ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

MAPK14

Full Name:

mitogen-activated protein kinase 14

Alias:

Organism:

Homo sapiens (Human)

Chromosome:

Genetic Location:

6p21.3-p21.2

Physical Location:

36103550-36186512 on NC_000006.10

Gene Type:

protein-coding

Orthologs:

This gene has Rat: 81649 ortholog(s) in other dataset(s).

Gene in Ethanol Study Datasets

Gene Information

Original ID1:

MAPK14

Dataset Information

Name:		18477577
Method:		Addiction array gene list
Publication:		Hodgkinson et al. Alcohol Alcohol. (2008) Addictions Biology: Haplotype-Based Analysis for 130 Candidate Genes on a Single Array. PubMed
Summary:		To develop a panel of markers able to extract full haplotype information for candidate genes in alcoholism, other addictions and disorders of mood and anxiety. Methods: A total of 130 genes were haplotype tagged and genotyped in 7 case/control populations and 51 reference populations using Illumina GoldenGate SNP genotyping technology, determining haplotype coverage. The 130 candidate genes were selected on the basis of their roles in functional domains important in the addictions and in the related phenotypes of anxiety and depression. The candidate genes included a limited number involved in the pharmacokinetic domain (e.g. several genes in the ADH gene cluster, and ALDH genes). The majority of the genes represent the domains of vulnerability to drug use and pharmacodynamic response. These include dopamine, serotonin, glutamine, GABA, and opioid neurotransmitter genes, signaling genes, and genes modulating stress resiliency and behavioral dyscontrol domains. There is a high degree of overlap between functional gene categories because of pleiotropic actions of molecules on behavior.

Gene Refseq Sequence Annotation

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005829	cytosol	Cellular Component	EXP (9687510)
GO:0005737	cytoplasm	Cellular Component	ISS
GO:0005654	nucleoplasm	Cellular Component	EXP (8846784)
GO:0005634	nucleus	Cellular Component	ISS
GO:0008339	MP kinase activity	Molecular Function	IDA (7997261)
GO:0000166	nucleotide binding	Molecular Function	IEA
GO:0005524	ATP binding	Molecular Function	IEA
GO:0005515	protein binding	Molecular Function	IPI (9792677\|12761180\|16189514\|16636664\|16751104)
GO:0004674	protein serine/threonine kinase activity	Molecular Function	EXP (8846784\|9687510)
GO:0016740	transferase activity	Molecular Function	IEA
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IEA
GO:0004707	MAP kinase activity	Molecular Function	IEA
GO:0004708	MAP kinase kinase activity	Molecular Function	TAS (10706854)
GO:0006468	protein amino acid phosphorylation	Biological Process	IEA
GO:0006928	cell motility	Biological Process	TAS (10912793)
GO:0006950	response to stress	Biological Process	IDA (7997261)
GO:0007166	cell surface receptor linked signal transduction	Biological Process	TAS (10706854)
GO:0007243	protein kinase cascade	Biological Process	IDA (10838079)
GO:0007265	Ras protein signal transduction	Biological Process	EXP (11520933)
GO:0006935	chemotaxis	Biological Process	TAS (10706854)