CleftGeneDB-Search

Gene: RFNG

Basic information

Tag	Content
Uniprot ID	Q9Y644; O00588;
Entrez ID	5986
Genbank protein ID	AAD34321.1; AAC51359.1;
Genbank nucleotide ID	NM_002917.1
Ensembl protein ID	ENSP00000307971
Ensembl nucleotide ID	ENSG00000169733
Gene name	Beta-1,3-N-acetylglucosaminyltransferase radical fringe
Gene symbol	RFNG
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Homology search
Reference
Functional description	Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis.
Sequence	MSRARGALCR ACLALAAALA ALLLLPLPLP RAPAPARTPA PAPRAPPSRP AAPSLRPDDV 60 FIAVKTTRKN HGPRLRLLLR TWISRARQQT FIFTDGDDPE LELQGGDRVI NTNCSAVRTR 120 QALCCKMSVE YDKFIESGRK WFCHVDDDNY VNARSLLHLL SSFSPSQDVY LGRPSLDHPI 180 EATERVQGGR TVTTVKFWFA TGGAGFCLSR GLALKMSPWA SLGSFMSTAE QVRLPDDCTV 240 GYIVEGLLGA RLLHSPLFHS HLENLQRLPP DTLLQQVTLS HGGPENPHNV VNVAGGFSLH 300 QDPTRFKSIH CLLYPDTDWC PRQKQGAPTS R 331

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Cleft type	Species	Evidence	Details
1:1 ortholog	RFNG	102178013	A0A452G5I0		Capra hircus	Prediction	More>>
1:1 ortholog	RFNG	5986	Q9Y644		Homo sapiens	Prediction	More>>
1:1 ortholog	Rfng	19719	O09009	CPO	Mus musculus	Publication	More>>
1:1 ortholog	RFNG	747153	A0A2I3RLY5		Pan troglodytes	Prediction	More>>
1:1 ortholog	RFNG		A0A286ZQY8		Sus scrofa	Prediction	More>>
1:1 ortholog	Rfng	60433	Q6P6T7		Rattus norvegicus	Prediction	More>>
1:1 ortholog	rfng	414848	F1QXC7		Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs1198034608	p.Arg3Pro	missense variant	-	NC_000017.11:g.82051759C>G	TOPMed
rs527415468	p.Arg3Cys	missense variant	-	NC_000017.11:g.82051760G>A	1000Genomes,TOPMed,gnomAD
rs1233998350	p.Ala4Pro	missense variant	-	NC_000017.11:g.82051757C>G	TOPMed
rs560366083	p.Ala4Val	missense variant	-	NC_000017.11:g.82051756G>A	1000Genomes
rs1180531087	p.Arg5Leu	missense variant	-	NC_000017.11:g.82051753C>A	TOPMed
rs1481890738	p.Arg5Gly	missense variant	-	NC_000017.11:g.82051754G>C	TOPMed
rs1402999980	p.Leu8Pro	missense variant	-	NC_000017.11:g.82051744A>G	TOPMed,gnomAD
rs1419505389	p.Leu15Met	missense variant	-	NC_000017.11:g.82051724G>T	TOPMed
rs1258024273	p.Ala17Val	missense variant	-	NC_000017.11:g.82051717G>A	gnomAD
rs1463630374	p.Ala17Thr	missense variant	-	NC_000017.11:g.82051718C>T	TOPMed
rs1214392814	p.Ala18Val	missense variant	-	NC_000017.11:g.82051714G>A	gnomAD
rs1271435966	p.Leu19Arg	missense variant	-	NC_000017.11:g.82051711A>C	gnomAD
rs1337114104	p.Leu19Met	missense variant	-	NC_000017.11:g.82051712G>T	gnomAD
rs1475750646	p.Ala21Ser	missense variant	-	NC_000017.11:g.82051706C>A	TOPMed,gnomAD
rs913438528	p.Ala21Val	missense variant	-	NC_000017.11:g.82051705G>A	TOPMed
rs1475750646	p.Ala21Thr	missense variant	-	NC_000017.11:g.82051706C>T	TOPMed,gnomAD
rs988937753	p.Leu22Pro	missense variant	-	NC_000017.11:g.82051702A>G	TOPMed
rs1244335832	p.Pro26Ser	missense variant	-	NC_000017.11:g.82051691G>A	gnomAD
rs1307417817	p.Pro28Ser	missense variant	-	NC_000017.11:g.82051685G>A	gnomAD
rs1208638254	p.Ala32Val	missense variant	-	NC_000017.11:g.82051672G>A	TOPMed
rs985878626	p.Pro35Ser	missense variant	-	NC_000017.11:g.82051664G>A	TOPMed,gnomAD
rs1190461255	p.Pro35Leu	missense variant	-	NC_000017.11:g.82051663G>A	TOPMed
rs985878626	p.Pro35Ala	missense variant	-	NC_000017.11:g.82051664G>C	TOPMed,gnomAD
rs996545970	p.Thr38Pro	missense variant	-	NC_000017.11:g.82051655T>G	TOPMed
rs1216387246	p.Pro39Ser	missense variant	-	NC_000017.11:g.82051652G>A	TOPMed,gnomAD
rs1411088799	p.Ala40Thr	missense variant	-	NC_000017.11:g.82051649C>T	TOPMed
rs954047714	p.Pro41Ala	missense variant	-	NC_000017.11:g.82051646G>C	TOPMed,gnomAD
rs1338785069	p.Pro43Arg	missense variant	-	NC_000017.11:g.82051639G>C	TOPMed
rs1435137340	p.Pro43Thr	missense variant	-	NC_000017.11:g.82051640G>T	TOPMed
rs1399620433	p.Ala45Pro	missense variant	-	NC_000017.11:g.82051634C>G	TOPMed
rs1282102564	p.Ser48Ala	missense variant	-	NC_000017.11:g.82051625A>C	TOPMed,gnomAD
rs1207827870	p.Arg49Trp	missense variant	-	NC_000017.11:g.82051622G>A	TOPMed,gnomAD
rs1162300435	p.Pro50Leu	missense variant	-	NC_000017.11:g.82051618G>A	gnomAD
rs1217495836	p.Pro50Ala	missense variant	-	NC_000017.11:g.82051619G>C	TOPMed
rs1278573828	p.Ala51Pro	missense variant	-	NC_000017.11:g.82051616C>G	TOPMed
rs1364064587	p.Ala52Val	missense variant	-	NC_000017.11:g.82051612G>A	TOPMed,gnomAD
rs767872701	p.Ser54Gly	missense variant	-	NC_000017.11:g.82051607T>C	ExAC,gnomAD
rs767872701	p.Ser54Cys	missense variant	-	NC_000017.11:g.82051607T>A	ExAC,gnomAD
rs1469825762	p.Leu55Pro	missense variant	-	NC_000017.11:g.82051603A>G	gnomAD
rs1209371800	p.Arg56Gln	missense variant	-	NC_000017.11:g.82051600C>T	TOPMed,gnomAD
rs1251246898	p.Arg56Trp	missense variant	-	NC_000017.11:g.82051601G>A	TOPMed,gnomAD
rs1188909073	p.Pro57Leu	missense variant	-	NC_000017.11:g.82051597G>A	TOPMed
rs1015473605	p.Asp58Glu	missense variant	-	NC_000017.11:g.82051593G>C	TOPMed,gnomAD
rs749521395	p.Asp59Gly	missense variant	-	NC_000017.11:g.82051591T>C	ExAC,TOPMed,gnomAD
rs1240906984	p.Asp59Asn	missense variant	-	NC_000017.11:g.82051592C>T	TOPMed,gnomAD
rs1240906984	p.Asp59Tyr	missense variant	-	NC_000017.11:g.82051592C>A	TOPMed,gnomAD
rs1308358715	p.Val60Ile	missense variant	-	NC_000017.11:g.82051589C>T	gnomAD
rs1372480558	p.Ile62Thr	missense variant	-	NC_000017.11:g.82051582A>G	gnomAD
rs1385771186	p.Ala63Thr	missense variant	-	NC_000017.11:g.82051580C>T	gnomAD
rs1302731434	p.Thr67Ser	missense variant	-	NC_000017.11:g.82051567G>C	TOPMed
rs745892405	p.Arg68Trp	missense variant	-	NC_000017.11:g.82051565G>A	ExAC,TOPMed,gnomAD
rs1380077887	p.Asn70Ser	missense variant	-	NC_000017.11:g.82051558T>C	gnomAD
rs757117555	p.Gly72Ala	missense variant	-	NC_000017.11:g.82051552C>G	ExAC,TOPMed,gnomAD
rs1393851694	p.Gly72Arg	missense variant	-	NC_000017.11:g.82051553C>T	TOPMed,gnomAD
rs1448340494	p.Pro73Leu	missense variant	-	NC_000017.11:g.82051549G>A	TOPMed
rs1447717174	p.Pro73Ser	missense variant	-	NC_000017.11:g.82051550G>A	TOPMed,gnomAD
rs747023686	p.Arg74Cys	missense variant	-	NC_000017.11:g.82051547G>A	ExAC,gnomAD
rs1285072186	p.Arg76Gln	missense variant	-	NC_000017.11:g.82051540C>T	gnomAD
rs1273072952	p.Arg80Cys	missense variant	-	NC_000017.11:g.82051529G>A	TOPMed,gnomAD
rs1468915003	p.Arg80His	missense variant	-	NC_000017.11:g.82051528C>T	TOPMed
rs1273072952	p.Arg80Ser	missense variant	-	NC_000017.11:g.82051529G>T	TOPMed,gnomAD
rs1297190275	p.Trp82Ter	stop gained	-	NC_000017.11:g.82051521C>T	gnomAD
rs1297190275	p.Trp82Cys	missense variant	-	NC_000017.11:g.82051521C>G	gnomAD
rs1469464173	p.Ser84Phe	missense variant	-	NC_000017.11:g.82051516G>A	TOPMed
rs758121697	p.Ala86Ser	missense variant	-	NC_000017.11:g.82051511C>A	ExAC,gnomAD
rs1437045911	p.Gln89Ter	stop gained	-	NC_000017.11:g.82051502G>A	gnomAD
rs1015650188	p.Phe91Tyr	missense variant	-	NC_000017.11:g.82051338A>T	TOPMed,gnomAD
rs1186686376	p.Ile92Met	missense variant	-	NC_000017.11:g.82051334G>C	gnomAD
rs1438298807	p.Phe93Leu	missense variant	-	NC_000017.11:g.82051333A>G	gnomAD
rs1227459014	p.Thr94Ser	missense variant	-	NC_000017.11:g.82051329G>C	TOPMed
rs1196198067	p.Asp95Asn	missense variant	-	NC_000017.11:g.82051327C>T	gnomAD
rs776558955	p.Gly96Glu	missense variant	-	NC_000017.11:g.82051323C>T	ExAC,TOPMed,gnomAD
rs1486815513	p.Asp97Gly	missense variant	-	NC_000017.11:g.82051320T>C	TOPMed
rs1324349986	p.Asp98Asn	missense variant	-	NC_000017.11:g.82051318C>T	gnomAD
rs777629635	p.Pro99Ser	missense variant	-	NC_000017.11:g.82051315G>A	ExAC,gnomAD
rs777629635	p.Pro99Ala	missense variant	-	NC_000017.11:g.82051315G>C	ExAC,gnomAD
rs778721960	p.Glu102Asp	missense variant	-	NC_000017.11:g.82051304C>G	ExAC,gnomAD
rs1001889356	p.Glu102Gln	missense variant	-	NC_000017.11:g.82051306C>G	TOPMed,gnomAD
rs1001889356	p.Glu102Lys	missense variant	-	NC_000017.11:g.82051306C>T	TOPMed,gnomAD
rs1376480637	p.Glu102Ala	missense variant	-	NC_000017.11:g.82051305T>G	TOPMed
rs1301910322	p.Gly106Asp	missense variant	-	NC_000017.11:g.82050764C>T	TOPMed,gnomAD
rs200724330	p.Gly106Ser	missense variant	-	NC_000017.11:g.82051294C>T	ESP,ExAC,TOPMed,gnomAD
rs1186692949	p.Asp107Asn	missense variant	-	NC_000017.11:g.82050762C>T	gnomAD
rs1186692949	p.Asp107His	missense variant	-	NC_000017.11:g.82050762C>G	gnomAD
rs766603555	p.Asp107Glu	missense variant	-	NC_000017.11:g.82050760G>C	ExAC,TOPMed,gnomAD
rs756341641	p.Arg108Leu	missense variant	-	NC_000017.11:g.82050758C>A	ExAC,TOPMed,gnomAD
rs756341641	p.Arg108Pro	missense variant	-	NC_000017.11:g.82050758C>G	ExAC,TOPMed,gnomAD
rs756341641	p.Arg108His	missense variant	-	NC_000017.11:g.82050758C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Val109Ile	missense variant	-	NC_000017.11:g.82050756C>T	NCI-TCGA
rs750576013	p.Ile110Val	missense variant	-	NC_000017.11:g.82050753T>C	ExAC,gnomAD
rs1228490734	p.Asn113Ser	missense variant	-	NC_000017.11:g.82050743T>C	TOPMed
rs542353354	p.Ala116Ser	missense variant	-	NC_000017.11:g.82050735C>A	1000Genomes,ExAC,gnomAD
rs761935342	p.Ala116Val	missense variant	-	NC_000017.11:g.82050734G>A	ExAC,TOPMed,gnomAD
rs146133084	p.Val117Met	missense variant	-	NC_000017.11:g.82050732C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs762755184	p.Arg118His	missense variant	-	NC_000017.11:g.82050728C>T	ExAC,TOPMed,gnomAD
rs761938920	p.Arg118Cys	missense variant	-	NC_000017.11:g.82050729G>A	ExAC,TOPMed,gnomAD
rs1464499396	p.Thr119Ser	missense variant	-	NC_000017.11:g.82050725G>C	TOPMed,gnomAD
rs1464499396	p.Thr119Ile	missense variant	-	NC_000017.11:g.82050725G>A	TOPMed,gnomAD
rs1170495071	p.Arg120His	missense variant	-	NC_000017.11:g.82050722C>T	gnomAD
rs769649627	p.Arg120Cys	missense variant	-	NC_000017.11:g.82050723G>A	ExAC,TOPMed,gnomAD
rs1466791581	p.Gln121Ter	stop gained	-	NC_000017.11:g.82050720G>A	gnomAD
rs1190575655	p.Ala122Val	missense variant	-	NC_000017.11:g.82050716G>A	TOPMed
rs1192489412	p.Leu123Phe	missense variant	-	NC_000017.11:g.82050714G>A	gnomAD
rs1453963563	p.Cys124Tyr	missense variant	-	NC_000017.11:g.82050710C>T	TOPMed
rs368526938	p.Cys125Tyr	missense variant	-	NC_000017.11:g.82050707C>T	ESP,ExAC,TOPMed,gnomAD
rs777107462	p.Met127Thr	missense variant	-	NC_000017.11:g.82050701A>G	ExAC,gnomAD
rs769227376	p.Met127Ile	missense variant	-	NC_000017.11:g.82050700C>T	ExAC,gnomAD
rs148620643	p.Ser128Ala	missense variant	-	NC_000017.11:g.82050699A>C	ESP,ExAC,TOPMed,gnomAD
rs1316161607	p.Val129Leu	missense variant	-	NC_000017.11:g.82050696C>G	gnomAD
rs750770009	p.Glu130Ala	missense variant	-	NC_000017.11:g.82050692T>G	ExAC,gnomAD
rs756535894	p.Glu130Ter	stop gained	-	NC_000017.11:g.82050693C>A	ExAC,TOPMed,gnomAD
rs756535894	p.Glu130Lys	missense variant	-	NC_000017.11:g.82050693C>T	ExAC,TOPMed,gnomAD
rs750770009	p.Glu130Gly	missense variant	-	NC_000017.11:g.82050692T>C	ExAC,gnomAD
COSM4828897	p.Asp132Asn	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000017.11:g.82050687C>T	NCI-TCGA Cosmic
rs764025962	p.Ile135Leu	missense variant	-	NC_000017.11:g.82050678T>G	ExAC,gnomAD
rs1298735833	p.Gly138Arg	missense variant	-	NC_000017.11:g.82050669C>T	TOPMed,gnomAD
rs1298735833	p.Gly138Arg	missense variant	-	NC_000017.11:g.82050669C>G	TOPMed,gnomAD
rs1169457660	p.Arg139His	missense variant	-	NC_000017.11:g.82050665C>T	gnomAD
rs1169457660	p.Arg139Leu	missense variant	-	NC_000017.11:g.82050665C>A	gnomAD
rs931541025	p.Arg139Cys	missense variant	-	NC_000017.11:g.82050666G>A	gnomAD
rs931541025	p.Arg139Ser	missense variant	-	NC_000017.11:g.82050666G>T	gnomAD
rs887192632	p.Trp141Ter	stop gained	-	NC_000017.11:g.82050552C>T	TOPMed
rs1360433612	p.His144Tyr	missense variant	-	NC_000017.11:g.82050545G>A	gnomAD
rs1467589494	p.Val145Met	missense variant	-	NC_000017.11:g.82050542C>T	gnomAD
rs1198312278	p.Asp147Tyr	missense variant	-	NC_000017.11:g.82050536C>A	gnomAD
rs1301001479	p.Asp147Gly	missense variant	-	NC_000017.11:g.82050535T>C	gnomAD
rs1229436243	p.Val151Met	missense variant	-	NC_000017.11:g.82050524C>T	TOPMed
rs112510774	p.Asn152Lys	missense variant	-	NC_000017.11:g.82050519G>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs202206613	p.Ala153Ser	missense variant	-	NC_000017.11:g.82050518C>A	ExAC,TOPMed,gnomAD
rs202206613	p.Ala153Thr	missense variant	-	NC_000017.11:g.82050518C>T	ExAC,TOPMed,gnomAD
rs767113527	p.Ala153Val	missense variant	-	NC_000017.11:g.82050517G>A	ExAC,gnomAD
rs202206613	p.Ala153Pro	missense variant	-	NC_000017.11:g.82050518C>G	ExAC,TOPMed,gnomAD
rs762449053	p.Arg154Lys	missense variant	-	NC_000017.11:g.82050514C>T	ExAC,TOPMed,gnomAD
rs763532196	p.Arg154Gly	missense variant	-	NC_000017.11:g.82050515T>C	ExAC,TOPMed,gnomAD
rs762449053	p.Arg154Thr	missense variant	-	NC_000017.11:g.82050514C>G	ExAC,TOPMed,gnomAD
rs771449990	p.Ser155Arg	missense variant	-	NC_000017.11:g.82050510G>C	ExAC,TOPMed,gnomAD
rs777184292	p.Ser155Asn	missense variant	-	NC_000017.11:g.82050511C>T	ExAC,TOPMed,gnomAD
rs747375805	p.Leu157Arg	missense variant	-	NC_000017.11:g.82050505A>C	ExAC,TOPMed,gnomAD
rs200562205	p.His158Tyr	missense variant	-	NC_000017.11:g.82050503G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1390390090	p.His158Arg	missense variant	-	NC_000017.11:g.82050502T>C	TOPMed
NCI-TCGA novel	p.Leu160Pro	missense variant	-	NC_000017.11:g.82050496A>G	NCI-TCGA
rs748322743	p.Leu160Phe	missense variant	-	NC_000017.11:g.82050497G>A	ExAC,gnomAD
rs755173803	p.Ser162Gly	missense variant	-	NC_000017.11:g.82050491T>C	ExAC,gnomAD
rs1425984583	p.Ser162Thr	missense variant	-	NC_000017.11:g.82050490C>G	gnomAD
rs377391019	p.Phe163Leu	missense variant	-	NC_000017.11:g.82050486G>C	ESP,ExAC,TOPMed,gnomAD
rs750212566	p.Pro165Ser	missense variant	-	NC_000017.11:g.82050482G>A	ExAC,gnomAD
rs751283445	p.Ser166Arg	missense variant	-	NC_000017.11:g.82050479T>G	ExAC,gnomAD
rs751283445	p.Ser166Gly	missense variant	-	NC_000017.11:g.82050479T>C	ExAC,gnomAD
rs1263039126	p.Asp168Asn	missense variant	-	NC_000017.11:g.82050473C>T	gnomAD
rs372993379	p.Val169Phe	missense variant	-	NC_000017.11:g.82050470C>A	ESP,ExAC,TOPMed,gnomAD
rs372993379	p.Val169Ile	missense variant	-	NC_000017.11:g.82050470C>T	ESP,ExAC,TOPMed,gnomAD
rs1216444133	p.Tyr170His	missense variant	-	NC_000017.11:g.82050467A>G	gnomAD
rs762263833	p.Arg173Gln	missense variant	-	NC_000017.11:g.82050457C>T	ExAC,TOPMed,gnomAD
rs564843474	p.Arg173Trp	missense variant	-	NC_000017.11:g.82050458G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs1334105403	p.Pro174Ser	missense variant	-	NC_000017.11:g.82050455G>A	gnomAD
rs1334105403	p.Pro174Thr	missense variant	-	NC_000017.11:g.82050455G>T	gnomAD
rs1248151294	p.Pro174Leu	missense variant	-	NC_000017.11:g.82050454G>A	TOPMed
rs112436072	p.Ser175Arg	missense variant	-	NC_000017.11:g.82050450G>C	gnomAD
rs768976736	p.Ser175Gly	missense variant	-	NC_000017.11:g.82050452T>C	ExAC,gnomAD
rs749417094	p.Asp177His	missense variant	-	NC_000017.11:g.82050446C>G	ExAC,gnomAD
rs780139221	p.Asp177Glu	missense variant	-	NC_000017.11:g.82050444G>T	ExAC,gnomAD
rs1178773217	p.Ile180Thr	missense variant	-	NC_000017.11:g.82050436A>G	TOPMed
rs1435072417	p.Glu181Lys	missense variant	-	NC_000017.11:g.82050434C>T	TOPMed
rs757105853	p.Ala182Val	missense variant	-	NC_000017.11:g.82050430G>A	ExAC,TOPMed,gnomAD
rs1186755783	p.Ala182Thr	missense variant	-	NC_000017.11:g.82050431C>T	TOPMed,gnomAD
rs751336435	p.Thr183Ala	missense variant	-	NC_000017.11:g.82050428T>C	ExAC,gnomAD
rs777445595	p.Thr183Ile	missense variant	-	NC_000017.11:g.82050427G>A	ExAC,gnomAD
rs370119266	p.Glu184Gln	missense variant	-	NC_000017.11:g.82050425C>G	ESP,ExAC,TOPMed,gnomAD
rs370119266	p.Glu184Lys	missense variant	-	NC_000017.11:g.82050425C>T	ESP,ExAC,TOPMed,gnomAD
rs1354698492	p.Val186Phe	missense variant	-	NC_000017.11:g.82050419C>A	gnomAD
rs1354698492	p.Val186Ile	missense variant	-	NC_000017.11:g.82050419C>T	gnomAD
rs761090207	p.Gln187Ter	stop gained	-	NC_000017.11:g.82050416G>A	ExAC,TOPMed,gnomAD
rs1241537000	p.Gln187Arg	missense variant	-	NC_000017.11:g.82050415T>C	gnomAD
NCI-TCGA novel	p.Gln187His	missense variant	-	NC_000017.11:g.82050414C>A	NCI-TCGA
rs751005205	p.Gly188Ser	missense variant	-	NC_000017.11:g.82050413C>T	ExAC,gnomAD
rs1446214395	p.Arg190Lys	missense variant	-	NC_000017.11:g.82050406C>T	gnomAD
rs375758380	p.Thr191Ile	missense variant	-	NC_000017.11:g.82050403G>A	ESP,ExAC,TOPMed,gnomAD
rs778468309	p.Val192Met	missense variant	-	NC_000017.11:g.82050006C>T	ExAC
rs753131665	p.Thr194Met	missense variant	-	NC_000017.11:g.82049999G>A	ExAC,TOPMed,gnomAD
rs755235445	p.Val195Ile	missense variant	-	NC_000017.11:g.82049997C>T	ExAC,gnomAD
rs147282261	p.Lys196Asn	missense variant	-	NC_000017.11:g.82049992C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs767519998	p.Trp198Ter	stop gained	-	NC_000017.11:g.82049986C>T	ExAC,gnomAD
rs1340261964	p.Trp198Ser	missense variant	-	NC_000017.11:g.82049987C>G	TOPMed
rs761603203	p.Phe199Leu	missense variant	-	NC_000017.11:g.82049985A>G	ExAC,gnomAD
rs1466842745	p.Phe199Tyr	missense variant	-	NC_000017.11:g.82049984A>T	gnomAD
rs1450256074	p.Ala200Gly	missense variant	-	NC_000017.11:g.82049981G>C	TOPMed,gnomAD
