CleftGeneDB-Search

Gene: CHST11

Basic information

Tag	Content
Uniprot ID	Q9NPF2; A8K4F8; Q9NXY6; Q9NY36;
Entrez ID	50515
Genbank protein ID	BAA95485.1; CAB87380.1; BAF83612.1; CAB92134.1; EAW97748.1; AAF81691.1; AAH13315.1;
Genbank nucleotide ID	NM_001173982.1; NM_018413.5;
Ensembl protein ID	ENSP00000450004; ENSP00000305725;
Ensembl nucleotide ID	ENSG00000171310
Gene name	Carbohydrate sulfotransferase 11
Gene symbol	CHST11
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
Sequence	MKPALLEVMR MNRICRMVLA TCLGSFILVI FYFQSMLHPV MRRNPFGVDI CCRKGSRSPL 60 QELYNPIQLE LSNTAVLHQM RRDQVTDTCR ANSATSRKRR VLTPNDLKHL VVDEDHELIY 120 CYVPKVACTN WKRLMMVLTG RGKYSDPMEI PANEAHVSAN LKTLNQYSIP EINHRLKSYM 180 KFLFVREPFE RLVSAYRNKF TQKYNISFHK RYGTKIIKRQ RKNATQEALR KGDDVKFEEF 240 VAYLIDPHTQ REEPFNEHWQ TVYSLCHPCH IHYDLVGKYE TLEEDSNYVL QLAGVGSYLK 300 FPTYAKSTRT TDEMTTEFFQ NISSEHQTQL YEVYKLDFLM FNYSVPSYLK LE 352

