CleftGeneDB-Search

Gene: HSPB11

Basic information

Tag	Content
Uniprot ID	Q9Y547; A6NG57; D3DQ45; Q9Y684;
Entrez ID	51668
Genbank protein ID	EAX06717.1; AAH05245.1; EAX06719.1; AAQ03618.1; AAD43011.1; AAQ03994.1;
Genbank nucleotide ID	NM_016126.3; NM_001316935.1;
Ensembl protein ID	ENSP00000194214
Ensembl nucleotide ID	ENSG00000081870
Gene name	Intraflagellar transport protein 25 homolog
Gene symbol	HSPB11
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity).
Sequence	MRKIDLCLSS EGSEVILATS SDEKHPPENI IDGNPETFWT TTGMFPQEFI ICFHKHVRIE 60 RLVIQSYFVQ TLKIEKSTSK EPVDFEQWIE KDLVHTEGQL QNEEIVAHDG SATYLRFIIV 120 SAFDHFASVH SVSAEGTVVS NLSS 144

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

PDB ID
1TVG
1XPW
1TVG

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	HSPB11	616194	Q17Q88		Bos taurus	Prediction	More>>
1:1 ortholog	HSPB11	100683945	F6X539		Canis lupus familiaris	Prediction	More>>
1:1 ortholog	HSPB11	102177677	A0A452G8H2		Capra hircus	Prediction	More>>
1:1 ortholog	HSPB11	51668	Q9Y547		Homo sapiens	Prediction	More>>
1:1 ortholog	Hspb11	72938	Q9D6H2	CPO	Mus musculus	Publication	More>>
1:1 ortholog	HSPB11	456868	H2PZ28		Pan troglodytes	Prediction	More>>
1:1 ortholog	HSPB11	100621426	I3LB08		Sus scrofa	Prediction	More>>
1:1 ortholog	YIPF1	100353611	G1SWV3		Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Hspb11	685284	A0A0G2K664		Rattus norvegicus	Prediction	More>>
1:1 ortholog	hspa5		A2BIN6		Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs573242280	p.Lys3Glu	missense variant	-	NC_000001.11:g.53940076T>C	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Lys3Asn	missense variant	-	NC_000001.11:g.53940074T>G	NCI-TCGA
rs200095391	p.Ile4Thr	missense variant	-	NC_000001.11:g.53940072A>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1396752834	p.Asp5Tyr	missense variant	-	NC_000001.11:g.53940070C>A	TOPMed,gnomAD
rs1396752834	p.Asp5His	missense variant	-	NC_000001.11:g.53940070C>G	TOPMed,gnomAD
rs980627724	p.Leu6Ile	missense variant	-	NC_000001.11:g.53940067G>T	TOPMed,gnomAD
rs774397250	p.Cys7Ser	missense variant	-	NC_000001.11:g.53940063C>G	ExAC,gnomAD
COSM464770	p.Leu8Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.53940060A>T	NCI-TCGA Cosmic
rs1309898266	p.Leu8Pro	missense variant	-	NC_000001.11:g.53940060A>G	TOPMed,gnomAD
NCI-TCGA novel	p.Glu11Lys	missense variant	-	NC_000001.11:g.53940052C>T	NCI-TCGA
rs1188585546	p.Gly12Arg	missense variant	-	NC_000001.11:g.53940049C>T	gnomAD
rs201720563	p.Glu14Lys	missense variant	-	NC_000001.11:g.53940043C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs201720563	p.Glu14Gln	missense variant	-	NC_000001.11:g.53940043C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1167114730	p.Ala18Thr	missense variant	-	NC_000001.11:g.53940031C>T	TOPMed,gnomAD
rs1425852767	p.Thr19Ile	missense variant	-	NC_000001.11:g.53940027G>A	gnomAD
rs1414966589	p.Ser20Thr	missense variant	-	NC_000001.11:g.53940025A>T	gnomAD
rs1182141590	p.Ser21Gly	missense variant	-	NC_000001.11:g.53940022T>C	gnomAD
rs776141122	p.His25Asn	missense variant	-	NC_000001.11:g.53940010G>T	ExAC,TOPMed,gnomAD
rs1477131139	p.Pro26Gln	missense variant	-	NC_000001.11:g.53940006G>T	TOPMed
rs1472246419	p.Asn29Ser	missense variant	-	NC_000001.11:g.53939997T>C	TOPMed,gnomAD
rs370367573	p.Ile30Thr	missense variant	-	NC_000001.11:g.53939994A>G	ESP,TOPMed,gnomAD
rs548680262	p.Ile31Thr	missense variant	-	NC_000001.11:g.53939991A>G	ExAC,TOPMed,gnomAD
rs748436535	p.Gly33Arg	missense variant	-	NC_000001.11:g.53939986C>T	ExAC,gnomAD
rs774579110	p.Pro35Thr	missense variant	-	NC_000001.11:g.53930141G>T	ExAC,gnomAD
NCI-TCGA novel	p.Glu36Ter	stop gained	-	NC_000001.11:g.53930138C>A	NCI-TCGA
rs769134105	p.Thr37Met	missense variant	-	NC_000001.11:g.53930134G>A	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Phe38Val	missense variant	-	NC_000001.11:g.53930132A>C	NCI-TCGA
NCI-TCGA novel	p.Thr40Ile	missense variant	-	NC_000001.11:g.53930125G>A	NCI-TCGA
rs780679621	p.Thr41Ala	missense variant	-	NC_000001.11:g.53930123T>C	ExAC,TOPMed,gnomAD
rs1335449507	p.Met44Thr	missense variant	-	NC_000001.11:g.53930113A>G	TOPMed
NCI-TCGA novel	p.Pro46Leu	missense variant	-	NC_000001.11:g.53930107G>A	NCI-TCGA
NCI-TCGA novel	p.Gln47His	missense variant	-	NC_000001.11:g.53930103C>A	NCI-TCGA
rs745958906	p.Ile50Val	missense variant	-	NC_000001.11:g.53930096T>C	ExAC,gnomAD
rs1418048144	p.Ile50Asn	missense variant	-	NC_000001.11:g.53930095A>T	gnomAD
NCI-TCGA novel	p.Phe53Cys	missense variant	-	NC_000001.11:g.53930086A>C	NCI-TCGA
COSM3985142	p.His54Tyr	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.53930084G>A	NCI-TCGA Cosmic
rs781293591	p.His54Leu	missense variant	-	NC_000001.11:g.53930083T>A	ExAC,gnomAD
rs781293591	p.His54Arg	missense variant	-	NC_000001.11:g.53930083T>C	ExAC,gnomAD
rs777486814	p.His56Leu	missense variant	-	NC_000001.11:g.53930077T>A	ExAC,gnomAD
rs777486814	p.His56Arg	missense variant	-	NC_000001.11:g.53930077T>C	ExAC,gnomAD
rs1486789772	p.Val57Ala	missense variant	-	NC_000001.11:g.53930074A>G	gnomAD
rs1211286843	p.Val57Ile	missense variant	-	NC_000001.11:g.53930075C>T	gnomAD
COSM4860088	p.Arg58Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.53930070C>A	NCI-TCGA Cosmic
rs1259234476	p.Arg58Met	missense variant	-	NC_000001.11:g.53930071C>A	gnomAD
NCI-TCGA novel	p.Ile59Asn	missense variant	-	NC_000001.11:g.53930068A>T	NCI-TCGA
rs752670381	p.Val63Ile	missense variant	-	NC_000001.11:g.53930057C>T	ExAC,TOPMed,gnomAD
