ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

rCG_48149

Full Name:

RAB1B, member RAS oncogene family

Alias:

Rab1b

Organism:

Rattus norvegicus (Rat)

Chromosome:

1

Genetic Location:

1q43

Gene Type:

protein-coding

Human Ortholog:

This gene has no human ortholog.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		X13905
Fold Change:		8.1
Tissue:		Amygdala

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005622	intracellular	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005525	GTP binding	Molecular Function	IEA
GO:0008134	transcription factor binding	Molecular Function	IEA
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	IEA
GO:0007264	small GTPase mediated signal transduction	Biological Process	IEA
GO:0015031	protein transport	Biological Process	IEA

Other Database Cross Links

NCBI Entrez Gene:

RGD:

Ensembl:

dbSNP: