| Tag | Content |
|---|---|
| Uniprot ID | Q9QXN0; Q3TNX1; Q6ZPP9; Q99L16; Q9QXM9; |
| Entrez ID | 27428 |
| Genbank protein ID | AAF13270.1; AAH03909.1; BAE37966.1; BAC98181.1; AAF13269.1; BAE27948.1; |
| Genbank nucleotide ID | XM_006534968.2; NM_001077595.2; NM_015756.2; NM_001077596.2; |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Protein Shroom3 |
| Gene symbol | Shroom3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 10589677 |
| Functional description | Controls cell shape changes in the neuroepithelium during neural tube closure (PubMed:10589677, PubMed:14680628). Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (PubMed:14680628, PubMed:16249236, PubMed:16684770, PubMed:22493320). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). |
| Sequence | MKTPENLEEP SATPNPSRTP TERFVYLEAL LEGGAPWGFT LKGGLERGEP LIISKIEEGG 60 KADSVSSGLQ AGDEVIHINE VALSSPRREA VSLVKGSYKT LRLVVRRDVC AAPGHADPGT 120 SKSLSSELLT CSPQHRKATW SGGVKLRLKQ RCSEPATRPH SWHTTKFGET QPDVSMMQIS 180 QGTMGPPWHQ SYHSSSSTSD LSNYDHAYLR RSPDQCSSQG SMESLEPSGG YPPCHLLSPA 240 KSTSSIDQLG HLHNKRDSAY SSFSTSSSIF EYPPPGGSAR ERSGSMDVIS ARGGLLEGMR 300 QADIRYVKTV YDTRRGVSSE YEVNPSALLL QGRDAHASAD SQGCAKWHSI PRGKGTPSPS 360 WSQQCSGSLE TATDNLPQKA GAPLPPTRSD SYAAFRHRER PSSWSSLDQK RFCRPQTNSS 420 GSQKTPFAED QLHTVPERSP ENSPPVKSKH NYTQKAQPGQ PLLPTGIYPV PSPEPHFAQV 480 PQPSVSSNGT VYPALVKESG YTAAQGTCNK MATLDENGNQ NEASRPGFAF CQPLEHNSVT 540 PVEKRPEPTA KYIYKVHFSS VPENEDSSLK RHITPPHGHS PYPSERKNIH GGSRACSNHH 600 SLSSPQAQAL HVGDDRRPSR LSQPWEGDFQ EDHNANLRQK VEREGQGQGL SGNSGRTRSA 660 FSSLQNIPES LRRQSNVELG EAQEVHPGGR SKVEDPGRKA GASDIRGYLD RSVSYPRPEG 720 KMNAVDSVHS ADSRYEESPA PALPQTSGAS QRRLSSSSSA APQYRKPHCS VLEKVSRIEE 780 REQGRHRPLS VGSSAYGPGY RPGRTGPTPS TSSSDLDDPK AGSVHFSEST EHLRNGEQNP 840 PNGEAKQEEA SRPQCSHLIR RAPADGRGPP ARGGEPSRPE ARLLRSQSTF QLYSEAEREA 900 SWSEDRPGTP ESPLLDAPFS RAYRNSIKDA QSRVLGATSF RRRDLEPGTP ATSRPWRPRP 960 ASAHVGMRSP EAAVPSSSPH TPRERHSVTP AAPQAARRGP RRRLTVEQKK RSYSEPEKMN 1020 EVGVSEEAEP TPCGPPRPAQ PRFSESTVAD RRRIFERDGK ACSTLSLSGP ELKQFQQSAL 1080 ADYIQRKTGK RPTGAACTPE AGLRERAQSA YLQAGPAAPD GPGLASACSL SSLREPEALP 1140 RKEHTHPSAA DGPQAPRDRS SSFASGRLVG ERRRWDPQVP RQLLSGANCE PRGVQRMDGA 1200 PGGPPSWGMV AGKAGKSKSA EDLLERSDTL AVPVHVRSRS SPTSDKKGQD VLLREGSNFG 1260 FVKDPCCLAG PGPRSLSCSD KGQNELALPL HHPTPCWNGS GCKATVASSA PPESSGAADH 1320 LKQRRAPGPR PLSAGMHGHF PDARAASLSS PLPSPVPSAS PVPSSYRSQL AMDQQTGQQP 1380 PSSPASAVTQ PTSPRSPELS SPAYGLGEGM WKRTSLPQRP PPPWVKWAHA VREDGLAEDT 1440 LAPEFANLKH YRNQPSRPSS CSTSDPDTPG RISLRISESA LQPSPPPRGD YDDEVFMKDL 1500 HPKVTSSPTF EALPPPPPPS PPSEEPLVNG TDDFPPPPPP QALCEVLLDG EASTEAGSGP 1560 CRIPRVMVTR EGHVPGAAHS EGSQIMTATP PQTSAKGSEA ESNTPSSASA QPQLNGSPGK 1620 QLCPSQTRNL TYEPVERTQD LGKKTHAEPQ KTSEDIRTEA LAKEIVHQDK SLADILDPDS 1680 RMKTTMDLME GLFPGDASVL MDSGAKRKAL DITARRAGCE AKASDHKEAV SVLVNCPAYY 1740 SVSAAKAELL NKIKDMPEEL QEEEGQEDVN EKKAELIGSL THKLESLQEA KGSLLTDIKL 1800 NNALGEEVEA LISELCKPNE FDKYKMFIGD LDKVVNLLLS LSGRLARVEN VLRGLGEDAS 1860 KEERSSLNEK RKVLAGQHED ARELKENLDR RERVVLDILA NYLSAEQLQD YQHFVKMKST 1920 LLIEQRKLDD KIKLGQEQVR CLLESLPSDF RPKAGAISLP PALTGHATPG GTSVFGGVFP 1980 TLTSPL 1986 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003779 | actin binding | IDA |
| GO:0051015 | actin filament binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000902 | cell morphogenesis | ISS |
| GO:0001843 | neural tube closure | IMP |
| GO:0002066 | columnar/cuboidal epithelial cell development | IDA |
| GO:0007015 | actin filament organization | IBA |
| GO:0007389 | pattern specification process | IMP |
| GO:0008360 | regulation of cell shape | IDA |
| GO:0030036 | actin cytoskeleton organization | IGI |
| GO:0030036 | actin cytoskeleton organization | IBA |
| GO:0043482 | cellular pigment accumulation | ISS |
| GO:0045176 | apical protein localization | ISS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005856 | cytoskeleton | IDA |
| GO:0005874 | microtubule | IEA |
| GO:0005912 | adherens junction | IDA |
| GO:0005912 | adherens junction | IBA |
| GO:0016324 | apical plasma membrane | IDA |
| GO:0016324 | apical plasma membrane | IBA |
| GO:0030864 | cortical actin cytoskeleton | IBA |
| GO:0043296 | apical junction complex | IDA |
| GO:0043296 | apical junction complex | IBA |
| GO:0045177 | apical part of cell | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0009 | Actin-binding |
| KW-0025 | Alternative splicing |
| KW-0965 | Cell junction |
| KW-1003 | Cell membrane |
| KW-0133 | Cell shape |
| KW-0175 | Coiled coil |
| KW-0963 | Cytoplasm |
| KW-0206 | Cytoskeleton |
| KW-0217 | Developmental protein |
| KW-0903 | Direct protein sequencing |
| KW-0472 | Membrane |
| KW-0493 | Microtubule |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |