CleftGeneDB-Search

Gene: CTNNBIP1

Basic information

Tag	Content
Uniprot ID	Q9NSA3; Q5T4V2;
Entrez ID	56998
Genbank protein ID	EAW71631.1; AAH14300.1; BAB03458.1; AAI46897.1; AAI46893.1;
Genbank nucleotide ID	XM_017001853.1; XM_017001855.1; NM_020248.2; NM_001012329.1; XM_017001854.1;
Ensembl protein ID	ENSP00000366474; ENSP00000366466; ENSP00000383696; ENSP00000366468;
Ensembl nucleotide ID	ENSG00000178585
Gene name	Beta-catenin-interacting protein 1
Gene symbol	CTNNBIP1
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway.
Sequence	MNREGAPGKS PEEMYIQQKV RVLLMLRKMG SNLTASEEEF LRTYAGVVNS QLSQLPPHSI 60 DQGAEDVVMA FSRSETEDRR Q 81

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
1LUJ
1M1E
1T08

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	CTNNBIP1	614630	Q5E9N2		Bos taurus	Prediction	More>>
1:1 ortholog	CLSTN1	479600	E2QVY5		Canis lupus familiaris	Prediction	More>>
1:1 ortholog	CTNNBIP1	102173591	A0A452FWJ1		Capra hircus	Prediction	More>>
1:1 ortholog	CTNNBIP1	56998	Q9NSA3		Homo sapiens	Prediction	More>>
1:1 ortholog	Ctnnbip1	67087	Q9JJN6	CPO	Mus musculus	Publication	More>>
1:1 ortholog	CTNNBIP1	749394	H2R3P1		Pan troglodytes	Prediction	More>>
1:1 ortholog	CTNNBIP1		A0A287ADI4		Sus scrofa	Prediction	More>>
1:1 ortholog	Ctnnbip1	503000	Q4KM58		Rattus norvegicus	Prediction	More>>
1:1 ortholog	ctnnbip1	58117	Q9I903		Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs1466076982	p.Asn2Tyr	missense variant	-	NC_000001.11:g.9872061T>A	gnomAD
rs771836718	p.Asn2Lys	missense variant	-	NC_000001.11:g.9872059G>T	ExAC,gnomAD
rs150360638	p.Arg3Leu	missense variant	-	NC_000001.11:g.9872057C>A	ESP,ExAC,TOPMed,gnomAD
rs150360638	p.Arg3His	missense variant	-	NC_000001.11:g.9872057C>T	ESP,ExAC,TOPMed,gnomAD
rs147067665	p.Arg3Cys	missense variant	-	NC_000001.11:g.9872058G>A	ESP,ExAC,TOPMed,gnomAD
rs1183573009	p.Glu4Asp	missense variant	-	NC_000001.11:g.9872053C>G	TOPMed
rs1230381774	p.Glu4Lys	missense variant	-	NC_000001.11:g.9872055C>T	TOPMed,gnomAD
rs1330002148	p.Gly5Val	missense variant	-	NC_000001.11:g.9872051C>A	gnomAD
rs1299911882	p.Ala6Val	missense variant	-	NC_000001.11:g.9872048G>A	TOPMed,gnomAD
rs761797446	p.Ala6Pro	missense variant	-	NC_000001.11:g.9872049C>G	ExAC,TOPMed,gnomAD
rs113935062	p.Gly8Arg	missense variant	-	NC_000001.11:g.9872043C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs781302251	p.Gly8Glu	missense variant	-	NC_000001.11:g.9872042C>T	ExAC,gnomAD
rs113935062	p.Gly8Arg	missense variant	-	NC_000001.11:g.9872043C>T	NCI-TCGA,NCI-TCGA Cosmic
rs751743905	p.Lys9Asn	missense variant	-	NC_000001.11:g.9872038C>A	ExAC,TOPMed,gnomAD
