Gene: Sgpl1

Basic information

Tag Content
Uniprot ID Q8R0X7; O54955; Q8C942;
Entrez ID 20397
Genbank protein ID AAH26135.1; AAC03768.1; BAC29872.1; BAC31437.1; BAC29562.1; BAC33695.1;
Genbank nucleotide ID XM_017313860.1; NM_001316673.1; NM_001316674.1; NM_009163.4;
Ensembl protein ID ENSMUSP00000090155; ENSMUSP00000112975;
Ensembl nucleotide ID ENSMUSG00000020097
Gene name Sphingosine-1-phosphate lyase 1
Gene symbol Sgpl1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage E14.5
Data sources Manually collected
Reference 17143286
Functional description Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (PubMed:9464245, PubMed:20097939). Elevates stress-induced ceramide production and apoptosis (PubMed:9464245). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts (PubMed:20097939, PubMed:28262793). Involved in the regulation of pro-inflammatory response and neutrophil trafficking (PubMed:21173151). Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (PubMed:28521611). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity).
Sequence
MPGTDLLKLK DFEPYLEILE SYSTKAKNYV NGYCTKYEPW QLIAWSVLCT LLIVWVYELI 60
FQPESLWSRF KKKLFKLIRK MPFIGRKIEQ QVSKAKKDLV KNMPFLKVDK DYVKTLPAQG 120
MGTAEVLERL KEYSSMDGSW QEGKASGAVY NGEPKLTELL VQAYGEFTWS NPLHPDIFPG 180
LRKLEAEIVR MTCSLFNGGP DSCGCVTSGG TESILMACKA YRDLALEKGI KTPEIVAPES 240
AHAAFDKAAH YFGMKIVRVA LKKNMEVDVQ AMKRAISRNT AMLVCSTPQF PHGVMDPVPE 300
VAKLAVRYKI PLHVDACLGG FLIVFMEKAG YPLEKPFDFR VKGVTSISAD THKYGYAPKG 360
SSVVMYSNEK YRTYQFFVGA DWQGGVYASP SIAGSRPGGI IAACWAALMH FGENGYVEAT 420
KQIIKTARFL KSELENIKNI FIFGDPQLSV IALGSNDFDI YRLSNMMSAK GWNFNYLQFP 480
RSIHFCITLV HTRKRVAIQF LKDIRESVTQ IMKNPKAKTT GMGAIYGMAQ ATIDRKLVAE 540
ISSVFLDCLY TTDPVTQGNQ MNGSPKPR 568

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

loading...

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Other genetic variants/mutations

loading...

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0008117 sphinganine-1-phosphate aldolase activityISS
GO:0008117 sphinganine-1-phosphate aldolase activityISO
GO:0008117 sphinganine-1-phosphate aldolase activityIBA
GO:0016831 carboxy-lyase activityIEA
GO:0030170 pyridoxal phosphate bindingIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0001553 luteinizationIMP
GO:0001570 vasculogenesisIMP
GO:0001667 ameboidal-type cell migrationIBA
GO:0001822 kidney developmentIMP
GO:0006631 fatty acid metabolic processISS
GO:0006631 fatty acid metabolic processISO
GO:0006665 sphingolipid metabolic processIBA
GO:0006672 ceramide metabolic processISS
GO:0006672 ceramide metabolic processISO
GO:0006807 nitrogen compound metabolic processIMP
GO:0007283 spermatogenesisIMP
GO:0008209 androgen metabolic processIMP
GO:0008210 estrogen metabolic processIMP
GO:0008585 female gonad developmentIMP
GO:0009791 post-embryonic developmentIMP
GO:0010761 fibroblast migrationIMP
GO:0030097 hemopoiesisIMP
GO:0030149 sphingolipid catabolic processISS
GO:0030149 sphingolipid catabolic processISO
GO:0030149 sphingolipid catabolic processIBA
GO:0033327 Leydig cell differentiationIMP
GO:0040014 regulation of multicellular organism growthIMP
GO:0048008 platelet-derived growth factor receptor signaling pathwayIMP
GO:0048705 skeletal system morphogenesisIMP
GO:0060021 roof of mouth developmentIMP
GO:0060325 face morphogenesisIMP
GO:0097190 apoptotic signaling pathwayISS
GO:0097190 apoptotic signaling pathwayISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005783 endoplasmic reticulumISO
GO:0005783 endoplasmic reticulumIBA
GO:0005783 endoplasmic reticulumIDA
GO:0005789 endoplasmic reticulum membraneIEA
GO:0016021 integral component of membraneIEA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1430728 MetabolismIEA
R-MMU-1660661 Sphingolipid de novo biosynthesisIEA
R-MMU-428157 Sphingolipid metabolismIEA
R-MMU-556833 Metabolism of lipidsIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0053 Apoptosis
KW-0256 Endoplasmic reticulum
KW-0443 Lipid metabolism
KW-0456 Lyase
KW-0472 Membrane
KW-0944 Nitration
KW-0597 Phosphoprotein
KW-0663 Pyridoxal phosphate
KW-1185 Reference proteome
KW-0735 Signal-anchor
KW-0746 Sphingolipid metabolism
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF00282 Pyridoxal_deC

Protein-protein interaction

Protein-miRNA interaction