rs1313892159	p.Gln65His	missense variant	-	NC_000001.11:g.53930049T>G	TOPMed,gnomAD
rs759417292	p.Gln65Arg	missense variant	-	NC_000001.11:g.53930050T>C	ExAC,gnomAD
rs1201147575	p.Ser66Asn	missense variant	-	NC_000001.11:g.53930047C>T	TOPMed
NCI-TCGA novel	p.Ser66Ile	missense variant	-	NC_000001.11:g.53930047C>A	NCI-TCGA
rs562499809	p.Tyr67Phe	missense variant	-	NC_000001.11:g.53930044T>A	1000Genomes
rs368867483	p.Thr71Ile	missense variant	-	NC_000001.11:g.53928434G>A	ESP,ExAC,TOPMed,gnomAD
rs368867483	p.Thr71Ser	missense variant	-	NC_000001.11:g.53928434G>C	ESP,ExAC,TOPMed,gnomAD
rs1228554363	p.Lys73Glu	missense variant	-	NC_000001.11:g.53928429T>C	gnomAD
rs770226191	p.Ile74Val	missense variant	-	NC_000001.11:g.53928426T>C	ExAC,TOPMed,gnomAD
rs1363764083	p.Lys76Glu	missense variant	-	NC_000001.11:g.53928420T>C	TOPMed
rs560478633	p.Thr78Met	missense variant	-	NC_000001.11:g.53928413G>A	1000Genomes,ExAC,gnomAD
rs1369627561	p.Lys80Glu	missense variant	-	NC_000001.11:g.53928408T>C	gnomAD
rs1385648298	p.Val83Leu	missense variant	-	NC_000001.11:g.53928399C>G	TOPMed
rs779438262	p.Val83Ala	missense variant	-	NC_000001.11:g.53928398A>G	ExAC,TOPMed,gnomAD
rs779438262	p.Val83Gly	missense variant	-	NC_000001.11:g.53928398A>C	ExAC,TOPMed,gnomAD
COSM910823	p.Trp88Arg	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.53928384A>G	NCI-TCGA Cosmic
NCI-TCGA novel	p.Trp88Ter	stop gained	-	NC_000001.11:g.53928383C>T	NCI-TCGA
rs777778737	p.Trp88Cys	missense variant	-	NC_000001.11:g.53928382C>A	ExAC,gnomAD
rs772309695	p.Lys91Thr	missense variant	-	NC_000001.11:g.53928374T>G	ExAC,TOPMed,gnomAD
rs748299089	p.Asp92His	missense variant	-	NC_000001.11:g.53928372C>G	ExAC,TOPMed,gnomAD
rs748423925	p.Glu97Ala	missense variant	-	NC_000001.11:g.53923932T>G	ExAC
rs774529000	p.Gln99Ter	stop gained	-	NC_000001.11:g.53923927G>A	ExAC,gnomAD
rs570139005	p.Leu100Pro	missense variant	-	NC_000001.11:g.53923923A>G	1000Genomes,ExAC,gnomAD
rs1220591599	p.Glu103Lys	missense variant	-	NC_000001.11:g.53923915C>T	gnomAD
rs1254315719	p.Glu104Gly	missense variant	-	NC_000001.11:g.53923911T>C	TOPMed
rs184845070	p.Glu104Asp	missense variant	-	NC_000001.11:g.53923910T>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs756083768	p.Ile105Thr	missense variant	-	NC_000001.11:g.53923908A>G	ExAC,TOPMed,gnomAD
rs779676824	p.Ile105Leu	missense variant	-	NC_000001.11:g.53923909T>G	ExAC,gnomAD
rs745744254	p.Val106Leu	missense variant	-	NC_000001.11:g.53923906C>A	ExAC,gnomAD
rs745868802	p.His108Arg	missense variant	-	NC_000001.11:g.53921763T>C	ExAC,gnomAD
rs374388539	p.His108Gln	missense variant	-	NC_000001.11:g.53921762A>T	ESP,ExAC,TOPMed,gnomAD