rs777994158	p.Pro11Leu	missense variant	-	NC_000001.11:g.9872033G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu12Gly	missense variant	-	NC_000001.11:g.9872030T>C	NCI-TCGA
rs1189131001	p.Glu13Asp	missense variant	-	NC_000001.11:g.9872026C>G	gnomAD
rs753671543	p.Met14Thr	missense variant	-	NC_000001.11:g.9872024A>G	ExAC,gnomAD
rs1187640116	p.Ile16Val	missense variant	-	NC_000001.11:g.9872019T>C	gnomAD
rs1442815862	p.Gln17Glu	missense variant	-	NC_000001.11:g.9872016G>C	TOPMed,gnomAD
rs1442815862	p.Gln17Ter	stop gained	-	NC_000001.11:g.9872016G>A	NCI-TCGA Cosmic
rs1442815862	p.Gln17Ter	stop gained	-	NC_000001.11:g.9872016G>A	TOPMed,gnomAD
rs1257745822	p.Gln17His	missense variant	-	NC_000001.11:g.9872014C>A	gnomAD
rs1343663953	p.Gln18Pro	missense variant	-	NC_000001.11:g.9872012T>G	gnomAD
rs367851454	p.Gln18Ter	stop gained	-	NC_000001.11:g.9872013G>A	ESP,ExAC,gnomAD
rs760722655	p.Lys19Arg	missense variant	-	NC_000001.11:g.9872009T>C	ExAC,gnomAD
rs761438511	p.Arg21Gln	missense variant	-	NC_000001.11:g.9872003C>T	ExAC,TOPMed,gnomAD
rs761438511	p.Arg21Leu	missense variant	-	NC_000001.11:g.9872003C>A	ExAC,TOPMed,gnomAD
rs749931176	p.Arg21Ter	stop gained	-	NC_000001.11:g.9872004G>A	ExAC,TOPMed,gnomAD
rs774094632	p.Val22Met	missense variant	-	NC_000001.11:g.9872001C>T	ExAC,gnomAD
rs763818220	p.Val22Ala	missense variant	-	NC_000001.11:g.9872000A>G	ExAC,gnomAD
NCI-TCGA novel	p.Leu24Ile	missense variant	-	NC_000001.11:g.9871995G>T	NCI-TCGA
rs1397261310	p.Met25Val	missense variant	-	NC_000001.11:g.9871992T>C	TOPMed,gnomAD
rs746418599	p.Arg27Gln	missense variant	-	NC_000001.11:g.9871985C>T	ExAC,TOPMed,gnomAD
rs770182367	p.Arg27Trp	missense variant	-	NC_000001.11:g.9871986G>A	ExAC,TOPMed,gnomAD
rs746418599	p.Arg27Pro	missense variant	-	NC_000001.11:g.9871985C>G	ExAC,TOPMed,gnomAD
COSM3493710	p.Met29Thr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.9871979A>G	NCI-TCGA Cosmic
rs1388200557	p.Gly30Arg	missense variant	-	NC_000001.11:g.9871977C>T	gnomAD
rs777156046	p.Gly30Glu	missense variant	-	NC_000001.11:g.9871976C>T	ExAC,gnomAD
rs1209572072	p.Leu33Val	missense variant	-	NC_000001.11:g.9871277G>C	gnomAD
rs1330245872	p.Leu33Arg	missense variant	-	NC_000001.11:g.9871276A>C	gnomAD
rs1212238107	p.Thr34Ala	missense variant	-	NC_000001.11:g.9871274T>C	TOPMed
rs1275561036	p.Glu37Val	missense variant	-	NC_000001.11:g.9871264T>A	gnomAD
rs777066136	p.Glu38Lys	missense variant	-	NC_000001.11:g.9871262C>T	ExAC,gnomAD
NCI-TCGA novel	p.Glu38Gln	missense variant	-	NC_000001.11:g.9871262C>G	NCI-TCGA
rs574333600	p.Glu39Lys	missense variant	-	NC_000001.11:g.9871259C>T	1000Genomes,ExAC,gnomAD
rs201081336	p.Arg42His	missense variant	-	NC_000001.11:g.9871249C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Arg42Pro	missense variant	-	NC_000001.11:g.9871249C>G	NCI-TCGA
rs773400948	p.Arg42Cys	missense variant	-	NC_000001.11:g.9871250G>A	ExAC,gnomAD
rs1410552050	p.Tyr44Asp	missense variant	-	NC_000001.11:g.9871244A>C	gnomAD
rs1191218589	p.Tyr44Cys	missense variant	-	NC_000001.11:g.9871243T>C	gnomAD
rs755922514	p.Val47Leu	missense variant	-	NC_000001.11:g.9871235C>A	ExAC,TOPMed,gnomAD
rs1241714108	p.Asn49Ser	missense variant	-	NC_000001.11:g.9871228T>C	TOPMed
rs745668650	p.Asn49Asp	missense variant	-	NC_000001.11:g.9871229T>C	ExAC,gnomAD
rs968654645	p.Ser50Arg	missense variant	-	NC_000001.11:g.9871224G>C	TOPMed,gnomAD
rs1022467751	p.Ser53Asn	missense variant	-	NC_000001.11:g.9871216C>T	TOPMed
rs1279634076	p.Gln54Ter	stop gained	-	NC_000001.11:g.9871214G>A	gnomAD
rs1201997978	p.Leu55Pro	missense variant	-	NC_000001.11:g.9871210A>G	TOPMed
rs757326660	p.Pro57Leu	missense variant	-	NC_000001.11:g.9871204G>A	ExAC,TOPMed,gnomAD
rs1273072507	p.Ile60Thr	missense variant	-	NC_000001.11:g.9871195A>G	TOPMed
rs1034308843	p.Asp61Asn	missense variant	-	NC_000001.11:g.9871193C>T	TOPMed,gnomAD
rs138271667	p.Gln62His	missense variant	-	NC_000001.11:g.9871188C>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1380242462	p.Gly63Val	missense variant	-	NC_000001.11:g.9850776C>A	TOPMed
rs1422513149	p.Gly63Ser	missense variant	-	NC_000001.11:g.9871187C>T	gnomAD
NCI-TCGA novel	p.Ala64Val	missense variant	-	NC_000001.11:g.9850773G>A	NCI-TCGA
rs1179763132	p.Asp66Asn	missense variant	-	NC_000001.11:g.9850768C>T	TOPMed
rs548974391	p.Val67Met	missense variant	-	NC_000001.11:g.9850765C>T	1000Genomes,ExAC,gnomAD
rs548974391	p.Val67Leu	missense variant	-	NC_000001.11:g.9850765C>A	1000Genomes,ExAC,gnomAD
rs1371142601	p.Val68Met	missense variant	-	NC_000001.11:g.9850762C>T	TOPMed,gnomAD
COSM4010830	p.Val68Ala	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.9850761A>G	NCI-TCGA Cosmic
rs372414829	p.Met69Leu	missense variant	-	NC_000001.11:g.9850759T>A	ESP,ExAC,TOPMed,gnomAD
rs781187269	p.Ser74Leu	missense variant	-	NC_000001.11:g.9850743G>A	ExAC,gnomAD
rs199900946	p.Thr76Arg	missense variant	-	NC_000001.11:g.9850737G>C	1000Genomes,ExAC,TOPMed,gnomAD
rs199900946	p.Thr76Met	missense variant	-	NC_000001.11:g.9850737G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs369249056	p.Asp78Ala	missense variant	-	NC_000001.11:g.9850731T>G	ESP,ExAC,TOPMed,gnomAD
rs778534202	p.Arg79Gln	missense variant	-	NC_000001.11:g.9850728C>T	ExAC,gnomAD
rs752154298	p.Arg79Trp	missense variant	-	NC_000001.11:g.9850729G>A	ExAC,TOPMed,gnomAD
rs1422466855	p.Arg80Thr	missense variant	-	NC_000001.11:g.9850725C>G	gnomAD
NCI-TCGA novel	p.Gln81Glu	missense variant	-	NC_000001.11:g.9850723G>C	NCI-TCGA

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0001418	Adenocarcinoma	group	LHGDN
C0007103	Malignant neoplasm of endometrium	disease	BEFREE
C0009404	Colorectal Neoplasms	group	BEFREE
C0014170	Endometrial Neoplasms	group	LHGDN
C0017638	Glioma	disease	BEFREE
C0025149	Medulloblastoma	disease	LHGDN
C0025202	melanoma	disease	BEFREE;LHGDN
C0027627	Neoplasm Metastasis	phenotype	BEFREE
C0027819	Neuroblastoma	group	BEFREE
C0027962	Melanocytic nevus	disease	BEFREE
C0032580	Adenomatous Polyposis Coli	disease	LHGDN
C0079218	Fibromatosis, Aggressive	disease	LHGDN
C0152013	Adenocarcinoma of lung (disorder)	disease	BEFREE
C0476089	Endometrial Carcinoma	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0700095	Central neuroblastoma	disease	BEFREE
C1140680	Malignant neoplasm of ovary	disease	BEFREE
C1883486	Uterine Corpus Cancer	disease	BEFREE
C2239176	Liver carcinoma	disease	BEFREE
C3665593	Melanocytic nevus of skin	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005515	protein binding	IPI
GO:0008013	beta-catenin binding	IPI
GO:0008013	beta-catenin binding	IBA
GO:0070016	armadillo repeat domain binding	IPI

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001658	branching involved in ureteric bud morphogenesis	IEA
GO:0002528	regulation of vascular permeability involved in acute inflammatory response	IMP
GO:0009952	anterior/posterior pattern specification	IEA
GO:0016055	Wnt signaling pathway	IEA
GO:0030178	negative regulation of Wnt signaling pathway	IBA
GO:0031333	negative regulation of protein-containing complex assembly	IEA
GO:0032091	negative regulation of protein binding	IDA
GO:0043392	negative regulation of DNA binding	IEA
GO:0043433	negative regulation of DNA-binding transcription factor activity	IMP
GO:0045657	positive regulation of monocyte differentiation	IMP
GO:0045669	positive regulation of osteoblast differentiation	IMP
GO:0048662	negative regulation of smooth muscle cell proliferation	IEA
GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter	IEA
GO:0072201	negative regulation of mesenchymal cell proliferation	IMP

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005634	nucleus	IDA
GO:0005634	nucleus	IBA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	IDA
GO:0005829	cytosol	IBA
GO:0030877	beta-catenin destruction complex	IDA
GO:0030877	beta-catenin destruction complex	IBA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-195721	Signaling by WNT	TAS
R-HSA-201681	TCF dependent signaling in response to WNT	TAS
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	TAS

Drugs and compounds information

ID	Drug Name	Action	PubMed
C070055	2,3',4,4',5-pentachlorobiphenyl	2,3',4,4',5-pentachlorobiphenyl results in increased expression of CTNNBIP1 mRNA	31388691
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in decreased expression of CTNNBIP1 mRNA	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNNBIP1 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNNBIP1 mRNA	27188386
C496492	abrine	abrine results in decreased expression of CTNNBIP1 mRNA	31054353
D000082	Acetaminophen	Acetaminophen affects the expression of CTNNBIP1 mRNA	17562736
D000171	Acrolein	Acrolein results in decreased expression of CTNNBIP1 mRNA	18515264
D020106	Acrylamide	Acrylamide results in decreased expression of CTNNBIP1 mRNA	28959563
D000661	Amphetamine	Amphetamine results in increased expression of CTNNBIP1 mRNA	30779732
C015001	arsenite	arsenite results in increased expression of CTNNBIP1 mRNA	18191166
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of CTNNBIP1 mRNA	20064835; 26238291;
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [AHR protein binds to CTNNBIP1 promoter]	19654925
C022921	benzo(k)fluoranthene	benzo(k)fluoranthene results in decreased expression of CTNNBIP1 mRNA	26377693
C044887	beta-methylcholine	beta-methylcholine affects the expression of CTNNBIP1 mRNA	21179406
C006780	bisphenol A	bisphenol A affects the expression of CTNNBIP1 mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased methylation of CTNNBIP1 intron	30906313
C006780	bisphenol A	bisphenol A affects the expression of CTNNBIP1 mRNA	30903817
C006780	bisphenol A	bisphenol A results in decreased expression of CTNNBIP1 mRNA	29161229
C006780	bisphenol A	bisphenol A results in decreased methylation of CTNNBIP1 promoter	27312807
C018475	butyraldehyde	butyraldehyde results in decreased expression of CTNNBIP1 mRNA	26079696
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of CTNNBIP1 mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of CTNNBIP1 mRNA	27392435
D002994	Clofibrate	Clofibrate results in decreased expression of CTNNBIP1 mRNA	23811191
D003042	Cocaine	Cocaine results in decreased expression of CTNNBIP1 mRNA	18000554
D003520	Cyclophosphamide	[Doxorubicin co-treated with Cyclophosphamide] affects the expression of CTNNBIP1 mRNA	16322899
D016572	Cyclosporine	Cyclosporine results in decreased expression of CTNNBIP1 mRNA	25562108
C516138	dorsomorphin	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNNBIP1 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNNBIP1 mRNA	27188386
D004317	Doxorubicin	[Doxorubicin co-treated with Cyclophosphamide] affects the expression of CTNNBIP1 mRNA	16322899
C118739	entinostat	entinostat results in decreased expression of CTNNBIP1 mRNA	26272509
C118739	entinostat	[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNNBIP1 mRNA	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CTNNBIP1 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of CTNNBIP1 mRNA	17557909
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of CTNNBIP1 mRNA	23129252
D017313	Fenretinide	Fenretinide results in increased expression of CTNNBIP1 mRNA	28973697
D006220	Haloperidol	Haloperidol results in decreased expression of CTNNBIP1 mRNA	29458080
D006997	Hypochlorous Acid	Hypochlorous Acid results in decreased expression of CTNNBIP1 mRNA	19376150
D007213	Indomethacin	Indomethacin results in increased expression of CTNNBIP1 mRNA	28201806
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CTNNBIP1 mRNA	25613284
D007501	Iron	Iron deficiency results in decreased expression of CTNNBIP1 mRNA	19821111
D007545	Isoproterenol	Isoproterenol results in decreased expression of CTNNBIP1 mRNA	20003209
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of CTNNBIP1 mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of CTNNBIP1 mRNA	27392435
D007657	Ketone Bodies	Ketone Bodies results in increased expression of CTNNBIP1 mRNA	16807920
D019344	Lactic Acid	Lactic Acid results in decreased expression of CTNNBIP1 mRNA	30851411
D009532	Nickel	Nickel results in decreased expression of CTNNBIP1 mRNA	24768652
C028007	nickel monoxide	nickel monoxide results in increased expression of CTNNBIP1 mRNA	19167457
D009534	Niclosamide	Niclosamide inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]	24534281
D019319	Okadaic Acid	Okadaic Acid promotes the reaction [CTNNB1 protein binds to CTNNBIP1 protein]	31115591
D010100	Oxygen	Oxygen deficiency affects the methylation of CTNNBIP1 promoter	24205000
D010100	Oxygen	Oxygen deficiency results in increased expression of CTNNBIP1 mRNA	24205000
D010269	Paraquat	Paraquat results in increased expression of CTNNBIP1 mRNA	28619522
D010662	Phenylmercuric Acetate	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CTNNBIP1 mRNA	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of CTNNBIP1 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in decreased expression of CTNNBIP1 mRNA	17426115; 20813756; 23811191;
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of CTNNBIP1 mRNA	25895662
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CTNNBIP1 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of CTNNBIP1 mRNA]	21215274
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of CTNNBIP1 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CTNNBIP1 mRNA	25613284
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of CTNNBIP1 mRNA	28111298
D014212	Tretinoin	Tretinoin results in decreased expression of CTNNBIP1 mRNA	21934132
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of CTNNBIP1 mRNA	26179874
D014635	Valproic Acid	Valproic Acid results in decreased expression of CTNNBIP1 mRNA	23179753; 25192806;
D014635	Valproic Acid	Valproic Acid results in decreased expression of CTNNBIP1 mRNA	21427059
C544261	XAV939	XAV939 inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]	24534281

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0963	Cytoplasm
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0879	Wnt signaling pathway

Interpro

InterPro ID	InterPro Term
IPR042999	CTNNBIP1
IPR009428	ICAT_dom
IPR036911	ICAT_sf

PROSITE

PROSITE ID	PROSITE Term

Pfam

Pfam ID	Pfam Term
PF06384	ICAT

Gene: CTNNBIP1

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction