Gene: Cilk1

Basic information

Tag Content
Uniprot ID Q9JKV2; Q8K138;
Entrez ID 56542
Genbank protein ID AAH28863.1; AAF37277.1;
Genbank nucleotide ID NM_019987.2; NM_001163780.1; XM_006511304.2;
Ensembl protein ID ENSMUSP00000048234; ENSMUSP00000112961;
Ensembl nucleotide ID ENSMUSG00000009828
Gene name Serine/threonine-protein kinase ICK
Gene symbol Cilk1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 24853502
Functional description Has an essential role in ciliogenesis, particularly in neuronal and retinal progenitor cells (PubMed:24797473). Phosphorylates KIF3A (PubMed:24797473). Involved in the control of ciliary length (PubMed:24853502). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (PubMed:24797473, PubMed:24853502). May play a role in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling -dependent manner and this regulation requires its kinase activity (PubMed:25243405).
Sequence
MNRYTTIKQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE VKSLKKLNHA 60
NIVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES AIRNIMYQIL QGLAFIHKHG 120
FFHRDLKPEN LLCMGPELVK IADFGLAREI RSRPPYTDYV STRWYRAPEV LLRSTNYSSP 180
IDIWAVGCIM AEVYTLRPLF PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFLWPQ 240
CIPNNLKTLI PNASSEAIQL LRDLLQWDPK KRPTASQALR YPYFQIGHPL GIISKDSGKP 300
QREVQDKTGP PPYIKPAPPA QAPAKAYTLI SSRPSQASQP PQHSVHPYKG DVSRTEQLSH 360
VQEGKPSPPF FPSLHNKNLQ PKILASLEQK NGEIKPKSRR RWGLISRSTK GSDDWADLDD 420
LDFSPSLTRI DVKNKKRQSD DTLCRFESVL DLKPSESVGT GTTVSTQASS QRRDTPTLQS 480
SAKQHYLKHS RYLPGINIRN GVLPNPGKDF LPSNSWSSSG LSGKSSGTVS VVSKITSVGS 540
GSASSSGLTG SYIPSFLKKE IGSVMQRVQL APLAAPPPGY SSLKAVRPHP GRPFFHTQPR 600
STPGLIPRPP AAQPVHGRID WSSKYPSRR 629

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Other genetic variants/mutations

loading...

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0000287 magnesium ion bindingISS
GO:0000287 magnesium ion bindingISO
GO:0004672 protein kinase activityISO
GO:0004674 protein serine/threonine kinase activityISS
GO:0004674 protein serine/threonine kinase activityISO
GO:0004674 protein serine/threonine kinase activityIDA
GO:0004674 protein serine/threonine kinase activityIBA
GO:0005524 ATP bindingISS
GO:0005524 ATP bindingISO

GO:Biological Process

GO ID GO Term Evidence
GO:0006468 protein phosphorylationISS
GO:0006468 protein phosphorylationISO
GO:0006468 protein phosphorylationIDA
GO:0007165 signal transductionTAS
GO:0007275 multicellular organism developmentIEA
GO:0010468 regulation of gene expressionIBA
GO:0035556 intracellular signal transductionISS
GO:0035556 intracellular signal transductionISO
GO:0035556 intracellular signal transductionIBA
GO:0035720 intraciliary anterograde transportIMP
GO:0035721 intraciliary retrograde transportIMP
GO:0042073 intraciliary transportIBA
GO:0042073 intraciliary transportIMP
GO:0060271 cilium assemblyISO
GO:0060271 cilium assemblyIBA
GO:0060271 cilium assemblyIMP

GO:Cellular Component

GO ID GO Term Evidence
GO:0001650 fibrillar centerISO
GO:0005634 nucleusISO
GO:0005634 nucleusIBA
GO:0005634 nucleusIDA
GO:0005737 cytoplasmISO
GO:0005737 cytoplasmIBA
GO:0005829 cytosolIEA
GO:0005929 ciliumIBA
GO:0005929 ciliumIDA
GO:0036064 ciliary basal bodyIDA
GO:0097542 ciliary tipISO
GO:0097542 ciliary tipIMP
GO:0097546 ciliary baseIDA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0067 ATP-binding
KW-0966 Cell projection
KW-0970 Cilium biogenesis/degradation
KW-0963 Cytoplasm
KW-0206 Cytoskeleton
KW-0217 Developmental protein
KW-0903 Direct protein sequencing
KW-0418 Kinase
KW-0460 Magnesium
KW-0479 Metal-binding
KW-0547 Nucleotide-binding
KW-0539 Nucleus
KW-0597 Phosphoprotein
KW-1185 Reference proteome
KW-0723 Serine/threonine-protein kinase
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

PROSITE

PROSITE ID PROSITE Term
PS00107 PROTEIN_KINASE_ATP
PS50011 PROTEIN_KINASE_DOM
PS00108 PROTEIN_KINASE_ST

Pfam

Pfam ID Pfam Term
PF00069 Pkinase