| Tag | Content |
|---|---|
| Uniprot ID | Q9Z1P4; Q3V1L2; |
| Entrez ID | 14160 |
| Genbank protein ID | EDL21773.1; AAD14684.1; BAE21138.1; |
| Genbank nucleotide ID | NM_010195.2 |
| Ensembl protein ID | ENSMUSP00000020350 |
| Ensembl nucleotide ID | ENSMUSG00000020140 |
| Gene name | Leucine-rich repeat-containing G-protein coupled receptor 5 |
| Gene symbol | Lgr5 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 29769720 |
| Functional description | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. |
| Sequence | MDTSCVHMLL SLLALLQLVA AGSSPGPDAI PRGCPSHCHC ELDGRMLLRV DCSDLGLSEL 60 PSNLSVFTSY LDLSMNNISQ LPASLLHRLC FLEELRLAGN ALTHIPKGAF TGLHSLKVLM 120 LQNNQLRQVP EEALQNLRSL QSLRLDANHI SYVPPSCFSG LHSLRHLWLD DNALTDVPVQ 180 AFRSLSALQA MTLALNKIHH IADYAFGNLS SLVVLHLHNN RIHSLGKKCF DGLHSLETLD 240 LNYNNLDEFP TAIKTLSNLK ELGFHSNNIR SIPERAFVGN PSLITIHFYD NPIQFVGVSA 300 FQHLPELRTL TLNGASHITE FPHLTGTATL ESLTLTGAKI SSLPQAVCDQ LPNLQVLDLS 360 YNLLEDLPSL SGCQKLQKID LRHNEIYEIK GSTFQQLFNL RSLNLAWNKI AIIHPNAFST 420 LPSLIKLDLS SNLLSSFPVT GLHGLTHLKL TGNRALQSLI PSANFPELKI IEMPSAYQCC 480 AFGGCENVYK ISNQWNKDDG NSVDDLHKKD AGLFQVQDER DLEDFLLDFE EDLKALHSVQ 540 CSPSPGPFKP CEHLFGSWLI RIGVWTTAVL ALSCNALVAL TVFRTPLYIS SIKLLIGVIA 600 VVDILMGVSS AVLAAVDAFT FGRFAQHGAW WEDGIGCQIV GFLSIFASES SIFLLTLAAL 660 ERGFSVKCSS KFEVKAPLFS LRAIVLLCVL LALTIATIPL LGGSKYNASP LCLPLPFGEP 720 STTGYMVALV LLNSLCFLIM TIAYTKLYCS LEKGELENLW DCSMVKHIAL LLFANCILYC 780 PVAFLSFSSL LNLTFISPDV IKFILLVIVP LPSCLNPLLY IVFNPHFKED MGSLGKHTRF 840 WMRSKHASLL SINSDDVEKR SCESTQALVS FTHASIAYDL PSTSGASPAY PMTESCHLSS 900 VAFVPCL 907 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | ISO |
| GO:0004888 | transmembrane signaling receptor activity | IDA |
| GO:0008528 | G protein-coupled peptide receptor activity | IBA |
| GO:0016500 | protein-hormone receptor activity | IEA |
| GO:0004930 | G protein-coupled receptor activity | ISS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001942 | hair follicle development | IGI |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IBA |
| GO:0007190 | activation of adenylate cyclase activity | IBA |
| GO:0009755 | hormone-mediated signaling pathway | IBA |
| GO:0009994 | oocyte differentiation | IMP |
| GO:0042127 | regulation of cell population proliferation | IGI |
| GO:0048839 | inner ear development | IDA |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | ISO |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | IMP |
| GO:2001013 | epithelial cell proliferation involved in renal tubule morphogenesis | IGI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005887 | integral component of plasma membrane | ISS |
| GO:0005887 | integral component of plasma membrane | ISO |
| GO:0005887 | integral component of plasma membrane | IBA |
| GO:0032588 | trans-Golgi network membrane | ISS |
| GO:0032588 | trans-Golgi network membrane | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-195721 | Signaling by WNT | IEA |
| R-MMU-201681 | TCF dependent signaling in response to WNT | IEA |
| R-MMU-4641263 | Regulation of FZD by ubiquitination | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-1003 | Cell membrane |
| KW-1015 | Disulfide bond |
| KW-0297 | G-protein coupled receptor |
| KW-0325 | Glycoprotein |
| KW-0333 | Golgi apparatus |
| KW-0433 | Leucine-rich repeat |
| KW-0472 | Membrane |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0807 | Transducer |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |