| Tag | Content |
|---|---|
| Uniprot ID | Q9JL19; Q9JLT9; |
| Entrez ID | |
| Genbank protein ID | AAH31113.1; AAF35973.1; AAF35860.1; |
| Genbank nucleotide ID | |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Nuclear receptor coactivator 6 |
| Gene symbol | Ncoa6 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 12446700 |
| Functional description | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development. |
| Sequence | MVLDDLPNFE DIYTSLCSST MGDSEVEFDS GLEDDDTKGD SILEDSTIFV AFKGNIDDKD 60 FKWKLDAILK NVPNLLHMES SKLKVQKVEP WNSVRVTFNI PREAAERLWI LAQSNNQQLR 120 DLGILSVQIE GEGAINLALG QNRSQDVRMN GPVASGNSVR MEAGFPMASG PGLIRMTSPA 180 AVMTPQGGNM SSSMMAPGPN PELQPRTPRP ASQSDAMDPL LSGLHIQQQS HPSGSLPPAH 240 HSMQPVPVNR QMNPANFPQL QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ LQTRPLQQHQ 300 QQPQGIRPQF TAPTQVPVPP GWNQLPSGAL QPPPAQGSLG TMTTNQGWKK APLPSPMQAQ 360 LQARPSLATV QTPSHPPPPY PFGSQQASQA HTNFPQMSNP GQFTAPQMKG LQGGPSRVPT 420 PLQQPHLTNK SPASSPSSFQ QGSPASSPTV NQTQQQMGPR PPQNNPLSQG FQQPVSSPGR 480 NPMVQQGNVP PNFMVMQQQP PNQGPQSLHP GLGGMPKRLP PGFSAGQANP NFMQGQVPST 540 TAATPGNSGA LQLQANQNVQ HAGGQGAGPP QNQMQVSHGP PNMMQPSLMG IHGNINNQQA 600 GSSGVPQVTL GNMQGQPQQG PPSQLMGMHQ QIVPSQGQMA QQQGTLNPQN PMILSRAQLM 660 PQGQMMVNAQ NQNLGPSPQR MTPPKQMLPQ QGPQMMAPHN QMMGPQGQVL LQQNPMIEQI 720 MTNQMQGNKA QFNSQNQSNV MPGPAQIMRG PTPNMQGNMV QFTGQMSGQM LPQQGPVNNS 780 PSQVMGIQGQ VLRPPGPSPH MAQQHTDPVT TANNDVNLSQ MMPDVSMQQA SMVPPHVQSM 840 QGNSASGSHF SGHGVSFNAP FGGAPNGSQM SCGQNPGFPV NKDVTLTSPL LVNLLQSDIS 900 AGHFGVNNKQ NNTNANKPKK KKPPRKKKNC HQDLNTPDNR PTGLEEVDQQ SLPGEQGINL 960 DTTGPKLPDF SNRPPGYPTQ PVEQRPLPQM PPQLMQHVAP PPQPPQQQPQ PQLPQQQQPP 1020 PPSQPQSQQQ QQQQQMMMML MMQQDPKSIR LPVSQNVHPP RGPLNPDSQR MPVQQSGNVP 1080 VMVGLQGPAS VPPSPDKQRM PMSVNTPMGS NSRKMVYQEN PQNSSSSPLG EMSSLPEASG 1140 SEVPSVAGGP NNMPSHLVVS QNQLMMTGPK PGPSPLSATQ GATPQQPPVN SLPSSHGHHF 1200 PNVAAPTQTS RPKTPNRASP RPYYPQTPNN RPPSTEPSEI SLSPERLNAS IAGLFPPQIN 1260 IPLPPRPNLN RGFDQQGLNP TTLKAIGQAP SNLTITNPPN FAAPQAHKLD SVVVNSGKQS 1320 NPGTTKRASP SNSRRSSPGS SRKTTPSPGR QNSKAPKLTL ASQTSTTMLQ NMELPRNVLV 1380 GPTPLANPPL PGSFPNNTGL NPQNPTVPVP AMGTVLEDNK ESVNIPQDSD CQNAQGRKEQ 1440 VNTELKVVPT QEAKMAVPED QSKKDGQPLD PNKLPSVEEN KNLMSPAMRE APTSLSQLLD 1500 NSGAPNVTIK PPGLTDLEVT PPVVSGEDLR KASVIPTLQD PPSKEPSTSL SSPHSSEPCS 1560 TLARSELSEV SSNAAPSIPP VMSRPVSSSS ISTPLPPNQI TVFVTSNPIT TSSNTSAALP 1620 THLQSALMST VVTMPNVGNK VMVSEGQSAA QSNARPQFIT PVFINSSSII QVMKGSQPST 1680 IPATPLTTNS GLMPPSVAVV GPLHIPQNIK FSSAPVTPNV PSSSPAPNIQ TGRPLVLSSR 1740 ATPVQLPSPP CTSSPVVAPN PSVQQVKELN PDEASPQTNT SADQSTLPPS QPTTVVSSLL 1800 TNSPGSSANR RSPVSSSKGK GKVDKIGQIL LTKACKKVTG SLEKGEEQYG ADGETEGPGL 1860 EITTPGLMGT EQCSTELDSK TPTPSAPTLL KMTSSPMAPS STSTGPILPG GALPTSVRSI 1920 VTTLVPSELI STAPTTKGNH GGVTSEPLAG GLVEEKVGSH PELLPSIAPS QNLAPKETPA 1980 TALQGSVARP ELEANAAIAS GQSCEPKEIV EKSKTLTSRR NSRTEEPTMA SESVENGHRK 2040 RSSRPASASS STKDITGAVQ SKRRKSK 2067 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003682 | chromatin binding | IDA |
| GO:0003713 | transcription coactivator activity | ISS |
| GO:0003713 | transcription coactivator activity | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0030374 | nuclear receptor transcription coactivator activity | IBA |
| GO:0046966 | thyroid hormone receptor binding | ISS |
| GO:0051427 | hormone receptor binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006974 | cellular response to DNA damage stimulus | ISO |
| GO:0007420 | brain development | IMP |
| GO:0007507 | heart development | IMP |
| GO:0010468 | regulation of gene expression | IMP |
| GO:0030099 | myeloid cell differentiation | ISS |
| GO:0045893 | positive regulation of transcription, DNA-templated | IDA |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA |
| GO:0060716 | labyrinthine layer blood vessel development | IMP |
| GO:0080182 | histone H3-K4 trimethylation | IGI |
| GO:0080182 | histone H3-K4 trimethylation | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | IDA |
| GO:0005634 | nucleus | ISO |
| GO:0005654 | nucleoplasm | TAS |
| GO:0005667 | transcription factor complex | IDA |
| GO:0005667 | transcription factor complex | IBA |
| GO:0035097 | histone methyltransferase complex | ISO |
| GO:0035097 | histone methyltransferase complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Pfam ID | Pfam Term |
|---|---|
| PF13820 | Nucleic_acid_bd |