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	CHST11	528860	F1N663		Bos taurus	Prediction	More>>
1:1 ortholog	CHST11	102184407	A0A452EQU9		Capra hircus	Prediction	More>>
1:1 ortholog	CHST11	100067989	F7E238		Equus caballus	Prediction	More>>
1:1 ortholog	CHST11	50515	Q9NPF2		Homo sapiens	Prediction	More>>
1:1 ortholog	Chst11	58250	Q9JME2	CPO	Mus musculus	Publication	More>>
1:1 ortholog	CHST11		A0A2I3TRV5		Pan troglodytes	Prediction	More>>
1:1 ortholog	Chst11	314694	P69478		Rattus norvegicus	Prediction	More>>
1:1 ortholog	chst11		F1REP6		Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs1315682263	p.Lys2Thr	missense variant	-	NC_000012.12:g.104457416A>C	TOPMed
rs1397742557	p.Lys2Glu	missense variant	-	NC_000012.12:g.104457415A>G	gnomAD
rs779782743	p.Ala4Val	missense variant	-	NC_000012.12:g.104457422C>T	ExAC,TOPMed,gnomAD
rs758033699	p.Ala4Ser	missense variant	-	NC_000012.12:g.104457421G>T	ExAC,gnomAD
rs779782743	p.Ala4Glu	missense variant	-	NC_000012.12:g.104457422C>A	ExAC,TOPMed,gnomAD
rs1294348579	p.Glu7Lys	missense variant	-	NC_000012.12:g.104457430G>A	gnomAD
NCI-TCGA novel	p.Glu7Asp	missense variant	-	NC_000012.12:g.104457432A>T	NCI-TCGA
rs1270126457	p.Val8Leu	missense variant	-	NC_000012.12:g.104457433G>T	TOPMed,gnomAD
rs1453684266	p.Val8Glu	missense variant	-	NC_000012.12:g.104457434T>A	gnomAD
rs749410967	p.Met9Lys	missense variant	-	NC_000012.12:g.104457437T>A	ExAC,TOPMed,gnomAD
rs1324335474	p.Met9Val	missense variant	-	NC_000012.12:g.104457436A>G	gnomAD
rs374980790	p.Arg10Lys	missense variant	-	NC_000012.12:g.104457440G>A	1000Genomes,ESP,TOPMed,gnomAD
rs374980790	p.Arg10Thr	missense variant	-	NC_000012.12:g.104457440G>C	1000Genomes,ESP,TOPMed,gnomAD
rs374980790	p.Arg10Met	missense variant	-	NC_000012.12:g.104457440G>T	1000Genomes,ESP,TOPMed,gnomAD
rs367648267	p.Met11Leu	missense variant	-	NC_000012.12:g.104457442A>T	ESP,TOPMed
rs894608163	p.Met11Arg	missense variant	-	NC_000012.12:g.104457443T>G	TOPMed,gnomAD
rs1218116202	p.Met11Ile	missense variant	-	NC_000012.12:g.104457444G>A	TOPMed
rs771170795	p.Arg13Lys	missense variant	-	NC_000012.12:g.104457449G>A	ExAC,gnomAD
rs1208614929	p.Ile14Val	missense variant	-	NC_000012.12:g.104457451A>G	gnomAD
rs774546652	p.Arg16Gly	missense variant	-	NC_000012.12:g.104457457C>G	ExAC,gnomAD
rs1486664513	p.Arg16Gln	missense variant	-	NC_000012.12:g.104457458G>A	gnomAD
rs144598269	p.Met17Ile	missense variant	-	NC_000012.12:g.104457462G>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs149731216	p.Met17Thr	missense variant	-	NC_000012.12:g.104457461T>C	ESP
rs746147552	p.Met17Val	missense variant	-	NC_000012.12:g.104457460A>G	ExAC
rs746147552	p.Met17Leu	missense variant	-	NC_000012.12:g.104457460A>T	ExAC
rs191879618	p.Leu19Pro	missense variant	-	NC_000012.12:g.104457467T>C	1000Genomes
rs1262781566	p.Thr21Ile	missense variant	-	NC_000012.12:g.104457473C>T	TOPMed
rs761054661	p.Cys22Phe	missense variant	-	NC_000012.12:g.104457476G>T	ExAC,gnomAD
rs1321160570	p.Gly24Glu	missense variant	-	NC_000012.12:g.104457482G>A	TOPMed
rs148490795	p.Phe26Leu	missense variant	-	NC_000012.12:g.104457489T>G	ESP,ExAC,gnomAD
NCI-TCGA novel	p.Leu28Arg	missense variant	-	NC_000012.12:g.104457494T>G	NCI-TCGA
rs1434735195	p.Val29Gly	missense variant	-	NC_000012.12:g.104457497T>G	gnomAD
COSM3455370	p.Phe31Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104457504C>G	NCI-TCGA Cosmic
rs1267864440	p.Tyr32Cys	missense variant	-	NC_000012.12:g.104457506A>G	TOPMed
NCI-TCGA novel	p.Tyr32IlePheSerTerUnkUnk	frameshift	-	NC_000012.12:g.104457504C>-	NCI-TCGA
rs1382231752	p.Pro39Ser	missense variant	-	NC_000012.12:g.104457526C>T	gnomAD
rs1334448459	p.Met41Thr	missense variant	-	NC_000012.12:g.104601909T>C	gnomAD
rs560982261	p.Arg42Gly	missense variant	-	NC_000012.12:g.104601911C>G	1000Genomes,ExAC,TOPMed,gnomAD
rs751265537	p.Arg42Gln	missense variant	-	NC_000012.12:g.104601912G>A	ExAC,gnomAD
rs751265537	p.Arg42Gln	missense variant	-	NC_000012.12:g.104601912G>A	NCI-TCGA,NCI-TCGA Cosmic
rs560982261	p.Arg42Trp	missense variant	-	NC_000012.12:g.104601911C>T	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg43Ser	missense variant	-	NC_000012.12:g.104601916G>T	NCI-TCGA
rs1309514255	p.Asn44Lys	missense variant	-	NC_000012.12:g.104601919T>A	TOPMed
