| Tag | Content |
|---|---|
| Uniprot ID | Q9HAY6; A0AV48; A0AV50; Q9NVH5; |
| Entrez ID | 53630 |
| Genbank protein ID | AAI26213.1; BAA91776.1; EAW95537.1; AAI26211.1; AAG15380.1; |
| Genbank nucleotide ID | NM_017429.2 |
| Ensembl protein ID | ENSP00000258168 |
| Ensembl nucleotide ID | ENSG00000135697 |
| Gene name | Beta,beta-carotene 15,15'-dioxygenase |
| Gene symbol | BCO1 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism. |
| Sequence | MDIIFGRNRK EQLEPVRAKV TGKIPAWLQG TLLRNGPGMH TVGESRYNHW FDGLALLHSF 60 TIRDGEVYYR SKYLRSDTYN TNIEANRIVV SEFGTMAYPD PCKNIFSKAF SYLSHTIPDF 120 TDNCLINIMK CGEDFYATSE TNYIRKINPQ TLETLEKVDY RKYVAVNLAT SHPHYDEAGN 180 VLNMGTSIVE KGKTKYVIFK IPATVPEGKK QGKSPWKHTE VFCSIPSRSL LSPSYYHSFG 240 VTENYVIFLE QPFRLDILKM ATAYIRRMSW ASCLAFHREE KTYIHIIDQR TRQPVQTKFY 300 TDAMVVFHHV NAYEEDGCIV FDVIAYEDNS LYQLFYLANL NQDFKENSRL TSVPTLRRFA 360 VPLHVDKNAE VGTNLIKVAS TTATALKEED GQVYCQPEFL YEGLELPRVN YAHNGKQYRY 420 VFATGVQWSP IPTKIIKYDI LTKSSLKWRE DDCWPAEPLF VPAPGAKDED DGVILSAIVS 480 TDPQKLPFLL ILDAKSFTEL ARASVDVDMH MDLHGLFITD MDWDTKKQAA SEEQRDRASD 540 CHGAPLT 547 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.