| Tag | Content |
|---|---|
| Uniprot ID | Q8VBV4; A2RRI5; D3YUA5; Q8CCS5; Q8VHP4; |
| Entrez ID | 50754 |
| Genbank protein ID | AAL50052.1; BAC27743.1; AAI31649.1; AAL40928.1; AAL40930.1; |
| Genbank nucleotide ID | XM_006501657.3; NM_001177774.1; XM_006501656.3; NM_080428.3; NM_001177773.1; |
| Ensembl protein ID | ENSMUSP00000103305; ENSMUSP00000029727; ENSMUSP00000103306; |
| Ensembl nucleotide ID | ENSMUSG00000028086 |
| Gene name | F-box/WD repeat-containing protein 7 |
| Gene symbol | Fbxw7 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 21503901; 10601039; |
| Functional description | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21953459, PubMed:22748924). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:22748924). Mediates ubiquitination and subsequent degradation of CCNE1 and MYC (PubMed:22748924). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1 and probably PSEN1 (By similarity). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (PubMed:21953459). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). |
| Sequence | MNQELLSVGS KRRRTGGSLR GNASSSQVDE GQMNRVVEED PQQQARHQEE EHTARNGELV 60 GANPRPGDQN DTQQGQVEEN NNRFISVDED SSGNQEEQEE DEEHAGEQEE EEEEEEEEEE 120 MDQESDDFDP SDDSSREDEH THNSNVTNCS SVSDLPAHQL SSPFYTKTTK MKRKLDHGSE 180 VRSFSLGKKP CKVSDYTSTT GLVPCSATPT TFGDLRAANG QGQQRRRITS VQPPTGLQEW 240 LKMFQSWSGP EKLLALDELI DSCEPTQVKH MMQVIEPQFQ RDFISLLPKE LALYVLSFLE 300 PKDLLQAAQT CRYWRILAED NLLWREKCKE EGIDEPLHIK RRKIIKPGFI HSPWKSAYIR 360 QHRIDTNWRR GELKSPKVLK GHDDHVITCL QFCGNRIVSG SDDNTLKVWS AVTGKCLRTL 420 VGHTGGVWSS QMRDNIIISG STDRTLKVWN AETGECIHTL YGHTSTVRCM HLHEKRVVSG 480 SRDATLRVWD IETGQCLHVL MGHVAAVRCV QYDGRRVVSG AYDFMVKVWD PETETCLHTL 540 QGHTNRVYSL QFDGIHVVSG SLDTSIRVWD VETGNCIHTL TGHQSLTSGM ELKDNILVSG 600 NADSTVKIWD IKTGQCLQTL QGPSKHQSAV TCLQFNKNFV ITSSDDGTVK LWDLKTGEFI 660 RNLVTLESGG SGGVVWRIRA SNTKLVCAVG SRNGTEETKL LVLDFDVDMK |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0030332 | cyclin binding | ISS |
| GO:0030332 | cyclin binding | ISO |
| GO:0030674 | protein binding, bridging | ISS |
| GO:0030674 | protein binding, bridging | ISO |
| GO:0031625 | ubiquitin protein ligase binding | ISS |
| GO:0031625 | ubiquitin protein ligase binding | ISO |
| GO:0042802 | identical protein binding | ISO |
| GO:0043130 | ubiquitin binding | IBA |
| GO:0050816 | phosphothreonine residue binding | ISS |
| GO:0050816 | phosphothreonine residue binding | ISO |
| GO:0061630 | ubiquitin protein ligase activity | TAS |
| GO:0097027 | ubiquitin-protein transferase activator activity | ISS |
| GO:0097027 | ubiquitin-protein transferase activator activity | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001570 | vasculogenesis | IMP |
| GO:0006974 | cellular response to DNA damage stimulus | ISS |
| GO:0006974 | cellular response to DNA damage stimulus | ISO |
| GO:0007062 | sister chromatid cohesion | ISS |
| GO:0007062 | sister chromatid cohesion | ISO |
| GO:0007219 | Notch signaling pathway | IDA |
| GO:0010629 | negative regulation of gene expression | ISO |
| GO:0010992 | ubiquitin recycling | IBA |
| GO:0016567 | protein ubiquitination | ISS |
| GO:0016567 | protein ubiquitination | ISO |
| GO:0030324 | lung development | IMP |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | ISS |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | ISO |
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | IDA |
| GO:0031398 | positive regulation of protein ubiquitination | ISS |
| GO:0031398 | positive regulation of protein ubiquitination | ISO |
| GO:0031648 | protein destabilization | IDA |
| GO:0034644 | cellular response to UV | ISS |
| GO:0034644 | cellular response to UV | ISO |
| GO:0042752 | regulation of circadian rhythm | ISO |
| GO:0042752 | regulation of circadian rhythm | IMP |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | ISO |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IBA |
| GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity | ISS |
| GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity | ISO |
| GO:0048511 | rhythmic process | IEA |
| GO:0050821 | protein stabilization | ISS |
| GO:0050821 | protein stabilization | ISO |
| GO:0051443 | positive regulation of ubiquitin-protein transferase activity | ISS |
| GO:0051443 | positive regulation of ubiquitin-protein transferase activity | ISO |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ISS |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ISO |
| GO:0090049 | regulation of cell migration involved in sprouting angiogenesis | IMP |
| GO:1901800 | positive regulation of proteasomal protein catabolic process | ISO |
| GO:1901800 | positive regulation of proteasomal protein catabolic process | IMP |
| GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding | IDA |
| GO:1903146 | regulation of autophagy of mitochondrion | ISO |
| GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | ISO |
| GO:1903378 | positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | IMP |
| GO:1903955 | positive regulation of protein targeting to mitochondrion | ISO |
| GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | ISS |
| GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | ISO |
| GO:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | IMP |
| GO:2001205 | negative regulation of osteoclast development | ISO |
| GO:2001205 | negative regulation of osteoclast development | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005623 | cell | IEA |
| GO:0005634 | nucleus | TAS |
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | IBA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005730 | nucleolus | ISO |
| GO:0005730 | nucleolus | IDA |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | TAS |
| GO:0005737 | cytoplasm | IBA |
| GO:0005739 | mitochondrion | IDA |
| GO:0005783 | endoplasmic reticulum | IDA |
| GO:0005794 | Golgi apparatus | IDA |
| GO:0005829 | cytosol | TAS |
| GO:0016021 | integral component of membrane | NAS |
| GO:0019005 | SCF ubiquitin ligase complex | ISS |
| GO:0019005 | SCF ubiquitin ligase complex | ISO |
| GO:0032991 | protein-containing complex | ISO |
| GO:0048471 | perinuclear region of cytoplasm | IDA |
| GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex | ISS |
| GO:1990452 | Parkin-FBXW7-Cul1 ubiquitin ligase complex | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1280218 | Adaptive Immune System | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |
| R-MMU-8951664 | Neddylation | IEA |
| R-MMU-983168 | Antigen processing: Ubiquitination & Proteasome degradation | IEA |
| R-MMU-983169 | Class I MHC mediated antigen processing & presentation | IEA |