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Gene Information
Gene ID:89808
Full Name:chemokine (C-X3-C motif) ligand 1
Organism:Rattus norvegicus (Rat)
Genetic Location:19p12
Physical Location:10666939-10676423 on NC_005118.2, complement
Gene Type:protein-coding
Human Ortholog:GeneID: 6376    Symbol (Name): CX3CL1 (chemokine (C-X3-C motif) ligand 1)
Ortholog Status:The human GeneID 6376 is not in current human dataset.
Gene in Ethanol Study Datasets
Gene Information
Original ID1:AF030358
Fold Change:3.9
Tissue:Medial prefrontal (cingulate) cortex
Gene Information
Original ID1:AF030358
Fold Change:2.7
Dataset Information
Tissue:Frontal cortex and amygdala
Phenotype:Ethanol response
Publication:Rimondini et al FASEB J. (2002) Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol. PubMed
Summary:Here we demonstrate that rats subjected to repeated cycles of intoxication and withdrawal develop a marked and long-lasting increase in voluntary ethanol intake. Exposure-induced but not spontaneous alcohol intake is antagonized by acamprosate, a compound clinically effective in human alcoholism. Expression analysis of cingulate cortex and amygdala reveals a set of long-term up-regulated transcripts in this model. Here lists the gene expression changes 3 wk after termination of 7 wk of intermittent ethanol exposure. Fold change values are ethanol exposed vs. control rats.
Gene Refseq Sequence Annotation
mRNAProteinReference assembly Genomic
NM_134455.1NP_604450.1NC_005118.2 range: 10666939..10676423, complement
Gene Ontology (GO) Annotation
GO IDGO TermCategoryEvidence (PubMed)
GO:0005576extracellular regionCellular ComponentIEA
GO:0005576extracellular regionCellular ComponentISS
GO:0005615extracellular spaceCellular ComponentIEA
GO:0005886plasma membraneCellular ComponentIEA
GO:0016021integral to membraneCellular ComponentISS
GO:0016021integral to membraneCellular ComponentIEA
GO:0009986cell surfaceCellular ComponentISS
GO:0009986cell surfaceCellular ComponentIEA
GO:0005515protein bindingMolecular FunctionIEA
GO:0008009chemokine activityMolecular FunctionIEA
GO:0008009chemokine activityMolecular FunctionIDA (9724801)
GO:0007155cell adhesionBiological ProcessIEA
GO:0006955immune responseBiological ProcessIEA
GO:0006935chemotaxisBiological ProcessIDA (9724801)
GO:0050729positive regulation of inflammatory responseBiological ProcessIEA
GO:0050729positive regulation of inflammatory responseBiological ProcessISS
GO:0051041positive regulation of calcium-independent cell-cell adhesionBiological ProcessIEA
GO:0051041positive regulation of calcium-independent cell-cell adhesionBiological ProcessISS
Other Database Cross Links
NCBI Entrez Gene:89808