rs746538301	p.Gly110Asp	missense variant	-	NC_000001.11:g.53921757C>T	ExAC,gnomAD
COSM4832589	p.Ser111Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.53921754G>C	NCI-TCGA Cosmic
rs184049812	p.Ala112Ser	missense variant	-	NC_000001.11:g.53921752C>A	1000Genomes,ExAC,TOPMed,gnomAD
rs184049812	p.Ala112Thr	missense variant	-	NC_000001.11:g.53921752C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs780521375	p.Thr113Ala	missense variant	-	NC_000001.11:g.53921749T>C	ExAC,TOPMed,gnomAD
COSM1343468	p.Thr113Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000001.11:g.53921748G>C	NCI-TCGA Cosmic
rs750981811	p.Tyr114Ter	stop gained	-	NC_000001.11:g.53921744G>T	ExAC,gnomAD
rs750981811	p.Tyr114Ter	stop gained	-	NC_000001.11:g.53921744G>C	ExAC,gnomAD
rs1212638637	p.Phe117Leu	missense variant	-	NC_000001.11:g.53921735G>T	gnomAD
rs1338468522	p.Ile118Val	missense variant	-	NC_000001.11:g.53921734T>C	TOPMed,gnomAD
rs1298693760	p.Val120Ile	missense variant	-	NC_000001.11:g.53921728C>T	gnomAD
rs140103685	p.Ala122Thr	missense variant	-	NC_000001.11:g.53921722C>T	1000Genomes,ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Asp124Ala	missense variant	-	NC_000001.11:g.53921715T>G	NCI-TCGA
rs1368887125	p.Asp124His	missense variant	-	NC_000001.11:g.53921716C>G	gnomAD
rs751666876	p.Ala127Ser	missense variant	-	NC_000001.11:g.53921707C>A	ExAC,gnomAD
rs558406534	p.Val129Leu	missense variant	-	NC_000001.11:g.53921701C>G	1000Genomes,ExAC,TOPMed,gnomAD
rs1220163114	p.His130Tyr	missense variant	-	NC_000001.11:g.53921698G>A	TOPMed
rs769672593	p.His130Arg	missense variant	-	NC_000001.11:g.53921697T>C	ExAC,gnomAD
rs759380969	p.Ser131Gly	missense variant	-	NC_000001.11:g.53921695T>C	ExAC,gnomAD
rs776516954	p.Ser131Asn	missense variant	-	NC_000001.11:g.53921694C>T	ExAC,TOPMed,gnomAD
rs377747922	p.Val132Ala	missense variant	-	NC_000001.11:g.53921691A>G	ESP,ExAC,TOPMed,gnomAD
rs746875573	p.Val132Ile	missense variant	-	NC_000001.11:g.53921692C>T	ExAC,TOPMed,gnomAD
rs771467847	p.Ser133Ala	missense variant	-	NC_000001.11:g.53921689A>C	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Ala134Thr	missense variant	-	NC_000001.11:g.53921686C>T	NCI-TCGA
rs1209581911	p.Val138Ile	missense variant	-	NC_000001.11:g.53921674C>T	TOPMed
NCI-TCGA novel	p.Ser140Leu	missense variant	-	NC_000001.11:g.53921667G>A	NCI-TCGA
rs1377690001	p.Asn141Asp	missense variant	-	NC_000001.11:g.53921665T>C	gnomAD
rs374128989	p.Leu142Pro	missense variant	-	NC_000001.11:g.53921661A>G	ESP,ExAC,TOPMed,gnomAD
rs1489385582	p.Ser144Leu	missense variant	-	NC_000001.11:g.53921655G>A	TOPMed
rs781473632	p.Ter145Gln	stop lost	-	NC_000001.11:g.53921653A>G	ExAC,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0006118	Brain Neoplasms	group	LHGDN

