CleftGeneDB-Search

Gene: WNT6

Basic information

Tag	Content
Uniprot ID	Q9Y6F9; Q9H1J6; Q9H238;
Entrez ID	7475
Genbank protein ID	AAG38661.1; AAP36124.1; BAB55603.1; AAH04329.1; AAG45154.1; AAD41674.1;
Genbank nucleotide ID	NM_006522.3
Ensembl protein ID	ENSP00000233948
Ensembl nucleotide ID	ENSG00000115596
Gene name	Protein Wnt-6
Gene symbol	WNT6
Organism	Homo sapiens
NCBI taxa ID	9606
Cleft type
Developmental stage
Data sources	Manually collected
Reference	16953426
Functional description	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.
Sequence	MLPPLPSRLG LLLLLLLCPA HVGGLWWAVG SPLVMDPTSI CRKARRLAGR QAELCQAEPE 60 VVAELARGAR LGVRECQFQF RFRRWNCSSH SKAFGRILQQ DIRETAFVFA ITAAGASHAV 120 TQACSMGELL QCGCQAPRGR APPRPSGLPG TPGPPGPAGS PEGSAAWEWG GCGDDVDFGD 180 EKSRLFMDAR HKRGRGDIRA LVQLHNNEAG RLAVRSHTRT ECKCHGLSGS CALRTCWQKL 240 PPFREVGARL LERFHGASRV MGTNDGKALL PAVRTLKPPG RADLLYAADS PDFCAPNRRT 300 GSPGTRGRAC NSSAPDLSGC DLLCCGRGHR QESVQLEENC LCRFHWCCVV QCHRCRVRKE 360 LSLCL 365

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation	Gene symbol	Entrez ID	UniProt ID	Developmental stage	Species	Evidence	Details
1:1 ortholog	WNT6	505075	F1MN70		Bos taurus	Prediction	More>>
1:1 ortholog	WNT6		A0A452FTD5		Capra hircus	Prediction	More>>
1:1 ortholog	WNT6	7475	Q9Y6F9		Homo sapiens	Publication	More>>
1:1 ortholog	Wnt6	22420	P22727	E14.5	Mus musculus	Prediction	More>>
1:1 ortholog	WNT6	742467	A0A2I3SR43		Pan troglodytes	Prediction	More>>
1:1 ortholog	WNT6		A0A287BRH3		Sus scrofa	Prediction	More>>
1:1 ortholog	WNT6		G1TQH3		Oryctolagus cuniculus	Prediction	More>>
1:1 ortholog	Wnt6	316526	D4A3W9		Rattus norvegicus	Prediction	More>>
1:1 ortholog	wnt6b		F1RAB5		Danio rerio	Prediction	More>>

