| Tag | Content |
|---|---|
| Uniprot ID | Q9NRA1; B4DU34; B9EGR8; Q4W5M9; Q9UL22; |
| Entrez ID | 56034 |
| Genbank protein ID | AAY40906.1; BAB03266.1; AAF00049.1; AAQ88857.1; EAX04874.1; EAX04875.1; CAP58278.1; AAK51637.1; AAI36663.1; AAF80597.1; BAG62196.1; |
| Genbank nucleotide ID | XM_017008456.1; NM_016205.2; |
| Ensembl protein ID | ENSP00000410048; ENSP00000422464; |
| Ensembl nucleotide ID | ENSG00000145431 |
| Gene name | Platelet-derived growth factor C |
| Gene symbol | PDGFC |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 23029525 |
| Functional description | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. |
| Sequence | MSLFGLLLLT SALAGQRQGT QAESNLSSKF QFSSNKEQNG VQDPQHERII TVSTNGSIHS 60 PRFPHTYPRN TVLVWRLVAV EENVWIQLTF DERFGLEDPE DDICKYDFVE VEEPSDGTIL 120 GRWCGSGTVP GKQISKGNQI RIRFVSDEYF PSEPGFCIHY NIVMPQFTEA VSPSVLPPSA 180 LPLDLLNNAI TAFSTLEDLI RYLEPERWQL DLEDLYRPTW QLLGKAFVFG RKSRVVDLNL 240 LTEEVRLYSC TPRNFSVSIR EELKRTDTIF WPGCLLVKRC GGNCACCLHN CNECQCVPSK 300 VTKKYHEVLQ LRPKTGVRGL HKSLTDVALE HHEECDCVCR GSTGG 345 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.