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005515	protein binding	IPI
GO:0046872	metal ion binding	IEA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001501	skeletal system development	IEA
GO:0001822	kidney development	ISS
GO:0007224	smoothened signaling pathway	IEA
GO:0007283	spermatogenesis	ISS
GO:0007507	heart development	IEA
GO:0030154	cell differentiation	IEA
GO:0030324	lung development	IEA
GO:0035735	intraciliary transport involved in cilium assembly	TAS
GO:0070986	left/right axis specification	IEA
GO:0060271	cilium assembly	ISS

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005813	centrosome	IBA
GO:0005929	cilium	IBA
GO:0005929	cilium	TAS
GO:0030992	intraciliary transport particle B	ISS
GO:0030992	intraciliary transport particle B	IBA
GO:0097542	ciliary tip	TAS

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-1852241	Organelle biogenesis and maintenance	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	IEA
R-HSA-5617833	Cilium Assembly	TAS
R-HSA-5617833	Cilium Assembly	IEA
R-HSA-5620924	Intraflagellar transport	TAS
R-HSA-5620924	Intraflagellar transport	IEA

Drugs and compounds information

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HSPB11 mRNA	25614096
C009407	2,5,2',5'-tetrachlorobiphenyl	2,5,2',5'-tetrachlorobiphenyl results in decreased expression of HSPB11 mRNA	23829299
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane affects the expression of HSPB11 mRNA	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HSPB11 mRNA	27188386
C029107	4-chlorophenol	4-chlorophenol results in increased expression of HSPB11 mRNA	27029555
D016718	Arachidonic Acid	Arachidonic Acid results in decreased expression of HSPB11 mRNA	16704987
D001387	Azinphosmethyl	Azinphosmethyl results in increased expression of HSPB11 mRNA	22205996; 27029555;
D001387	Azinphosmethyl	tricaine inhibits the reaction [Azinphosmethyl results in increased expression of HSPB11 mRNA]	27029555
C006780	bisphenol A	bisphenol A affects the expression of HSPB11 mRNA	30903817
D002110	Caffeine	Caffeine results in increased expression of HSPB11 mRNA	22205996
C004519	caramiphen	caramiphen inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of HSPB11 mRNA]	27655295
D007631	Chlordecone	Chlordecone results in increased expression of HSPB11 mRNA	29458080
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of HSPB11 mRNA	27029555
D002945	Cisplatin	Cisplatin affects the expression of HSPB11 mRNA	23300844
D002945	Cisplatin	Cisplatin results in increased expression of HSPB11 mRNA	27594783
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of HSPB11 mRNA	24386269
C000541	cyclopamine	cyclopamine results in decreased expression of HSPB11 mRNA	22265815
D016572	Cyclosporine	Cyclosporine results in decreased expression of HSPB11 mRNA	20106945; 25562108;
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of HSPB11 mRNA	24317228
D000077209	Decitabine	Decitabine affects the expression of HSPB11 mRNA	23300844
D003703	Demecolcine	Demecolcine results in decreased expression of HSPB11 mRNA	23649840
C016366	dibenzothiophene	dibenzothiophene affects the expression of HSPB11 mRNA	23656968
D003993	Dibutyl Phthalate	Dibutyl Phthalate affects the expression of HSPB11 mRNA	27029555
C000944	dicrotophos	dicrotophos results in decreased expression of HSPB11 mRNA	28302478
C025605	diisobutyl phthalate	diisobutyl phthalate results in increased expression of HSPB11 mRNA	29458080
D004222	Disulfoton	Disulfoton results in increased expression of HSPB11 mRNA	22205996
C516138	dorsomorphin	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HSPB11 mRNA	27188386
D004732	Endrin	Endrin results in increased expression of HSPB11 mRNA	29458080
D004958	Estradiol	Estradiol results in decreased expression of HSPB11 mRNA	23019147
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of HSPB11 mRNA	29458080
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of HSPB11 mRNA	23129252
C017690	fenvalerate	fenvalerate results in increased expression of HSPB11 mRNA	27029555
C082360	fipronil	fipronil results in increased expression of HSPB11 mRNA	23962444
C027975	flucythrinate	flucythrinate results in increased expression of HSPB11 mRNA	27029555
D005557	Formaldehyde	Formaldehyde results in increased expression of HSPB11 mRNA	23649840
D005702	Galantamine	Galantamine results in increased expression of HSPB11 mRNA	22205996; 27029555;
D005702	Galantamine	tricaine inhibits the reaction [Galantamine results in increased expression of HSPB11 mRNA]	27029555
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPB11 mRNA	25613284
C410337	K 7174	K 7174 results in decreased expression of HSPB11 mRNA	24086573
D000077339	Leflunomide	Leflunomide results in decreased expression of HSPB11 mRNA	28988120
D008559	Memantine	Memantine inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of HSPB11 mRNA]	27655295
D008694	Methamphetamine	Methamphetamine results in increased expression of HSPB11 mRNA	29802913
