| Tag | Content |
|---|---|
| Uniprot ID | Q99JW4; Q3UAT7; Q8BTR6; Q9D5T4; |
| Entrez ID | 110829 |
| Genbank protein ID | AAH05621.1; BAB29637.1; BAE31922.1; BAE31411.1; BAC40663.1; BAE30814.1; BAE30227.1; BAC38699.1; |
| Genbank nucleotide ID | XM_006513073.2; NM_026148.3; |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | LIM and senescent cell antigen-like-containing domain protein 1 |
| Gene symbol | Lims1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 17272814 |
| Functional description | Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation. |
| Sequence | MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF YEFEGRKYCE 60 HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC QEVLADIGFV KNAGRHLCRP 120 CHNREKARGL GKYICQKCHA IIDEQPLIFK NDPYHPDHFN CANCGKELTA DARELKGELY 180 CLPCHDKMGV PICGACRRPI EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC 240 ETHYNQLFGD VCFHCNRVIE GDVVSALNKA WCVSCFACST CNTKLTLKNK FVEFDMKPVC 300 KKCYEKFPLE LKKRLKKLSE TLGRK 325 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0008270 | zinc ion binding | ISO |
| GO:0019901 | protein kinase binding | ISO |
| GO:0044877 | protein-containing complex binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007160 | cell-matrix adhesion | IMP |
| GO:0007163 | establishment or maintenance of cell polarity | IMP |
| GO:0010628 | positive regulation of gene expression | ISO |
| GO:0010811 | positive regulation of cell-substrate adhesion | ISO |
| GO:0033209 | tumor necrosis factor-mediated signaling pathway | ISO |
| GO:0043009 | chordate embryonic development | IMP |
| GO:0043066 | negative regulation of apoptotic process | IGI |
| GO:0043547 | positive regulation of GTPase activity | ISO |
| GO:0045184 | establishment of protein localization | ISO |
| GO:0045216 | cell-cell junction organization | IGI |
| GO:0045216 | cell-cell junction organization | IBA |
| GO:0045892 | negative regulation of transcription, DNA-templated | ISO |
| GO:0050680 | negative regulation of epithelial cell proliferation | IGI |
| GO:0051894 | positive regulation of focal adhesion assembly | ISO |
| GO:0098609 | cell-cell adhesion | IMP |
| GO:0098609 | cell-cell adhesion | IBA |
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | ISO |
| GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading | IBA |
| GO:1901224 | positive regulation of NIK/NF-kappaB signaling | ISO |
| GO:2000178 | negative regulation of neural precursor cell proliferation | IGI |
| GO:2000346 | negative regulation of hepatocyte proliferation | IGI |
| GO:2001046 | positive regulation of integrin-mediated signaling pathway | IGI |
| GO:2001046 | positive regulation of integrin-mediated signaling pathway | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005737 | cytoplasm | IBA |
| GO:0005886 | plasma membrane | IEA |
| GO:0005911 | cell-cell junction | ISO |
| GO:0005911 | cell-cell junction | IBA |
| GO:0005925 | focal adhesion | ISO |
| GO:0005925 | focal adhesion | IDA |
| GO:0005925 | focal adhesion | IBA |
| GO:0032991 | protein-containing complex | ISO |
| GO:0048471 | perinuclear region of cytoplasm | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1500931 | Cell-Cell communication | IEA |
| R-MMU-446353 | Cell-extracellular matrix interactions | IEA |
| R-MMU-446388 | Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | IEA |
| R-MMU-446728 | Cell junction organization | IEA |
| Pfam ID | Pfam Term |
|---|---|
| PF00412 | LIM |