ERGR - Ethanol-Related Gene Resource

Gene Information

Gene ID:

Symbol:

Cx3cl1

Full Name:

chemokine (C-X3-C motif) ligand 1

Alias:

Cx3c|Scyd1

Organism:

Rattus norvegicus (Rat)

Chromosome:

Genetic Location:

19p12

Physical Location:

10666939-10676423 on NC_005118.2, complement

Gene Type:

protein-coding

Human Ortholog:

GeneID: 6376 Symbol (Name): CX3CL1 (chemokine (C-X3-C motif) ligand 1)

Ortholog Status:

The human GeneID 6376 is not in current human dataset.

Gene in Ethanol Study Datasets

Gene Information

Original ID1:		AF030358
Fold Change:		3.9
Tissue:		Medial prefrontal (cingulate) cortex

Gene Information

Dataset Information

Name:		11772933
Method:		Microarray
Tissue:		Frontal cortex and amygdala
Phenotype:		Ethanol response
Publication:		Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:		Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.

Gene Refseq Sequence Annotation

mRNA	Protein	Reference assembly Genomic
NM_134455.1	NP_604450.1	NC_005118.2 range: 10666939..10676423, complement

Gene Ontology (GO) Annotation

GO ID	GO Term	Category	Evidence (PubMed)
GO:0005576	extracellular region	Cellular Component	IEA
GO:0005576	extracellular region	Cellular Component	ISS
GO:0005615	extracellular space	Cellular Component	IEA
GO:0005886	plasma membrane	Cellular Component	IEA
GO:0016021	integral to membrane	Cellular Component	ISS
GO:0016021	integral to membrane	Cellular Component	IEA
GO:0009986	cell surface	Cellular Component	ISS
GO:0009986	cell surface	Cellular Component	IEA
GO:0005515	protein binding	Molecular Function	IEA
GO:0008009	chemokine activity	Molecular Function	IEA
GO:0008009	chemokine activity	Molecular Function	IDA (9724801)
GO:0007155	cell adhesion	Biological Process	IEA
GO:0006955	immune response	Biological Process	IEA
GO:0006935	chemotaxis	Biological Process	IDA (9724801)
GO:0050729	positive regulation of inflammatory response	Biological Process	IEA
GO:0050729	positive regulation of inflammatory response	Biological Process	ISS
GO:0051041	positive regulation of calcium-independent cell-cell adhesion	Biological Process	IEA
GO:0051041	positive regulation of calcium-independent cell-cell adhesion	Biological Process	ISS