rs774207300	p.Thr201Ile	missense variant	-	NC_000017.11:g.82049978G>A	ExAC,gnomAD
rs1424772863	p.Gly202Asp	missense variant	-	NC_000017.11:g.82049975C>T	TOPMed,gnomAD
rs1482917544	p.Gly205Arg	missense variant	-	NC_000017.11:g.82049967C>T	TOPMed
rs769544939	p.Gly205Glu	missense variant	-	NC_000017.11:g.82049966C>T	ExAC,TOPMed,gnomAD
rs201812335	p.Cys207Ser	missense variant	-	NC_000017.11:g.82049960C>G	ESP,ExAC,TOPMed,gnomAD
rs201812335	p.Cys207Tyr	missense variant	-	NC_000017.11:g.82049960C>T	ESP,ExAC,TOPMed,gnomAD
rs1251022459	p.Leu208His	missense variant	-	NC_000017.11:g.82049957A>T	gnomAD
rs779473081	p.Ser209Arg	missense variant	-	NC_000017.11:g.82049953G>C	ExAC,gnomAD
rs1411996467	p.Ser209Ile	missense variant	-	NC_000017.11:g.82049954C>A	TOPMed
rs755357276	p.Arg210Gly	missense variant	-	NC_000017.11:g.82049952T>C	ExAC,gnomAD
rs754177910	p.Gly211Asp	missense variant	-	NC_000017.11:g.82049948C>T	ExAC,TOPMed,gnomAD
rs754177910	p.Gly211Val	missense variant	-	NC_000017.11:g.82049948C>A	ExAC,TOPMed,gnomAD
rs767226162	p.Leu212Phe	missense variant	-	NC_000017.11:g.82049946G>A	gnomAD
NCI-TCGA novel	p.Ala213Val	missense variant	-	NC_000017.11:g.82049942G>A	NCI-TCGA
rs767434700	p.Leu214Phe	missense variant	-	NC_000017.11:g.82049940G>A	ExAC,gnomAD
rs761810901	p.Lys215Glu	missense variant	-	NC_000017.11:g.82049937T>C	ExAC,gnomAD
rs751515518	p.Ser217Arg	missense variant	-	NC_000017.11:g.82049929G>C	ExAC,gnomAD
rs1044444069	p.Pro218Leu	missense variant	-	NC_000017.11:g.82049927G>A	TOPMed,gnomAD
rs1304617958	p.Pro218Thr	missense variant	-	NC_000017.11:g.82049928G>T	TOPMed
rs1444533773	p.Trp219Gly	missense variant	-	NC_000017.11:g.82049925A>C	gnomAD
rs1381552424	p.Trp219Ter	stop gained	-	NC_000017.11:g.82049923C>T	gnomAD
rs764075934	p.Ala220Thr	missense variant	-	NC_000017.11:g.82049922C>T	ExAC,gnomAD
rs757464403	p.Gly223Ser	missense variant	-	NC_000017.11:g.82049838C>T	ExAC,gnomAD
rs1376068755	p.Met226Val	missense variant	-	NC_000017.11:g.82049829T>C	gnomAD
rs1176019611	p.Ser227Asn	missense variant	-	NC_000017.11:g.82049825C>T	gnomAD
rs1017363835	p.Glu230Lys	missense variant	-	NC_000017.11:g.82049817C>T	TOPMed,gnomAD
rs1195631810	p.Gln231Ter	stop gained	-	NC_000017.11:g.82049814G>A	gnomAD
rs1202124625	p.Val232Met	missense variant	-	NC_000017.11:g.82049811C>T	TOPMed
rs758418861	p.Arg233Gln	missense variant	-	NC_000017.11:g.82049807C>T	ExAC,gnomAD
rs534584318	p.Arg233Trp	missense variant	-	NC_000017.11:g.82049808G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs752750346	p.Pro235Ala	missense variant	-	NC_000017.11:g.82049802G>C	ExAC,gnomAD
rs765253576	p.Pro235Leu	missense variant	-	NC_000017.11:g.82049801G>A	ExAC,TOPMed,gnomAD
rs1222545975	p.Asp237Glu	missense variant	-	NC_000017.11:g.82049794G>C	gnomAD
NCI-TCGA novel	p.Asp237Asn	missense variant	-	NC_000017.11:g.82049796C>T	NCI-TCGA
rs753639592	p.Thr239Ala	missense variant	-	NC_000017.11:g.82049790T>C	ExAC,TOPMed,gnomAD
rs1225778807	p.Tyr242Cys	missense variant	-	NC_000017.11:g.82049780T>C	gnomAD
rs1326343841	p.Ile243Val	missense variant	-	NC_000017.11:g.82049778T>C	gnomAD
rs765977318	p.Val244Met	missense variant	-	NC_000017.11:g.82049775C>T	ExAC,TOPMed,gnomAD
NCI-TCGA novel	p.Glu245Val	missense variant	-	NC_000017.11:g.82049771T>A	NCI-TCGA
rs899061044	p.Leu248Pro	missense variant	-	NC_000017.11:g.82049762A>G	gnomAD
rs761303825	p.Gly249Asp	missense variant	-	NC_000017.11:g.82049759C>T	ExAC,gnomAD
rs770261294	p.Ala250Thr	missense variant	-	NC_000017.11:g.82049757C>T	ExAC,TOPMed,gnomAD
rs1424987754	p.Ala250Val	missense variant	-	NC_000017.11:g.82049756G>A	gnomAD
rs771075644	p.Arg251Cys	missense variant	-	NC_000017.11:g.82049754G>A	ExAC,gnomAD
rs747191255	p.Arg251His	missense variant	-	NC_000017.11:g.82049753C>T	ExAC,TOPMed,gnomAD
rs771075644	p.Arg251Ser	missense variant	-	NC_000017.11:g.82049754G>T	ExAC,gnomAD
rs1239545201	p.His254Arg	missense variant	-	NC_000017.11:g.82049744T>C	gnomAD
rs1339173511	p.Pro256Leu	missense variant	-	NC_000017.11:g.82049738G>A	gnomAD
rs772335800	p.Pro256Ser	missense variant	-	NC_000017.11:g.82049739G>A	ExAC,TOPMed,gnomAD
rs1247601504	p.Leu257His	missense variant	-	NC_000017.11:g.82049735A>T	gnomAD
NCI-TCGA novel	p.Leu257Ile	missense variant	-	NC_000017.11:g.82049736G>T	NCI-TCGA
