| Tag | Content |
|---|---|
| Uniprot ID | Q9BYV7; B0YIX5; B4DNC3; E9PBI8; E9PJJ1; Q8IUS0; Q96JC8; Q96JY5; |
| Entrez ID | 83875 |
| Genbank protein ID | EAW67192.1; AAH41656.2; CAC27994.1; BAG60185.1; BAB55379.1; ACA05952.1; AAK69433.1; |
| Genbank nucleotide ID | NM_001037290.2; NM_001256397.1; NM_031938.5; NM_001256400.1; NM_001256398.1; |
| Ensembl protein ID | ENSP00000437053; ENSP00000414843; ENSP00000431802; ENSP00000350314; ENSP00000354338; ENSP00000436615; |
| Ensembl nucleotide ID | ENSG00000197580 |
| Gene name | Beta,beta-carotene 9',10'-oxygenase |
| Gene symbol | BCO2 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. |
| Sequence | MFFRVFLHFI RSHSATAVDF LPVMVHRLPV FKRYMGNTPQ KKAVFGQCRG LPCVAPLLTT 60 VEEAPRGISA RVWGHFPKWL NGSLLRIGPG KFEFGKDKYN HWFDGMALLH QFRMAKGTVT 120 YRSKFLQSDT YKANSAKNRI VISEFGTLAL PDPCKNVFER FMSRFELPGK AAAMTDNTNV 180 NYVRYKGDYY LCTETNFMNK VDIETLEKTE KVDWSKFIAV NGATAHPHYD LDGTAYNMGN 240 SFGPYGFSYK VIRVPPEKVD LGETIHGVQV ICSIASTEKG KPSYYHSFGM TRNYIIFIEQ 300 PLKMNLWKIA TSKIRGKAFS DGISWEPQCN TRFHVVEKRT GQLLPGRYYS KPFVTFHQIN 360 AFEDQGCVII DLCCQDNGRT LEVYQLQNLR KAGEGLDQVH NSAAKSFPRR FVLPLNVSLN 420 APEGDNLSPL SYTSASAVKQ ADGTIWCSHE NLHQEDLEKE GGIEFPQIYY DRFSGKKYHF 480 FYGCGFRHLV GDSLIKVDVV NKTLKVWRED GFYPSEPVFV PAPGTNEEDG GVILSVVITP 540 NQNESNFILV LDAKNFEELG RAEVPVQMPY GFHGTFIPI 579 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.