKP PPAVSTTKIP PVTNIFPLPE RFCEALDWKG 480 IKWPQTQRGM MVERPCPKGT RGTASYLCMA STGTWNPKGP DLSNCTSHWV NQLAQKIRSG 540 ENAASLANEL AKHTKGHVFA GDVSSSVRLM EQLVDILDAQ LQELKPSEKD SAGRSYNKLQ 600 KREKTCRAYL KAIVDTVDNL LRAEALESWK HMNSSEQAHT ATMLLDTLEE GAFVLADNLL 660 EPTRVSMPTE NIVLEVAVLS TEGQVQDFKF PLGLKGLGSS IQLSANTVKQ NSRNGLAKLV 720 FIIYRSLGQF LSTENATIKL GADLMGRNST IAVNSPVISV SINKESSRVY LTDPVLFTLP 780 HIDPDNYFNA NCSFWNYSER TMMGYWSTQG CKLVDTNKTR TTCACSHLTN FAILMAHREI 840 AYKDGVHHLL LTVITWVGIV VSLVCLAICI FTFCFFRGLQ SDRNTIHKNL CINLFIAEFI 900 FLIGIDKTKY TIACPVFAGL LHFFFLAAFS WMCLEGVQLY LMLVEVFESE YSRKKYYYVA 960 GYLFPATVVG VSAAIDYKSY GTVQACWLHV DNYFIWSFIG PVTFIILLNI IFLVITLCKM 1020 VKHSNTLKPD SSRLENINNY RVCDGYYNTD LPGYEDNKPF IKSWVLGAFA LLCLLGLTWS 1080 FGLLFVNEET VVMAYLFTAF NAFQGLFIFI FHCALQKKVR KEYGKCFRHW YCCGGLPTES 1140 PHSSVKASTT RTSARYSSGT QSRIRRMWND TVRKQSESSF ISGDINSTST LNQGMTGNYL 1200 LTNPLLRPHG TNNPYNTLLA ETVVCNAPSA PAFNSPGHSL NNARDTSAMD TLPLNGNFNN 1260 SYSLRKADYH DGVQVVDCGL SLNDTAFEKM IISELVHNNL RGGNKTHNLE LKLPVKPVIG 1320 GSSSEDDAIV ADASSLMHGD NPGLEFRHKE LEAPLIPQRT HSLLYQPQKK VKPEATDSYV 1380 SQLTAEADDH LQSPNRDSLY TSMPNLRDSP YPESSPDMAE DLSPSRRSEN EDIYYKSMPN 1440 LGAGRHLHMC YQISRGNSDG YIIPINKEGC IPEGDVREGQ MQLVTSL 1487 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ADGRL2 | A0A3Q1MQ77 | Bos taurus | Prediction | More>> | |||
| 1:1 ortholog | ADGRL2 | E2RKN9 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | ADGRL2 | A0A452F6H6 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ADGRL2 | 23266 | O95490 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Adgrl2 | Q8JZZ7 | Mus musculus | Prediction | More>> | |||
| 1:1 ortholog | ADGRL2 | 456974 | A0A2J8LKF3 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | ADGRL2 | G1T5U9 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Adgrl2 | F1M7T0 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | adgrl2a | A0A0R4IX48 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IBA |
| GO:0030165 | PDZ domain binding | ISO |
| GO:0030246 | carbohydrate binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007166 | cell surface receptor signaling pathway | IEA |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IBA |
| GO:0007420 | brain development | IBA |
| GO:0009617 | response to bacterium | IEP |
| GO:0050808 | synapse organization | IDA |
| GO:0050808 | synapse organization | IMP |
| GO:0051965 | positive regulation of synapse assembly | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005887 | integral component of plasma membrane | IBA |
| GO:0043005 | neuron projection | ISO |
| GO:0043005 | neuron projection | IBA |
| GO:0098978 | glutamatergic synapse | IDA |
| GO:0098978 | glutamatergic synapse | IMP |
| GO:0099055 | integral component of postsynaptic membrane | IDA |
| GO:0099055 | integral component of postsynaptic membrane | IMP |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0025 | Alternative splicing |
| KW-0903 | Direct protein sequencing |
| KW-0297 | G-protein coupled receptor |
| KW-0325 | Glycoprotein |
| KW-0472 | Membrane |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| KW-0807 | Transducer |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| InterPro ID | InterPro Term |
|---|---|
| IPR032471 | GAIN_dom_N |
| IPR017981 | GPCR_2-like |
| IPR036445 | GPCR_2_extracell_dom_sf |
| IPR001879 | GPCR_2_extracellular_dom |
| IPR003924 | GPCR_2_latrophilin |
| IPR003334 | GPCR_2_latrophilin_rcpt_C |
| IPR000832 | GPCR_2_secretin-like |
| IPR017983 | GPCR_2_secretin-like_CS |
| IPR000203 | GPS |
| IPR031240 | Latrophilin-2 |
| IPR000922 | Lectin_gal-bd_dom |
| IPR043159 | Lectin_gal-bd_sf |
| IPR003112 | Olfac-like_dom |