Gene: Gab1

Basic information

Tag Content
Uniprot ID Q9QYY0; Q91VW7;
Entrez ID 14388
Genbank protein ID AAH07483.1; CAB59832.1;
Genbank nucleotide ID NM_021356.2
Ensembl protein ID ENSMUSP00000034150
Ensembl nucleotide ID ENSMUSG00000031714
Gene name GRB2-associated-binding protein 1
Gene symbol Gab1
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 17881575
Functional description Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway.
Sequence
MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN DHAKKPIRII 60
DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS EEDMNKWVRC ICDICGFNPT 120
EEDPVKPLTG SSQAPVDSPF AISTAPASSQ MEASSVALPP PYQVISLPPH PDTLGLQDDP 180
QDYLLLINCQ SKKPEPNRTL FDSAKPTFSE TDCNDNVPSH QTPASSQSKH GMNGFFQQQM 240
MYDCPPSRLT SVSGESSLYN LPRSYSHDVL PKESPSSTEA DGELYTFNTP SGTAGVETQM 300
RHVSISYDIP PTPGNTYQIP RTFPESTLGQ SSKLDTIPDI PPPRPPKPHP THDRSPVETC 360
GVPRTASDTD SSYCIPPPAG MTPSRSNTIS TVDLNKLRKD ASSQDCYDIP RTFPSDRSSS 420
LEGFHSQYKI KSVLTAGGVS GEELDENYVP MNPNSPPRQH SGSFTEPIQE PNYVPMTPGT 480
FDFSSFGMQV PPPAHMGFRS SPKTPPRRPV PVADCEPPPV DRNLKPDRKV KPAPLDIKPL 540
SEWEELQAPV RSPITRSFAR DSSRFPMSPR PDSVHSTTSS SDSHDSEENY VPMNPNLSGE 600
DPNLFASNSL DGGSSPMNKP KGDKQVEYLD LDLDSGKSTP PRKQKSSGSG SSMADERVDY 660
VVVDQQKTLA LKSTREAWTD GRQSTESETP TKNVK 695

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

There is no orthologous record for this gene !

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005515 protein bindingIPI

GO:Biological Process

GO ID GO Term Evidence
GO:0000187 activation of MAPK activityIDA
GO:0001525 angiogenesisISO
GO:0006979 response to oxidative stressIDA
GO:0007165 signal transductionIDA
GO:0007173 epidermal growth factor receptor signaling pathwayIMP
GO:0007257 activation of JUN kinase activityIMP
GO:0007507 heart developmentIMP
GO:0008544 epidermis developmentIMP
GO:0030334 regulation of cell migrationIGI
GO:0031532 actin cytoskeleton reorganizationISO
GO:0035728 response to hepatocyte growth factorISO
GO:0035924 cellular response to vascular endothelial growth factor stimulusIDA
GO:0038084 vascular endothelial growth factor signaling pathwayISO
GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathwayIDA
GO:0043410 positive regulation of MAPK cascadeIMP
GO:0045766 positive regulation of angiogenesisISO
GO:0048008 platelet-derived growth factor receptor signaling pathwayIMP
GO:0060711 labyrinthine layer developmentIMP
GO:0070102 interleukin-6-mediated signaling pathwayIMP
GO:0090668 endothelial cell chemotaxis to vascular endothelial growth factorISO

GO:Cellular Component

GO ID GO Term Evidence
GO:0005737 cytoplasmIDA
GO:0005829 cytosolTAS
GO:0005911 cell-cell junctionISO

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-109704 PI3K CascadeIEA
R-MMU-112399 IRS-mediated signallingIEA
R-MMU-1227986 Signaling by ERBB2IEA
R-MMU-1257604 PIP3 activates AKT signalingIEA
R-MMU-1266738 Developmental BiologyIEA
R-MMU-1280215 Cytokine Signaling in Immune systemIEA
R-MMU-162582 Signal TransductionIEA
R-MMU-168256 Immune SystemIEA
R-MMU-177929 Signaling by EGFRIEA
R-MMU-180292 GAB1 signalosomeIEA
R-MMU-190236 Signaling by FGFRIEA
R-MMU-1963642 PI3K events in ERBB2 signalingIEA
R-MMU-199418 Negative regulation of the PI3K/AKT networkIEA
R-MMU-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)IEA
R-MMU-2428924 IGF1R signaling cascadeIEA
R-MMU-2428928 IRS-related events triggered by IGF1RIEA
R-MMU-422475 Axon guidanceIEA
R-MMU-5654687 Downstream signaling of activated FGFR1IEA
R-MMU-5654689 PI-3K cascade:FGFR1IEA
R-MMU-5654695 PI-3K cascade:FGFR2IEA
R-MMU-5654696 Downstream signaling of activated FGFR2IEA
R-MMU-5654708 Downstream signaling of activated FGFR3IEA
R-MMU-5654710 PI-3K cascade:FGFR3IEA
R-MMU-5654716 Downstream signaling of activated FGFR4IEA
R-MMU-5654720 PI-3K cascade:FGFR4IEA
R-MMU-5654736 Signaling by FGFR1IEA
R-MMU-5654738 Signaling by FGFR2IEA
R-MMU-5654741 Signaling by FGFR3IEA
R-MMU-5654743 Signaling by FGFR4IEA
R-MMU-6806834 Signaling by METIEA
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingIEA
R-MMU-74751 Insulin receptor signalling cascadeIEA
R-MMU-74752 Signaling by Insulin receptorIEA
R-MMU-8851907 MET activates PI3K/AKT signalingIEA
R-MMU-8853659 RET signalingIEA
R-MMU-8865999 MET activates PTPN11IEA
R-MMU-8875555 MET activates RAP1 and RAC1IEA
R-MMU-8875656 MET receptor recyclingIEA
R-MMU-8875878 MET promotes cell motilityIEA
R-MMU-9006335 Signaling by ErythropoietinIEA
R-MMU-9006925 Intracellular signaling by second messengersIEA
R-MMU-9006934 Signaling by Receptor Tyrosine KinasesIEA
R-MMU-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K)IEA
R-MMU-9607240 FLT3 SignalingIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0597 Phosphoprotein
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

PROSITE

PROSITE ID PROSITE Term
PS50003 PH_DOMAIN

Pfam

Pfam ID Pfam Term
PF00169 PH

Protein-protein interaction

Protein-miRNA interaction