Gene: STK32B

Basic information

Tag Content
Uniprot ID Q9NY57; Q6UXH3; Q8IY14;
Entrez ID 55351
Genbank protein ID AAH38238.1; CAB76471.1; AAQ88719.1;
Genbank nucleotide ID NM_001306082.1; NM_018401.2;
Ensembl protein ID ENSP00000420984; ENSP00000282908;
Ensembl nucleotide ID ENSG00000152953
Gene name Serine/threonine-protein kinase 32B
Gene symbol STK32B
Organism Homo sapiens
NCBI taxa ID 9606
Cleft type
Developmental stage
Data sources Manually collected
Reference 20087401
Functional description
Sequence
MGGNHSHKPP VFDENEEVNF DHFQILRAIG KGSFGKVCIV QKRDTKKMYA MKYMNKQKCI 60
ERDEVRNVFR ELQIMQGLEH PFLVNLWYSF QDEEDMFMVV DLLLGGDLRY HLQQNVHFTE 120
GTVKLYICEL ALALEYLQRY HIIHRDIKPD NILLDEHGHV HITDFNIATV VKGAERASSM 180
AGTKPYMAPE VFQVYMDRGP GYSYPVDWWS LGITAYELLR GWRPYEIHSV TPIDEILNMF 240
KVERVHYSST WCKGMVALLR KLLTKDPESR VSSLHDIQSV PYLADMNWDA VFKKALMPGF 300
VPNKGRLNCD PTFELEEMIL ESKPLHKKKK RLAKNRSRDG TKDSCPLNGH LQHCLETVRE 360
EFIIFNREKL RRQQGQGSQL LDTDSRGGGQ AQSKLQDGCN NNLLTHTCTR GCSS 414

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

  

Gene expression in different tissues (ENCODE)

  

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologSTK32BA0A452FIT8Capra hircusPredictionMore>>
1:1 orthologSTK32B55351Q9NY57Homo sapiensPublicationMore>>
1:1 orthologStk32b64293Q9JJX8Mus musculusPredictionMore>>
1:1 orthologSTK32BA0A2I3SQX6Pan troglodytesPredictionMore>>
1:1 orthologSTK32BA0A287BIJ9Sus scrofaPredictionMore>>
1:1 orthologStk32b305431F1M3G9Rattus norvegicusPredictionMore>>

Other genetic variants/mutations

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Disease or phenotype associated information

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0004674 protein serine/threonine kinase activityIBA
GO:0005524 ATP bindingIEA
GO:0046872 metal ion bindingIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0018105 peptidyl-serine phosphorylationIBA
GO:0035556 intracellular signal transductionIBA

GO:Cellular Component

GO ID GO Term Evidence

Reactome Pathway

Reactome ID Reactome Term Evidence

Drugs and compounds information

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Functional annotations

Keywords

Keyword ID Keyword Term
KW-0025 Alternative splicing
KW-0067 ATP-binding
KW-0418 Kinase
KW-0460 Magnesium
KW-0479 Metal-binding
KW-0547 Nucleotide-binding
KW-0621 Polymorphism
KW-1185 Reference proteome
KW-0723 Serine/threonine-protein kinase
KW-0808 Transferase

Interpro

InterPro ID InterPro Term
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

PROSITE

PROSITE ID PROSITE Term
PS00107 PROTEIN_KINASE_ATP
PS50011 PROTEIN_KINASE_DOM
PS00108 PROTEIN_KINASE_ST

Pfam

Pfam ID Pfam Term
PF00069 Pkinase

Protein-protein interaction