Other genetic variants/mutations

ID	Variant	Type	Disease	Chromosome\Coordinate	Evidence
rs1340798671	p.Leu2Met	missense variant	-	NC_000002.12:g.218860041C>A	TOPMed
rs1199015326	p.Pro3Thr	missense variant	-	NC_000002.12:g.218860044C>A	TOPMed,gnomAD
rs1195489024	p.Ser7Cys	missense variant	-	NC_000002.12:g.218860057C>G	TOPMed,gnomAD
rs1424085664	p.Arg8Cys	missense variant	-	NC_000002.12:g.218860059C>T	TOPMed,gnomAD
rs1197189059	p.Leu11Gln	missense variant	-	NC_000002.12:g.218860069T>A	TOPMed
rs1392847695	p.Leu13Pro	missense variant	-	NC_000002.12:g.218860075T>C	gnomAD
rs1407136575	p.Leu15Pro	missense variant	-	NC_000002.12:g.218860081T>C	gnomAD
rs1440637041	p.Leu16Phe	missense variant	-	NC_000002.12:g.218860083C>T	TOPMed,gnomAD
rs1398389545	p.Pro19Ser	missense variant	-	NC_000002.12:g.218860092C>T	gnomAD
rs1369314126	p.Ala20Val	missense variant	-	NC_000002.12:g.218860096C>T	gnomAD
rs1031355350	p.Gly23Asp	missense variant	-	NC_000002.12:g.218860105G>A	TOPMed
rs1341507897	p.Gly24Arg	missense variant	-	NC_000002.12:g.218860107G>C	gnomAD
rs1359103727	p.Trp26Ter	stop gained	-	NC_000002.12:g.218860115G>A	gnomAD
rs1209872593	p.Trp27Leu	missense variant	-	NC_000002.12:g.218860117G>T	gnomAD
COSM3577819	p.Trp27Ter	stop gained	Variant assessed as Somatic; HIGH impact.	NC_000002.12:g.218871027G>A	NCI-TCGA Cosmic
rs780785339	p.Val29Met	missense variant	-	NC_000002.12:g.218871031G>A	ExAC,gnomAD
rs1181153824	p.Pro32Leu	missense variant	-	NC_000002.12:g.218871041C>T	TOPMed
rs145172448	p.Leu33Phe	missense variant	-	NC_000002.12:g.218871045G>T	ESP,ExAC,gnomAD
rs201489407	p.Asp36Glu	missense variant	-	NC_000002.12:g.218871054C>A	ExAC,TOPMed,gnomAD
rs201489407	p.Asp36Glu	missense variant	-	NC_000002.12:g.218871054C>G	ExAC,TOPMed,gnomAD
rs1301398523	p.Pro37Thr	missense variant	-	NC_000002.12:g.218871055C>A	gnomAD
rs769180401	p.Pro37Leu	missense variant	-	NC_000002.12:g.218871056C>T	ExAC,gnomAD
rs1301398523	p.Pro37Ser	missense variant	-	NC_000002.12:g.218871055C>T	gnomAD
rs1278580129	p.Thr38Ile	missense variant	-	NC_000002.12:g.218871059C>T	TOPMed
rs1485479603	p.Thr38Ala	missense variant	-	NC_000002.12:g.218871058A>G	TOPMed
rs1376891264	p.Ser39Asn	missense variant	-	NC_000002.12:g.218871062G>A	TOPMed
NCI-TCGA novel	p.Cys41Trp	missense variant	-	NC_000002.12:g.218871069C>G	NCI-TCGA
rs772203707	p.Lys43Glu	missense variant	-	NC_000002.12:g.218871073A>G	ExAC,TOPMed,gnomAD
rs1241626877	p.Ala44Val	missense variant	-	NC_000002.12:g.218871077C>T	gnomAD
rs140352698	p.Arg45Gln	missense variant	-	NC_000002.12:g.218871080G>A	ESP,ExAC,TOPMed,gnomAD
rs773512750	p.Arg45Trp	missense variant	-	NC_000002.12:g.218871079C>T	ExAC,TOPMed,gnomAD
rs140352698	p.Arg45Pro	missense variant	-	NC_000002.12:g.218871080G>C	ESP,ExAC,TOPMed,gnomAD
rs200973144	p.Arg46Gln	missense variant	-	NC_000002.12:g.218871083G>A	1000Genomes,ExAC,gnomAD
rs766635655	p.Arg46Trp	missense variant	-	NC_000002.12:g.218871082C>T	ExAC,gnomAD
rs1345449697	p.Leu47Val	missense variant	-	NC_000002.12:g.218871085C>G	gnomAD
rs751343972	p.Arg50Trp	missense variant	-	NC_000002.12:g.218871094C>T	ExAC,TOPMed,gnomAD
rs1432729218	p.Arg50Gln	missense variant	-	NC_000002.12:g.218871095G>A	gnomAD
rs1174212096	p.Gln51His	missense variant	-	NC_000002.12:g.218871099G>T	gnomAD
NCI-TCGA novel	p.Gln51Ter	stop gained	-	NC_000002.12:g.218871097C>T	NCI-TCGA
NCI-TCGA novel	p.Gln51Leu	missense variant	-	NC_000002.12:g.218871098A>T	NCI-TCGA
rs62193325	p.Glu53Asp	missense variant	-	NC_000002.12:g.218871105G>C	TOPMed
rs750141599	p.Leu54Ser	missense variant	-	NC_000002.12:g.218871107T>C	ExAC,gnomAD
rs1398691691	p.Ala57Thr	missense variant	-	NC_000002.12:g.218871115G>A	gnomAD
COSM4909936	p.Ala57Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000002.12:g.218871115G>T	NCI-TCGA Cosmic
rs1449661909	p.Ala57Val	missense variant	-	NC_000002.12:g.218871116C>T	gnomAD
rs755750604	p.Val61Ala	missense variant	-	NC_000002.12:g.218871128T>C	ExAC,gnomAD
NCI-TCGA novel	p.Val62Ala	missense variant	-	NC_000002.12:g.218871131T>C	NCI-TCGA
NCI-TCGA novel	p.Ala63Thr	missense variant	-	NC_000002.12:g.218871133G>A	NCI-TCGA
rs779584695	p.Glu64Lys	missense variant	-	NC_000002.12:g.218871136G>A	ExAC,gnomAD
rs779584695	p.Glu64Gln	missense variant	-	NC_000002.12:g.218871136G>C	ExAC,gnomAD
NCI-TCGA novel	p.Arg67Gln	missense variant	-	NC_000002.12:g.218871146G>A	NCI-TCGA
rs142171369	p.Arg70Trp	missense variant	-	NC_000002.12:g.218871154C>T	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs142171369	p.Arg70Gly	missense variant	-	NC_000002.12:g.218871154C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs769072287	p.Arg70Gln	missense variant	-	NC_000002.12:g.218871155G>A	ExAC,TOPMed,gnomAD
rs779424323	p.Gly72Arg	missense variant	-	NC_000002.12:g.218871160G>A	ExAC,gnomAD
rs748477624	p.Gly72Ala	missense variant	-	NC_000002.12:g.218871161G>C	ExAC,TOPMed,gnomAD
rs1199175142	p.Val73Met	missense variant	-	NC_000002.12:g.218871163G>A	gnomAD
rs772501701	p.Arg74Pro	missense variant	-	NC_000002.12:g.218871167G>C	ExAC,gnomAD
rs1272538134	p.Arg74Ter	stop gained	-	NC_000002.12:g.218871166C>T	gnomAD
rs773710947	p.Glu75Gly	missense variant	-	NC_000002.12:g.218871170A>G	ExAC,gnomAD
rs1160038499	p.Cys76Phe	missense variant	-	NC_000002.12:g.218871173G>T	TOPMed
rs761039722	p.Phe80Leu	missense variant	-	NC_000002.12:g.218871184T>C	ExAC,gnomAD
rs771256486	p.Arg81Leu	missense variant	-	NC_000002.12:g.218871188G>T	ExAC,gnomAD
COSM442329	p.Arg81His	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000002.12:g.218871188G>A	NCI-TCGA Cosmic
