Gene: APAF1

Basic information

Tag Content
Uniprot ID Q9GL23
Entrez ID
Genbank protein ID CAC17122.1
Genbank nucleotide ID
Ensembl protein ID
Ensembl nucleotide ID
Gene name Apoptotic protease-activating factor 1
Gene symbol APAF1
Organism Canis lupus familiaris
NCBI taxa ID 9615
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase 9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity).
Sequence
ILKKDNYSYI SFYNALIHEG YKDLAALLHS GIPVISSSNG GKDSVGGITS

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Gene ontology

GO ID GO Term
GO:0005524 ATP binding
GO:0006915 apoptotic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0053 Apoptosis
KW-0067 ATP-binding
KW-0106 Calcium
KW-0547 Nucleotide-binding
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term