| Tag | Content |
|---|---|
| Uniprot ID | Q9Z319; B2RRC6; Q566K6; |
| Entrez ID | 53419 |
| Genbank protein ID | AAH93485.1; AAI38341.1; EDL37819.1; AAI38340.1; BAA34371.1; |
| Genbank nucleotide ID | NM_016869.3; NM_001122756.1; |
| Ensembl protein ID | ENSMUSP00000005352; ENSMUSP00000127389; |
| Ensembl nucleotide ID | ENSMUSG00000005220 |
| Gene name | Atrial natriuretic peptide-converting enzyme |
| Gene symbol | Corin |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 6391574 |
| Functional description | Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. |
| Sequence | MGRVSFSVRV SSVRRARCSC PGRCYLSCRV PPTTALRALN GLGCAGVPGE TAGGAVGPGP 60 LGTRGFLSGS KFQAPGSWKD CFGAPPAPDV LRADRSVGEG CPQKLVTANL LRFLLLVLIP 120 CICALIVLLA ILLSFVGTLK RVYFKSNDSE PLVTDGEARV PGVIPVNTVY YENTGAPSLP 180 PSQSTPAWTP RAPSPEDQSH RNTSTCMNIT HSQCQILPYH STLAPLLPIV KNMDMEKFLK 240 FFTYLHRLSC YQHILLFGCS LAFPECVVDG DDRHGLLPCR SFCEAAKEGC ESVLGMVNSS 300 WPDSLRCSQF RDHTETNSSV RKSCFSLQQE HGKQSLCGGG ESFLCTSGLC VPKKLQCNGY 360 NDCDDWSDEA HCNCSKDLFH CGTGKCLHYS LLCDGYDDCG DLSDEQNCDC NLTKEHRCGD 420 GRCIAAEWVC DGDHDCVDKS DEVNCSCHSQ GLVECRSGQC IPSTFQCDGD EDCKDGSDEE 480 NCSDSQTPCP EGEQGCLGSS CVESCAGSSL CDSDSSLSNC SQCEPITLEL CMNLPYNHTH 540 YPNYLGHRTQ KEASISWESS LFPALVQTNC YKYLMFFACT ILVPKCDVNT GQRIPPCRLL 600 CEHSKERCES VLGIVGLQWP EDTDCNQFPE ESSDNQTCLL PNEDVEECSP SHFKCRSGRC 660 VLGSRRCDGQ ADCDDDSDEE NCGCKERALW ECPFNKQCLK HTLICDGFPD CPDSMDEKNC 720 SFCQDNELEC ANHECVPRDL WCDGWVDCSD SSDEWGCVTL SKNGNSSSLL TVHKSAKEHH 780 VCADGWRETL SQLACKQMGL GEPSVTKLIP GQEGQQWLRL YPNWENLNGS TLQELLVYRH 840 SCPSRSEISL LCSKQDCGRR PAARMNKRIL GGRTSRPGRW PWQCSLQSEP SGHICGCVLI 900 AKKWVLTVAH CFEGREDADV WKVVFGINNL DHPSGFMQTR FVKTILLHPR YSRAVVDYDI 960 SVVELSDDIN ETSYVRPVCL PSPEEYLEPD TYCYITGWGH MGNKMPFKLQ EGEVRIIPLE 1020 QCQSYFDMKT ITNRMICAGY ESGTVDSCMG DSGGPLVCER PGGQWTLFGL TSWGSVCFSK 1080 VLGPGVYSNV SYFVGWIERQ IYIQTFLQKK SQG 1113 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004252 | serine-type endopeptidase activity | ISS |
| GO:0004252 | serine-type endopeptidase activity | ISO |
| GO:0004252 | serine-type endopeptidase activity | IMP |
| GO:0005044 | scavenger receptor activity | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003050 | regulation of systemic arterial blood pressure by atrial natriuretic peptide | ISO |
| GO:0003050 | regulation of systemic arterial blood pressure by atrial natriuretic peptide | IMP |
| GO:0006897 | endocytosis | IEA |
| GO:0007565 | female pregnancy | ISO |
| GO:0007565 | female pregnancy | IMP |
| GO:0008217 | regulation of blood pressure | ISO |
| GO:0008217 | regulation of blood pressure | IMP |
| GO:0016486 | peptide hormone processing | ISO |
| GO:0016486 | peptide hormone processing | IMP |
| GO:0030182 | neuron differentiation | ISO |
| GO:0035813 | regulation of renal sodium excretion | ISO |
| GO:0035813 | regulation of renal sodium excretion | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | IEA |
| GO:0005886 | plasma membrane | ISO |
| GO:0005887 | integral component of plasma membrane | ISO |
| GO:0009986 | cell surface | IDA |
| GO:0015629 | actin cytoskeleton | ISO |
| GO:0016604 | nuclear body | ISO |
| GO:0031410 | cytoplasmic vesicle | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-397014 | Muscle contraction | IEA |
| R-MMU-5576891 | Cardiac conduction | IEA |
| R-MMU-5578768 | Physiological factors | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0025 | Alternative splicing |
| KW-1003 | Cell membrane |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0378 | Hydrolase |
| KW-0472 | Membrane |
| KW-0645 | Protease |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0964 | Secreted |
| KW-0720 | Serine protease |
| KW-0735 | Signal-anchor |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0865 | Zymogen |
| InterPro ID | InterPro Term |
|---|---|
| IPR017052 | Corin |
| IPR041762 | Corin_CRD_1 |
| IPR041763 | Corin_CRD_2 |
| IPR020067 | Frizzled_dom |
| IPR036790 | Frizzled_dom_sf |
| IPR036055 | LDL_receptor-like_sf |
| IPR023415 | LDLR_class-A_CS |
| IPR002172 | LDrepeatLR_classA_rpt |
| IPR009003 | Peptidase_S1_PA |
| IPR001190 | SRCR |
| IPR017448 | SRCR-like_dom |
| IPR036772 | SRCR-like_dom_sf |
| IPR001254 | Trypsin_dom |
| IPR033116 | TRYPSIN_SER |