| Tag | Content |
|---|---|
| Uniprot ID | Q9R087 |
| Entrez ID | 23888 |
| Genbank protein ID | AAD55750.1 |
| Genbank nucleotide ID | NM_011821.3 |
| Ensembl protein ID | ENSMUSP00000085835; ENSMUSP00000077893; |
| Ensembl nucleotide ID | ENSMUSG00000058571 |
| Gene name | Glypican-6 |
| Gene symbol | Gpc6 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 28696225; 20562862; |
| Functional description | Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling (By similarity). |
| Sequence | MPSWIRAVIL PLSGLLLTLP AAADVKARSC SEVRQAYGAK GFSLADIPYQ EIAGEHLRIC 60 PQEYTCCTTE MEDKLSQQSK LEFENLVEET SHFVRTTFVS RHKKFDEFFR ELLENAEKSL 120 NDMFVRTYGM LYMQNSEVFQ DLFTELKRYY TGGNVNLEEM LNDFWARLLE RMFQLINPQY 180 HFSEDYLECV SKYTDQLKPF GDVPRKLKIQ VTRAFIAART FVQGLTVGRE VANRVSKVSP 240 TPGCIRALMK MLYCPYCRGL PTVRPCNNYC LNVMKGCLAN QADLDTEWNL FIDAMLLVAE 300 RLEGPFNIES VMDPIDVKIS EAIMNMQENS MQVSAKVFQG CGQPKPAPAL RSARSAPENF 360 NTRFRPYNPE ERPTTAAGTS LDRLVTDIKE KLKLSKKVWS ALPYTICKDE RVTAGTSNEE 420 ECWNGHSKAR YLPEIMNDGL TNQINNPEVE VDITRPDTFI RQQIMALRVM TNKLKNAYNG 480 NDVNFQDTSD ESSGSGSGSG CMDDVCPTEF EFVTTEAPAV DPDRREEESS ASKFSSSLIS 540 WSLVCMVLAL QRLYR 555 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0009966 | regulation of signal transduction | IEA |
| GO:0016477 | cell migration | ISS |
| GO:0016477 | cell migration | ISO |
| GO:0016477 | cell migration | IBA |
| GO:0098696 | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane | ISO |
| GO:0098696 | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane | IBA |
| GO:0099560 | synaptic membrane adhesion | IBA |
| GO:1905475 | regulation of protein localization to membrane | IBA |
| GO:1905606 | regulation of presynapse assembly | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | IBA |
| GO:0005615 | extracellular space | IEA |
| GO:0005796 | Golgi lumen | TAS |
| GO:0005887 | integral component of plasma membrane | ISS |
| GO:0009986 | cell surface | IBA |
| GO:0045202 | synapse | EXP |
| GO:0045202 | synapse | IDA |
| GO:0045202 | synapse | IBA |
| GO:0046658 | anchored component of plasma membrane | IEA |
| GO:0062023 | collagen-containing extracellular matrix | IEA |
| GO:0098978 | glutamatergic synapse | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1430728 | Metabolism | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-1630316 | Glycosaminoglycan metabolism | IEA |
| R-MMU-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism | IEA |
| R-MMU-1793185 | Chondroitin sulfate/dermatan sulfate metabolism | IEA |
| R-MMU-196854 | Metabolism of vitamins and cofactors | IEA |
| R-MMU-1971475 | A tetrasaccharide linker sequence is required for GAG synthesis | IEA |
| R-MMU-2022928 | HS-GAG biosynthesis | IEA |
| R-MMU-2024096 | HS-GAG degradation | IEA |
| R-MMU-2187338 | Visual phototransduction | IEA |
| R-MMU-372790 | Signaling by GPCR | IEA |
| R-MMU-388396 | GPCR downstream signalling | IEA |
| R-MMU-418594 | G alpha (i) signalling events | IEA |
| R-MMU-6806667 | Metabolism of fat-soluble vitamins | IEA |
| R-MMU-71387 | Metabolism of carbohydrates | IEA |
| R-MMU-975634 | Retinoid metabolism and transport | IEA |
| PROSITE ID | PROSITE Term |
|---|---|
| PS01207 | GLYPICAN |
| Pfam ID | Pfam Term |
|---|---|
| PF01153 | Glypican |