rs1225153063	p.Phe258Leu	missense variant	-	NC_000017.11:g.82049733A>G	TOPMed
rs1250112433	p.His259Asn	missense variant	-	NC_000017.11:g.82049730G>T	TOPMed
rs1012968896	p.His261Gln	missense variant	-	NC_000017.11:g.82049722G>C	TOPMed,gnomAD
rs368469722	p.Arg267Lys	missense variant	-	NC_000017.11:g.82049705C>T	ESP,ExAC,TOPMed,gnomAD
rs1383377005	p.Pro269Leu	missense variant	-	NC_000017.11:g.82049699G>A	TOPMed,gnomAD
rs1426835718	p.Pro270Leu	missense variant	-	NC_000017.11:g.82049696G>A	TOPMed
rs1239545635	p.Asp271Asn	missense variant	-	NC_000017.11:g.82049694C>T	gnomAD
rs370979534	p.Thr278Ile	missense variant	-	NC_000017.11:g.82049112G>A	ESP,ExAC,TOPMed,gnomAD
rs750384196	p.Thr278Ala	missense variant	-	NC_000017.11:g.82049113T>C	ExAC,TOPMed,gnomAD
rs1243956307	p.His281Tyr	missense variant	-	NC_000017.11:g.82049104G>A	TOPMed
rs1425036581	p.His281Arg	missense variant	-	NC_000017.11:g.82049103T>C	gnomAD
rs1187640863	p.Gly283Ser	missense variant	-	NC_000017.11:g.82049098C>T	gnomAD
rs774244196	p.Pro284Ser	missense variant	-	NC_000017.11:g.82049095G>A	ExAC,gnomAD
rs762633441	p.Glu285Gln	missense variant	-	NC_000017.11:g.82049092C>G	ExAC,TOPMed
rs762633441	p.Glu285Ter	stop gained	-	NC_000017.11:g.82049092C>A	ExAC,TOPMed
rs775279163	p.Asn286Lys	missense variant	-	NC_000017.11:g.82049087G>C	ExAC,TOPMed,gnomAD
rs143662745	p.Pro287Ala	missense variant	-	NC_000017.11:g.82049086G>C	ESP,ExAC,TOPMed,gnomAD
rs143662745	p.Pro287Ser	missense variant	-	NC_000017.11:g.82049086G>A	ESP,ExAC,TOPMed,gnomAD
rs1265250180	p.Pro287Arg	missense variant	-	NC_000017.11:g.82049085G>C	gnomAD
rs74659471	p.His288Arg	missense variant	-	NC_000017.11:g.82049082T>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs12948507	p.His288Gln	missense variant	-	NC_000017.11:g.82049081A>C	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs12948507	p.His288Gln	missense variant	-	NC_000017.11:g.82049081A>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs201463115	p.Val290Met	missense variant	-	NC_000017.11:g.82049077C>T	1000Genomes,ExAC,TOPMed,gnomAD
rs1267878963	p.Val291Gly	missense variant	-	NC_000017.11:g.82049073A>C	TOPMed,gnomAD
rs1364073477	p.Val291Met	missense variant	-	NC_000017.11:g.82049074C>T	TOPMed,gnomAD
rs377490634	p.Val293Leu	missense variant	-	NC_000017.11:g.82049068C>G	ESP,TOPMed,gnomAD
rs377490634	p.Val293Met	missense variant	-	NC_000017.11:g.82049068C>T	ESP,TOPMed,gnomAD
rs755199513	p.Ala294Val	missense variant	-	NC_000017.11:g.82049064G>A	ExAC,TOPMed
rs373836166	p.Ala294Thr	missense variant	-	NC_000017.11:g.82049065C>T	ESP
rs755199513	p.Ala294Gly	missense variant	-	NC_000017.11:g.82049064G>C	ExAC,TOPMed
rs1338333976	p.Gly295Glu	missense variant	-	NC_000017.11:g.82049061C>T	gnomAD
rs749577038	p.Gly296Asp	missense variant	-	NC_000017.11:g.82049058C>T	ExAC,gnomAD
NCI-TCGA novel	p.Gly296Ser	missense variant	-	NC_000017.11:g.82049059C>T	NCI-TCGA
rs1322101427	p.Phe297Val	missense variant	-	NC_000017.11:g.82049056A>C	TOPMed
rs750480756	p.Ser298Arg	missense variant	-	NC_000017.11:g.82049051G>C	ExAC,TOPMed,gnomAD
rs1418062884	p.Leu299Val	missense variant	-	NC_000017.11:g.82049050G>C	gnomAD
rs143745130	p.His300Pro	missense variant	-	NC_000017.11:g.82049046T>G	1000Genomes,ExAC,TOPMed,gnomAD
rs751411901	p.His300Tyr	missense variant	-	NC_000017.11:g.82049047G>A	ExAC,TOPMed,gnomAD
rs762830482	p.Gln301Ter	stop gained	-	NC_000017.11:g.82049044G>A	ExAC,gnomAD
rs145447246	p.Asp302Glu	missense variant	-	NC_000017.11:g.82049039G>T	ESP,ExAC,TOPMed,gnomAD
rs1483070373	p.Asp302Val	missense variant	-	NC_000017.11:g.82049040T>A	gnomAD
rs997941687	p.Pro303Leu	missense variant	-	NC_000017.11:g.82049037G>A	gnomAD
rs997941687	p.Pro303His	missense variant	-	NC_000017.11:g.82049037G>T	gnomAD
rs1205025770	p.Thr304Ala	missense variant	-	NC_000017.11:g.82049035T>C	gnomAD
rs138202141	p.Arg305Trp	missense variant	-	NC_000017.11:g.82049032G>A	ESP,ExAC,TOPMed,gnomAD
rs1027817427	p.Arg305Gln	missense variant	-	NC_000017.11:g.82049031C>T	TOPMed,gnomAD
rs1027817427	p.Arg305Leu	missense variant	-	NC_000017.11:g.82049031C>A	TOPMed,gnomAD
rs771239830	p.Ile309Leu	missense variant	-	NC_000017.11:g.82048797T>G	ExAC,TOPMed,gnomAD
rs1310473479	p.Ile309Asn	missense variant	-	NC_000017.11:g.82048796A>T	TOPMed,gnomAD
rs771239830	p.Ile309Val	missense variant	-	NC_000017.11:g.82048797T>C	ExAC,TOPMed,gnomAD
rs1470129785	p.His310Tyr	missense variant	-	NC_000017.11:g.82048794G>A	gnomAD
rs755250241	p.Leu312Phe	missense variant	-	NC_000017.11:g.82048788G>A	TOPMed,gnomAD
rs777945991	p.Pro315Ser	missense variant	-	NC_000017.11:g.82048779G>A	ExAC,TOPMed,gnomAD
rs777945991	p.Pro315Ala	missense variant	-	NC_000017.11:g.82048779G>C	ExAC,TOPMed,gnomAD
rs1314828121	p.Pro315Gln	missense variant	-	NC_000017.11:g.82048778G>T	TOPMed
rs1451887978	p.Asp316His	missense variant	-	NC_000017.11:g.82048776C>G	TOPMed,gnomAD
rs778704463	p.Thr317Met	missense variant	-	NC_000017.11:g.82048772G>A	ExAC,TOPMed,gnomAD
rs778704463	p.Thr317Arg	missense variant	-	NC_000017.11:g.82048772G>C	ExAC,TOPMed,gnomAD
rs1187821563	p.Thr317Ala	missense variant	-	NC_000017.11:g.82048773T>C	gnomAD
rs1326127269	p.Trp319Ter	stop gained	-	NC_000017.11:g.82048766C>T	gnomAD
rs1204661259	p.Trp319Arg	missense variant	-	NC_000017.11:g.82048767A>T	gnomAD
rs1437310602	p.Cys320Tyr	missense variant	-	NC_000017.11:g.82048763C>T	TOPMed
rs753542213	p.Pro321Ala	missense variant	-	NC_000017.11:g.82048761G>C	ExAC,TOPMed,gnomAD
rs1460176868	p.Arg322Lys	missense variant	-	NC_000017.11:g.82048757C>T	TOPMed
rs755709933	p.Gln323Ter	stop gained	-	NC_000017.11:g.82048755G>A	ExAC,gnomAD
rs1045904695	p.Gln325Glu	missense variant	-	NC_000017.11:g.82048749G>C	TOPMed,gnomAD
rs1045904695	p.Gln325Ter	stop gained	-	NC_000017.11:g.82048749G>A	TOPMed,gnomAD
rs749948798	p.Gly326Ser	missense variant	-	NC_000017.11:g.82048746C>T	ExAC,gnomAD
rs144203478	p.Ala327Thr	missense variant	-	NC_000017.11:g.82048743C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs367653769	p.Pro328Leu	missense variant	-	NC_000017.11:g.82048739G>A	ESP,ExAC,TOPMed,gnomAD
rs1054503623	p.Thr329Ile	missense variant	-	NC_000017.11:g.82048736G>A	TOPMed
rs776812647	p.Arg331Trp	missense variant	-	NC_000017.11:g.82048731G>A	ExAC,TOPMed,gnomAD
rs766721516	p.Arg331Gln	missense variant	-	NC_000017.11:g.82048730C>T	ExAC,TOPMed,gnomAD
rs776812647	p.Arg331Gly	missense variant	-	NC_000017.11:g.82048731G>C	ExAC,TOPMed,gnomAD
rs150121399	p.Ter332Cys	stop lost	-	NC_000017.11:g.82048726T>G	ESP,ExAC,gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0043094	Weight Gain	phenotype	CTD_human
C0338831	Manic	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0003674	molecular_function	ND
GO:0008375	acetylglucosaminyltransferase activity	IBA
GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity	IBA
GO:0046872	metal ion binding	IEA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0007389	pattern specification process	IEA
GO:0007399	nervous system development	IEA
GO:0008593	regulation of Notch signaling pathway	ISS
GO:0008593	regulation of Notch signaling pathway	IBA
GO:0009887	animal organ morphogenesis	NAS
GO:0030154	cell differentiation	IEA
GO:0032092	positive regulation of protein binding	IEA
GO:0036066	protein O-linked fucosylation	ISS
GO:0036066	protein O-linked fucosylation	IBA
GO:0045747	positive regulation of Notch signaling pathway	IEA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	NAS
GO:0030173	integral component of Golgi membrane	IEA

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-157118	Signaling by NOTCH	IEA
R-HSA-162582	Signal Transduction	IEA
R-HSA-1912420	Pre-NOTCH Processing in Golgi	IEA
R-HSA-1912422	Pre-NOTCH Expression and Processing	IEA

Drugs and compounds information

ID	Drug Name	Action	PubMed
D020001	1-Butanol	[[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of RFNG mRNA	29432896
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RFNG mRNA	28628672
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of RFNG mRNA	24810058
C511295	2,2',4,4'-tetrabromodiphenyl ether	2,2',4,4'-tetrabromodiphenyl ether results in increased expression of RFNG mRNA	27291303
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of RFNG mRNA	19770486
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of RFNG mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of RFNG gene	25304211
D017638	Asbestos, Crocidolite	Asbestos, Crocidolite results in increased expression of RFNG mRNA	29523930
