| Tag | Content |
|---|---|
| Uniprot ID | Q9Z138; E9QKB3; |
| Entrez ID | |
| Genbank protein ID | BAA75481.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSMUSP00000021918 |
| Ensembl nucleotide ID | ENSMUSG00000021464 |
| Gene name | Tyrosine-protein kinase transmembrane receptor ROR2 |
| Gene symbol | Ror2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5 |
| Data sources | Manually collected |
| Reference | 10700181; 14745966; 18948417; |
| Functional description | Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (PubMed:10700181). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (By similarity). |
| Sequence | MARGWVRPSR VPLCARAVWT AAALLLWTPW TAGEVEDSEA IDTLGQPDGP DSPLPTLKGY 60 FLNFLEPVNN ITIVQGQTAI LHCKVAGNPP PNVRWLKNDA PVVQEPRRVI IRKTEYGSRL 120 RIQDLDTTDT GYYQCVATNG LKTITATGVL YVRLGPTHSP NHNFQDDDQE DGFCQPYRGI 180 ACARFIGNRT IYVDSLQMQG EIENRITAAF TMIGTSTQLS DQCSQFAIPS FCHFVFPLCD 240 ARSRAPKPRE LCRDECEVLE NDLCRQEYTI ARSNPLILMR LQLPKCEALP MPESPDAANC 300 MRIGIPAERL GRYHQCYNGS GADYRGMAST TKSGHQCQPW ALQHPHSHRL SSTEFPELGG 360 GHAYCRNPGG QVEGPWCFTQ NKNVRVELCD VPPCSPRDGS KMGILYILVP SIAIPLVIAC 420 LFFLVCMCRN KQKASASTPQ RRQLMASPSQ DMEMPLISQH KQAKLKEISL STVRFMEELG 480 EDRFGKVYKG HLFGPAPGEP TQAVAIKTLK DKAEGPLREE FRQEAMLRAR LQHPNIVCLL 540 GVVTKDQPLS MIFSYCSHGD LHEFLVMRSP HSDVGSTDDD RTVKSALEPP DFVHVVAQIA 600 AGMEFLSSHH VVHKDLATRN VLVYDKLNVR ISDLGLFREV YSADYYKLMG NSLLPIRWMS 660 PEAVMYGKFS IDSDIWSYGV VLWEVFSYGL QPYCGYSNQD VVEMIRSRQV LPCPDDCPAW 720 VYALMIECWN EFPSRRPRFK DIHSRLRSWG NLSNYNSSAQ TSGASNTTQT SSLSTSPVSN 780 VSNARYMAPK QKAQPFPQPQ FIPMKGQIRP LVPPAQLYIP VNGYQPVPAY GAYLPNFYPV 840 QIPMQMAPQQ VPPQMVPKPS SHHSGSGSTS TGYVTTAPSN TSVADRAALL SEGTEDAQNI 900 AEDVAQSPVQ EAEEEEEGSV PETELLGDND TLQVTEAAHV QLEA 944 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | TAS |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IBA |
| GO:0005109 | frizzled binding | IPI |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | IEA |
| GO:0017147 | Wnt-protein binding | ISO |
| GO:0017147 | Wnt-protein binding | IPI |
| GO:0017147 | Wnt-protein binding | IBA |
| GO:0031435 | mitogen-activated protein kinase kinase kinase binding | ISO |
| GO:0031435 | mitogen-activated protein kinase kinase kinase binding | IPI |
| GO:0046872 | metal ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001501 | skeletal system development | IMP |
| GO:0001502 | cartilage condensation | IMP |
| GO:0001756 | somitogenesis | IMP |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA |
| GO:0007223 | Wnt signaling pathway, calcium modulating pathway | IPI |
| GO:0007224 | smoothened signaling pathway | IMP |
| GO:0007254 | JNK cascade | IDA |
| GO:0007275 | multicellular organism development | IBA |
| GO:0007399 | nervous system development | IBA |
| GO:0008285 | negative regulation of cell population proliferation | ISO |
| GO:0010976 | positive regulation of neuron projection development | IBA |
| GO:0014002 | astrocyte development | ISO |
| GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | IBA |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IEA |
| GO:0030154 | cell differentiation | IMP |
| GO:0030282 | bone mineralization | IEA |
| GO:0030335 | positive regulation of cell migration | ISO |
| GO:0030509 | BMP signaling pathway | IMP |
| GO:0030538 | embryonic genitalia morphogenesis | IMP |
| GO:0030539 | male genitalia development | IEA |
| GO:0033674 | positive regulation of kinase activity | IBA |
| GO:0042472 | inner ear morphogenesis | IMP |
| GO:0042733 | embryonic digit morphogenesis | IGI |
| GO:0042733 | embryonic digit morphogenesis | IMP |
| GO:0043408 | regulation of MAPK cascade | IBA |
| GO:0043410 | positive regulation of MAPK cascade | IBA |
| GO:0043507 | positive regulation of JUN kinase activity | ISO |
| GO:0045165 | cell fate commitment | IMP |
| GO:0045651 | positive regulation of macrophage differentiation | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | IDA |
| GO:0048856 | anatomical structure development | IBA |
| GO:0051968 | positive regulation of synaptic transmission, glutamatergic | ISO |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | IMP |
| GO:0060395 | SMAD protein signal transduction | IMP |
| GO:0060828 | regulation of canonical Wnt signaling pathway | IMP |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway | IGI |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | IDA |
| GO:1900020 | positive regulation of protein kinase C activity | ISO |
| GO:1905517 | macrophage migration | ISO |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005737 | cytoplasm | ISO |
| GO:0005874 | microtubule | ISO |
| GO:0005886 | plasma membrane | TAS |
| GO:0005887 | integral component of plasma membrane | ISS |
| GO:0005887 | integral component of plasma membrane | IBA |
| GO:0009986 | cell surface | ISO |
| GO:0030424 | axon | IBA |
| GO:0030425 | dendrite | ISO |
| GO:0043025 | neuronal cell body | ISO |
| GO:0043235 | receptor complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0420 | Kringle |
| KW-0460 | Magnesium |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0488 | Methylation |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0879 | Wnt signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR020067 | Frizzled_dom |
| IPR036790 | Frizzled_dom_sf |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR011009 | Kinase-like_dom_sf |
| IPR000001 | Kringle |
| IPR013806 | Kringle-like |
| IPR018056 | Kringle_CS |
| IPR038178 | Kringle_sf |
| IPR000719 | Prot_kinase_dom |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR016247 | Tyr_kinase_rcpt_ROR |