| Tag | Content |
|---|---|
| Uniprot ID | Q9H237; B2RBN8; B7ZAR3; Q14829; Q9H234; Q9H235; Q9H236; Q9UJU7; |
| Entrez ID | 64840 |
| Genbank protein ID | AAA74510.1; BAG37285.1; AAG39628.1; AAG39629.1; AAH19080.1; EAW50780.1; AAG39630.1; AAG39631.1; BAH14749.1; |
| Genbank nucleotide ID | NM_022825.3; NM_203474.1; XM_011543948.2; XM_006724546.3; XM_017029736.1; NM_001282167.1; NM_203473.2; NM_203475.2; |
| Ensembl protein ID | ENSP00000354978; ENSP00000322304; ENSP00000352946; ENSP00000356546; ENSP00000348233; ENSP00000446401; |
| Ensembl nucleotide ID | ENSG00000102312 |
| Gene name | Protein-serine O-palmitoleoyltransferase porcupine |
| Gene symbol | PORCN |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins. Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors. |
| Sequence | MATFSRQEFF QQLLQGCLLP TAQQGLDQIW LLLAICLACR LLWRLGLPSY LKHASTVAGG 60 FFSLYHFFQL HMVWVVLLSL LCYLVLFLCR HSSHRGVFLS VTILIYLLMG EMHMVDTVTW 120 HKMRGAQMIV AMKAVSLGFD LDRGEVGTVP SPVEFMGYLY FVGTIVFGPW ISFHSYLQAV 180 QGRPLSCRWL QKVARSLALA LLCLVLSTCV GPYLFPYFIP LNGDRLLRNK KRKARGTMVR 240 WLRAYESAVS FHFSNYFVGF LSEATATLAG AGFTEEKDHL EWDLTVSKPL NVELPRSMVE 300 VVTSWNLPMS YWLNNYVFKN ALRLGTFSAV LVTYAASALL HGFSFHLAAV LLSLAFITYV 360 EHVLRKRLAR ILSACVLSKR CPPDCSHQHR LGLGVRALNL LFGALAIFHL AYLGSLFDVD 420 VDDTTEEQGY GMAYTVHKWS ELSWASHWVT FGCWIFYRLI G 461 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.