| Tag | Content |
|---|---|
| Uniprot ID | Q9Y618; O00613; O15416; O15421; Q13354; Q56D06; Q59GM0; Q9Y5U0; |
| Entrez ID | 9612 |
| Genbank protein ID | AAB91446.1; BAD92326.1; AAB91452.1; AAD22973.1; AAD20946.1; AAC50236.1; AAB50847.1; AAX77219.1; |
| Genbank nucleotide ID | NM_001206654.1; NM_001077261.3; NM_006312.5; |
| Ensembl protein ID | ENSP00000384018 |
| Ensembl nucleotide ID | ENSG00000196498 |
| Gene name | Nuclear receptor corepressor 2 |
| Gene symbol | NCOR2 |
| Organism | Homo sapiens |
| NCBI taxa ID | 9606 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). |
| Sequence | MSGSTQPVAQ TWRATEPRYP PHSLSYPVQI ARTHTDVGLL EYQHHSRDYA SHLSPGSIIQ 60 PQRRRPSLLS EFQPGNERSQ ELHLRPESHS YLPELGKSEM EFIESKRPRL ELLPDPLLRP 120 SPLLATGQPA GSEDLTKDRS LTGKLEPVSP PSPPHTDPEL ELVPPRLSKE ELIQNMDRVD 180 REITMVEQQI SKLKKKQQQL EEEAAKPPEP EKPVSPPPIE SKHRSLVQII YDENRKKAEA 240 AHRILEGLGP QVELPLYNQP SDTRQYHENI KINQAMRKKL ILYFKRRNHA RKQWEQKFCQ 300 RYDQLMEAWE KKVERIENNP RRRAKESKVR EYYEKQFPEI RKQRELQERM QSRVGQRGSG 360 LSMSAARSEH EVSEIIDGLS EQENLEKQMR QLAVIPPMLY DADQQRIKFI NMNGLMADPM 420 KVYKDRQVMN MWSEQEKETF REKFMQHPKN FGLIASFLER KTVAECVLYY YLTKKNENYK 480 SLVRRSYRRR GKSQQQQQQQ QQQQQQQQQQ PMPRSSQEEK DEKEKEKEAE KEEEKPEVEN 540 DKEDLLKEKT DDTSGEDNDE KEAVASKGRK TANSQGRRKG RITRSMANEA NSEEAITPQQ 600 SAELASMELN ESSRWTEEEM ETAKKGLLEH GRNWSAIARM VGSKTVSQCK NFYFNYKKRQ 660 NLDEILQQHK LKMEKERNAR RKKKKAPAAA SEEAAFPPVV EDEEMEASGV SGNEEEMVEE 720 AEALHASGNE VPRGECSGPA TVNNSSDTES IPSPHTEAAK DTGQNGPKPP ATLGADGPPP 780 GPPTPPPEDI PAPTEPTPAS EATGAPTPPP APPSPSAPPP VVPKEEKEEE TAAAPPVEEG 840 EEQKPPAAEE LAVDTGKAEE PVKSECTEEA EEGPAKGKDA EAAEATAEGA LKAEKKEGGS 900 GRATTAKSSG APQDSDSSAT CSADEVDEAE GGDKNRLLSP RPSLLTPTGD PRANASPQKP 960 LDLKQLKQRA AAIPPIQVTK VHEPPREDAA PTKPAPPAPP PPQNLQPESD APQQPGSSPR 1020 GKSRSPAPPA DKEAFAAEAQ KLPGDPPCWT SGLPFPVPPR EVIKASPHAP DPSAFSYAPP 1080 GHPLPLGLHD TARPVLPRPP TISNPPPLIS SAKHPSVLER QIGAISQGMS VQLHVPYSEH 1140 AKAPVGPVTM GLPLPMDPKK LAPFSGVKQE QLSPRGQAGP PESLGVPTAQ EASVLRGTAL 1200 GSVPGGSITK GIPSTRVPSD SAITYRGSIT HGTPADVLYK GTITRIIGED SPSRLDRGRE 1260 DSLPKGHVIY EGKKGHVLSY EGGMSVTQCS KEDGRSSSGP PHETAAPKRT YDMMEGRVGR 1320 AISSASIEGL MGRAIPPERH SPHHLKEQHH IRGSITQGIP RSYVEAQEDY LRREAKLLKR 1380 EGTPPPPPPS RDLTEAYKTQ ALGPLKLKPA HEGLVATVKE AGRSIHEIPR EELRHTPELP 1440 LAPRPLKEGS ITQGTPLKYD TGASTTGSKK HDVRSLIGSP GRTFPPVHPL DVMADARALE 1500 RACYEESLKS RPGTASSSGG SIARGAPVIV PELGKPRQSP LTYEDHGAPF AGHLPRGSPV 1560 TTREPTPRLQ EGSLSSSKAS QDRKLTSTPR EIAKSPHSTV PEHHPHPISP YEHLLRGVSG 1620 VDLYRSHIPL AFDPTSIPRG IPLDAAAAYY LPRHLAPNPT YPHLYPPYLI RGYPDTAALE 1680 NRQTIINDYI TSQQMHHNAA TAMAQRADML RGLSPRESSL ALNYAAGPRG IIDLSQVPHL 1740 PVLVPPTPGT PATAMDRLAY LPTAPQPFSS RHSSSPLSPG GPTHLTKPTT TSSSERERDR 1800 DRERDRDRER EKSILTSTTT VEHAPIWRPG TEQSSGSSGG GGGSSSRPAS HSHAHQHSPI 1860 SPRTQDALQQ RPSVLHNTGM KGIITAVEPS TPTVLRSTST SSPVRPAATF PPATHCPLGG 1920 TLDGVYPTLM EPVLLPKEAP RVARPERPRA DTGHAFLAKP PARSGLEPAS SPSKGSEPRP 1980 LVPPVSGHAT IARTPAKNLA PHHASPDPPA PPASASDPHR EKTQSKPFSI QELELRSLGY 2040 HGSSYSPEGV EPVSPVSSPS LTHDKGLPKH LEELDKSHLE GELRPKQPGP VKLGGEAAHL 2100 PHLRPLPESQ PSSSPLLQTA PGVKGHQRVV TLAQHISEVI TQDYTRHHPQ QLSAPLPAPL 2160 YSFPGASCPV LDLRRPPSDL YLPPPDHGAP ARGSPHSEGG KRSPEPNKTS VLGGGEDGIE 2220 PVSPPEGMTE PGHSRSAVYP LLYRDGEQTE PSRMGSKSPG NTSQPPAFFS KLTESNSAMV 2280 KSKKQEINKK LNTHNRNEPE YNISQPGTEI FNMPAITGTG LMTYRSQAVQ EHASTNMGLE 2340 AIIRKALMGK YDQWEESPPL SANAFNPLNA SASLPAAMPI TAADGRSDHT LTSPGGGGKA 2400 KVSGRPSSRK AKSPAPGLAS GDRPPSVSSV HSEGDCNRRT PLTNRVWEDR PSSAGSTPFP 2460 YNPLIMRLQA GVMASPPPPG LPAGSGPLAG PHHAWDEEPK PLLCSQYETL SDSE 2514 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.