rs1177107880	p.Asn44Ser	missense variant	-	NC_000012.12:g.104601918A>G	gnomAD
rs1469232542	p.Asn44Tyr	missense variant	-	NC_000012.12:g.104601917A>T	gnomAD
rs1224400118	p.Pro45Ser	missense variant	-	NC_000012.12:g.104601920C>T	TOPMed
rs1370351299	p.Phe46Ser	missense variant	-	NC_000012.12:g.104601924T>C	TOPMed
rs1302499312	p.Cys51Tyr	missense variant	-	NC_000012.12:g.104601939G>A	TOPMed
rs759088814	p.Cys52Tyr	missense variant	-	NC_000012.12:g.104601942G>A	ExAC,gnomAD
rs767399314	p.Arg53Trp	missense variant	-	NC_000012.12:g.104601944C>T	ExAC,TOPMed,gnomAD
rs147660307	p.Arg53Gln	missense variant	-	NC_000012.12:g.104601945G>A	ESP,ExAC,TOPMed,gnomAD
rs147660307	p.Arg53Gln	missense variant	-	NC_000012.12:g.104601945G>A	NCI-TCGA
COSM346997	p.Arg57Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104601957G>A	NCI-TCGA Cosmic
rs756121766	p.Ser58Arg	missense variant	-	NC_000012.12:g.104601959A>C	ExAC,gnomAD
rs750565191	p.Pro59Ala	missense variant	-	NC_000012.12:g.104601962C>G	ExAC,TOPMed,gnomAD
rs750565191	p.Pro59Ser	missense variant	-	NC_000012.12:g.104601962C>T	ExAC,TOPMed,gnomAD
rs750565191	p.Pro59Thr	missense variant	-	NC_000012.12:g.104601962C>A	ExAC,TOPMed,gnomAD
COSM934262	p.Tyr64Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104601978A>G	NCI-TCGA Cosmic
rs1375460341	p.Asn65Ser	missense variant	-	NC_000012.12:g.104601981A>G	gnomAD
rs779979438	p.Ile67Thr	missense variant	-	NC_000012.12:g.104601987T>C	ExAC,gnomAD
rs760385003	p.Leu69Pro	missense variant	-	NC_000012.12:g.104756950T>C	ExAC,TOPMed
rs1331592239	p.Leu69Val	missense variant	-	NC_000012.12:g.104756949C>G	TOPMed
rs764043426	p.Leu71Phe	missense variant	-	NC_000012.12:g.104756955C>T	ExAC,gnomAD
rs761815306	p.Ser72Pro	missense variant	-	NC_000012.12:g.104756958T>C	ExAC,gnomAD
rs1324917543	p.Ser72Leu	missense variant	-	NC_000012.12:g.104756959C>T	TOPMed
rs1386894435	p.Thr74Ile	missense variant	-	NC_000012.12:g.104756965C>T	TOPMed
rs765027997	p.Ala75Thr	missense variant	-	NC_000012.12:g.104756967G>A	ExAC,gnomAD
NCI-TCGA novel	p.Gln79His	missense variant	-	NC_000012.12:g.104756981G>C	NCI-TCGA
NCI-TCGA novel	p.Arg81Leu	missense variant	-	NC_000012.12:g.104756986G>T	NCI-TCGA
COSM5040226	p.Arg81Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104756986G>A	NCI-TCGA Cosmic
COSM3416414	p.Arg81Trp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104756985C>T	NCI-TCGA Cosmic
rs962938638	p.Arg82Trp	missense variant	-	NC_000012.12:g.104756988C>T	TOPMed
rs962938638	p.Arg82Trp	missense variant	-	NC_000012.12:g.104756988C>T	NCI-TCGA
rs767553479	p.Arg82Gln	missense variant	-	NC_000012.12:g.104756989G>A	ExAC,gnomAD
rs531548327	p.Asp83Gly	missense variant	-	NC_000012.12:g.104756992A>G	1000Genomes
rs1171840707	p.Gln84Lys	missense variant	-	NC_000012.12:g.104756994C>A	TOPMed
rs1213176015	p.Gln84Arg	missense variant	-	NC_000012.12:g.104756995A>G	gnomAD
rs890008188	p.Val85Gly	missense variant	-	NC_000012.12:g.104756998T>G	gnomAD
rs1465265548	p.Val85Leu	missense variant	-	NC_000012.12:g.104756997G>T	gnomAD
NCI-TCGA novel	p.Asp87Tyr	missense variant	-	NC_000012.12:g.104757003G>T	NCI-TCGA
rs1192792573	p.Thr88Met	missense variant	-	NC_000012.12:g.104757007C>T	TOPMed,gnomAD
rs749545581	p.Arg90Gln	missense variant	-	NC_000012.12:g.104757013G>A	ExAC,TOPMed,gnomAD
rs778174141	p.Arg90Gly	missense variant	-	NC_000012.12:g.104757012C>G	ExAC,gnomAD
rs749545581	p.Arg90Gln	missense variant	-	NC_000012.12:g.104757013G>A	NCI-TCGA,NCI-TCGA Cosmic
rs140550570	p.Ala94Thr	missense variant	-	NC_000012.12:g.104757024G>A	ESP,ExAC,TOPMed,gnomAD
rs140550570	p.Ala94Pro	missense variant	-	NC_000012.12:g.104757024G>C	ESP,ExAC,TOPMed,gnomAD
rs112075588	p.Thr95Ile	missense variant	-	NC_000012.12:g.104757028C>T	ExAC,gnomAD
rs112075588	p.Thr95Lys	missense variant	-	NC_000012.12:g.104757028C>A	ExAC,gnomAD
rs112075588	p.Thr95Arg	missense variant	-	NC_000012.12:g.104757028C>G	ExAC,gnomAD
NCI-TCGA novel	p.Thr95Ala	missense variant	-	NC_000012.12:g.104757027A>G	NCI-TCGA
rs1219052668	p.Ser96Gly	missense variant	-	NC_000012.12:g.104757030A>G	TOPMed
rs1436190915	p.Arg97Cys	missense variant	-	NC_000012.12:g.104757033C>T	gnomAD
rs150467488	p.Arg97His	missense variant	-	NC_000012.12:g.104757034G>A	ESP,ExAC,TOPMed,gnomAD
rs759769235	p.Arg99Trp	missense variant	-	NC_000012.12:g.104757039C>T	ExAC,TOPMed,gnomAD
