CleftGeneDB-Search

Gene: STK32B

Basic information

Tag	Content
Uniprot ID	Q9NY57; Q6UXH3; Q8IY14;
Entrez ID	55351
Genbank protein ID	AAH38238.1; CAB76471.1; AAQ88719.1;
Genbank nucleotide ID	NM_001306082.1; NM_018401.2;
Ensembl protein ID	ENSP00000420984; ENSP00000282908;
Ensembl nucleotide ID	ENSG00000152953
Gene name	Serine/threonine-protein kinase 32B
Gene symbol	STK32B
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Manually collected
Reference	20087401
Functional description
Sequence	MGGNHSHKPP VFDENEEVNF DHFQILRAIG KGSFGKVCIV QKRDTKKMYA MKYMNKQKCI 60 ERDEVRNVFR ELQIMQGLEH PFLVNLWYSF QDEEDMFMVV DLLLGGDLRY HLQQNVHFTE 120 GTVKLYICEL ALALEYLQRY HIIHRDIKPD NILLDEHGHV HITDFNIATV VKGAERASSM 180 AGTKPYMAPE VFQVYMDRGP GYSYPVDWWS LGITAYELLR GWRPYEIHSV TPIDEILNMF 240 KVERVHYSST WCKGMVALLR KLLTKDPESR VSSLHDIQSV PYLADMNWDA VFKKALMPGF 300 VPNKGRLNCD PTFELEEMIL ESKPLHKKKK RLAKNRSRDG TKDSCPLNGH LQHCLETVRE 360 EFIIFNREKL RRQQGQGSQL LDTDSRGGGQ AQSKLQDGCN NNLLTHTCTR GCSS 414

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

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Relation	Gene symbol	Entrez ID	UniProt ID	Species	Evidence	Details
1:1 ortholog	STK32B	55351	Q9NY57	Homo sapiens	Publication	More>>
1:1 ortholog	STK32B		A0A452FIT8	Capra hircus	Prediction	More>>
1:1 ortholog	Stk32b	64293	Q9JJX8	Mus musculus	Prediction	More>>
1:1 ortholog	STK32B		A0A2I3SQX6	Pan troglodytes	Prediction	More>>
1:1 ortholog	STK32B		A0A287BIJ9	Sus scrofa	Prediction	More>>
1:1 ortholog	Stk32b	305431	F1M3G9	Rattus norvegicus	Prediction	More>>

Showing 1 to 6 of 6 entries

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Other genetic variants/mutations

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ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs3733182	p.Arg198Gly	missense variant	-	NC_000004.12:g.5446702A>G	UniProt,dbSNP
rs35207488	p.Arg244His	missense variant	-	NC_000004.12:g.5456871G>A	UniProt,dbSNP
rs55961955	p.Lys342Thr	missense variant	-	NC_000004.12:g.5466818A>C	UniProt,dbSNP
VAR_041166	p.Gly35Glu	Missense	-	-	UniProt
VAR_025899	p.Arg198Gly	missense variant	-	NC_000004.12:g.5446702A>G	UniProt
VAR_041167	p.Arg244His	missense variant	-	NC_000004.12:g.5456871G>A	UniProt
VAR_041169	p.Lys342Thr	missense variant	-	NC_000004.12:g.5466818A>C	UniProt
rs1197877399	p.His7Gln	missense variant	-	NC_000004.12:g.5051884C>G	TOPMed,gnomAD
rs1388650594	p.Asn55His	missense variant	-	NC_000004.12:g.5168353A>C	TOPMed,gnomAD
rs1388650594	p.Asn55Asp	missense variant	-	NC_000004.12:g.5168353A>G	TOPMed,gnomAD
rs988960010	p.Gln73Ter	stop gained	-	NC_000004.12:g.5168407C>T	TOPMed,gnomAD
rs1218432857	p.Gln76His	missense variant	-	NC_000004.12:g.5168418A>T	TOPMed,gnomAD
rs1201342426	p.Glu94Lys	missense variant	-	NC_000004.12:g.5331239G>A	TOPMed,gnomAD
rs1343231990	p.Tyr126His	missense variant	-	NC_000004.12:g.5331335T>C	TOPMed,gnomAD
rs1343231990	p.Tyr126Asp	missense variant	-	NC_000004.12:g.5331335T>G	TOPMed,gnomAD
rs1415117623	p.His141Asn	missense variant	-	NC_000004.12:g.5331380C>A	TOPMed,gnomAD
rs1453797701	p.Asn151Ser	missense variant	-	NC_000004.12:g.5398224A>G	TOPMed,gnomAD
rs1451090370	p.His157Arg	missense variant	-	NC_000004.12:g.5398242A>G	TOPMed,gnomAD
rs1403270244	p.Ala177Asp	missense variant	-	NC_000004.12:g.5416902C>A	TOPMed,gnomAD
rs1289790004	p.Met187Val	missense variant	-	NC_000004.12:g.5416931A>G	TOPMed,gnomAD

Showing 1 to 20 of 470 entries

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Disease or phenotype associated information

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Disease ID	Disease Name	Disease Type	Source
C0002395	Alzheimer's Disease	disease	GWASCAT;GWASDB
C0010068	Coronary heart disease	disease	GWASDB
C0013903	Ellis-Van Creveld Syndrome	disease	BEFREE
C0026106	Mild Mental Retardation	disease	BEFREE
C0027627	Neoplasm Metastasis	phenotype	BEFREE
C0270736	Essential Tremor	disease	GWASCAT
C0278883	Metastatic melanoma	disease	UNIPROT
C0585362	Squamous cell carcinoma of mouth	disease	BEFREE
C0810364	Cleft Lip with or without Cleft Palate	disease	BEFREE
C1611184	Calcification of coronary artery	phenotype	GWASDB

Showing 1 to 10 of 10 entries

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

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GO ID	GO Term	Evidence
GO:0004674	protein serine/threonine kinase activity	IBA
GO:0005524	ATP binding	IEA
GO:0046872	metal ion binding	IEA

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GO:Biological Process

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GO ID	GO Term	Evidence
GO:0018105	peptidyl-serine phosphorylation	IBA
GO:0035556	intracellular signal transduction	IBA

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GO:Cellular Component

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GO ID	GO Term	Evidence
No data available in table

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Reactome Pathway

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Reactome ID	Reactome Term	Evidence
No data available in table

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Drugs and compounds information

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ID	Drug Name	Action	PubMed
C006780	bisphenol A	bisphenol A results in decreased expression of STK32B mRNA	25181051
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in increased expression of STK32B mRNA	18648102
C017947	sodium arsenite	sodium arsenite affects the expression of STK32B mRNA	29319823
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of STK32B mRNA	19320972
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of STK32B mRNA	28511854
C026487	benzo(e)pyrene	benzo(e)pyrene results in increased methylation of STK32B intron	30157460
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of STK32B mRNA	26682919
C029753	aflatoxin B2	aflatoxin B2 results in increased methylation of STK32B intron	30157460
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in decreased expression of STK32B mRNA	27392435
C558012	diisononyl 1,2-cyclohexanedicarboxylic acid	diisononyl 1,2-cyclohexanedicarboxylic acid results in decreased expression of STK32B mRNA	29945229
D000077211	Zoledronic Acid	Zoledronic Acid results in decreased expression of STK32B mRNA	24714768
D001280	Atrazine	Atrazine results in increased expression of STK32B mRNA	22378314
D001335	Vehicle Emissions	Vehicle Emissions affects the methylation of STK32B gene	25560391
D001564	Benzo(a)pyrene	Benzo(a)pyrene affects the methylation of STK32B intron	30157460
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of STK32B mRNA	22228805
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in decreased expression of STK32B mRNA	27392435
D004041	Dietary Fats	Dietary Fats results in increased expression of STK32B mRNA	25016146
D008701	Methapyrilene	Methapyrilene results in increased methylation of STK32B intron	30157460
D011441	Propylthiouracil	Propylthiouracil results in increased expression of STK32B mRNA	24780913
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of STK32B mRNA	21570461

Showing 1 to 20 of 27 entries

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Functional annotations

Keywords

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Keyword ID	Keyword Term
KW-0025	Alternative splicing
KW-0067	ATP-binding
KW-0418	Kinase
KW-0460	Magnesium
KW-0479	Metal-binding
KW-0547	Nucleotide-binding
KW-0621	Polymorphism
KW-0723	Serine/threonine-protein kinase
KW-0808	Transferase
KW-1185	Reference proteome

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Interpro

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InterPro ID	InterPro Term
IPR000719	Prot_kinase_dom
IPR008271	Ser/Thr_kinase_AS
IPR011009	Kinase-like_dom_sf
IPR017441	Protein_kinase_ATP_BS

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PROSITE

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PROSITE ID	PROSITE Term
PS00107	PROTEIN_KINASE_ATP
PS00108	PROTEIN_KINASE_ST
PS50011	PROTEIN_KINASE_DOM

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Pfam

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Pfam ID	Pfam Term
PF00069	Pkinase

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Gene: STK32B

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction