| Tag | Content |
|---|---|
| Uniprot ID | Q9P0R6; B3KSZ0; Q9BST1; Q9NWK0; |
| Entrez ID | 51527 |
| Genbank protein ID | AAH04818.1; BAG52902.1; EAW81634.1; AAF36130.1; BAA91380.1; |
| Genbank nucleotide ID | NM_016472.4; NM_001271904.1; NM_001271906.1; XM_017021365.1; NM_001271905.1; |
| Ensembl protein ID | ENSP00000451188; ENSP00000450420; ENSP00000412315; ENSP00000451384; |
| Ensembl nucleotide ID | ENSG00000100744 |
| Gene name | GSK3B-interacting protein |
| Gene symbol | GSKIP |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:27484798, PubMed:25920809, PubMed:16981698). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:27484798, PubMed:16981698). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702). |
| Sequence | METDCNPMEL SSMSGFEEGS ELNGFEGTDM KDMRLEAEAV VNDVLFAVNN MFVSKSLRCA 60 DDVAYINVET KERNRYCLEL TEAGLKVVGY AFDQVDDHLQ TPYHETVYSL LDTLSPAYRE 120 AFGNALLQRL EALKRDGQS 139 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.