rs138320785	p.Arg99Gln	missense variant	-	NC_000012.12:g.104757040G>A	ESP,ExAC,TOPMed,gnomAD
rs759769235	p.Arg99Gly	missense variant	-	NC_000012.12:g.104757039C>G	ExAC,TOPMed,gnomAD
rs138320785	p.Arg99Pro	missense variant	-	NC_000012.12:g.104757040G>C	ESP,ExAC,TOPMed,gnomAD
rs1276006485	p.Arg100Gly	missense variant	-	NC_000012.12:g.104757042A>G	gnomAD
rs773060984	p.Val101Met	missense variant	-	NC_000012.12:g.104757045G>A	ExAC,gnomAD
rs1285849422	p.Val101Glu	missense variant	-	NC_000012.12:g.104757046T>A	gnomAD
rs1363740493	p.Pro104Leu	missense variant	-	NC_000012.12:g.104757055C>T	TOPMed
rs762854414	p.Asn105Ser	missense variant	-	NC_000012.12:g.104757058A>G	ExAC,TOPMed,gnomAD
rs145169297	p.Asp106Asn	missense variant	-	NC_000012.12:g.104757060G>A	ESP,ExAC,TOPMed,gnomAD
rs145169297	p.Asp106His	missense variant	-	NC_000012.12:g.104757060G>C	ESP,ExAC,TOPMed,gnomAD
rs764239451	p.His116Gln	missense variant	-	NC_000012.12:g.104757092C>G	ExAC,gnomAD
COSM934263	p.Glu117Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757093G>A	NCI-TCGA Cosmic
rs1342258519	p.Ile119Leu	missense variant	-	NC_000012.12:g.104757099A>C	TOPMed,gnomAD
rs1414368138	p.Cys121Ter	stop gained	-	NC_000012.12:g.104757107C>A	gnomAD
NCI-TCGA novel	p.Cys121Tyr	missense variant	-	NC_000012.12:g.104757106G>A	NCI-TCGA
rs1457954410	p.Tyr122Phe	missense variant	-	NC_000012.12:g.104757109A>T	gnomAD
rs750953406	p.Val123Met	missense variant	-	NC_000012.12:g.104757111G>A	ExAC,gnomAD
rs1448807477	p.Arg133Trp	missense variant	-	NC_000012.12:g.104757141C>T	TOPMed
rs1448807477	p.Arg133Trp	missense variant	-	NC_000012.12:g.104757141C>T	NCI-TCGA Cosmic
COSM200209	p.Arg133Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757142G>A	NCI-TCGA Cosmic
rs1389618311	p.Leu134Phe	missense variant	-	NC_000012.12:g.104757144C>T	TOPMed
rs779716339	p.Met135Thr	missense variant	-	NC_000012.12:g.104757148T>C	ExAC,gnomAD
rs1335704550	p.Met136Val	missense variant	-	NC_000012.12:g.104757150A>G	gnomAD
rs746461296	p.Met136Ile	missense variant	-	NC_000012.12:g.104757152G>T	ExAC,gnomAD
rs1489204578	p.Val137Ile	missense variant	-	NC_000012.12:g.104757153G>A	gnomAD
rs1186832093	p.Val137Ala	missense variant	-	NC_000012.12:g.104757154T>C	TOPMed
rs1451527053	p.Thr139Ile	missense variant	-	NC_000012.12:g.104757160C>T	TOPMed
rs780670108	p.Gly140Arg	missense variant	-	NC_000012.12:g.104757162G>A	ExAC,TOPMed,gnomAD
rs780670108	p.Gly140Arg	missense variant	-	NC_000012.12:g.104757162G>A	NCI-TCGA
rs1232266665	p.Arg141Trp	missense variant	-	NC_000012.12:g.104757165C>T	gnomAD
rs374628300	p.Arg141Gln	missense variant	-	NC_000012.12:g.104757166G>A	ESP,ExAC,TOPMed,gnomAD
rs1232266665	p.Arg141Trp	missense variant	-	NC_000012.12:g.104757165C>T	NCI-TCGA Cosmic
rs1210226686	p.Lys143Met	missense variant	-	NC_000012.12:g.104757172A>T	gnomAD
rs1210226686	p.Lys143Arg	missense variant	-	NC_000012.12:g.104757172A>G	gnomAD
NCI-TCGA novel	p.Lys143Glu	missense variant	-	NC_000012.12:g.104757171A>G	NCI-TCGA
NCI-TCGA novel	p.Lys143Thr	missense variant	-	NC_000012.12:g.104757172A>C	NCI-TCGA
rs762944913	p.Asp146Asn	missense variant	-	NC_000012.12:g.104757180G>A	ExAC,gnomAD
rs762944913	p.Asp146Asn	missense variant	-	NC_000012.12:g.104757180G>A	NCI-TCGA
rs371299013	p.Pro151Leu	missense variant	-	NC_000012.12:g.104757196C>T	ESP,ExAC,TOPMed,gnomAD
COSM3455372	p.Ala152Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757199C>T	NCI-TCGA Cosmic
rs137859649	p.Glu154Ala	missense variant	-	NC_000012.12:g.104757205A>C	ESP,ExAC,gnomAD
rs201140777	p.Glu154Lys	missense variant	-	NC_000012.12:g.104757204G>A	NCI-TCGA
rs201140777	p.Glu154Lys	missense variant	-	NC_000012.12:g.104757204G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs568223914	p.Ala155Thr	missense variant	-	NC_000012.12:g.104757207G>A	1000Genomes,ExAC,gnomAD
rs765591058	p.Val157Ile	missense variant	-	NC_000012.12:g.104757213G>A	ExAC,gnomAD
COSM691502	p.Val157Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757213G>T	NCI-TCGA Cosmic
rs751147954	p.Ala159Val	missense variant	-	NC_000012.12:g.104757220C>T	ExAC,gnomAD
rs758987438	p.Ala159Ser	missense variant	-	NC_000012.12:g.104757219G>T	ExAC,TOPMed,gnomAD
rs758987438	p.Ala159Thr	missense variant	-	NC_000012.12:g.104757219G>A	NCI-TCGA,NCI-TCGA Cosmic
rs758987438	p.Ala159Thr	missense variant	-	NC_000012.12:g.104757219G>A	ExAC,TOPMed,gnomAD
rs200936081	p.Asn160Ser	missense variant	-	NC_000012.12:g.104757223A>G	ExAC,TOPMed,gnomAD
rs747812654	p.Leu161Pro	missense variant	-	NC_000012.12:g.104757226T>C	ExAC,gnomAD
VAR_081477	p.Leu161_Asn165del	inframe_deletion	Osteochondrodysplasia, brachydactyly, and overlapping malformed digits (OCBMD) [MIM:618167]	-	UniProt
rs757358769	p.Lys162Asn	missense variant	-	NC_000012.12:g.104757230G>C	ExAC,TOPMed,gnomAD
rs1210277340	p.Gln166Leu	missense variant	-	NC_000012.12:g.104757241A>T	TOPMed,gnomAD
rs770874557	p.Tyr167Ter	stop gained	-	NC_000012.12:g.104757245C>G	ExAC,gnomAD
COSM4921138	p.Tyr167Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000012.12:g.104757245C>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ser168LeuPheSerTerUnkUnk	frameshift	-	NC_000012.12:g.104757245_104757246insTTGCCTGA	NCI-TCGA
COSM4672318	p.Ser168Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757247G>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Glu171Ter	stop gained	-	NC_000012.12:g.104757255G>T	NCI-TCGA
rs1444343479	p.Asn173Ser	missense variant	-	NC_000012.12:g.104757262A>G	gnomAD
rs745785558	p.His174Gln	missense variant	-	NC_000012.12:g.104757266C>G	ExAC,gnomAD
rs745785558	p.His174Gln	missense variant	-	NC_000012.12:g.104757266C>A	ExAC,gnomAD
rs1188563357	p.His174Tyr	missense variant	-	NC_000012.12:g.104757264C>T	gnomAD
rs527621055	p.Arg175His	missense variant	-	NC_000012.12:g.104757268G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs201920162	p.Arg175Cys	missense variant	-	NC_000012.12:g.104757267C>T	gnomAD
COSM4826617	p.Leu176Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757272G>C	NCI-TCGA Cosmic
NCI-TCGA novel	p.Ser178Gly	missense variant	-	NC_000012.12:g.104757276A>G	NCI-TCGA
rs761946477	p.Tyr179Cys	missense variant	-	NC_000012.12:g.104757280A>G	ExAC,gnomAD
rs765446759	p.Met180Thr	missense variant	-	NC_000012.12:g.104757283T>C	ExAC
rs1015775127	p.Met180Leu	missense variant	-	NC_000012.12:g.104757282A>T	TOPMed
rs1396230324	p.Arg186Gln	missense variant	-	NC_000012.12:g.104757301G>A	TOPMed,gnomAD
rs1403794941	p.Arg186Trp	missense variant	-	NC_000012.12:g.104757300C>T	gnomAD
COSM3870595	p.Glu187Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757303G>A	NCI-TCGA Cosmic
rs773737557	p.Phe189Leu	missense variant	-	NC_000012.12:g.104757311C>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Phe189Ser	missense variant	-	NC_000012.12:g.104757310T>C	NCI-TCGA
rs763372855	p.Glu190Lys	missense variant	-	NC_000012.12:g.104757312G>A	ExAC,TOPMed,gnomAD
rs763372855	p.Glu190Lys	missense variant	-	NC_000012.12:g.104757312G>A	NCI-TCGA,NCI-TCGA Cosmic
rs752158020	p.Arg191Lys	missense variant	-	NC_000012.12:g.104757316G>A	ExAC,gnomAD
NCI-TCGA novel	p.Leu192Gln	missense variant	-	NC_000012.12:g.104757319T>A	NCI-TCGA
rs1347070916	p.Val193Met	missense variant	-	NC_000012.12:g.104757321G>A	gnomAD
rs1278251473	p.Ser194Pro	missense variant	-	NC_000012.12:g.104757324T>C	gnomAD
rs200986753	p.Ala195Thr	missense variant	-	NC_000012.12:g.104757327G>A	ExAC,gnomAD
rs200986753	p.Ala195Pro	missense variant	-	NC_000012.12:g.104757327G>C	ExAC,gnomAD
rs142353826	p.Arg197His	missense variant	-	NC_000012.12:g.104757334G>A	ESP,TOPMed,gnomAD
rs201004289	p.Gln202Arg	missense variant	-	NC_000012.12:g.104757349A>G	1000Genomes,ExAC,gnomAD
rs373587217	p.Ile206Met	missense variant	-	NC_000012.12:g.104757362C>G	ESP,ExAC,TOPMed,gnomAD
rs757081540	p.Ile206Phe	missense variant	-	NC_000012.12:g.104757360A>T	ExAC,gnomAD
NCI-TCGA novel	p.Phe208Ile	missense variant	-	NC_000012.12:g.104757366T>A	NCI-TCGA
NCI-TCGA novel	p.His209ProPheSerTerUnkUnk	frameshift	-	NC_000012.12:g.104757365_104757366insT	NCI-TCGA
rs745873622	p.Arg211Leu	missense variant	-	NC_000012.12:g.104757376G>T	ExAC,TOPMed,gnomAD
rs745873622	p.Arg211Gln	missense variant	-	NC_000012.12:g.104757376G>A	ExAC,TOPMed,gnomAD
rs1466133972	p.Arg211Trp	missense variant	-	NC_000012.12:g.104757375C>T	gnomAD
rs773612441	p.Lys218Gln	missense variant	-	NC_000012.12:g.104757396A>C	ExAC,gnomAD
rs766906152	p.Arg219His	missense variant	-	NC_000012.12:g.104757400G>A	ExAC,gnomAD
rs766906152	p.Arg219Leu	missense variant	-	NC_000012.12:g.104757400G>T	ExAC,gnomAD
rs763247584	p.Arg219Cys	missense variant	-	NC_000012.12:g.104757399C>T	ExAC,TOPMed,gnomAD
rs1313972477	p.Gln220Arg	missense variant	-	NC_000012.12:g.104757403A>G	gnomAD
rs1348803637	p.Arg221Gln	missense variant	-	NC_000012.12:g.104757406G>A	gnomAD
rs759962153	p.Arg221Trp	missense variant	-	NC_000012.12:g.104757405C>T	ExAC,gnomAD
rs144669669	p.Lys222Glu	missense variant	-	NC_000012.12:g.104757408A>G	ESP,TOPMed
rs148230565	p.Ala224Thr	missense variant	-	NC_000012.12:g.104757414G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs148230565	p.Ala224Pro	missense variant	-	NC_000012.12:g.104757414G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs755609952	p.Ala224Val	missense variant	-	NC_000012.12:g.104757415C>T	ExAC,gnomAD
rs187748990	p.Ala228Val	missense variant	-	NC_000012.12:g.104757427C>T	1000Genomes,ExAC,gnomAD
NCI-TCGA novel	p.Ala228Gly	missense variant	-	NC_000012.12:g.104757427C>G	NCI-TCGA
rs375679211	p.Arg230Leu	missense variant	-	NC_000012.12:g.104757433G>T	ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg230Cys	missense variant	-	NC_000012.12:g.104757432C>T	NCI-TCGA
rs375679211	p.Arg230His	missense variant	-	NC_000012.12:g.104757433G>A	ESP,ExAC,TOPMed,gnomAD
rs770160219	p.Asp234Asn	missense variant	-	NC_000012.12:g.104757444G>A	ExAC,TOPMed,gnomAD
COSM4038200	p.Val235Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757448T>A	NCI-TCGA Cosmic
NCI-TCGA novel	p.Phe237Leu	missense variant	-	NC_000012.12:g.104757455C>A	NCI-TCGA
rs758294420	p.Glu238Lys	missense variant	-	NC_000012.12:g.104757456G>A	ExAC,TOPMed,gnomAD
rs1459696154	p.Glu238Gly	missense variant	-	NC_000012.12:g.104757457A>G	gnomAD
rs758294420	p.Glu238Gln	missense variant	-	NC_000012.12:g.104757456G>C	ExAC,TOPMed,gnomAD
COSM4038201	p.Glu238Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757458G>T	NCI-TCGA Cosmic
rs1481281701	p.Val241Met	missense variant	-	NC_000012.12:g.104757465G>A	TOPMed
rs780005312	p.Tyr243Ser	missense variant	-	NC_000012.12:g.104757472A>C	ExAC,gnomAD
rs746893347	p.Ile245Val	missense variant	-	NC_000012.12:g.104757477A>G	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ile245Asn	missense variant	-	NC_000012.12:g.104757478T>A	NCI-TCGA
rs1306366889	p.Asp246Gly	missense variant	-	NC_000012.12:g.104757481A>G	gnomAD
rs1431608363	p.Asp246Asn	missense variant	-	NC_000012.12:g.104757480G>A	gnomAD
rs1334559199	p.Arg251Gln	missense variant	-	NC_000012.12:g.104757496G>A	gnomAD
rs1040579491	p.Arg251Trp	missense variant	-	NC_000012.12:g.104757495C>T	TOPMed,gnomAD
rs771207447	p.Glu252Lys	missense variant	-	NC_000012.12:g.104757498G>A	ExAC,gnomAD
NCI-TCGA novel	p.Glu253Ala	missense variant	-	NC_000012.12:g.104757502A>C	NCI-TCGA
COSM934266	p.Glu253Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757503G>T	NCI-TCGA Cosmic
rs1489092828	p.Pro254Ser	missense variant	-	NC_000012.12:g.104757504C>T	gnomAD
rs1489092828	p.Pro254Thr	missense variant	-	NC_000012.12:g.104757504C>A	gnomAD
rs1195791519	p.Phe255Leu	missense variant	-	NC_000012.12:g.104757509C>A	TOPMed,gnomAD
rs947193135	p.Glu257Lys	missense variant	-	NC_000012.12:g.104757513G>A	TOPMed
rs1473302019	p.Trp259Arg	missense variant	-	NC_000012.12:g.104757519T>C	gnomAD
rs1182404881	p.Thr261Ile	missense variant	-	NC_000012.12:g.104757526C>T	TOPMed,gnomAD
COSM4038202	p.Thr261Pro	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757525A>C	NCI-TCGA Cosmic
rs776103813	p.Val262Ile	missense variant	-	NC_000012.12:g.104757528G>A	ExAC,gnomAD
rs1461393817	p.CysHis266Ter	stop gained	-	NC_000012.12:g.104757542_104757543del	gnomAD
rs1296431757	p.His267Tyr	missense variant	-	NC_000012.12:g.104757543C>T	gnomAD
rs1456930882	p.His272Arg	missense variant	-	NC_000012.12:g.104757559A>G	TOPMed
COSM3455375	p.His272Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757558C>T	NCI-TCGA Cosmic
rs900419455	p.Asp274Val	missense variant	-	NC_000012.12:g.104757565A>T	TOPMed
rs1039005602	p.Asp274Asn	missense variant	-	NC_000012.12:g.104757564G>A	TOPMed,gnomAD
rs1039005602	p.Asp274His	missense variant	-	NC_000012.12:g.104757564G>C	TOPMed,gnomAD
rs761468974	p.Asp274Glu	missense variant	-	NC_000012.12:g.104757566C>G	ExAC,TOPMed,gnomAD
rs764821818	p.Leu275Phe	missense variant	-	NC_000012.12:g.104757567C>T	ExAC,TOPMed,gnomAD
rs758257983	p.Val276Met	missense variant	-	NC_000012.12:g.104757570G>A	ExAC,gnomAD
rs779695030	p.Tyr279Ter	stop gained	-	NC_000012.12:g.104757581C>A	ExAC,gnomAD
COSM3967939	p.Glu280Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757584G>C	NCI-TCGA Cosmic
rs751574857	p.Glu283Lys	missense variant	-	NC_000012.12:g.104757591G>A	ExAC,gnomAD
COSM3416416	p.Glu284Asp	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757596G>T	NCI-TCGA Cosmic
rs1273148539	p.Asp285Glu	missense variant	-	NC_000012.12:g.104757599T>A	gnomAD
NCI-TCGA novel	p.Asp285Gly	missense variant	-	NC_000012.12:g.104757598A>G	NCI-TCGA
rs150778990	p.Val289Ile	missense variant	-	NC_000012.12:g.104757609G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1482069541	p.Ala293Ser	missense variant	-	NC_000012.12:g.104757621G>T	gnomAD
rs1183278790	p.Gly294Arg	missense variant	-	NC_000012.12:g.104757624G>A	gnomAD
NCI-TCGA novel	p.Pro302Ser	missense variant	-	NC_000012.12:g.104757648C>T	NCI-TCGA
COSM3455376	p.Pro302Leu	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757649C>T	NCI-TCGA Cosmic
rs779155570	p.Thr303Pro	missense variant	-	NC_000012.12:g.104757651A>C	ExAC,gnomAD
rs1378459312	p.Thr303Ile	missense variant	-	NC_000012.12:g.104757652C>T	TOPMed,gnomAD
rs1237957348	p.Lys306Arg	missense variant	-	NC_000012.12:g.104757661A>G	gnomAD
NCI-TCGA novel	p.Thr308Met	missense variant	-	NC_000012.12:g.104757667C>T	NCI-TCGA
rs746045401	p.Thr308Pro	missense variant	-	NC_000012.12:g.104757666A>C	ExAC,TOPMed,gnomAD
rs746045401	p.Thr308Ala	missense variant	-	NC_000012.12:g.104757666A>G	ExAC,TOPMed,gnomAD
rs772534949	p.Glu313Asp	missense variant	-	NC_000012.12:g.104757683A>C	ExAC,gnomAD
COSM3792124	p.Glu313Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757681G>A	NCI-TCGA Cosmic
rs1434649038	p.Met314Ile	missense variant	-	NC_000012.12:g.104757686G>T	TOPMed
rs761251103	p.Glu317Asp	missense variant	-	NC_000012.12:g.104757695A>C	ExAC,gnomAD
rs775701869	p.Glu317Ter	stop gained	-	NC_000012.12:g.104757693G>T	ExAC
NCI-TCGA novel	p.Phe318Leu	missense variant	-	NC_000012.12:g.104757698C>A	NCI-TCGA
rs1023049855	p.Ile322Val	missense variant	-	NC_000012.12:g.104757708A>G	TOPMed
rs529714210	p.Glu325Asp	missense variant	-	NC_000012.12:g.104757719G>C	TOPMed
rs1322946006	p.Glu325Gly	missense variant	-	NC_000012.12:g.104757718A>G	TOPMed
NCI-TCGA novel	p.Glu325Ter	stop gained	-	NC_000012.12:g.104757717G>T	NCI-TCGA
rs1374991787	p.His326Asn	missense variant	-	NC_000012.12:g.104757720C>A	gnomAD
rs769094029	p.His326Gln	missense variant	-	NC_000012.12:g.104757722C>G	ExAC,gnomAD
rs1374991787	p.His326Tyr	missense variant	-	NC_000012.12:g.104757720C>T	gnomAD
rs776141915	p.Gln327Lys	missense variant	-	NC_000012.12:g.104757723C>A	ExAC,gnomAD
rs887814138	p.Thr328Met	missense variant	-	NC_000012.12:g.104757727C>T	TOPMed,gnomAD
rs764698900	p.Gln329Leu	missense variant	-	NC_000012.12:g.104757730A>T	ExAC,TOPMed,gnomAD
COSM691500	p.Tyr331Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757736A>G	NCI-TCGA Cosmic
rs139158533	p.Glu332Lys	missense variant	-	NC_000012.12:g.104757738G>A	ESP,ExAC,TOPMed,gnomAD
rs1309982184	p.Val333Ala	missense variant	-	NC_000012.12:g.104757742T>C	gnomAD
NCI-TCGA novel	p.Asp337Asn	missense variant	-	NC_000012.12:g.104757753G>A	NCI-TCGA
rs751243533	p.Met340Thr	missense variant	-	NC_000012.12:g.104757763T>C	ExAC,gnomAD
COSM934268	p.Asn342Lys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757770T>G	NCI-TCGA Cosmic
COSM274547	p.Tyr343Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000012.12:g.104757772A>G	NCI-TCGA Cosmic
rs754975544	p.Ser344Pro	missense variant	-	NC_000012.12:g.104757774T>C	ExAC,gnomAD
rs754001693	p.Leu351Trp	missense variant	-	NC_000012.12:g.104757796T>G	ExAC,TOPMed,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0006142	Malignant neoplasm of breast	disease	BEFREE
C0023434	Chronic Lymphocytic Leukemia	disease	BEFREE
C0027627	Neoplasm Metastasis	phenotype	BEFREE
C0029408	Degenerative polyarthritis	disease	BEFREE
C0029925	Ovarian Carcinoma	disease	BEFREE
C0036341	Schizophrenia	disease	GWASDB
C0178874	Tumor Progression	phenotype	BEFREE
C0587248	Costello syndrome (disorder)	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0853879	Invasive carcinoma of breast	disease	BEFREE
C1140680	Malignant neoplasm of ovary	disease	BEFREE
C1611184	Calcification of coronary artery	phenotype	GWASDB