rs375560904	p.Arg83His	missense variant	-	NC_000002.12:g.218871194G>A	ESP,ExAC,TOPMed,gnomAD
rs1056076691	p.Arg83Cys	missense variant	-	NC_000002.12:g.218871193C>T	TOPMed
rs140404341	p.Arg84His	missense variant	-	NC_000002.12:g.218871197G>A	ESP,ExAC,gnomAD
rs140404341	p.Arg84Leu	missense variant	-	NC_000002.12:g.218871197G>T	ESP,ExAC,gnomAD
rs1172007017	p.Arg84Gly	missense variant	-	NC_000002.12:g.218871196C>G	gnomAD
rs751445354	p.Asn86Ile	missense variant	-	NC_000002.12:g.218871203A>T	ExAC
rs761650162	p.Cys87Ser	missense variant	-	NC_000002.12:g.218871206G>C	ExAC,gnomAD
rs767357421	p.Ser88Pro	missense variant	-	NC_000002.12:g.218871208T>C	ExAC,gnomAD
rs750196516	p.His90Asp	missense variant	-	NC_000002.12:g.218871214C>G	ExAC,gnomAD
rs1275969767	p.Lys92Asn	missense variant	-	NC_000002.12:g.218871222G>C	TOPMed,gnomAD
rs1203845521	p.Ala93Thr	missense variant	-	NC_000002.12:g.218871223G>A	TOPMed
rs1342132970	p.Gly95Arg	missense variant	-	NC_000002.12:g.218871229G>A	gnomAD
rs1219050043	p.Arg96Gly	missense variant	-	NC_000002.12:g.218871232C>G	TOPMed,gnomAD
rs1269438985	p.Arg96His	missense variant	-	NC_000002.12:g.218871233G>A	TOPMed
rs779638051	p.Gln100Leu	missense variant	-	NC_000002.12:g.218871245A>T	ExAC,TOPMed,gnomAD
rs779638051	p.Gln100Pro	missense variant	-	NC_000002.12:g.218871245A>C	ExAC,TOPMed,gnomAD
rs753307256	p.Asp101Asn	missense variant	-	NC_000002.12:g.218871247G>A	ExAC
rs752129836	p.Ile102Leu	missense variant	-	NC_000002.12:g.218871487A>C	ExAC,gnomAD
rs1333199200	p.Arg103Gln	missense variant	-	NC_000002.12:g.218871491G>A	gnomAD
rs759013954	p.Thr105Met	missense variant	-	NC_000002.12:g.218871497C>T	ExAC,TOPMed,gnomAD
rs747402701	p.Phe107Leu	missense variant	-	NC_000002.12:g.218871504C>A	ExAC,gnomAD
rs749339350	p.Ala110Ser	missense variant	-	NC_000002.12:g.218871511G>T	TOPMed,gnomAD
rs1356049756	p.Ala110Val	missense variant	-	NC_000002.12:g.218871512C>T	gnomAD
rs781404768	p.Ile111Met	missense variant	-	NC_000002.12:g.218871516C>G	ExAC,TOPMed,gnomAD
rs894739463	p.Thr112Ile	missense variant	-	NC_000002.12:g.218871518C>T	TOPMed,gnomAD
rs200758649	p.Ala116Pro	missense variant	-	NC_000002.12:g.218871529G>C	ExAC,gnomAD
rs1176164524	p.Ser117Thr	missense variant	-	NC_000002.12:g.218871533G>C	gnomAD
rs1239483344	p.Ala119Val	missense variant	-	NC_000002.12:g.218871539C>T	gnomAD
rs1239483344	p.Ala119Gly	missense variant	-	NC_000002.12:g.218871539C>G	gnomAD
rs1310349406	p.Ala119Ser	missense variant	-	NC_000002.12:g.218871538G>T	TOPMed
rs1310349406	p.Ala119Thr	missense variant	-	NC_000002.12:g.218871538G>A	TOPMed
rs760465554	p.Val120Phe	missense variant	-	NC_000002.12:g.218871541G>T	ExAC,gnomAD
rs1422669348	p.Thr121Lys	missense variant	-	NC_000002.12:g.218871545C>A	gnomAD
rs766266841	p.Cys124Gly	missense variant	-	NC_000002.12:g.218871553T>G	ExAC,gnomAD
COSM3909614	p.Ser125Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000002.12:g.218871557C>T	NCI-TCGA Cosmic
rs1043210101	p.Ser125Tyr	missense variant	-	NC_000002.12:g.218871557C>A	TOPMed
rs1399409294	p.Met126Thr	missense variant	-	NC_000002.12:g.218871560T>C	gnomAD
rs759285421	p.Met126Ile	missense variant	-	NC_000002.12:g.218871561G>C	ExAC,TOPMed,gnomAD
rs759285421	p.Met126Ile	missense variant	-	NC_000002.12:g.218871561G>A	ExAC,TOPMed,gnomAD
rs776280458	p.Met126Val	missense variant	-	NC_000002.12:g.218871559A>G	ExAC,gnomAD
rs757934074	p.Glu128Gly	missense variant	-	NC_000002.12:g.218871566A>G	ExAC,gnomAD
rs752283594	p.Glu128Lys	missense variant	-	NC_000002.12:g.218871565G>A	ExAC,TOPMed,gnomAD
COSM73299	p.Leu130Met	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000002.12:g.218871571C>A	NCI-TCGA Cosmic
rs1264151347	p.Gln131Pro	missense variant	-	NC_000002.12:g.218871575A>C	gnomAD
rs997212826	p.Gly133Val	missense variant	-	NC_000002.12:g.218871581G>T	TOPMed
rs752176348	p.Gly133Cys	missense variant	-	NC_000002.12:g.218871580G>T	ExAC,TOPMed,gnomAD
rs757823920	p.Ala136Glu	missense variant	-	NC_000002.12:g.218871590C>A	ExAC,gnomAD
NCI-TCGA novel	p.Ala136Val	missense variant	-	NC_000002.12:g.218871590C>T	NCI-TCGA
rs781657115	p.Pro137Ser	missense variant	-	NC_000002.12:g.218871592C>T	ExAC,gnomAD
rs1029048951	p.Arg138Cys	missense variant	-	NC_000002.12:g.218871595C>T	TOPMed
rs1244576079	p.Gly139Arg	missense variant	-	NC_000002.12:g.218871598G>A	TOPMed,gnomAD
rs1244576079	p.Gly139Trp	missense variant	-	NC_000002.12:g.218871598G>T	TOPMed,gnomAD
rs780086487	p.Arg140Gln	missense variant	-	NC_000002.12:g.218871602G>A	ExAC,gnomAD
rs1478825467	p.Arg140Trp	missense variant	-	NC_000002.12:g.218871601C>T	TOPMed,gnomAD
rs749380897	p.Ala141Ser	missense variant	-	NC_000002.12:g.218871604G>T	ExAC,TOPMed,gnomAD
rs749380897	p.Ala141Thr	missense variant	-	NC_000002.12:g.218871604G>A	ExAC,TOPMed,gnomAD
rs1445154539	p.Pro142Ser	missense variant	-	NC_000002.12:g.218871607C>T	gnomAD
rs1463926853	p.Pro143Ala	missense variant	-	NC_000002.12:g.218871610C>G	TOPMed,gnomAD
rs1463926853	p.Pro143Ser	missense variant	-	NC_000002.12:g.218871610C>T	TOPMed,gnomAD
rs1316298187	p.Arg144Pro	missense variant	-	NC_000002.12:g.218871614G>C	TOPMed
rs1172687654	p.Arg144Trp	missense variant	-	NC_000002.12:g.218871613C>T	gnomAD
rs768654253	p.Pro145Ser	missense variant	-	NC_000002.12:g.218871616C>T	ExAC,gnomAD
rs1266278571	p.Gly147Asp	missense variant	-	NC_000002.12:g.218871623G>A	TOPMed
rs757834664	p.Leu148Gln	missense variant	-	NC_000002.12:g.218871626T>A	ExAC,TOPMed,gnomAD
rs969854226	p.Gly150Arg	missense variant	-	NC_000002.12:g.218871631G>C	TOPMed
rs969854226	p.Gly150Ser	missense variant	-	NC_000002.12:g.218871631G>A	TOPMed
