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Gene Information
Gene ID:81649
Symbol:Mapk14
Full Name:mitogen activated protein kinase 14
Alias:CSBP|CSPB1|Csbp1|Csbp2|Exip|Hog|MGC105413|Mxi2|Prkm14|Prkm15|RK|Sapk2A|p38|p38Hog|p38alpha
Organism:Rattus norvegicus (Rat)
Chromosome:20
Genetic Location:20p12
Physical Location:6939248-7000376 on NC_005119.2
Gene Type:protein-coding
Human Ortholog:GeneID: 1432    Symbol (Name): MAPK14 (mitogen-activated protein kinase 14)
Ortholog Status:The human GeneID 1432 is also in human dataset(s).
Gene in Ethanol Study Datasets
Gene Information
Original ID1:U73142
Fold Change:3.3
Tissue:Medial prefrontal (cingulate) cortex
Dataset Information
Name:11772933
Method:Microarray
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_031020.2NP_112282.2NC_005119.2 range: 6939248..7000376
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005634nucleusCellular ComponentIDA (16407200)
GO:0005623cellCellular ComponentISS
GO:0005634nucleusCellular ComponentISS
GO:0005737cytoplasmCellular ComponentISS
GO:0005829cytosolCellular ComponentIDA (9779826)
GO:0044445cytosolic partCellular ComponentIDA (16407200)
GO:0000922spindle poleCellular ComponentISS
GO:0016740transferase activityMolecular FunctionIEA
GO:0016301kinase activityMolecular FunctionISS
GO:0008339MP kinase activityMolecular FunctionISS
GO:0008022protein C-terminus bindingMolecular FunctionIDA (16407200)
GO:0005524ATP bindingMolecular FunctionIEA
GO:0005515protein bindingMolecular FunctionISS
GO:0004672protein kinase activityMolecular FunctionISS
GO:0000166nucleotide bindingMolecular FunctionIEA
GO:0004674protein serine/threonine kinase activityMolecular FunctionIEA
GO:0004707MAP kinase activityMolecular FunctionIDA (16407200)
GO:0004707MAP kinase activityMolecular FunctionIEA
GO:0004707MAP kinase activityMolecular FunctionISS
GO:0004707MAP kinase activityMolecular FunctionTAS (11687663)
GO:0046777protein amino acid autophosphorylationBiological ProcessIDA (16407200)
GO:0045944positive regulation of transcription from RNA polymerase II promoterBiological ProcessISS
GO:0019395fatty acid oxidationBiological ProcessISS
GO:0031663lipopolysaccharide-mediated signaling pathwayBiological ProcessISS
GO:0032495response to muramyl dipeptideBiological ProcessISS
GO:0032496response to lipopolysaccharideBiological ProcessISS
GO:0045648positive regulation of erythrocyte differentiationBiological ProcessISS
GO:0000077DNA damage checkpointBiological ProcessISS
GO:0007519skeletal muscle developmentBiological ProcessISS
GO:0001525angiogenesisBiological ProcessISS
GO:0002062chondrocyte differentiationBiological ProcessISS
GO:0006006glucose metabolic processBiological ProcessISS
GO:0006468protein amino acid phosphorylationBiological ProcessIDA (16407200)
GO:0006468protein amino acid phosphorylationBiological ProcessISS
GO:0006468protein amino acid phosphorylationBiological ProcessTAS (9779826)
GO:0006950response to stressBiological ProcessISS
GO:0007243protein kinase cascadeBiological ProcessISS
GO:0007243protein kinase cascadeBiological ProcessTAS (9779826)
GO:0051403stress-activated MAPK cascadeBiological ProcessIDA (16407200)
Other Database Cross Links
NCBI Entrez Gene:81649
RGD:70496
Ensembl:ENSRNOG00000000513
dbSNP:Mapk14