| Tag | Content |
|---|---|
| Uniprot ID | Q9H3D4; O75080; O75195; O75922; O76078; Q6VEG2; Q6VEG3; Q6VEG4; Q6VFJ1; Q6VFJ2; Q6VFJ3; Q6VH20; Q7LDI3; Q7LDI4; Q7LDI5; Q96KR0; Q9H3D2; Q9H3D3; Q9H3P8; Q9NPH7; Q9P1B4; Q9P1B5; Q9P1B6; Q9P1B7; Q9UBV9; Q9UE10; Q9UP26; Q9UP27; Q9UP28; Q9UP74; |
| Entrez ID | 8626 |
| Genbank protein ID | AAG45612.1; BAB20591.1; BAA32593.1; AAG45608.1; AAQ63453.1; AAF43493.1; CAC48053.1; AAQ63448.1; AAC62633.1; CAA76562.1; AAF61624.1; BAA32592.1; AAG45610.1; AAF43490.1; AAC62637.1; AAC43038.1; AAQ63449.1; AAC62638.1; AAG45609.1; AAF43491.1; AAC62635.1; AAC62634.1; AAF43488.1; AAQ63450.1; AAF43492.1; AAG45611.1; AAG45607.1; AAQ63454.1; AAF43486.1; BAA32433.1; AAF43487.1; AAQ63451.1; AAQ63452.1; AAC24830.1; AAF43489.1; AAH39815.1; AAC62636.1; |
| Genbank nucleotide ID | NM_001114981.1; NM_001114978.1; NM_001329144.1; NM_001114979.1; NM_001114980.1; NM_001114982.1; NM_001329145.1; NM_001329146.1; XM_017007387.1; NM_003722.4; NM_001329148.1; |
| Ensembl protein ID | ENSP00000407144; ENSP00000346614; ENSP00000376256; ENSP00000394337; ENSP00000389485; ENSP00000387839; ENSP00000392488; ENSP00000264731; ENSP00000317510; ENSP00000376253; ENSP00000376254; |
| Ensembl nucleotide ID | ENSG00000073282 |
| Gene name | Tumor protein 63 |
| Gene symbol | TP63 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 11159940 |
| Functional description | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. |
| Sequence | MNFETSRCAT LQYCPDPYIQ RFVETPAHFS WKESYYRSTM SQSTQTNEFL SPEVFQHIWD 60 FLEQPICSVQ PIDLNFVDEP SEDGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNSM 120 DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS 180 FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV 240 VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 300 TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR 360 KQQVSDSTKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES 420 LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSIQSPSSYG NSSPPLNKMN SMNKLPSVSQ 480 LINPQQRNAL TPTTIPDGMG ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP 540 PPYPTDCSIV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG 600 ILDHRQLHEF SSPSHLLRTP SSASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND 660 FNFDMDARRN KQQRIKEEGE |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.