| Tag | Content |
|---|---|
| Uniprot ID | Q9JJ11; Q9WVK9; |
| Entrez ID | |
| Genbank protein ID | AAF85763.1; AAD25963.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Transforming acidic coiled-coil-containing protein 3 |
| Gene symbol | Tacc3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 11847113 |
| Functional description | Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (PubMed:17920017). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (By similarity). May be involved in the control of cell growth and differentiation. May have a role in embryonic development. |
| Sequence | MSLHVLNDEN VPNEKSSQCR DFQFLPPELT GRSSVLCLSQ KENVPPQSQA KATNVTFQTP 60 PRDPQTHRIL SPNMTNKREA PFGLQNDHCV FLQKENQRPL APVDDAPVVQ MAAEILRAEG 120 ELQEGILTSS SLSASTSLLD SELVTPPIEP VLEPSHQGLE PVLESELVTP PVEPVLEPSH 180 QELEPVLESE LVTPPIEPVL EPSHQGLEPV LDSELVTPPI EPVLEPSHQG LEPVLESELV 240 TPPIEPVLEP SHQGLEPVLD SELVTPPIEP VLEPSHQGLE PVLDSELVTP PIEPLLEPSH 300 QGLEPVVDLK EESFRDPSEV LGTGAEVDYL EQFGTSSFKE SAWRKQSLYV KFDPLLKDSP 360 LRPMPVAPIT NSTQDTEEES GSGKPTEAEL VNLDFLGDLD VPVSAPTPVW SLEPRGLLPA 420 EPIVDVLKYS QKDLDAVVNV MQQENLELKS KYEDLNTKYL EMGKSVDEFE KIAYKSLEEA 480 EKQRELKEIA EDKIQKVLKE RDQLNADLNS MEKSFSDLFK RFEKRKEVIE GYQKNEESLK 540 KYVGECIVKI EKEGQRYQAL KIHAEEKLRL ANEEIAQVHS KAQAEVLALQ ASLRKAQMQN 600 HSLEMTLEQK TKEIDELTRI CDDLISKMEK I 631 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005515 | protein binding | IPI |
| GO:0019904 | protein domain specific binding | IPI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000226 | microtubule cytoskeleton organization | IMP |
| GO:0000226 | microtubule cytoskeleton organization | IBA |
| GO:0001666 | response to hypoxia | IDA |
| GO:0007052 | mitotic spindle organization | IEA |
| GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | ISO |
| GO:0008283 | cell population proliferation | IMP |
| GO:0008283 | cell population proliferation | IBA |
| GO:0021987 | cerebral cortex development | IMP |
| GO:0021987 | cerebral cortex development | IBA |
| GO:0022008 | neurogenesis | IMP |
| GO:0022027 | interkinetic nuclear migration | IMP |
| GO:0030097 | hemopoiesis | IMP |
| GO:0030953 | astral microtubule organization | IDA |
| GO:0032886 | regulation of microtubule-based process | IMP |
| GO:0042994 | cytoplasmic sequestering of transcription factor | IDA |
| GO:0051301 | cell division | IEA |
| GO:0051726 | regulation of cell cycle | IGI |
| GO:0060236 | regulation of mitotic spindle organization | ISO |
| GO:1902850 | microtubule cytoskeleton organization involved in mitosis | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000922 | spindle pole | IEA |
| GO:0005737 | cytoplasm | IDA |
| GO:0005737 | cytoplasm | IBA |
| GO:0005813 | centrosome | IDA |
| GO:0005813 | centrosome | TAS |
| GO:0005829 | cytosol | ISO |
| GO:0005829 | cytosol | TAS |
| GO:0034451 | centriolar satellite | ISO |
| GO:0043231 | intracellular membrane-bounded organelle | ISO |
| GO:0072686 | mitotic spindle | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|
| Pfam ID | Pfam Term |
|---|---|
| PF05010 | TACC_C |