D001280	Atrazine	Atrazine results in increased expression of RFNG mRNA	25929836
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of RFNG mRNA	22228805
C006780	bisphenol A	bisphenol A affects the expression of RFNG mRNA	21786754
C006780	bisphenol A	bisphenol A results in decreased methylation of RFNG intron	30906313
C006780	bisphenol A	bisphenol A results in decreased methylation of RFNG promoter	27312807
C006780	bisphenol A	bisphenol A results in increased methylation of RFNG gene	28505145
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RFNG mRNA	28628672
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of RFNG mRNA	27392435
D016572	Cyclosporine	Cyclosporine results in decreased expression of RFNG mRNA	25562108
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in increased expression of RFNG mRNA	23640034
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RFNG mRNA	28628672
D004041	Dietary Fats	Dietary Fats results in decreased expression of RFNG mRNA	19030233
D004041	Dietary Fats	Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RFNG mRNA]	19030233
D004317	Doxorubicin	Doxorubicin results in decreased expression of RFNG mRNA	29803840
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RFNG mRNA	17942748
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of RFNG mRNA	23649840
D005742	Gasoline	[[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of RFNG mRNA	29432896
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of RFNG mRNA	28628672
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of RFNG mRNA	27392435
C544151	jinfukang	jinfukang results in increased expression of RFNG mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of RFNG mRNA	23086925
D037742	Nanotubes, Carbon	Nanotubes, Carbon results in decreased expression of RFNG mRNA	25620056
C022838	nickel chloride	nickel chloride affects the expression of RFNG mRNA	22110744
C028007	nickel monoxide	nickel monoxide results in increased expression of RFNG mRNA	19167457
D052638	Particulate Matter	[[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of RFNG mRNA	29432896
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of RFNG mRNA]	19482888
D010634	Phenobarbital	Phenobarbital results in decreased expression of RFNG mRNA	19482888
C006253	pirinixic acid	pirinixic acid results in decreased expression of RFNG mRNA	17426115
D011084	Polycyclic Aromatic Hydrocarbons	[[Gasoline co-treated with 1-Butanol] results in increased chemical synthesis of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of RFNG mRNA	29432896
D011794	Quercetin	Quercetin results in increased expression of RFNG mRNA	21632981
D000077285	Rimonabant	Rimonabant affects the expression of RFNG mRNA	19030233
D000077285	Rimonabant	Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of RFNG mRNA]	19030233
C017947	sodium arsenite	sodium arsenite results in decreased expression of RFNG mRNA	29361514
D000077210	Sunitinib	Sunitinib results in increased expression of RFNG mRNA	31533062
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RFNG mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of RFNG mRNA	26290441
D013750	Tetrachloroethylene	Tetrachloroethylene results in decreased expression of RFNG mRNA	28973375
D019284	Thapsigargin	Thapsigargin results in increased expression of RFNG mRNA	22378314
D014415	Tunicamycin	Tunicamycin results in increased expression of RFNG mRNA	22378314
D014635	Valproic Acid	Valproic Acid results in increased methylation of RFNG gene	29154799
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of RFNG gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of RFNG mRNA	19015723
D014810	Vitamin E	Vitamin E results in increased expression of RFNG mRNA	19244175

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0217	Developmental protein
KW-0221	Differentiation
KW-1015	Disulfide bond
KW-0325	Glycoprotein
KW-0328	Glycosyltransferase
KW-0333	Golgi apparatus
KW-0464	Manganese
KW-0472	Membrane
KW-0479	Metal-binding
KW-0524	Neurogenesis
KW-1185	Reference proteome
KW-0735	Signal-anchor
KW-0808	Transferase
KW-0812	Transmembrane
KW-1133	Transmembrane helix

Interpro

InterPro ID	InterPro Term
IPR017374	Fringe
IPR003378	Fringe-like

PROSITE

PROSITE ID	PROSITE Term

Pfam

Pfam ID	Pfam Term
PF02434	Fringe