Gene: Fbxw7

Basic information

Tag Content
Uniprot ID Q8VBV4; A2RRI5; D3YUA5; Q8CCS5; Q8VHP4;
Entrez ID 50754
Genbank protein ID AAL50052.1; BAC27743.1; AAI31649.1; AAL40928.1; AAL40930.1;
Genbank nucleotide ID XM_006501657.3; NM_001177774.1; XM_006501656.3; NM_080428.3; NM_001177773.1;
Ensembl protein ID ENSMUSP00000103305; ENSMUSP00000029727; ENSMUSP00000103306;
Ensembl nucleotide ID ENSMUSG00000028086
Gene name F-box/WD repeat-containing protein 7
Gene symbol Fbxw7
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 21503901; 10601039;
Functional description Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21953459, PubMed:22748924). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:22748924). Mediates ubiquitination and subsequent degradation of CCNE1 and MYC (PubMed:22748924). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1 and probably PSEN1 (By similarity). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (PubMed:21953459). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018).
Sequence
MNQELLSVGS KRRRTGGSLR GNASSSQVDE GQMNRVVEED PQQQARHQEE EHTARNGELV 60
GANPRPGDQN DTQQGQVEEN NNRFISVDED SSGNQEEQEE DEEHAGEQEE EEEEEEEEEE 120
MDQESDDFDP SDDSSREDEH THNSNVTNCS SVSDLPAHQL SSPFYTKTTK MKRKLDHGSE 180
VRSFSLGKKP CKVSDYTSTT GLVPCSATPT TFGDLRAANG QGQQRRRITS VQPPTGLQEW 240
LKMFQSWSGP EKLLALDELI DSCEPTQVKH MMQVIEPQFQ RDFISLLPKE LALYVLSFLE 300
PKDLLQAAQT CRYWRILAED NLLWREKCKE EGIDEPLHIK RRKIIKPGFI HSPWKSAYIR 360
QHRIDTNWRR GELKSPKVLK GHDDHVITCL QFCGNRIVSG SDDNTLKVWS AVTGKCLRTL 420
VGHTGGVWSS QMRDNIIISG STDRTLKVWN AETGECIHTL YGHTSTVRCM HLHEKRVVSG 480
SRDATLRVWD IETGQCLHVL MGHVAAVRCV QYDGRRVVSG AYDFMVKVWD PETETCLHTL 540
QGHTNRVYSL QFDGIHVVSG SLDTSIRVWD VETGNCIHTL TGHQSLTSGM ELKDNILVSG 600
NADSTVKIWD IKTGQCLQTL QGPSKHQSAV TCLQFNKNFV ITSSDDGTVK LWDLKTGEFI 660
RNLVTLESGG SGGVVWRIRA SNTKLVCAVG SRNGTEETKL LVLDFDVDMK

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005515 protein bindingIPI
GO:0030332 cyclin bindingISS
GO:0030332 cyclin bindingISO
GO:0030674 protein binding, bridgingISS
GO:0030674 protein binding, bridgingISO
GO:0031625 ubiquitin protein ligase bindingISS
GO:0031625 ubiquitin protein ligase bindingISO
GO:0042802 identical protein bindingISO
GO:0043130 ubiquitin bindingIBA
GO:0050816 phosphothreonine residue bindingISS
GO:0050816 phosphothreonine residue bindingISO
GO:0061630 ubiquitin protein ligase activityTAS
GO:0097027 ubiquitin-protein transferase activator activityISS
GO:0097027 ubiquitin-protein transferase activator activityISO

GO:Biological Process

GO ID GO Term Evidence
GO:0001570 vasculogenesisIMP
GO:0006974 cellular response to DNA damage stimulusISS
GO:0006974 cellular response to DNA damage stimulusISO
GO:0007062 sister chromatid cohesionISS
GO:0007062 sister chromatid cohesionISO
GO:0007219 Notch signaling pathwayIDA
GO:0010629 negative regulation of gene expressionISO
GO:0010992 ubiquitin recyclingIBA
GO:0016567 protein ubiquitinationISS
GO:0016567 protein ubiquitinationISO
GO:0030324 lung developmentIMP
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic processISS
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic processISO
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic processIDA
GO:0031398 positive regulation of protein ubiquitinationISS
GO:0031398 positive regulation of protein ubiquitinationISO
GO:0031648 protein destabilizationIDA
GO:0034644 cellular response to UVISS
GO:0034644 cellular response to UVISO
GO:0042752 regulation of circadian rhythmISO
GO:0042752 regulation of circadian rhythmIMP
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic processISO
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic processIBA
GO:0045741 positive regulation of epidermal growth factor-activated receptor activityISS
GO:0045741 positive regulation of epidermal growth factor-activated receptor activityISO
GO:0048511 rhythmic processIEA
GO:0050821 protein stabilizationISS
GO:0050821 protein stabilizationISO
GO:0051443 positive regulation of ubiquitin-protein transferase activityISS
GO:0051443 positive regulation of ubiquitin-protein transferase activityISO
GO:0070374 positive regulation of ERK1 and ERK2 cascadeISS
GO:0070374 positive regulation of ERK1 and ERK2 cascadeISO
GO:0090049 regulation of cell migration involved in sprouting angiogenesisIMP
GO:1901800 positive regulation of proteasomal protein catabolic processISO
GO:1901800 positive regulation of proteasomal protein catabolic processIMP
GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA bindingIDA
GO:1903146 regulation of autophagy of mitochondrionISO
GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwayISO
GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwayIMP
GO:1903955 positive regulation of protein targeting to mitochondrionISO
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic processISS
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic processISO
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic processIMP
GO:2001205 negative regulation of osteoclast developmentISO
GO:2001205 negative regulation of osteoclast developmentIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005623 cellIEA
GO:0005634 nucleusTAS
GO:0005634 nucleusIDA
GO:0005634 nucleusIBA
GO:0005654 nucleoplasmISO
GO:0005730 nucleolusISO
GO:0005730 nucleolusIDA
GO:0005737 cytoplasmISO
GO:0005737 cytoplasmTAS
GO:0005737 cytoplasmIBA
GO:0005739 mitochondrionIDA
GO:0005783 endoplasmic reticulumIDA
GO:0005794 Golgi apparatusIDA
GO:0005829 cytosolTAS
GO:0016021 integral component of membraneNAS
GO:0019005 SCF ubiquitin ligase complexISS
GO:0019005 SCF ubiquitin ligase complexISO
GO:0032991 protein-containing complexISO
GO:0048471 perinuclear region of cytoplasmIDA
GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complexISS
GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complexISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1280218 Adaptive Immune SystemIEA
R-MMU-168256 Immune SystemIEA
R-MMU-392499 Metabolism of proteinsIEA
R-MMU-597592 Post-translational protein modificationIEA
R-MMU-8951664 NeddylationIEA
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradationIEA
R-MMU-983169 Class I MHC mediated antigen processing & presentationIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0090 Biological rhythms
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0677 Repeat
KW-0832 Ubl conjugation
KW-0833 Ubl conjugation pathway
KW-0853 WD repeat

Interpro

InterPro ID InterPro Term
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

PROSITE

PROSITE ID PROSITE Term
PS50181 FBOX
PS00678 WD_REPEATS_1
PS50082 WD_REPEATS_2
PS50294 WD_REPEATS_REGION

Pfam

Pfam ID Pfam Term
PF12937 F-box-like
PF00400 WD40

Protein-protein interaction

Protein-miRNA interaction