Gene: CRAMP1

Basic information

Tag Content
Uniprot ID Q96RY5; A8MZL1; B1AJY1; Q8NDN1; Q9P2C1;
Entrez ID 57585
Genbank protein ID AAK61288.1; CAD38692.1; BAA92664.2;
Genbank nucleotide ID NM_020825.3
Ensembl protein ID ENSP00000293925; ENSP00000380559;
Ensembl nucleotide ID ENSG00000007545
Gene name Protein cramped-like
Gene symbol CRAMP1
Organism Homo sapiens
NCBI taxa ID 9606
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MTVKLGDGGS GEDGLKKLGK RAADEESLEG EGAGGADAAE ESSGTKRDEK TPRAGADGPP 60
APPGAPQAPS PPQGSPQDQH HFLRSSVRPQ SKRPRKDPPS AVGSGNAGGS GPRGKGAEGG 120
GSSSGNVSGV APAAPAGGSR SSSRNLGSSG GEKEEGKKVR RQWESWSTED KNTFFEGLYE 180
HGKDFEAIQN NIALKYKKKG KPASMVKNKE QVRHFYYRTW HKITKYIDFD HVFSRGLKKS 240
SQELYGLICY GELRKKIGGC MDDKNATKLN ELIQVGATTV RYKGRNLRIK APMCRALKKL 300
CDPDGLSDEE DQKPVRLPLK VPIELQPRNN HAWARVQSLA QNPRLRMIVE LHRKVSSLIE 360
FLKQKWALHE VRVRKTLEER QLQDSCSAPM QEKVTLHLFP GENCTLTPLP GVARVVHSKA 420
FCTVHWQEGG RCKQSAKDAH VLPPAQILGI QSGQGTARGQ VKCPRSGAEG KGVGRPPPAA 480
DALQSSGESS PESAPGEGAA LSLSSPDAPD RPPPRHQDTG PCLEKTPAEG RDSPTREPGA 540
LPCACGQLPD LEDELSLLDP LPRYLKSCQD LIVPEQCRCA DTRPGSEQPP LGGAASPEVL 600
APVSKEAADL APTGPSPRPG PGLLLDVCTK DLADAPAEEL QEKGSPAGPP PSQGQPAARP 660
PKEVPASRLA QQLREEGWNL QTSESLTLAE VYLMMGKPSK LQLEYDWLGP GRQDPRPGSL 720
PTALHKQRLL SCLLKLISTE VNPKLALEAN TISTASVRPA QEEQSMTPPG KVVTVSSRSP 780
RCPRNQASLR SSKTFPPSSA PCSSGLRNPP RPLLVPGPSS TGSNDSDGGL FAVPTTLPPN 840
SRHGKLFSPS KEAELTFRQH LNSISMQSDF FLPKPRKLRN RHLRKPLVVQ RTLLPRPSEN 900
QSHNVCSFSI LSNSSVTGRG SFRPIQSSLT KAALSRPIVP KVLPPQATSH LASAIDLAAT 960
SAGILSGNPL PALDTEGLSG ISPLSSDEVT GAISGQDSTG THQDGDTLPT VGGSDPFVSI 1020
PSRPEQEPVA DSFQGSSVLS LSELPKAPLQ NGLSIPLSSS ESSSTRLSPP DVSALLDISL 1080
PGPPEDALSQ GEPATHISDS IIEIAISSGQ YGEGVPLSPA KLNGSDSSKS LPSPSSSPQP 1140
HWIASPTHDP QWYPSDSTDS SLSSLFASFI SPEKSRKMLP TPIGTNSGTS LLGPSLLDGN 1200
SRDSFVSRSL ADVAEVVDSQ LVCMMNENSI DYISRFNDLA QELSIAEPGR REALFDGGGG 1260
GPAVSDLSQ 1269

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologCRAMP1520515E1BN92Bos taurusPredictionMore>>
1:1 orthologCRAMP1F1P887Canis lupus familiarisPredictionMore>>
1:1 orthologCRAMP1A0A452DN69Capra hircusPredictionMore>>
1:1 orthologCRAMP157585Q96RY5Homo sapiensPredictionMore>>
1:1 orthologCramp157354Q6PG95CPOMus musculusPublicationMore>>
1:1 orthologCRAMP1453823A0A2J8J7V5Pan troglodytesPredictionMore>>
1:1 orthologCRAMP1G1SMY0Oryctolagus cuniculusPredictionMore>>
1:1 orthologCramp1D3ZNU3Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

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Disease or phenotype associated information

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specificISM
GO:0003677 DNA bindingIEA
GO:0003682 chromatin bindingIBA

GO:Biological Process

GO ID GO Term Evidence
GO:0006357 regulation of transcription by RNA polymerase IIIEA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005634 nucleusIBA

Reactome Pathway

Reactome ID Reactome Term Evidence

Drugs and compounds information

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Functional annotations

Keywords

Keyword ID Keyword Term
KW-0238 DNA-binding
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR001005 SANT/Myb
IPR017884 SANT_dom

PROSITE

PROSITE ID PROSITE Term
PS51293 SANT

Pfam

Pfam ID Pfam Term

Protein-miRNA interaction