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Gene Information
Gene ID:25662
Full Name:insulin-like growth factor binding protein 2
Organism:Rattus norvegicus (Rat)
Genetic Location:9q33
Physical Location:71966872-71994205 on NC_005108.2
Gene Type:protein-coding
Human Ortholog:GeneID: 3485    Symbol (Name): IGFBP2 (insulin-like growth factor binding protein 2, 36kDa)
Ortholog Status:The human GeneID 3485 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:M91595
Fold Change:3.5
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_013122.2NP_037254.2NC_005108.2 range: 71966872..71994205
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005615extracellular spaceCellular ComponentISS
GO:0005576extracellular regionCellular ComponentIEA
GO:0005615extracellular spaceCellular ComponentIDA (9396554)
GO:0005615extracellular spaceCellular ComponentIMP (2538475)
GO:0016324apical plasma membraneCellular ComponentIDA (10842239)
GO:0031410cytoplasmic vesicleCellular ComponentIDA (15705658)
GO:0031995insulin-like growth factor II bindingMolecular FunctionIMP (2538475)
GO:0031994insulin-like growth factor I bindingMolecular FunctionIMP (2538475)
GO:0031995insulin-like growth factor II bindingMolecular FunctionIDA (1709938)
GO:0005520insulin-like growth factor bindingMolecular FunctionISS
GO:0032355response to estradiol stimulusBiological ProcessIEP (10842239)
GO:0032526response to retinoic acidBiological ProcessIEP (11880314)
GO:0032870cellular response to hormone stimulusBiological ProcessIEP (16720626)
GO:0042493response to drugBiological ProcessIEP (15613074)
GO:0043627response to estrogen stimulusBiological ProcessIEP (12801995)
GO:0048545response to steroid hormone stimulusBiological ProcessIEP (10842239)
GO:0001558regulation of cell growthBiological ProcessIEA
GO:0010226response to lithium ionBiological ProcessIEP (16738484)
GO:0009612response to mechanical stimulusBiological ProcessIEP (17308996)
GO:0007584response to nutrientBiological ProcessIEP (15576465)
GO:0007568agingBiological ProcessIEP (10191834)
GO:0007565female pregnancyBiological ProcessIEP (17123939)
GO:0007165signal transductionBiological ProcessIEP (11914028)
GO:0006950response to stressBiological ProcessIEP (16848927)
GO:0051384response to glucocorticoid stimulusBiological ProcessIEP (15705658)
Other Database Cross Links
NCBI Entrez Gene:25662