| Tag | Content |
|---|---|
| Uniprot ID | Q8R418; Q8R419; |
| Entrez ID | |
| Genbank protein ID | BAC15765.1; AAM21495.1; AAL84638.1; AAL84637.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Endoribonuclease Dicer |
| Gene symbol | Dicer1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 23716939; 20144605; 21256960; 20457670; 22753148; 20102707; |
| Functional description | Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity). |
| Sequence | MKSPALQPLS MAGLQLMTPA SSPMGPFFGL PWQQEAIHDN IYTPRKYQVE LLEAALDHNT 60 IVCLNTGSGK TFIAVLLTKE LAHQIRGDLN PHAKRTVFLV NSANQVAQQV SAVRTHSDLK 120 VGEYSDLEVN ASWTKERWSQ EFTKHQVLIM TCYVALTVLK NGYLSLSDIN LLVFDECHLA 180 ILDHPYREIM KLCESCPSCP RILGLTASIL NGKCDPEELE EKIQKLERIL RSDAETATDL 240 VVLDRYTSQP CEIVVDCGPF TDRSGLYERL LMELEAALDF INDCNVAVHS KERDSTLISK 300 QILSDCRAVL VVLGPWCADK VAGMMVRELQ KYIKHEQEEL HRKFLLFTDT LLRKIHALCE 360 EYFSPASLDL KYVTPKVMKL LEILRKYKPY ERQQFESVEW YNNRNQDNYV SWSDSEDDDD 420 DEEIEEKEKP ETNFPSPFTN ILCGIIFVER RYTAVVLNRL IKEAGKQDPE LAYISSNFIT 480 GHGIGKNQPR SKQMEAEFRK QEEVLRKFRA HETNLLIATS VVEEGVDIPK CNLVVRFDLP 540 TEYRSYVQSK GRARAPISNY VMLADTDKIK SFEEDLKTYK AIEKILRNKC SKSADGAEAD 600 VHAGVDDEDA FPPYVLRPDD GGPRVTINTA IGHINRYCAR LPSDPFTHLA PKCRTRELPD 660 GTFYSTLYLP INSPLRASIV GPPMDSVRLA ERVVALICCE KLHKIGELDE HLMPVGKETV 720 KYEEELDLHD EEETSVPGRP GSTKRRQCYP KAIPECLRES YPKPDQPCYL YVIGMVLTTP 780 LPDELNFRRR KLYPPEDTTR CFGILTAKPI PQIPHFPVYT RSGEVTISIE LKKSGFTLSQ 840 QMLELITRLH QYIFSHILRL EKPALEFKPT GAESAYCVLP LNVVNDSGTL DIDFKFMEDI 900 EKSEARIGIP STKYSKETPF VFKLEDYQDA VIIPRYRNFD QPHRFYVADV YTDLTPLSKF 960 PSPEYETFAE YYKTKYNLDL TNLNQPLLDV DHTSSRLNLL TPRHLNQKGK ALPLSSAEKR 1020 KAKWESLQNK QILVPELCAI HPIPASLWRK AVCLPSILYR LHCLLTAEEL RAQTASDAGV 1080 GVRSLPVDFR YPNLDFGWKK SIDSKSFIST CNSSLAESDN YCKHSTTVVP EHAAHQGATR 1140 PSLENHDQMS VNCKRLPAES PAKLQSEVST DLTAINGLSY NKNLANGSYD LVNRDFCQGN 1200 QLNYFKQEIP VQPTTSYPIQ NLYNYENQPK PSNECPLLSN TYLDGNANTS TSDGSPAVST 1260 MPAMMNAVKA LKDRMDSEQS PSVGYSSRTL GPNPGLILQA LTLSNASDGF NLERLEMLGD 1320 SFLKHAITTY LFCTYPDAHE GRLSYMRSKK VSNCNLYRLG KKKGLPSRMV VSIFDPPVNW 1380 LPPGYVVNQD KSNSEKWEKD EMTKDCLLAN GKLGEACEEE EDLTWRAPKE EAEDEDDFLE 1440 YDQEHIQFID SMLMGSGAFV RKISLSPFSA SDSAYEWKMP KKASLGSMPF ASGLEDFDYS 1500 SWDAMCYLDP SKAVEEDDFV VGFWNPSEEN CGVDTGKQSI SYDLHTEQCI ADKSIADCVE 1560 ALLGCYLTSC GERAAQLFLC SLGLKVLPVI KRTSREKALD PAQENGSSQQ KSLSGSCAAP 1620 VGPRSSAGKD LEYGCLKIPP RCMFDHPDAE KTLNHLISGF ETFEKKINYR FKNKAYLLQA 1680 FTHASYHYNT ITDCYQRLEF LGDAILDYLI TKHLYEDPRQ HSPGVLTDLR SALVNNTIFA 1740 SLAVKYDYHK YFKAVSPELF HVIDDFVKFQ LEKNEMQGMD SELRRSEEDE EKEEDIEVPK 1800 AMGDIFESLA GAIYMDSGMS LEVVWQVYYP MMQPLIEKFS ANVPRSPVRE LLEMEPETAK 1860 FSPAERTYDG KVRVTVEVVG KGKFKGVGRS YRIAKSAAAR RALRSLKANQ PQVPNS 1916 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | DICER1 | 480426 | E2RIN4 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | 102175335 | A0A452ESG3 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | 23405 | Q9UPY3 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Dicer1 | Q8R418 | CPO | Mus musculus | Publication | More>> | ||
| 1:1 ortholog | DICER1 | 453137 | H2R458 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | DICER1 | A0A287A263 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Dicer1 | 299284 | E9PU15 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | dicer1 | 324724 | Q6TV19 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003677 | DNA binding | IEA |
| GO:0003723 | RNA binding | IBA |
| GO:0003725 | double-stranded RNA binding | ISO |
| GO:0004386 | helicase activity | IEA |
| GO:0004521 | endoribonuclease activity | ISO |
| GO:0004525 | ribonuclease III activity | ISO |
| GO:0004525 | ribonuclease III activity | ISA |
| GO:0004525 | ribonuclease III activity | IDA |
| GO:0004525 | ribonuclease III activity | IBA |
| GO:0004530 | deoxyribonuclease I activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GO:0019904 | protein domain specific binding | ISO |
| GO:0035197 | siRNA binding | ISO |
| GO:0035198 | miRNA binding | IDA |
| GO:0046872 | metal ion binding | IEA |
| GO:0070883 | pre-miRNA binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP |
| GO:0001525 | angiogenesis | IMP |
| GO:0001834 | trophectodermal cell proliferation | IMP |
| GO:0001932 | regulation of protein phosphorylation | IMP |
| GO:0001942 | hair follicle development | IMP |
| GO:0006309 | apoptotic DNA fragmentation | IBA |
| GO:0006396 | RNA processing | IDA |
| GO:0006396 | RNA processing | IMP |
| GO:0007284 | spermatogonial cell division | IMP |
| GO:0008283 | cell population proliferation | IMP |
| GO:0008593 | regulation of Notch signaling pathway | IC |
| GO:0009791 | post-embryonic development | IMP |
| GO:0010070 | zygote asymmetric cell division | IMP |
| GO:0010468 | regulation of gene expression | IMP |
| GO:0010626 | negative regulation of Schwann cell proliferation | IMP |
| GO:0010628 | positive regulation of gene expression | IMP |
| GO:0010629 | negative regulation of gene expression | ISO |
| GO:0010660 | regulation of muscle cell apoptotic process | IMP |
| GO:0014040 | positive regulation of Schwann cell differentiation | IMP |
| GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration | IMP |
| GO:0016075 | rRNA catabolic process | IEA |
| GO:0016246 | RNA interference | IMP |
| GO:0019827 | stem cell population maintenance | IMP |
| GO:0021522 | spinal cord motor neuron differentiation | IMP |
| GO:0021675 | nerve development | IMP |
| GO:0021889 | olfactory bulb interneuron differentiation | IMP |
| GO:0021987 | cerebral cortex development | IMP |
| GO:0030324 | lung development | IMP |
| GO:0030326 | embryonic limb morphogenesis | IMP |
| GO:0030422 | production of siRNA involved in RNA interference | ISS |
| GO:0030422 | production of siRNA involved in RNA interference | ISO |
| GO:0030422 | production of siRNA involved in RNA interference | IDA |
| GO:0030422 | production of siRNA involved in RNA interference | IBA |
| GO:0030423 | targeting of mRNA for destruction involved in RNA interference | ISS |
| GO:0030423 | targeting of mRNA for destruction involved in RNA interference | ISO |
| GO:0031054 | pre-miRNA processing | ISS |
| GO:0031054 | pre-miRNA processing | ISO |
| GO:0031054 | pre-miRNA processing | IDA |
| GO:0031054 | pre-miRNA processing | IBA |
| GO:0031069 | hair follicle morphogenesis | IMP |
| GO:0031641 | regulation of myelination | IMP |
| GO:0031643 | positive regulation of myelination | IMP |
| GO:0032290 | peripheral nervous system myelin formation | IMP |
| GO:0032720 | negative regulation of tumor necrosis factor production | ISO |
| GO:0033168 | conversion of ds siRNA to ss siRNA involved in RNA interference | ISO |
| GO:0035087 | siRNA loading onto RISC involved in RNA interference | ISO |
| GO:0035116 | embryonic hindlimb morphogenesis | IMP |
| GO:0035148 | tube formation | ISO |
| GO:0035196 | production of miRNAs involved in gene silencing by miRNA | ISO |
