Gene: Trps1

Basic information

Tag Content
Uniprot ID Q925H1
Entrez ID
Genbank protein ID AAK39508.1
Genbank nucleotide ID
Ensembl protein ID
Ensembl nucleotide ID
Gene name Zinc finger transcription factor Trps1
Gene symbol Trps1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 31130868
Functional description Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.
Sequence
MVRKKHPPLR NVASEGEGQT LEPTATESKV SGKNKELSAD QMSENTDQSD VAELNSKEEH 60
STHGQEPSSS GKKDLQISGL SEKAGFNYES PSKGGSLVSF PHDEVTDRNM LAFSSPAAGG 120
VCEPLKSPQR AEADDPQDMA CTPSGDSLET KEEHKMSPKA TEETGPVQSG QANCQGLSPV 180
SVASKNPQVP SDGGVRLSKP KGDLLVNDNP DPAPLSPELQ DFKCNICGYG YYGNDPTDLI 240
KHFRKYHLGL HNRTRQDAEL DSKILALHNM VQFSHSKDFQ KVNRSVLSGV LQDISSSRPA 300
LLNGTYDVQV TSGGTFIGIG RKTPDCQGNT KYFRCKFCNF TYMGNSSTEL EQHFLQTHPN 360
KIKVSLPSSE GVKPSEKNSN KSIPALRASD SGDVGKWQDK MTVKAGDDTP VGYSVPIKPL 420
DSSRQNGTEA TSYYWCKFCS FSCESSSSLK LLEHYGKQHG AVQSGGLNPE LNDKLPRGSV 480
INQNDLAKSV EGEPLTKPEK GLSGAKKKDF PSKGAEDNMV TSYNCQFCDF RYSKSHGPDV 540
IVVGPLLRHY QQLHNIHKCT IKHCPFCPRG LCSPEKHLGE ITYPFACRKS NCSHCALLLL 600
HLSPGVAGSS RVKHQCHQCS FSTPDVDVLL FHYETVHESQ ASDVKQEANH LLGSDGQQAV 660
RDSKEHSCTK CDFITQVEEE ISRHYRRAHS CYKCRQCSFT AADTQSLLEH FNTVHCQEQE 720
ITTANGEEGG HAIPTIKEEP KIDLKVYSLL NPDSKMGETV PESIVKREKL DDKEGLKDKI 780
WTESSTDDLR GVAWRGADIL RGSPSYTQAS LGLLTPVSSS QEQTKTLRDS PNVEAAHLAR 840
PMYGLAVDTK GFLQGAPAGS EKSASLTQQY PASGESKTKD ESQSLLRRRR GSGVFCANCL 900
TTKTSLWRKN ANGGYVCNAC GLYQKLHSTP RPLNIIKQNN GEQIIRRRTR KRLNPEALQA 960
EQLNKQQRGS GEEQVNGSPL ERRSEDHLSE SHPREIPLPS LSKYEAQGSL TKSHSAQQPV 1020
LVSQALDIHK RMQPLHIQIK SPQESTGDPG NSSSVSDGKG SSERGSPIEK YMRPAKHPNY 1080
SPPGSPIEKY QYPLFGVPFV HNDFQSEADW LRFWSKYKLS VPGNPHYLSH VPGLPNPCQN 1140
YVPYPTFNLP PHFSAVGSDN DIPLDLAIKH SRPGPTANGA SKEKTKAPPT VKNEDPLNVV 1200
KTEKVDRSTQ DELSTKCVHC GIVFLDEVMY ALHMSCHGDS GPFQCSICQH LCTDKYDFTT 1260
HIQRGLHRNN AQAEKNGKPK E 1281

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA bindingISO
GO:0003700 DNA-binding transcription factor activityIEA
GO:0005515 protein bindingIPI
GO:0008270 zinc ion bindingIEA
GO:0019904 protein domain specific bindingISO

GO:Biological Process

GO ID GO Term Evidence
GO:0000122 negative regulation of transcription by RNA polymerase IIISS
GO:0000122 negative regulation of transcription by RNA polymerase IIISO
GO:0001501 skeletal system developmentISO
GO:0001942 hair follicle developmentIMP
GO:0002062 chondrocyte differentiationIGI
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathwayIGI
GO:0032330 regulation of chondrocyte differentiationIMP
GO:0045892 negative regulation of transcription, DNA-templatedIPI
GO:0045892 negative regulation of transcription, DNA-templatedIMP
GO:0051291 protein heterooligomerizationISO
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsIGI

GO:Cellular Component

GO ID GO Term Evidence
GO:0000790 nuclear chromatinISO
GO:0005634 nucleusISS
GO:0005634 nucleusISO
GO:0005634 nucleusIDA
GO:0005654 nucleoplasmISO
GO:0032991 protein-containing complexISO

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-1017 Isopeptide bond
KW-0479 Metal-binding
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0677 Repeat
KW-0678 Repressor
KW-0804 Transcription
KW-0805 Transcription regulation
KW-0832 Ubl conjugation
KW-0862 Zinc
KW-0863 Zinc-finger

Interpro

InterPro ID InterPro Term
IPR028440 TRPS1
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA

PROSITE

PROSITE ID PROSITE Term
PS00344 GATA_ZN_FINGER_1
PS50114 GATA_ZN_FINGER_2
PS00028 ZINC_FINGER_C2H2_1
PS50157 ZINC_FINGER_C2H2_2

Pfam

Pfam ID Pfam Term
PF00320 GATA

Protein-miRNA interaction