ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

81649

Symbol:

Mapk14

Full Name:

mitogen activated protein kinase 14

Alias:

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

20p12

Physical Location:

6939248-7000376 on NC_005119.2

Gene Type:

protein-coding

Human Ortholog:

GeneID: 1432 Symbol (Name): MAPK14 (mitogen-activated protein kinase 14)

Ortholog Status:

The human GeneID 1432 is also in human dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		U73142
Fold Change:		3.3
Tissue:		Medial prefrontal (cingulate) cortex

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_031020.2	NP_112282.2	NC_005119.2 range: 6939248..7000376

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005634	nucleus	Cellular Component	IDA (16407200)
GO:0005623	cell	Cellular Component	ISS
GO:0005634	nucleus	Cellular Component	ISS
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005829	cytosol	Cellular Component	IDA (9779826)
GO:0044445	cytosolic part	Cellular Component	IDA (16407200)
GO:0000922	spindle pole	Cellular Component	ISS
GO:0016740	transferase activity	Molecular Function	IEA
GO:0016301	kinase activity	Molecular Function	ISS
GO:0008339	MP kinase activity	Molecular Function	ISS
GO:0008022	protein C-terminus binding	Molecular Function	IDA (16407200)
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	ISS
GO:0004672	protein kinase activity	Molecular Function	ISS
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004707	MAP kinase activity	Molecular Function	IDA (16407200)
GO:0004707	MAP kinase activity	Molecular Function	IEA
GO:0004707	MAP kinase activity	Molecular Function	ISS
GO:0004707	MAP kinase activity	Molecular Function	TAS (11687663)
GO:0046777	protein amino acid autophosphorylation	Biological Process	IDA (16407200)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	ISS
GO:0019395	fatty acid oxidation	Biological Process	ISS
GO:0031663	lipopolysaccharide-mediated signaling pathway	Biological Process	ISS
GO:0032495	response to muramyl dipeptide	Biological Process	ISS
GO:0032496	response to lipopolysaccharide	Biological Process	ISS
GO:0045648	positive regulation of erythrocyte differentiation	Biological Process	ISS
GO:0000077	DNA damage checkpoint	Biological Process	ISS
GO:0007519	skeletal muscle development	Biological Process	ISS
GO:0001525	angiogenesis	Biological Process	ISS
GO:0002062	chondrocyte differentiation	Biological Process	ISS
GO:0006006	glucose metabolic process	Biological Process	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	IDA (16407200)
GO:0006468	protein amino acid phosphorylation	Biological Process	ISS
GO:0006468	protein amino acid phosphorylation	Biological Process	TAS (9779826)
GO:0006950	response to stress	Biological Process	ISS
GO:0007243	protein kinase cascade	Biological Process	ISS
GO:0007243	protein kinase cascade	Biological Process	TAS (9779826)
GO:0051403	stress-activated MAPK cascade	Biological Process	IDA (16407200)