D008731	Methoxychlor	Methoxychlor results in increased expression of HSPB11 mRNA	27029555
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of HSPB11 mRNA	23458150
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of HSPB11 mRNA	28001369
D008767	Methylmercury Compounds	Methylmercury Compounds results in increased expression of HSPB11 mRNA	27029555
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of HSPB11 mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of HSPB11 mRNA	23649840
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	caramiphen inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of HSPB11 mRNA]	27655295
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	Memantine inhibits the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of HSPB11 mRNA]	27655295
C009618	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate	O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate results in increased expression of HSPB11 mRNA	27655295
D000077767	Panobinostat	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of HSPB11 mRNA	27188386
D000077767	Panobinostat	Panobinostat results in decreased expression of HSPB11 mRNA	26272509
D052638	Particulate Matter	Particulate Matter results in decreased expression of HSPB11 mRNA	29703138
D010634	Phenobarbital	Phenobarbital affects the expression of HSPB11 mRNA	23091169
C006253	pirinixic acid	pirinixic acid results in increased expression of HSPB11 mRNA	23811191
D010936	Plant Extracts	Plant Extracts results in increased expression of HSPB11 mRNA	23557933
D001074	Propoxur	Propoxur results in increased expression of HSPB11 mRNA	22205996; 27029555;
D001074	Propoxur	tricaine inhibits the reaction [Propoxur results in increased expression of HSPB11 mRNA]	27029555
C513635	S-2-pentyl-4-pentynoic hydroxamic acid	S-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of HSPB11 mRNA	21427059
D012835	Silver Nitrate	Silver Nitrate analog results in decreased expression of HSPB11 mRNA	22831968
C017947	sodium arsenite	sodium arsenite results in increased expression of HSPB11 mRNA	29361514
C017947	sodium arsenite	sodium arsenite results in decreased expression of HSPB11 mRNA	29301061
D012969	Sodium Fluoride	Sodium Fluoride results in increased expression of HSPB11 protein	28918527
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of HSPB11 mRNA	20106945
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of HSPB11 mRNA	21215274
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HSPB11 mRNA	25613284
D019284	Thapsigargin	Thapsigargin results in increased expression of HSPB11 mRNA	22205996
D014212	Tretinoin	Tretinoin results in decreased expression of HSPB11 mRNA	21934132
C034613	triacsin C	triacsin C results in decreased expression of HSPB11 mRNA	16704987
C003636	tricaine	tricaine inhibits the reaction [Azinphosmethyl results in increased expression of HSPB11 mRNA]	27029555
C003636	tricaine	tricaine inhibits the reaction [Galantamine results in increased expression of HSPB11 mRNA]	27029555
C003636	tricaine	tricaine inhibits the reaction [Propoxur results in increased expression of HSPB11 mRNA]	27029555
C003636	tricaine	tricaine inhibits the reaction [Veratridine results in increased expression of HSPB11 mRNA]	27029555
C003636	tricaine	tricaine results in decreased expression of HSPB11 mRNA	22205996
D014241	Trichloroethylene	Trichloroethylene results in increased methylation of HSPB11 gene	27618143
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HSPB11 mRNA	26179874
D014520	Urethane	Urethane results in decreased expression of HSPB11 mRNA	28818685
C406224	valdecoxib	valdecoxib results in increased expression of HSPB11 mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of HSPB11 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of HSPB11 mRNA	23179753; 27188386; 28001369;
D014635	Valproic Acid	Valproic Acid results in increased expression of HSPB11 mRNA	21427059
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of HSPB11 gene	25560391
D014701	Veratridine	tricaine inhibits the reaction [Veratridine results in increased expression of HSPB11 mRNA]	27029555
D014701	Veratridine	Veratridine results in increased expression of HSPB11 mRNA	27029555
C025643	vinclozolin	vinclozolin results in increased expression of HSPB11 mRNA	23034163
D014750	Vincristine	Vincristine results in decreased expression of HSPB11 mRNA	23649840
D000077337	Vorinostat	Vorinostat results in increased expression of HSPB11 mRNA	27188386

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0002	3D-structure
KW-0106	Calcium
KW-0966	Cell projection
KW-0969	Cilium
KW-0221	Differentiation
KW-0479	Metal-binding
KW-0653	Protein transport
KW-1185	Reference proteome
KW-0744	Spermatogenesis
KW-0346	Stress response
KW-0813	Transport

Interpro

InterPro ID	InterPro Term
IPR000421	FA58C
IPR008979	Galactose-bd-like_sf
IPR033558	IFT25

PROSITE

PROSITE ID	PROSITE Term

Pfam

Pfam ID	Pfam Term
PF00754	F5_F8_type_C

Gene: HSPB11

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction