| Tag | Content |
|---|---|
| Uniprot ID | Q925H1 |
| Entrez ID | |
| Genbank protein ID | AAK39508.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Zinc finger transcription factor Trps1 |
| Gene symbol | Trps1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 31130868 |
| Functional description | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. |
| Sequence | MVRKKHPPLR NVASEGEGQT LEPTATESKV SGKNKELSAD QMSENTDQSD VAELNSKEEH 60 STHGQEPSSS GKKDLQISGL SEKAGFNYES PSKGGSLVSF PHDEVTDRNM LAFSSPAAGG 120 VCEPLKSPQR AEADDPQDMA CTPSGDSLET KEEHKMSPKA TEETGPVQSG QANCQGLSPV 180 SVASKNPQVP SDGGVRLSKP KGDLLVNDNP DPAPLSPELQ DFKCNICGYG YYGNDPTDLI 240 KHFRKYHLGL HNRTRQDAEL DSKILALHNM VQFSHSKDFQ KVNRSVLSGV LQDISSSRPA 300 LLNGTYDVQV TSGGTFIGIG RKTPDCQGNT KYFRCKFCNF TYMGNSSTEL EQHFLQTHPN 360 KIKVSLPSSE GVKPSEKNSN KSIPALRASD SGDVGKWQDK MTVKAGDDTP VGYSVPIKPL 420 DSSRQNGTEA TSYYWCKFCS FSCESSSSLK LLEHYGKQHG AVQSGGLNPE LNDKLPRGSV 480 INQNDLAKSV EGEPLTKPEK GLSGAKKKDF PSKGAEDNMV TSYNCQFCDF RYSKSHGPDV 540 IVVGPLLRHY QQLHNIHKCT IKHCPFCPRG LCSPEKHLGE ITYPFACRKS NCSHCALLLL 600 HLSPGVAGSS RVKHQCHQCS FSTPDVDVLL FHYETVHESQ ASDVKQEANH LLGSDGQQAV 660 RDSKEHSCTK CDFITQVEEE ISRHYRRAHS CYKCRQCSFT AADTQSLLEH FNTVHCQEQE 720 ITTANGEEGG HAIPTIKEEP KIDLKVYSLL NPDSKMGETV PESIVKREKL DDKEGLKDKI 780 WTESSTDDLR GVAWRGADIL RGSPSYTQAS LGLLTPVSSS QEQTKTLRDS PNVEAAHLAR 840 PMYGLAVDTK GFLQGAPAGS EKSASLTQQY PASGESKTKD ESQSLLRRRR GSGVFCANCL 900 TTKTSLWRKN ANGGYVCNAC GLYQKLHSTP RPLNIIKQNN GEQIIRRRTR KRLNPEALQA 960 EQLNKQQRGS GEEQVNGSPL ERRSEDHLSE SHPREIPLPS LSKYEAQGSL TKSHSAQQPV 1020 LVSQALDIHK RMQPLHIQIK SPQESTGDPG NSSSVSDGKG SSERGSPIEK YMRPAKHPNY 1080 SPPGSPIEKY QYPLFGVPFV HNDFQSEADW LRFWSKYKLS VPGNPHYLSH VPGLPNPCQN 1140 YVPYPTFNLP PHFSAVGSDN DIPLDLAIKH SRPGPTANGA SKEKTKAPPT VKNEDPLNVV 1200 KTEKVDRSTQ DELSTKCVHC GIVFLDEVMY ALHMSCHGDS GPFQCSICQH LCTDKYDFTT 1260 HIQRGLHRNN AQAEKNGKPK E 1281 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.