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0001537	N-acetylgalactosamine 4-O-sulfotransferase activity	IDA
GO:0008146	sulfotransferase activity	IBA
GO:0047756	chondroitin 4-sulfotransferase activity	IDA
GO:0050659	N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity	IEA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001701	in utero embryonic development	IEA
GO:0002063	chondrocyte development	IEA
GO:0007585	respiratory gaseous exchange by respiratory system	IEA
GO:0009791	post-embryonic development	IEA
GO:0016051	carbohydrate biosynthetic process	IEA
GO:0030166	proteoglycan biosynthetic process	IBA
GO:0030206	chondroitin sulfate biosynthetic process	IDA
GO:0030206	chondroitin sulfate biosynthetic process	TAS
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	IEA
GO:0033037	polysaccharide localization	IEA
GO:0036342	post-anal tail morphogenesis	IEA
GO:0042127	regulation of cell population proliferation	IEA
GO:0042733	embryonic digit morphogenesis	IEA
GO:0043066	negative regulation of apoptotic process	IEA
GO:0048589	developmental growth	IEA
GO:0048703	embryonic viscerocranium morphogenesis	IEA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0000139	Golgi membrane	TAS
GO:0016020	membrane	HDA
GO:0016021	integral component of membrane	NAS

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1630316	Glycosaminoglycan metabolism	TAS
R-HSA-1793185	Chondroitin sulfate/dermatan sulfate metabolism	TAS
R-HSA-2022870	Chondroitin sulfate biosynthesis	TAS
R-HSA-71387	Metabolism of carbohydrates	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CHST11 mRNA	19933214
D000082	Acetaminophen	Acetaminophen results in increased expression of CHST11 mRNA	29067470
D020106	Acrylamide	Acrylamide affects the expression of CHST11 mRNA	28959563
D016604	Aflatoxin B1	Aflatoxin B1 results in increased methylation of CHST11 intron	30157460
C029753	aflatoxin B2	aflatoxin B2 results in increased methylation of CHST11 intron	30157460
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of CHST11 mRNA	24449571
D001280	Atrazine	Atrazine results in decreased expression of CHST11 mRNA	29505797
D001280	Atrazine	Atrazine affects the methylation of CHST11 gene	28931070
D001397	Azoxymethane	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CHST11 mRNA	29950665
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the methylation of CHST11 intron	30157460
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CHST11 mRNA	20064835
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to CHST11 promoter]	19654925
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CHST11 mRNA	21569818
C026487	benzo(e)pyrene	benzo(e)pyrene results in increased methylation of CHST11 intron	30157460
C006780	bisphenol A	bisphenol A results in decreased methylation of CHST11 intron	30906313
C006780	bisphenol A	bisphenol A results in decreased expression of CHST11 mRNA	25181051; 30816183;
C006780	bisphenol A	bisphenol A results in increased methylation of CHST11 gene	28505145
D000069286	Bortezomib	Bortezomib results in decreased expression of CHST11 mRNA	20977926
C018475	butyraldehyde	butyraldehyde results in increased expression of CHST11 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of CHST11 mRNA	23741332
D002117	Calcitriol	Calcitriol results in increased expression of CHST11 mRNA	16002434
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of CHST11 mRNA	17484886
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHST11 mRNA	20938992
C074702	chromium hexavalent ion	chromium hexavalent ion results in decreased expression of CHST11 mRNA	30690063
D002945	Cisplatin	Cisplatin results in decreased expression of CHST11 mRNA	19561079
D016572	Cyclosporine	Cyclosporine results in increased expression of CHST11 mRNA	20106945
D016264	Dextran Sulfate	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CHST11 mRNA	29950665
D004041	Dietary Fats	Dietary Fats results in decreased expression of CHST11 mRNA	18042831
D004041	Dietary Fats	Dietary Fats results in increased expression of CHST11 mRNA	30120929
D004317	Doxorubicin	Doxorubicin results in decreased expression of CHST11 mRNA	29803840
D004811	Epichlorohydrin	CHST11 gene SNP affects the susceptibility to Epichlorohydrin	25622337
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CHST11 mRNA	22079256
D004958	Estradiol	[Estradiol co-treated with TGFB1 protein] results in increased expression of CHST11 mRNA	30165855
D000431	Ethanol	Ethanol affects the splicing of CHST11 mRNA	30319688
D000431	Ethanol	Ethanol results in increased expression of CHST11 mRNA	30319688
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CHST11 mRNA	23129252
D017313	Fenretinide	Fenretinide results in increased expression of CHST11 mRNA	28973697
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHST11 mRNA	20938992
C409722	hexaconazole	hexaconazole results in increased expression of CHST11 mRNA	22045034
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CHST11 mRNA	25613284
D007854	Lead	Lead affects the splicing of CHST11 mRNA	28903495
C031895	lead chromate	lead chromate results in decreased expression of CHST11 mRNA	23584427
D008701	Methapyrilene	Methapyrilene results in increased methylation of CHST11 intron	30157460
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of CHST11 mRNA	20938992
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of CHST11 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of CHST11 mRNA	26011545
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of CHST11 mRNA	26924002
C523799	MRK 003	CHST11 results in increased susceptibility to MRK 003	19903844
D037742	Nanotubes, Carbon	Nanotubes, Carbon analog results in increased expression of CHST11 mRNA	25554681
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in increased expression of CHST11 mRNA	25554681
D009532	Nickel	Nickel results in increased expression of CHST11 mRNA	24768652; 25583101;
C029938	nickel sulfate	nickel sulfate results in decreased expression of CHST11 mRNA	22714537
D000073878	Palm Oil	Palm Oil results in decreased expression of CHST11 mRNA	18042831
D010634	Phenobarbital	Phenobarbital affects the expression of CHST11 mRNA	19159669
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of CHST11 mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of CHST11 mRNA	22079256; 22714537;
D011374	Progesterone	Progesterone results in increased expression of CHST11 mRNA	21540246
C005556	propionaldehyde	propionaldehyde results in increased expression of CHST11 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of CHST11 mRNA	24780913
D011692	Puromycin Aminonucleoside	Puromycin Aminonucleoside results in decreased expression of CHST11 mRNA	15585670
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CHST11 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in increased expression of CHST11 mRNA	23221170; 29203145;
C017947	sodium arsenite	sodium arsenite affects the methylation of CHST11 gene	28589171
C017947	sodium arsenite	sodium arsenite results in decreased expression of CHST11 mRNA	22714537
D000077210	Sunitinib	Sunitinib results in increased expression of CHST11 mRNA	31533062
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CHST11 mRNA	19933214
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CHST11 mRNA	19465110
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CHST11 mRNA	25613284
C009495	titanium dioxide	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of CHST11 mRNA	29950665
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased methylation of CHST11 intron	31039056
D014212	Tretinoin	Tretinoin results in increased expression of CHST11 mRNA	23724009
C011559	tributyltin	tributyltin results in decreased expression of CHST11 mRNA	29505797
D014260	Triclosan	Triclosan results in decreased expression of CHST11 mRNA	30510588
D000077288	Troglitazone	Troglitazone results in increased expression of CHST11 mRNA	28973697
D014635	Valproic Acid	Valproic Acid affects the expression of CHST11 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of CHST11 mRNA	23179753; 24935251; 27188386; 29154799;
D014635	Valproic Acid	Valproic Acid results in increased expression of CHST11 mRNA	22045034
D014638	Vanadates	Vanadates results in increased expression of CHST11 mRNA	22714537
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of CHST11 mRNA	26682919

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0025	Alternative splicing
KW-0119	Carbohydrate metabolism
KW-0160	Chromosomal rearrangement
KW-0225	Disease mutation
KW-0242	Dwarfism
KW-0325	Glycoprotein
KW-0333	Golgi apparatus
KW-0472	Membrane
KW-1185	Reference proteome
KW-0735	Signal-anchor
KW-0808	Transferase
KW-0812	Transmembrane
KW-1133	Transmembrane helix

Interpro

InterPro ID	InterPro Term
IPR018011	Carb_sulfotrans_8-10
IPR005331	Sulfotransferase

PROSITE

PROSITE ID	PROSITE Term

Pfam

Pfam ID	Pfam Term
PF03567	Sulfotransfer_2

Gene: CHST11

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction