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Dataset Description
  • Dataset Name: 11772933
  • Species: Rat
  • Method: Microarray
  • No. of Genes: 30
  • Tissue: Frontal cortex and amygdala
  • Phenotype: Ethanol response
  • Publication: Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
  • Dataset Summary: Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

    Gene list of this dataset (30 genes)
    GeneIDSymbolNameGenetic locationOriginal ID1Original ID2
    29483Slc1a3solute carrier family 1 (glial high affinity glutamate transporter), member 32q16X63744 
    24176Adrb2adrenergic receptor, beta 218q12.1X17607 
    25248Cnr1cannabinoid receptor 1 (brain)5q21X55812 
    29253Maoamonoamine oxidase A-D00688 
    29627Gria2glutamate receptor, ionotropic, AMPA22q33M38061 
    50658Mapk9mitogen-activated protein kinase 910q22L27112 
    29431Pak1p21 (CDKN1A)-activated kinase 11q32NM_017198 
    116590Mapk1mitogen activated protein kinase 111q23M64300 
    81649Mapk14mitogen activated protein kinase 1420p12U73142 
    170851Map2k1mitogen activated protein kinase kinase 18q24L04485 
    81800St13suppression of tumorigenicity 137q34X82021 
    81005Nptxrneuronal pentraxin receptor7q34AF005099 
    89808Cx3cl1chemokine (C-X3-C motif) ligand 119p12AF030358 
    24708Rb1retinoblastoma 115q12D25233 
    81736Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1052q43L26267 
    64678Tfrctransferrin receptor11q22M58040 
    25390Atp1b3ATPase, Na+/K+ transporting, beta 3 polypeptide8q31D84450 
    25513Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)2q12U50412 
    24483Igf2insulin-like growth factor 21q41X17012 
    25662Igfbp2insulin-like growth factor binding protein 29q33M91595 
    100126191rCG_48149RAB1B, member RAS oncogene family1q43X13905 
    81005Nptxrneuronal pentraxin receptor7q34AF005099 
    25388Arrb2arrestin, beta 210q24M91590 
    84016Grip1glutamate receptor interacting protein 17q22U88572 
    89808Cx3cl1chemokine (C-X3-C motif) ligand 119p12AF030358 
    84050Enpp2ectonucleotide pyrophosphatase/phosphodiesterase 27q31D28560 
    29560Hif1ahypoxia inducible factor 1, alpha subunit6q24Y09507 
    29598Atp2b1ATPase, Ca++ transporting, plasma membrane 17q13J03753 
    29154Capn2calpain 213q26L09120