rs747009211	p.Thr151Pro	missense variant	-	NC_000002.12:g.218871634A>C	ExAC,gnomAD
rs375766200	p.Thr151Ile	missense variant	-	NC_000002.12:g.218871635C>T	gnomAD
rs770754878	p.Pro152Thr	missense variant	-	NC_000002.12:g.218871637C>A	ExAC
rs1223014604	p.Pro154Thr	missense variant	-	NC_000002.12:g.218871643C>A	TOPMed,gnomAD
rs1340294840	p.Pro154Leu	missense variant	-	NC_000002.12:g.218871644C>T	gnomAD
rs1223014604	p.Pro154Ala	missense variant	-	NC_000002.12:g.218871643C>G	TOPMed,gnomAD
rs141494427	p.Pro155Arg	missense variant	-	NC_000002.12:g.218871647C>G	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1430595816	p.Pro155Ala	missense variant	-	NC_000002.12:g.218871646C>G	TOPMed
rs759212149	p.Gly156Val	missense variant	-	NC_000002.12:g.218871650G>T	ExAC,gnomAD
rs1280629180	p.Gly156Arg	missense variant	-	NC_000002.12:g.218871649G>C	gnomAD
rs769509450	p.Pro157His	missense variant	-	NC_000002.12:g.218871653C>A	ExAC,TOPMed,gnomAD
rs769509450	p.Pro157Leu	missense variant	-	NC_000002.12:g.218871653C>T	ExAC,TOPMed,gnomAD
rs775227227	p.Ala158Val	missense variant	-	NC_000002.12:g.218871656C>T	ExAC,TOPMed,gnomAD
rs762558422	p.Ser160Thr	missense variant	-	NC_000002.12:g.218871661T>A	ExAC,gnomAD
rs763752944	p.Pro161Ala	missense variant	-	NC_000002.12:g.218871664C>G	ExAC,gnomAD
rs1351823154	p.Pro161Leu	missense variant	-	NC_000002.12:g.218871665C>T	TOPMed,gnomAD
rs375682009	p.Gly163Asp	missense variant	-	NC_000002.12:g.218871671G>A	ESP,ExAC,TOPMed,gnomAD
rs1373531426	p.Ser164Arg	missense variant	-	NC_000002.12:g.218871675C>A	gnomAD
rs767870771	p.Ala165Thr	missense variant	-	NC_000002.12:g.218871676G>A	ExAC,TOPMed,gnomAD
rs767870771	p.Ala165Pro	missense variant	-	NC_000002.12:g.218871676G>C	ExAC,TOPMed,gnomAD
rs371038367	p.Ala166Thr	missense variant	-	NC_000002.12:g.218871679G>A	ESP,ExAC,TOPMed,gnomAD
rs371038367	p.Ala166Ser	missense variant	-	NC_000002.12:g.218871679G>T	ESP,ExAC,TOPMed,gnomAD
COSM4091542	p.Ala166Val	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000002.12:g.218871680C>T	NCI-TCGA Cosmic
rs780325149	p.Trp167Cys	missense variant	-	NC_000002.12:g.218871684G>C	ExAC,TOPMed,gnomAD
rs780325149	p.Trp167Ter	stop gained	-	NC_000002.12:g.218871684G>A	ExAC,TOPMed,gnomAD
rs1246175923	p.Glu168Gly	missense variant	-	NC_000002.12:g.218871686A>G	TOPMed
rs754124545	p.Trp169Leu	missense variant	-	NC_000002.12:g.218871689G>T	ExAC,TOPMed,gnomAD
rs746914545	p.Gly170Arg	missense variant	-	NC_000002.12:g.218871691G>A	ExAC,TOPMed,gnomAD
rs746914545	p.Gly170Arg	missense variant	-	NC_000002.12:g.218871691G>C	ExAC,TOPMed,gnomAD
rs1242818101	p.Gly173Ser	missense variant	-	NC_000002.12:g.218871700G>A	TOPMed
rs1327465741	p.Gly173Asp	missense variant	-	NC_000002.12:g.218871701G>A	gnomAD
NCI-TCGA novel	p.Asp174Gly	missense variant	-	NC_000002.12:g.218871704A>G	NCI-TCGA
NCI-TCGA novel	p.Asp174Asn	missense variant	-	NC_000002.12:g.218871703G>A	NCI-TCGA
rs770932846	p.Asp175His	missense variant	-	NC_000002.12:g.218871706G>C	ExAC,gnomAD
rs1357809521	p.Val176Leu	missense variant	-	NC_000002.12:g.218871709G>T	gnomAD
rs1313845014	p.Asp177Val	missense variant	-	NC_000002.12:g.218871713A>T	TOPMed
rs1363628520	p.Gly179Arg	missense variant	-	NC_000002.12:g.218871718G>C	TOPMed
rs780946149	p.Gly179Glu	missense variant	-	NC_000002.12:g.218871719G>A	ExAC,TOPMed,gnomAD
rs745692608	p.Glu181Lys	missense variant	-	NC_000002.12:g.218871724G>A	ExAC,TOPMed,gnomAD
rs745692608	p.Glu181Gln	missense variant	-	NC_000002.12:g.218871724G>C	ExAC,TOPMed,gnomAD
rs1487121889	p.Glu181Gly	missense variant	-	NC_000002.12:g.218871725A>G	gnomAD
rs1262181701	p.Ser183Ala	missense variant	-	NC_000002.12:g.218871730T>G	gnomAD
rs1441690607	p.Ser183Leu	missense variant	-	NC_000002.12:g.218871731C>T	gnomAD
rs762741441	p.Phe186Cys	missense variant	-	NC_000002.12:g.218871740T>G	ExAC,gnomAD
rs768388767	p.Ala189Ser	missense variant	-	NC_000002.12:g.218871748G>T	ExAC,gnomAD
rs768388767	p.Ala189Thr	missense variant	-	NC_000002.12:g.218871748G>A	ExAC,gnomAD
rs761179896	p.Arg190Trp	missense variant	-	NC_000002.12:g.218871751C>T	ExAC,TOPMed,gnomAD
rs768082435	p.Arg190Gln	missense variant	-	NC_000002.12:g.218871752G>A	ExAC,gnomAD
rs928721796	p.Lys192Arg	missense variant	-	NC_000002.12:g.218871758A>G	TOPMed
rs371832438	p.Arg193Gln	missense variant	-	NC_000002.12:g.218871761G>A	ESP,ExAC,TOPMed,gnomAD
rs766789342	p.Arg195His	missense variant	-	NC_000002.12:g.218871767G>A	ExAC,TOPMed,gnomAD
rs766789342	p.Arg195Pro	missense variant	-	NC_000002.12:g.218871767G>C	ExAC,TOPMed,gnomAD
rs1208178990	p.Gly196Arg	missense variant	-	NC_000002.12:g.218871769G>A	TOPMed
rs149156287	p.Arg199Cys	missense variant	-	NC_000002.12:g.218871778C>T	ESP,ExAC,gnomAD
rs149156287	p.Arg199Ser	missense variant	-	NC_000002.12:g.218871778C>A	ESP,ExAC,gnomAD
rs1350974775	p.Ala200Thr	missense variant	-	NC_000002.12:g.218871781G>A	gnomAD
rs1350974775	p.Ala200Ser	missense variant	-	NC_000002.12:g.218871781G>T	gnomAD
rs1261019580	p.Leu201Trp	missense variant	-	NC_000002.12:g.218871785T>G	gnomAD
rs752801056	p.Val202Leu	missense variant	-	NC_000002.12:g.218871787G>C	ExAC,gnomAD
rs758355759	p.Asn207Ser	missense variant	-	NC_000002.12:g.218871803A>G	ExAC,gnomAD
rs781196612	p.Ala209Thr	missense variant	-	NC_000002.12:g.218871808G>A	ExAC,gnomAD
rs1237660450	p.Gly210Ser	missense variant	-	NC_000002.12:g.218871811G>A	gnomAD
rs758645392	p.Val214Met	missense variant	-	NC_000002.12:g.218873387G>A	ExAC,gnomAD
rs1344178652	p.Arg215Gln	missense variant	-	NC_000002.12:g.218873391G>A	TOPMed
rs542982949	p.Arg215Trp	missense variant	-	NC_000002.12:g.218873390C>T	1000Genomes,gnomAD