| GO:0035196 | production of miRNAs involved in gene silencing by miRNA | IMP |
| GO:0035264 | multicellular organism growth | IMP |
| GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA | ISO |
| GO:0036404 | conversion of ds siRNA to ss siRNA | ISO |
| GO:0038061 | NIK/NF-kappaB signaling | ISO |
| GO:0042487 | regulation of odontogenesis of dentin-containing tooth | IMP |
| GO:0045069 | regulation of viral genome replication | IMP |
| GO:0045589 | regulation of regulatory T cell differentiation | IMP |
| GO:0045595 | regulation of cell differentiation | IMP |
| GO:0045664 | regulation of neuron differentiation | IMP |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IMP |
| GO:0048255 | mRNA stabilization | IMP |
| GO:0048536 | spleen development | IMP |
| GO:0048565 | digestive tract development | IMP |
| GO:0048608 | reproductive structure development | IMP |
| GO:0048713 | regulation of oligodendrocyte differentiation | IMP |
| GO:0048730 | epidermis morphogenesis | IMP |
| GO:0048754 | branching morphogenesis of an epithelial tube | IMP |
| GO:0048812 | neuron projection morphogenesis | IMP |
| GO:0048856 | anatomical structure development | IMP |
| GO:0050727 | regulation of inflammatory response | IMP |
| GO:0050767 | regulation of neurogenesis | IMP |
| GO:0051216 | cartilage development | IMP |
| GO:0051225 | spindle assembly | IMP |
| GO:0051252 | regulation of RNA metabolic process | IMP |
| GO:0051607 | defense response to virus | IMP |
| GO:0051726 | regulation of cell cycle | IMP |
| GO:0055013 | cardiac muscle cell development | IMP |
| GO:0060119 | inner ear receptor cell development | IMP |
| GO:0060253 | negative regulation of glial cell proliferation | IMP |
| GO:0060576 | intestinal epithelial cell development | IGI |
| GO:0061309 | cardiac neural crest cell development involved in outflow tract morphogenesis | IMP |
| GO:0061548 | ganglion development | IMP |
| GO:0070173 | regulation of enamel mineralization | IMP |
| GO:0071335 | hair follicle cell proliferation | IMP |
| GO:0090501 | RNA phosphodiester bond hydrolysis | IBA |
| GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic | ISO |
| GO:1990141 | chromatin silencing at centromere outer repeat region | IMP |
| GO:2000628 | regulation of miRNA metabolic process | IMP |
| GO:2000630 | positive regulation of miRNA metabolic process | IMP |
| GO:2000736 | regulation of stem cell differentiation | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IBA |
| GO:0005737 | cytoplasm | IBA |
| GO:0005737 | cytoplasm | IDA |
| GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment | ISO |
| GO:0016442 | RISC complex | IBA |
| GO:0016442 | RISC complex | IDA |
| GO:0030424 | axon | ISO |
| GO:0030425 | dendrite | ISO |
| GO:0030426 | growth cone | ISO |
| GO:0034507 | chromosome, centromeric outer repeat region | IEA |
| GO:0070062 | extracellular exosome | ISO |
| GO:0070578 | RISC-loading complex | ISS |
| GO:0070578 | RISC-loading complex | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0877 | Alternative promoter usage |
| KW-0067 | ATP-binding |
| KW-0963 | Cytoplasm |
| KW-0255 | Endonuclease |
| KW-0347 | Helicase |
| KW-0378 | Hydrolase |
| KW-0460 | Magnesium |
| KW-0464 | Manganese |
| KW-0479 | Metal-binding |
| KW-0540 | Nuclease |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0694 | RNA-binding |
| KW-0943 | RNA-mediated gene silencing |