| Tag | Content |
|---|---|
| Uniprot ID | Q8R2Y9 |
| Entrez ID | 69917 |
| Genbank protein ID | AAZ85395.1; AAH26942.1; |
| Genbank nucleotide ID | XM_006514067.2; NM_027257.1; XM_006514068.1; XM_006514066.3; |
| Ensembl protein ID | ENSMUSP00000026439; ENSMUSP00000128634; |
| Ensembl nucleotide ID | ENSMUSG00000025374 |
| Gene name | SOSS complex subunit B1 |
| Gene symbol | Nabp2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 23408915; 22940690; |
| Functional description | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). |
| Sequence | MTTETFVKDI KPGLKNLNLI FIVLETGRVT KTKDGHEVRT CKVADKTGSI NISVWDDVGN 60 LIQPGDIIRL TKGYASVFKG CLTLYTGRGG DLQKIGEFCM VYSEVPNFSE PNPEYNTQQA 120 PNKSVQNNDN SPTAPQATTG PPAASPASEN QNGNGLSTQL GPVGGPHPSH TPSHPPSTRI 180 TRSQPNHTPS GPPGPSSNPV SNGKETRRSS KR 212 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003677 | DNA binding | IBA |
| GO:0003697 | single-stranded DNA binding | ISS |
| GO:0003697 | single-stranded DNA binding | ISO |
| GO:0070182 | DNA polymerase binding | ISO |
| GO:0098505 | G-rich strand telomeric DNA binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000724 | double-strand break repair via homologous recombination | ISS |
| GO:0000724 | double-strand break repair via homologous recombination | ISO |
| GO:0000724 | double-strand break repair via homologous recombination | IBA |
| GO:0006281 | DNA repair | ISS |
| GO:0006281 | DNA repair | ISO |
| GO:0006281 | DNA repair | IMP |
| GO:0006974 | cellular response to DNA damage stimulus | ISS |
| GO:0006974 | cellular response to DNA damage stimulus | ISO |
| GO:0007093 | mitotic cell cycle checkpoint | ISS |
| GO:0007093 | mitotic cell cycle checkpoint | ISO |
| GO:0007093 | mitotic cell cycle checkpoint | IBA |
| GO:0010212 | response to ionizing radiation | ISS |
| GO:0010212 | response to ionizing radiation | ISO |
| GO:0010212 | response to ionizing radiation | IBA |
| GO:0070200 | establishment of protein localization to telomere | ISO |
| GO:1904355 | positive regulation of telomere capping | ISO |
| GO:1904355 | positive regulation of telomere capping | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000784 | nuclear chromosome, telomeric region | ISO |
| GO:0000784 | nuclear chromosome, telomeric region | IBA |
| GO:0000784 | nuclear chromosome, telomeric region | IDA |
| GO:0005634 | nucleus | ISS |
| GO:0005634 | nucleus | ISO |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005829 | cytosol | ISO |
| GO:0070876 | SOSS complex | ISS |
| GO:0070876 | SOSS complex | ISO |
| GO:0070876 | SOSS complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-6807505 | RNA polymerase II transcribes snRNA genes | IEA |
| R-MMU-73857 | RNA Polymerase II Transcription | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| Pfam ID | Pfam Term |
|---|---|
| PF01336 | tRNA_anti-codon |