rs1490609771	p.Ser216Asn	missense variant	-	NC_000002.12:g.218873394G>A	gnomAD
rs1422060201	p.Glu221Lys	missense variant	-	NC_000002.12:g.218873408G>A	gnomAD
rs1170468518	p.Cys224Ser	missense variant	-	NC_000002.12:g.218873417T>A	gnomAD
rs1367367634	p.Cys224Tyr	missense variant	-	NC_000002.12:g.218873418G>A	gnomAD
rs1455994673	p.Gly226Arg	missense variant	-	NC_000002.12:g.218873423G>A	gnomAD
rs1455994673	p.Gly226Trp	missense variant	-	NC_000002.12:g.218873423G>T	gnomAD
rs935852608	p.Cys231Ter	stop gained	-	NC_000002.12:g.218873440C>A	TOPMed
rs1052853628	p.Ala232Thr	missense variant	-	NC_000002.12:g.218873441G>A	TOPMed,gnomAD
rs1296116840	p.Ala232Val	missense variant	-	NC_000002.12:g.218873442C>T	gnomAD
rs1296116840	p.Ala232Gly	missense variant	-	NC_000002.12:g.218873442C>G	gnomAD
rs533712317	p.Arg234Ser	missense variant	-	NC_000002.12:g.218873447C>A	1000Genomes,ExAC,TOPMed,gnomAD
rs1051611538	p.Arg234His	missense variant	-	NC_000002.12:g.218873448G>A	TOPMed
rs1312001134	p.Trp237Ter	stop gained	-	NC_000002.12:g.218873457G>A	TOPMed,gnomAD
rs933076369	p.Gln238Pro	missense variant	-	NC_000002.12:g.218873460A>C	TOPMed,gnomAD
rs933076369	p.Gln238Arg	missense variant	-	NC_000002.12:g.218873460A>G	TOPMed,gnomAD
rs1321166448	p.Gln238Ter	stop gained	-	NC_000002.12:g.218873459C>T	gnomAD
rs1490584103	p.Arg244His	missense variant	-	NC_000002.12:g.218873478G>A	gnomAD
rs1317949387	p.Glu245Lys	missense variant	-	NC_000002.12:g.218873480G>A	TOPMed
rs1289576821	p.Val246Ala	missense variant	-	NC_000002.12:g.218873484T>C	TOPMed
rs1261502638	p.Gly247Asp	missense variant	-	NC_000002.12:g.218873487G>A	gnomAD
rs1187613828	p.Arg249Gln	missense variant	-	NC_000002.12:g.218873493G>A	gnomAD
rs1256125666	p.Leu251Pro	missense variant	-	NC_000002.12:g.218873499T>C	gnomAD
rs1362160477	p.Glu252Gln	missense variant	-	NC_000002.12:g.218873501G>C	TOPMed
rs1007289265	p.Glu252Gly	missense variant	-	NC_000002.12:g.218873502A>G	TOPMed
rs1164962396	p.Arg253Pro	missense variant	-	NC_000002.12:g.218873505G>C	TOPMed,gnomAD
rs1164962396	p.Arg253Leu	missense variant	-	NC_000002.12:g.218873505G>T	TOPMed,gnomAD
rs1385396012	p.His255Tyr	missense variant	-	NC_000002.12:g.218873510C>T	gnomAD
rs1418728580	p.Gly256Cys	missense variant	-	NC_000002.12:g.218873513G>T	TOPMed,gnomAD
rs1418728580	p.Gly256Ser	missense variant	-	NC_000002.12:g.218873513G>A	TOPMed,gnomAD
rs1156519656	p.Gly256Val	missense variant	-	NC_000002.12:g.218873514G>T	gnomAD
rs1346740666	p.Ala257Ser	missense variant	-	NC_000002.12:g.218873516G>T	gnomAD
rs1302171406	p.Arg259His	missense variant	-	NC_000002.12:g.218873523G>A	gnomAD
rs1017221529	p.Arg259Gly	missense variant	-	NC_000002.12:g.218873522C>G	TOPMed,gnomAD
rs994352872	p.Val260Ile	missense variant	-	NC_000002.12:g.218873525G>A	TOPMed,gnomAD
rs1317262363	p.Met261Leu	missense variant	-	NC_000002.12:g.218873528A>C	gnomAD
rs1239684208	p.Gly262Asp	missense variant	-	NC_000002.12:g.218873532G>A	gnomAD
rs1360372895	p.Gly262Ser	missense variant	-	NC_000002.12:g.218873531G>A	gnomAD
rs1319077270	p.Thr263Ser	missense variant	-	NC_000002.12:g.218873535C>G	gnomAD
rs1255878884	p.Asp265Asn	missense variant	-	NC_000002.12:g.218873540G>A	TOPMed,gnomAD
rs1255878884	p.Asp265His	missense variant	-	NC_000002.12:g.218873540G>C	TOPMed,gnomAD
rs1482563216	p.Gly266Ser	missense variant	-	NC_000002.12:g.218873543G>A	TOPMed,gnomAD
rs1482563216	p.Gly266Arg	missense variant	-	NC_000002.12:g.218873543G>C	TOPMed,gnomAD
rs889980241	p.Lys267Arg	missense variant	-	NC_000002.12:g.218873547A>G	TOPMed
rs1243203754	p.Ala268Val	missense variant	-	NC_000002.12:g.218873550C>T	gnomAD
rs767256680	p.Ala268Thr	missense variant	-	NC_000002.12:g.218873549G>A	TOPMed,gnomAD
rs767256680	p.Ala268Pro	missense variant	-	NC_000002.12:g.218873549G>C	TOPMed,gnomAD
rs778846147	p.Leu270Val	missense variant	-	NC_000002.12:g.218873555C>G	ExAC,gnomAD
rs560783536	p.Pro271Ser	missense variant	-	NC_000002.12:g.218873558C>T	1000Genomes,ExAC,gnomAD
rs771736077	p.Ala272Ser	missense variant	-	NC_000002.12:g.218873561G>T	ExAC,gnomAD
rs1486294656	p.Arg274His	missense variant	-	NC_000002.12:g.218873568G>A	TOPMed
rs1357292601	p.Thr275Met	missense variant	-	NC_000002.12:g.218873571C>T	gnomAD
rs1337379664	p.Pro278Leu	missense variant	-	NC_000002.12:g.218873580C>T	gnomAD
rs1383614639	p.Pro279Leu	missense variant	-	NC_000002.12:g.218873583C>T	TOPMed,gnomAD
rs1383614639	p.Pro279Gln	missense variant	-	NC_000002.12:g.218873583C>A	TOPMed,gnomAD
rs567728114	p.Gly280Asp	missense variant	-	NC_000002.12:g.218873586G>A	1000Genomes,ExAC,TOPMed,gnomAD
rs759901601	p.Arg281Gln	missense variant	-	NC_000002.12:g.218873589G>A	ExAC,TOPMed,gnomAD
rs759901601	p.Arg281Leu	missense variant	-	NC_000002.12:g.218873589G>T	ExAC,TOPMed,gnomAD
rs775911870	p.Ala282Val	missense variant	-	NC_000002.12:g.218873592C>T	ExAC,gnomAD
rs763122265	p.Leu284Phe	missense variant	-	NC_000002.12:g.218873597C>T	ExAC,gnomAD
rs1456913037	p.Leu285Phe	missense variant	-	NC_000002.12:g.218873600C>T	gnomAD
rs1456913037	p.Leu285Ile	missense variant	-	NC_000002.12:g.218873600C>A	gnomAD
rs1234218918	p.Ala287Thr	missense variant	-	NC_000002.12:g.218873606G>A	gnomAD
rs1408841347	p.Ala287Val	missense variant	-	NC_000002.12:g.218873607C>T	TOPMed,gnomAD
rs751610006	p.Ala288Thr	missense variant	-	NC_000002.12:g.218873609G>A	ExAC,gnomAD
rs751610006	p.Ala288Ser	missense variant	-	NC_000002.12:g.218873609G>T	ExAC,gnomAD
rs1422789669	p.Ser290Leu	missense variant	-	NC_000002.12:g.218873616C>T	gnomAD
rs935885236	p.Pro291Arg	missense variant	-	NC_000002.12:g.218873619C>G	TOPMed,gnomAD
rs753892359	p.Asp292Tyr	missense variant	-	NC_000002.12:g.218873621G>T	ExAC,gnomAD
rs754951141	p.Ala295Ser	missense variant	-	NC_000002.12:g.218873630G>T	ExAC,gnomAD
rs1356434597	p.Ala295Val	missense variant	-	NC_000002.12:g.218873631C>T	gnomAD
rs754951141	p.Ala295Thr	missense variant	-	NC_000002.12:g.218873630G>A	ExAC,gnomAD
rs1443183664	p.Pro296Ser	missense variant	-	NC_000002.12:g.218873633C>T	gnomAD
rs778620463	p.Asn297Thr	missense variant	-	NC_000002.12:g.218873637A>C	ExAC,TOPMed,gnomAD
rs778620463	p.Asn297Ser	missense variant	-	NC_000002.12:g.218873637A>G	ExAC,TOPMed,gnomAD
rs758018720	p.Arg298Ter	stop gained	-	NC_000002.12:g.218873639C>T	ExAC,gnomAD
rs777435419	p.Arg298Gln	missense variant	-	NC_000002.12:g.218873640G>A	ExAC,TOPMed,gnomAD
rs1317873348	p.Arg299Cys	missense variant	-	NC_000002.12:g.218873642C>T	gnomAD
rs1317873348	p.Arg299Ser	missense variant	-	NC_000002.12:g.218873642C>A	gnomAD
rs1212230501	p.Arg299His	missense variant	-	NC_000002.12:g.218873643G>A	gnomAD
rs1274520165	p.Gly301Ser	missense variant	-	NC_000002.12:g.218873648G>A	gnomAD
rs1274520165	p.Gly301Cys	missense variant	-	NC_000002.12:g.218873648G>T	gnomAD
COSM3909615	p.Ser302Phe	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000002.12:g.218873652C>T	NCI-TCGA Cosmic
rs771206925	p.Pro303Ala	missense variant	-	NC_000002.12:g.218873654C>G	TOPMed,gnomAD
rs1199916860	p.Thr305Met	missense variant	-	NC_000002.12:g.218873661C>T	gnomAD
rs1034394582	p.Arg306Cys	missense variant	-	NC_000002.12:g.218873663C>T	TOPMed,gnomAD
rs1034394582	p.Arg306Gly	missense variant	-	NC_000002.12:g.218873663C>G	TOPMed,gnomAD
rs1481656337	p.Gly307Ala	missense variant	-	NC_000002.12:g.218873667G>C	TOPMed
COSM26563	p.Gly307Ser	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000002.12:g.218873666G>A	NCI-TCGA Cosmic
rs745952229	p.Arg308His	missense variant	-	NC_000002.12:g.218873670G>A	TOPMed,gnomAD
rs1421733507	p.Arg308Cys	missense variant	-	NC_000002.12:g.218873669C>T	TOPMed,gnomAD
rs1421733507	p.Arg308Ser	missense variant	-	NC_000002.12:g.218873669C>A	TOPMed,gnomAD
rs1323115870	p.Asn311Ser	missense variant	-	NC_000002.12:g.218873679A>G	gnomAD
rs746435150	p.Ser312Asn	missense variant	-	NC_000002.12:g.218873682G>A	ExAC,gnomAD
rs770265789	p.Ser312Arg	missense variant	-	NC_000002.12:g.218873683C>A	ExAC,TOPMed,gnomAD
rs1340393231	p.Ser313Thr	missense variant	-	NC_000002.12:g.218873685G>C	gnomAD
rs1429223480	p.Ala314Asp	missense variant	-	NC_000002.12:g.218873688C>A	gnomAD
rs1249134400	p.Ala314Ser	missense variant	-	NC_000002.12:g.218873687G>T	TOPMed
rs1276802842	p.Gly319Asp	missense variant	-	NC_000002.12:g.218873703G>A	gnomAD
rs1227293965	p.Cys320Arg	missense variant	-	NC_000002.12:g.218873705T>C	TOPMed,gnomAD
rs1361151666	p.Cys324Tyr	missense variant	-	NC_000002.12:g.218873718G>A	gnomAD
rs768769875	p.Cys325Trp	missense variant	-	NC_000002.12:g.218873722C>G	ExAC,gnomAD
rs1262183703	p.Gly326Ser	missense variant	-	NC_000002.12:g.218873723G>A	gnomAD
rs1195199650	p.Gly328Trp	missense variant	-	NC_000002.12:g.218873729G>T	TOPMed,gnomAD
rs774566053	p.Gly328Glu	missense variant	-	NC_000002.12:g.218873730G>A	ExAC,gnomAD
rs1195199650	p.Gly328Arg	missense variant	-	NC_000002.12:g.218873729G>A	TOPMed,gnomAD
rs189995485	p.Arg330His	missense variant	-	NC_000002.12:g.218873736G>A	1000Genomes,ESP,ExAC,TOPMed,gnomAD
rs1345871655	p.Arg330Ser	missense variant	-	NC_000002.12:g.218873735C>A	gnomAD
rs1426803969	p.Glu332Lys	missense variant	-	NC_000002.12:g.218873741G>A	gnomAD
rs767762590	p.Ser333Asn	missense variant	-	NC_000002.12:g.218873745G>A	ExAC,gnomAD
rs750505957	p.Val334Met	missense variant	-	NC_000002.12:g.218873747G>A	ExAC,gnomAD
rs759589107	p.Glu337Gln	missense variant	-	NC_000002.12:g.218873756G>C	ExAC,gnomAD
rs1446556962	p.Glu338Asp	missense variant	-	NC_000002.12:g.218873761G>C	gnomAD
rs914366914	p.Glu338Lys	missense variant	-	NC_000002.12:g.218873759G>A	gnomAD
COSM1306439	p.Glu338Gln	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000002.12:g.218873759G>C	NCI-TCGA Cosmic
rs1390772760	p.Cys340Ter	stop gained	-	NC_000002.12:g.218873767C>A	TOPMed
rs1312291344	p.Cys340Tyr	missense variant	-	NC_000002.12:g.218873766G>A	gnomAD
rs1246249807	p.Arg343Ser	missense variant	-	NC_000002.12:g.218873774C>A	gnomAD
rs1246249807	p.Arg343Cys	missense variant	-	NC_000002.12:g.218873774C>T	gnomAD
rs1284914451	p.Arg343Leu	missense variant	-	NC_000002.12:g.218873775G>T	gnomAD
rs1206695898	p.Phe344Leu	missense variant	-	NC_000002.12:g.218873777T>C	gnomAD
rs1038351907	p.His345Arg	missense variant	-	NC_000002.12:g.218873781A>G	TOPMed
rs977335454	p.Val349Ile	missense variant	-	NC_000002.12:g.218873792G>A	TOPMed,gnomAD
rs977335454	p.Val349Leu	missense variant	-	NC_000002.12:g.218873792G>T	TOPMed,gnomAD
rs1174611058	p.Val350Ala	missense variant	-	NC_000002.12:g.218873796T>C	TOPMed
rs1471058472	p.Gln351Arg	missense variant	-	NC_000002.12:g.218873799A>G	TOPMed
rs752458659	p.Gln351His	missense variant	-	NC_000002.12:g.218873800G>C	ExAC,gnomAD
rs758154086	p.Arg356His	missense variant	-	NC_000002.12:g.218873814G>A	ExAC,gnomAD
COSM73300	p.Arg356Cys	missense variant	Variant assessed as Somatic; MODERATE impact.	NC_000002.12:g.218873813C>T	NCI-TCGA Cosmic
rs1446593576	p.Arg358Leu	missense variant	-	NC_000002.12:g.218873820G>T	gnomAD
rs548768289	p.Leu361Phe	missense variant	-	NC_000002.12:g.218873828C>T	gnomAD
rs1363491561	p.Leu363Phe	missense variant	-	NC_000002.12:g.218873834C>T	gnomAD
rs1452023449	p.Cys364Arg	missense variant	-	NC_000002.12:g.218873837T>C	gnomAD

Disease or phenotype associated information

Disease ID	Disease Name	Disease Type	Source
C0005684	Malignant neoplasm of urinary bladder	disease	BEFREE
C0005695	Bladder Neoplasm	group	BEFREE
C0006142	Malignant neoplasm of breast	disease	BEFREE
C0024623	Malignant neoplasm of stomach	disease	BEFREE
C0678222	Breast Carcinoma	disease	BEFREE
C0699791	Stomach Carcinoma	disease	BEFREE
C0699885	Carcinoma of bladder	disease	BEFREE

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID	GO Term	Evidence
GO:0005109	frizzled binding	IBA

GO:Biological Process

GO ID	GO Term	Evidence
GO:0001658	branching involved in ureteric bud morphogenesis	IEA
GO:0009798	axis specification	IEA
GO:0010628	positive regulation of gene expression	IMP
GO:0016055	Wnt signaling pathway	IBA
GO:0016055	Wnt signaling pathway	TAS
GO:0030182	neuron differentiation	ISS
GO:0030182	neuron differentiation	IBA
GO:0042475	odontogenesis of dentin-containing tooth	IMP
GO:0045165	cell fate commitment	IBA
GO:0045893	positive regulation of transcription, DNA-templated	IEA
GO:0060684	epithelial-mesenchymal cell signaling	IEA
GO:0061303	cornea development in camera-type eye	ISS
GO:0070172	positive regulation of tooth mineralization	IMP
GO:0071300	cellular response to retinoic acid	ISS
GO:0072079	nephron tubule formation	IEA

GO:Cellular Component

GO ID	GO Term	Evidence
GO:0005576	extracellular region	TAS
GO:0005615	extracellular space	IBA
GO:0005788	endoplasmic reticulum lumen	TAS
GO:0005796	Golgi lumen	TAS
GO:0005886	plasma membrane	TAS
GO:0009986	cell surface	IEA
GO:0030666	endocytic vesicle membrane	TAS
GO:0031012	extracellular matrix	IEA
GO:0070062	extracellular exosome	TAS

Reactome Pathway

Reactome ID	Reactome Term	Evidence
R-HSA-162582	Signal Transduction	TAS
R-HSA-162582	Signal Transduction	IEA
R-HSA-195721	Signaling by WNT	TAS
R-HSA-195721	Signaling by WNT	IEA
R-HSA-3238698	WNT ligand biogenesis and trafficking	TAS
R-HSA-3238698	WNT ligand biogenesis and trafficking	IEA
R-HSA-372790	Signaling by GPCR	IEA
R-HSA-373080	Class B/2 (Secretin family receptors)	IEA
R-HSA-500792	GPCR ligand binding	IEA

Drugs and compounds information

ID	Drug Name	Action	PubMed
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of WNT6 mRNA	28801915
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of WNT6 mRNA	19191707
C058722	5-hydroxy-6,8,11,14,17-eicosapentaenoic acid	5-hydroxy-6,8,11,14,17-eicosapentaenoic acid affects the expression of WNT6 mRNA	26984781
C496492	abrine	abrine results in decreased expression of WNT6 mRNA	31054353
D000082	Acetaminophen	Acetaminophen results in decreased expression of WNT6 mRNA	22230336; 29067470;
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of WNT6 mRNA	21632981
C543008	bis(4-hydroxyphenyl)sulfone	bis(4-hydroxyphenyl)sulfone results in increased expression of WNT6 mRNA	30951980
C006780	bisphenol A	bisphenol A affects the expression of WNT6 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of WNT6 mRNA	30816183; 31129395;
C000611646	bisphenol F	bisphenol F results in increased expression of WNT6 mRNA	30951980
C027561	butylbenzyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of WNT6 mRNA	31199487
D002104	Cadmium	Cadmium results in increased expression of WNT6 mRNA	22562489
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of WNT6 mRNA	20478370
D012721	Carbaryl	Carbaryl results in decreased expression of WNT6 mRNA	27829164
D003976	Diazinon	Diazinon results in increased expression of WNT6 mRNA	19130878
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of WNT6 mRNA	17361019; 21266533;
D003993	Dibutyl Phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of WNT6 mRNA	31199487
D004026	Dieldrin	Dieldrin results in increased expression of WNT6 mRNA	19130878
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of WNT6 mRNA	31163220
D004051	Diethylhexyl Phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of WNT6 mRNA	31199487
C007379	diethyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of WNT6 mRNA	31199487
C025605	diisobutyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of WNT6 mRNA	31199487
C012125	diisononyl phthalate	[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of WNT6 mRNA	31199487
C051904	dinophysistoxin 1	dinophysistoxin 1 results in decreased expression of WNT6 mRNA	28939011
C516138	dorsomorphin	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
C516138	dorsomorphin	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
D004958	Estradiol	Estradiol results in increased expression of WNT6 mRNA	23144751
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WNT6 mRNA	17942748
D005492	Folic Acid	[Folic Acid co-treated with sodium arsenite] results in increased methylation of WNT6 mRNA	22959928
D005557	Formaldehyde	Formaldehyde results in increased expression of WNT6 mRNA	28937961
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of WNT6 mRNA	20044591
D018021	Lithium Chloride	Lithium Chloride results in increased expression of WNT6 mRNA	17506889
C025340	manganese chloride	manganese chloride results in decreased expression of WNT6 mRNA	28801915
C042720	mercuric bromide	[NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
D009532	Nickel	Nickel results in decreased expression of WNT6 mRNA	19130878
D000077767	Panobinostat	[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
D052638	Particulate Matter	Particulate Matter results in decreased expression of WNT6 mRNA	28341207
D020245	p-Chloromercuribenzoic Acid	[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in increased expression of WNT6 mRNA	26272509
D010662	Phenylmercuric Acetate	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of WNT6 mRNA	26272509
C006253	pirinixic acid	NCF1 protein promotes the reaction [pirinixic acid results in decreased expression of WNT6 mRNA]	17950772
C006253	pirinixic acid	pirinixic acid results in decreased expression of WNT6 mRNA	17950772
C005556	propionaldehyde	propionaldehyde results in decreased expression of WNT6 mRNA	26079696
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of WNT6 mRNA	24780913
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of WNT6 mRNA	25895662
C017947	sodium arsenite	[Folic Acid co-treated with sodium arsenite] results in increased methylation of WNT6 mRNA	22959928
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of WNT6 mRNA	20106945; 21296121; 21632981;
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of WNT6 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WNT6 mRNA	17942748
C009495	titanium dioxide	titanium dioxide results in decreased expression of WNT6 mRNA	29264374
D014212	Tretinoin	Tretinoin results in decreased expression of WNT6 mRNA	16604517
C012589	trichostatin A	trichostatin A results in increased expression of WNT6 mRNA	24935251
D014260	Triclosan	Triclosan results in decreased expression of WNT6 mRNA	30510588
C016805	tris(1,3-dichloro-2-propyl)phosphate	tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of WNT6 mRNA	26179874
D014635	Valproic Acid	[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of WNT6 mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of WNT6 mRNA	23179753; 24383497; 26272509;
D014635	Valproic Acid	Valproic Acid results in increased expression of WNT6 mRNA	29427782
C025643	vinclozolin	vinclozolin results in increased expression of WNT6 mRNA	20566332
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of WNT6 mRNA	17506889

Functional annotations

Keywords

Keyword ID	Keyword Term
KW-0217	Developmental protein
KW-1015	Disulfide bond
KW-0272	Extracellular matrix
KW-0325	Glycoprotein
KW-0449	Lipoprotein
KW-1185	Reference proteome
KW-0964	Secreted
KW-0732	Signal
KW-0879	Wnt signaling pathway

Interpro

InterPro ID	InterPro Term
IPR005817	Wnt
IPR009143	Wnt6
IPR043158	Wnt_C
IPR018161	Wnt_CS

PROSITE

PROSITE ID	PROSITE Term
PS00246	WNT1

Pfam

Pfam ID	Pfam Term
PF00110	wnt

Gene: WNT6

Basic information

Gene expression information

Gene expression in different tissues (GTEx V7)

Gene expression in different tissues (ENCODE)

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Other genetic variants/mutations

Disease or phenotype associated information

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO:Biological Process

GO:Cellular Component

Reactome Pathway

Drugs and compounds information

Functional annotations

Keywords

Interpro

PROSITE

Pfam

Protein-protein interaction

Protein-miRNA interaction